DGIdb - PGR Gene Record

PGR 5241 Druggable Genome

Alternate Names:

5241
PROGESTERONE RECEPTOR
PGR
NR3C3
PR
607311
8910
ENSG00000082175
OTTHUMG00000167531
Nuclear receptor subfamily 3 group C member 3
P06401
PRGR_HUMAN
PROGESTERONE RECEPTOR (PR). [SOURCE:UNIPROT/SWISSPROT;ACC:P06401]
PA266
T22939

Gene Info:

Target Class	Receptors
Target Subclass	Nuclear receptor
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Initial Gene Query	NR3C3
Counted Citations from 1950-2000	9831
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Interpro Acc	IPR000536
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME

Publications:

Helguero et al., 2003, Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment., Breast Cancer Res. Treat.
Luconi et al., 1998, Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane., J. Clin. Endocrinol. Metab.
Boonyaratanakornkit et al., 2007, The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle., Mol. Endocrinol.
Gizard et al., 2006, TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone., Mol. Cell. Biol.
Madauss et al., 2007, The evolution of progesterone receptor ligands., Med Res Rev
Tranguch et al., 2006, Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation., Reprod. Biomed. Online
Wu et al., 2006, Progesterone receptors activation after acute cocaine administration., Brain Res.
Alvarez LD et al., 2011, Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone., Bioorg Med Chem
Okada H et al., 2018, Decidualization of the human endometrium., Reprod Med Biol
Sitruk-Ware, 2004, New progestogens: a review of their effects in perimenopausal and postmenopausal women., Drugs Aging
Bray et al., 2005, Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells., J. Steroid Biochem. Mol. Biol.
Arias-Loza et al., 2006, Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats., Hypertension
Krattenmacher, 2000, Drospirenone: pharmacology and pharmacokinetics of a unique progestogen., Contraception
Sitruk-Ware, New progestagens for contraceptive use., Hum. Reprod. Update
Fuhrmann et al., 1996, The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential., Contraception
Muhn et al., 1995, Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity., Ann. N. Y. Acad. Sci.
London et al., 1992, Comparative contraceptive efficacy and mechanism of action of the norgestimate-containing triphasic oral contraceptive., Acta Obstet Gynecol Scand Suppl
Juchem et al., 1993, Receptor binding of norgestimate--a new orally active synthetic progestational compound., Contraception
Graziottin, 2006, A review of transdermal hormonal contraception : focus on the ethinylestradiol/norelgestromin contraceptive patch., Treat Endocrinol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kuhnz et al., 1995, Comparative progestational activity of norgestimate, levonorgestrel-oxime and levonorgestrel in the rat and binding of these compounds to the progesterone receptor., Contraception
Hompes et al., 2007, Endometriosis: the way forward., Gynecol. Endocrinol.
Mirkin et al., 2005, Effect of 17 beta-estradiol, progesterone, synthetic progestins, tibolone, and tibolone metabolites on vascular endothelial growth factor mRNA in breast cancer cells., Fertil. Steril.
Maruo et al., 2007, Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas., Contraception
Creinin et al., 2006, Progesterone receptor modulator for emergency contraception: a randomized controlled trial., Obstet Gynecol
Gemzell-Danielsson et al., 2013, Emergency contraception., Gynecol. Endocrinol.
Madauss et al., 2004, Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes., J. Med. Chem.
Mendoza-Rodríguez et al., 1999, Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites., Contraception
García-Becerra et al., 2004, Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins., J. Steroid Biochem. Mol. Biol.
Pasapera et al., 1995, Norethisterone metabolites modulate the uteroglobin and progesterone receptor gene expression in prepubertal rabbits., Biol. Reprod.
