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PGR Gene Record

  • Summary
  • Interactions
  • Claims
  • PGR 5241 Druggable Genome

    Alternate Names:

    5241
    PROGESTERONE RECEPTOR
    PGR
    NR3C3
    PR
    607311
    8910
    ENSG00000082175
    OTTHUMG00000167531
    Nuclear receptor subfamily 3 group C member 3
    P06401
    PRGR_HUMAN
    PROGESTERONE RECEPTOR (PR). [SOURCE:UNIPROT/SWISSPROT;ACC:P06401]
    PA266
    T22939

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Initial Gene Query NR3C3
    Counted Citations from 1950-2000 9831
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Acc IPR000536
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Helguero et al., 2003, Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment., Breast Cancer Res. Treat.
    Luconi et al., 1998, Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane., J. Clin. Endocrinol. Metab.
    Boonyaratanakornkit et al., 2007, The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle., Mol. Endocrinol.
    Gizard et al., 2006, TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone., Mol. Cell. Biol.
    Madauss et al., 2007, The evolution of progesterone receptor ligands., Med Res Rev
    Tranguch et al., 2006, Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation., Reprod. Biomed. Online
    Wu et al., 2006, Progesterone receptors activation after acute cocaine administration., Brain Res.
    Alvarez LD et al., 2011, Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone., Bioorg Med Chem
    Okada H et al., 2018, Decidualization of the human endometrium., Reprod Med Biol
    Sitruk-Ware, 2004, New progestogens: a review of their effects in perimenopausal and postmenopausal women., Drugs Aging
    Bray et al., 2005, Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells., J. Steroid Biochem. Mol. Biol.
    Arias-Loza et al., 2006, Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats., Hypertension
    Krattenmacher, 2000, Drospirenone: pharmacology and pharmacokinetics of a unique progestogen., Contraception
    Sitruk-Ware, New progestagens for contraceptive use., Hum. Reprod. Update
    Fuhrmann et al., 1996, The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential., Contraception
    Muhn et al., 1995, Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity., Ann. N. Y. Acad. Sci.
    London et al., 1992, Comparative contraceptive efficacy and mechanism of action of the norgestimate-containing triphasic oral contraceptive., Acta Obstet Gynecol Scand Suppl
    Juchem et al., 1993, Receptor binding of norgestimate--a new orally active synthetic progestational compound., Contraception
    Graziottin, 2006, A review of transdermal hormonal contraception : focus on the ethinylestradiol/norelgestromin contraceptive patch., Treat Endocrinol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kuhnz et al., 1995, Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor., Contraception
    Hompes et al., 2007, Endometriosis: the way forward., Gynecol. Endocrinol.
    Mirkin et al., 2005, Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells., Fertil. Steril.
    Maruo et al., 2007, Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas., Contraception
    Creinin et al., 2006, Progesterone receptor modulator for emergency contraception: a randomized controlled trial., Obstet Gynecol
    Gemzell-Danielsson et al., 2013, Emergency contraception., Gynecol. Endocrinol.
    Madauss et al., 2004, Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes., J. Med. Chem.
    Mendoza-Rodríguez et al., 1999, Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites., Contraception
    García-Becerra et al., 2004, Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins., J. Steroid Biochem. Mol. Biol.
    Pasapera et al., 1995, Norethisterone metabolites modulate the uteroglobin and progesterone receptor gene expression in prepubertal rabbits., Biol. Reprod.
    Sitruk-Ware, 2004, Pharmacological profile of progestins., Maturitas
    Charnock-Jones et al., 2000, The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium., Hum. Reprod.
    Macpherson et al., 1999, The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium., Hum. Reprod.
    Tamaya et al., 1977, Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus., Endocrinology
    Briggs, 1975, Contraceptive steroid binding to the human uterine progesterone-receptor., Curr Med Res Opin
    Kloosterboer et al., 1988, Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives., Contraception
    Bergink et al., 1983, Binding of progestagens to receptor proteins in MCF-7 cells., J. Steroid Biochem.
    Fuhrmann et al., 1995, Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays., Contraception
    Hammond et al., 2001, Preclinical profiles of progestins used in formulations of oral contraceptives and hormone replacement therapy., Am. J. Obstet. Gynecol.
    Sun et al., 1998, [Effect of mifepristone on the expression of progesterone receptor messenger RNA and protein in uterine leiomyomata]., Zhonghua Fu Chan Ke Za Zhi
    Hazra et al., 2000, Synthesis of 11beta-(4-dimethylaminophenyl)-17beta-hydroxy-17alpha- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11beta-(4-acetophenyl)- 17beta-hydroxy-17alpha-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486)., Steroids
    Jiang et al., 2001, [Effects of mifepristone on expression of estrogen receptor and progesterone receptor in cultured human eutopic and ectopic endometria]., Zhonghua Fu Chan Ke Za Zhi
    Greb et al., 1999, Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium., Hum. Reprod.
    Gao et al., 1998, [Failure of mifepristone induced interruption of pregnancy: point mutation at genetic codon 722 in human progesterone receptor gene]., Zhonghua Fu Chan Ke Za Zhi
    Grenman et al., 1987, In vitro effects of tamoxifen on UM-SCC head and neck cancer cell lines: correlation with the estrogen and progesterone receptor content., Int. J. Cancer
    Pasqualini, 2009, Breast cancer and steroid metabolizing enzymes: the role of progestogens., Maturitas
    Benagiano G et al., 2004, Clinical profile of contraceptive progestins., Eur J Contracept Reprod Health Care
    Sasagawa et al., 2008, Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile., Steroids
    Tamaya et al., 1979, Chromatin transcription by progesterone-receptor complex in rabbit uterus., Endocrinol. Jpn.
    Raghupathy et al., 2005, Modulation of cytokine production by dydrogesterone in lymphocytes from women with recurrent miscarriage., BJOG
    Tamaya et al., 1983, Nuclear translocation of progesterone receptor--progestogen complex in vitro., Nippon Sanka Fujinka Gakkai Zasshi
    Blois et al., 2004, Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile., J. Immunol.
    Okada, 1993, [Metabolism, structure and biological activity of sex steroids]., Nihon Naibunpi Gakkai Zasshi
    Renoir et al., 1992, [Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?]., C. R. Acad. Sci. III, Sci. Vie
    Schubert G et al., 2005, Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11beta-benzaldoxime substituted selective progesterone receptor modulators (SPRMs)., Semin Reprod Med
    Chwalisz K et al., 2005, Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis., Endocr Rev
    Huang et al., 1994, [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]., Zhongguo Zhong Xi Yi Jie He Za Zhi
    Beaumont et al., 2007, Danazol for heavy menstrual bleeding., Cochrane Database Syst Rev
    Dmowski, 1990, Danazol. A synthetic steroid with diverse biologic effects., J Reprod Med
    Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett
    Valavaara et al., 1990, Predictive value of tumor estrogen and progesterone receptor levels in postmenopausal women with advanced breast cancer treated with toremifene., Cancer
  • ULIPRISTAL   PGR