Sitruk-Ware, 2004, Pharmacological profile of progestins., Maturitas
Charnock-Jones et al., 2000, The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium., Hum. Reprod.
Macpherson et al., 1999, The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium., Hum. Reprod.
Tamaya et al., 1977, Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus., Endocrinology
Briggs, 1975, Contraceptive steroid binding to the human uterine progesterone-receptor., Curr Med Res Opin
Kloosterboer et al., 1988, Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives., Contraception
Bergink et al., 1983, Binding of progestagens to receptor proteins in MCF-7 cells., J. Steroid Biochem.
Fuhrmann et al., 1995, Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays., Contraception
Hammond et al., 2001, Preclinical profiles of progestins used in formulations of oral contraceptives and hormone replacement therapy., Am. J. Obstet. Gynecol.
Sun et al., 1998, [Effect of mifepristone on the expression of progesterone receptor messenger RNA and protein in uterine leiomyomata]., Zhonghua Fu Chan Ke Za Zhi
Hazra et al., 2000, Synthesis of 11beta-(4-dimethylaminophenyl)-17beta-hydroxy-17alpha- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11beta-(4-acetophenyl)- 17beta-hydroxy-17alpha-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486)., Steroids
Jiang et al., 2001, [Effects of mifepristone on expression of estrogen receptor and progesterone receptor in cultured human eutopic and ectopic endometria]., Zhonghua Fu Chan Ke Za Zhi
Greb et al., 1999, Disparate actions of mifepristone (RU 486) on glands and stroma in the primate endometrium., Hum. Reprod.
Gao et al., 1998, [Failure of mifepristone induced interruption of pregnancy: point mutation at genetic codon 722 in human progesterone receptor gene]., Zhonghua Fu Chan Ke Za Zhi
Grenman et al., 1987, In vitro effects of tamoxifen on UM-SCC head and neck cancer cell lines: correlation with the estrogen and progesterone receptor content., Int. J. Cancer
Pasqualini, 2009, Breast cancer and steroid metabolizing enzymes: the role of progestogens., Maturitas
Benagiano G et al., 2004, Clinical profile of contraceptive progestins., Eur J Contracept Reprod Health Care
Sasagawa et al., 2008, Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile., Steroids
Tamaya et al., 1979, Chromatin transcription by progesterone-receptor complex in rabbit uterus., Endocrinol. Jpn.
Raghupathy et al., 2005, Modulation of cytokine production by dydrogesterone in lymphocytes from women with recurrent miscarriage., BJOG
Tamaya et al., 1983, Nuclear translocation of progesterone receptor--progestogen complex in vitro., Nippon Sanka Fujinka Gakkai Zasshi
Blois et al., 2004, Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile., J. Immunol.
Okada, 1993, [Metabolism, structure and biological activity of sex steroids]., Nihon Naibunpi Gakkai Zasshi
Renoir et al., 1992, [Effect of immunosuppressants FK506 and rapamycin on the function of progesterone receptor: protein "p59-HBI", intersection between immunology and endocrinology?]., C. R. Acad. Sci. III, Sci. Vie
Schubert G et al., 2005, Discovery, chemistry, and reproductive pharmacology of asoprisnil and related 11beta-benzaldoxime substituted selective progesterone receptor modulators (SPRMs)., Semin Reprod Med
Chwalisz K et al., 2005, Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis., Endocr Rev
Huang et al., 1994, [Effects of gossypol acetate, danazol, progesterone and GnRH-A on estrogen and progesterone receptors of human endometrial cells]., Zhongguo Zhong Xi Yi Jie He Za Zhi
Beaumont et al., 2007, Danazol for heavy menstrual bleeding., Cochrane Database Syst Rev
Dmowski, 1990, Danazol. A synthetic steroid with diverse biologic effects., J Reprod Med
Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett
Valavaara et al., 1990, Predictive value of tumor estrogen and progesterone receptor levels in postmenopausal women with advanced breast cancer treated with toremifene., Cancer