    Interaction Score: 6.06

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Trial Name Ulipristal
    Novel drug target Established target
    Mechanism of Interaction Progesterone receptor modulator

    PMIDs:
    23437846


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • DYDROGESTERONE   PGR

    Interaction Score: 4.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    436795 16045524 6827166 11752352 15128769 8486204


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • LEVONORGESTREL   PGR

    Interaction Score: 4.04

    Interaction Types & Directionality:
    agonist (activating)
    binder
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor agonist
    Trial Name SOH-075,NorLevo

    PMIDs:
    16157482 17484506 16084894 17531625 17077229 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ASOPRISNIL   PGR

    Interaction Score: 3.64

    Interaction Types & Directionality:
    antagonist (inhibitory)
    modulator

    Interaction Info:
    Mechanism of Interaction Progesterone receptor modulator
    Direct Interaction yes

    PMIDs:
    15714390 15857972


    Sources:
    ChemblInteractions

  • NORGESTIMATE   PGR

    Interaction Score: 3.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    1324557 8384965 17107221 11752352 7750291


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • DESOGESTREL   PGR

    Interaction Score: 3.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    3139361 11041225 6645495 10601100 11752352 7750284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • DROSPIRENONE   PGR

    Interaction Score: 3.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor agonist
    Trial Name drospirenone plus estradiol,Angeliq

    PMIDs:
    15493951 16157482 17000933 11024226 16291771 8922878 7625729


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • NORELGESTROMIN   PGR

    Interaction Score: 2.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name norelgestromin/ethinyl estradiol,Ortho Evra
    Novel drug target Established target
    Mechanism of Interaction Progesterone receptor agonist

    PMIDs:
    1324557 7750291 19962254 8384965 17107221


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ONAPRISTONE   PGR

    Interaction Score: 2.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ETONOGESTREL   PGR

    Interaction Score: 2.42

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name etonogestrel implant,Implanon
    Novel drug target Established target
    Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

    PMIDs:
    11041225 15063480 10601100 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • MEGESTROL   PGR

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND TTD

  • ETHYNODIOL DIACETATE   PGR

    Interaction Score: 1.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes

    PMIDs:
    858280 11752352 166800


    Sources:
    ChemblInteractions

  • NORETHINDRONE   PGR

    Interaction Score: 1.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Warner
    Novel drug target Established target
    Trial Name -

    PMIDs:
    15189034 16084894 11752352 10494488 15261304 7711211 15063480


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • TOSAGESTIN   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PF-05019702   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VILAPRISAN   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LONAPRISAN   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIENOGEST   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name estradiol valerate + dienogest,Natazia, Qlaira
    Novel drug target Established target

    PMIDs:
    18061638


    Sources:
    TdgClinicalTrial

  • PROGESTOGEN   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name oral contraceptive,Pill-Plus
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • GESTODENE   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    activator (activating)
    binder

    Interaction Info:
    Trial Name contraceptive patch, ethinylestradiol + gestodene,FC Patch Fidencia
    Novel drug target Established target

    PMIDs:
    15697108


    Sources:
    TdgClinicalTrial

  • ULIPRISTAL ACETATE   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TELAPRISTONE ACETATE   PGR

    Interaction Score: 1.21

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL2059711   PGR

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24915879


    Sources:
    DTC

  • NORGESTREL   PGR

    Interaction Score: 0.81

    Interaction Types & Directionality:
    agonist (activating)
    binder

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Progesterone receptor agonist

    PMIDs:
    11521119


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • NORETHYNODREL   PGR

    Interaction Score: 0.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NORETHINDRONE ACETATE   PGR

    Interaction Score: 0.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MIFEPRISTONE   PGR

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor antagonist
    Direct Interaction yes
    Trial Name Mifepristone, RU486

    PMIDs:
    10682471 10699595 11783365 10374120 11752352 10806733


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • GOSERELIN   PGR

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ERIBULIN   PGR

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • DANAZOL   PGR

    Interaction Score: 0.38

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes

    PMIDs:
    8000225 17636649 18061638 2404115


    Sources:
    ChemblInteractions

  • TOREMIFENE   PGR

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2147123


    Sources:
    NCI

  • MEDROXYPROGESTERONE ACETATE   PGR

    Interaction Score: 0.35

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor agonist

    PMIDs:
    12846422


    Sources:
    ChemblInteractions NCI TTD

  • PERTUZUMAB   PGR

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • HYDROXYPROGESTERONE CAPROATE   PGR

    Interaction Score: 0.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Progesterone receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEGESTROL ACETATE   PGR

    Interaction Score: 0.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Progesterone receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ANASTROZOLE   PGR

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers PharmGKB FDA

  • LETROZOLE   PGR

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationBiomarkers PharmGKB FDA

  • PROGESTERONE   PGR

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name BHR-100
    Novel drug target Established target
    Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

    PMIDs:
    9506743 17138644 17015480 17013809 17169175 17109827 21315613 30013421


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • NERATINIB   PGR

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • FULVESTRANT   PGR

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • EXEMESTANE   PGR

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • RIBOCICLIB   PGR

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • IXABEPILONE   PGR

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TRASTUZUMAB   PGR

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • TAMOXIFEN   PGR

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3793272


    Sources:
    ClearityFoundationBiomarkers NCI PharmGKB FDA

  • OLAPARIB   PGR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • LAPATINIB   PGR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ABEMACICLIB   PGR

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SIROLIMUS   PGR

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1284044


    Sources:
    NCI

  • DOCETAXEL   PGR

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • PALBOCICLIB   PGR

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000082175

    • Version: 101_38

    Alternate Names:
    PGR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P06401

    • Version: 01-August-2011

    Alternate Names:
    PRGR_HUMAN Uniprot Id
    ENSG00000082175 Ensembl Gene Id
    P06401 Uniprot Accession

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • BaderLabGenes: PGR

    • Version: February-2014

    Alternate Names:
    5241 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR3C3
    Counted Citations from 1950-2000 9831

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: P06401

    • Version: 11-September-2012

    Alternate Names:
    P06401 Uniprot Accession
    PRGR_HUMAN Uniprot Id
    5241 Entrez Gene Id

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Interpro Acc IPR000536
    Interpro Type Domain

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P06401

    • Version: January-2014

    Alternate Names:
    PGR Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • RussLampel: ENSG00000082175

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000082175 Ensembl Gene Id
    PGR Display Id
    PROGESTERONE RECEPTOR (PR). [SOURCE:UNIPROT/SWISSPROT;ACC:P06401] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: PGR

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Grenman et al., 1987, In vitro effects of tamoxifen on UM-SCC head and neck cancer cell lines: correlation with the estrogen and progesterone receptor content., Int. J. Cancer
    Valavaara et al., 1990, Predictive value of tumor estrogen and progesterone receptor levels in postmenopausal women with advanced breast cancer treated with toremifene., Cancer
    Helguero et al., 2003, Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment., Breast Cancer Res. Treat.

  • DTC: PGR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett
    Alvarez LD et al., 2011, Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone., Bioorg Med Chem

  • ChemblInteractions: NR3C3

    • Version: chembl_23

    Alternate Names:
    NR3C3 GENE_SYMBOL
    PGR GENE_SYMBOL
    Progesterone receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000082175

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000082175 Gene Symbol
    PGR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: PGR

    • Version: 18-August-2020

    Alternate Names:
    PA266 PharmGKB ID

    Gene Info:

    Publications:

  • GO: PGR

    • Version: 01-February-2022

    Alternate Names:
    NR3C3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: PGR

    • Version: 27-Jun-2013

    Alternate Names:
    5241 Gene ID
    NR3C3 dGene Synonym
    PR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Progesterone receptor

    • Version: 2020.06.01

    Alternate Names:
    PGR TTD Gene Abbreviation
    T22939 TTD Target ID

    Gene Info:

    Publications:

  • ClearityFoundationBiomarkers: PGR

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • FDA: PGR

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21