ULIPRISTAL PGR

Interaction Score: 6.06

Interaction Types & Directionality:

modulator

Interaction Info:

Trial Name Ulipristal

Novel drug target Established target

Mechanism of Interaction Progesterone receptor modulator

PMIDs:
23437846

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DYDROGESTERONE PGR

Interaction Score: 4.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
436795 16045524 6827166 11752352 15128769 8486204

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
LEVONORGESTREL PGR

Interaction Score: 4.04

Interaction Types & Directionality:

agonist (activating)

binder

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name SOH-075,NorLevo

PMIDs:
16157482 17484506 16084894 17531625 17077229 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ASOPRISNIL PGR

Interaction Score: 3.64

Interaction Types & Directionality:

antagonist (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Progesterone receptor modulator

Direct Interaction yes

PMIDs:
15714390 15857972

Sources:
ChemblInteractions
NORGESTIMATE PGR

Interaction Score: 3.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
1324557 8384965 17107221 11752352 7750291

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DESOGESTREL PGR

Interaction Score: 3.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
3139361 11041225 6645495 10601100 11752352 7750284

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DROSPIRENONE PGR

Interaction Score: 3.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name drospirenone plus estradiol,Angeliq

PMIDs:
15493951 16157482 17000933 11024226 16291771 8922878 7625729

Sources:
TdgClinicalTrial ChemblInteractions TEND
NORELGESTROMIN PGR

Interaction Score: 2.83

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name norelgestromin/ethinyl estradiol,Ortho Evra

Novel drug target Established target

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
1324557 7750291 19962254 8384965 17107221

Sources:
TdgClinicalTrial ChemblInteractions
ONAPRISTONE PGR

Interaction Score: 2.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
ETONOGESTREL PGR

Interaction Score: 2.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name etonogestrel implant,Implanon

Novel drug target Established target

Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs:
11041225 15063480 10601100 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MEGESTROL PGR

Interaction Score: 1.82

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD
ETHYNODIOL DIACETATE PGR

Interaction Score: 1.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
858280 11752352 166800

Sources:
ChemblInteractions
NORETHINDRONE PGR

Interaction Score: 1.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Warner

Novel drug target Established target

Trial Name -

PMIDs:
15189034 16084894 11752352 10494488 15261304 7711211 15063480

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
TOSAGESTIN PGR

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PF-05019702 PGR

Interaction Score: 1.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VILAPRISAN PGR

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LONAPRISAN PGR

Interaction Score: 1.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIENOGEST PGR

Interaction Score: 1.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name estradiol valerate + dienogest,Natazia, Qlaira

Novel drug target Established target

PMIDs:
18061638

Sources:
TdgClinicalTrial
PROGESTOGEN PGR

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name oral contraceptive,Pill-Plus

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
GESTODENE PGR

Interaction Score: 1.21

Interaction Types & Directionality:

activator (activating)

binder

Interaction Info:

Trial Name contraceptive patch, ethinylestradiol + gestodene,FC Patch Fidencia

Novel drug target Established target

PMIDs:
15697108

Sources:
TdgClinicalTrial
ULIPRISTAL ACETATE PGR

Interaction Score: 1.21

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions
TELAPRISTONE ACETATE PGR

Interaction Score: 1.21

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL2059711 PGR

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24915879

Sources:
DTC
NORGESTREL PGR

Interaction Score: 0.81

Interaction Types & Directionality:

agonist (activating)

binder

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
11521119

Sources:
TdgClinicalTrial ChemblInteractions TEND
NORETHYNODREL PGR

Interaction Score: 0.61

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NORETHINDRONE ACETATE PGR

Interaction Score: 0.61

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIFEPRISTONE PGR

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

Trial Name Mifepristone, RU486

PMIDs:
10682471 10699595 11783365 10374120 11752352 10806733

Sources:
TdgClinicalTrial ChemblInteractions TEND
GOSERELIN PGR

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
ERIBULIN PGR

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
DANAZOL PGR

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
8000225 17636649 18061638 2404115

Sources:
ChemblInteractions
TOREMIFENE PGR

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2147123

Sources:
NCI
MEDROXYPROGESTERONE ACETATE PGR

Interaction Score: 0.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
12846422

Sources:
ChemblInteractions NCI TTD
PERTUZUMAB PGR

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
HYDROXYPROGESTERONE CAPROATE PGR

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
MEGESTROL ACETATE PGR

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANASTROZOLE PGR

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers PharmGKB FDA
LETROZOLE PGR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers PharmGKB FDA
PROGESTERONE PGR

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name BHR-100

Novel drug target Established target

Trial Name conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

PMIDs:
9506743 17138644 17015480 17013809 17169175 17109827 21315613 30013421

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
NERATINIB PGR

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
FULVESTRANT PGR

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
EXEMESTANE PGR

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
RIBOCICLIB PGR

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
IXABEPILONE PGR

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
TRASTUZUMAB PGR

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
TAMOXIFEN PGR

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3793272

Sources:
ClearityFoundationBiomarkers NCI PharmGKB FDA
OLAPARIB PGR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
LAPATINIB PGR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
ABEMACICLIB PGR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SIROLIMUS PGR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1284044

Sources:
NCI
DOCETAXEL PGR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
PALBOCICLIB PGR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000082175
- Version: 101_38
Alternate Names:

PGR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P06401
- Version: 01-August-2011
Alternate Names:

PRGR_HUMAN Uniprot Id

ENSG00000082175 Ensembl Gene Id

P06401 Uniprot Accession

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Publications:
BaderLabGenes: PGR
- Version: February-2014
Alternate Names:

5241 Entrez Gene ID

Gene Info:

Initial Gene Query NR3C3

Counted Citations from 1950-2000 9831

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P06401
- Version: 11-September-2012
Alternate Names:

P06401 Uniprot Accession

PRGR_HUMAN Uniprot Id

5241 Entrez Gene Id

Gene Info:

Interpro Name Nuclear hormone receptor, ligand-binding, core

Interpro Acc IPR000536

Interpro Type Domain

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P06401
- Version: January-2014
Alternate Names:

PGR Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
RussLampel: ENSG00000082175
- Version: 26-July-2011
Alternate Names:

ENSG00000082175 Ensembl Gene Id

PGR Display Id

PROGESTERONE RECEPTOR (PR). [SOURCE:UNIPROT/SWISSPROT;ACC:P06401] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: PGR

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Grenman et al., 1987, In vitro effects of tamoxifen on UM-SCC head and neck cancer cell lines: correlation with the estrogen and progesterone receptor content., Int. J. Cancer

Valavaara et al., 1990, Predictive value of tumor estrogen and progesterone receptor levels in postmenopausal women with advanced breast cancer treated with toremifene., Cancer

Helguero et al., 2003, Progesterone receptor expression in medroxyprogesterone acetate-induced murine mammary carcinomas and response to endocrine treatment., Breast Cancer Res. Treat.

DTC: PGR

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lin HR, 2014, Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists., Bioorg Med Chem Lett

Alvarez LD et al., 2011, Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone., Bioorg Med Chem

ChemblInteractions: NR3C3
- Version: chembl_23
Alternate Names:

NR3C3 GENE_SYMBOL

PGR GENE_SYMBOL

Progesterone receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000082175
- Version: 31-May-2017
Alternate Names:

ENSG00000082175 Gene Symbol

PGR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: PGR
- Version: 18-August-2020
Alternate Names:

PA266 PharmGKB ID

Gene Info:

Publications:
GO: PGR
- Version: 01-February-2022
Alternate Names:

NR3C3 GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: PGR
- Version: 27-Jun-2013
Alternate Names:

5241 Gene ID

NR3C3 dGene Synonym

PR dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Progesterone receptor
- Version: 2020.06.01
Alternate Names:

PGR TTD Gene Abbreviation

T22939 TTD Target ID

Gene Info:

Publications:
ClearityFoundationBiomarkers: PGR
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:
FDA: PGR
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Trial Name	Ulipristal
Novel drug target	Established target
Mechanism of Interaction	Progesterone receptor modulator

Mechanism of Interaction	Progesterone receptor agonist
Direct Interaction	yes
Trial Name	-

Trial Name	norelgestromin/ethinyl estradiol,Ortho Evra
Novel drug target	Established target
Mechanism of Interaction	Progesterone receptor agonist

Direct Interaction	yes
Mechanism of Interaction	Progesterone receptor antagonist

Trial Name	etonogestrel implant,Implanon
Novel drug target	Established target
Trial Name	etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

Trial Name	Warner
Novel drug target	Established target
Trial Name	-

Trial Name	estradiol valerate + dienogest,Natazia, Qlaira
Novel drug target	Established target

Trial Name	oral contraceptive,Pill-Plus
Novel drug target	Established target

Trial Name	contraceptive patch, ethinylestradiol + gestodene,FC Patch Fidencia
Novel drug target	Established target

Trial Name	BHR-100
Novel drug target	Established target
Trial Name	conjugated estrogens/medroxyprogesterone acetate,Prempro, Premphase

agonist (activating)
binder
modulator

PRGR_HUMAN	Uniprot Id
ENSG00000082175	Ensembl Gene Id
P06401	Uniprot Accession

ENSG00000082175	Ensembl Gene Id
PGR	Display Id
PROGESTERONE RECEPTOR (PR). [SOURCE:UNIPROT/SWISSPROT;ACC:P06401]	Description

PGR Gene Record

PGR 5241 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: modulator

Interaction Info: Trial Name Ulipristal Novel drug target Established target Mechanism of Interaction Progesterone receptor modulator

PMIDs: 23437846

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Progesterone receptor agonist Direct Interaction yes Trial Name -

PMIDs: 436795 16045524 6827166 11752352 15128769 8486204

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating) binder modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Progesterone receptor agonist Trial Name SOH-075,NorLevo

PMIDs: 16157482 17484506 16084894 17531625 17077229 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory) modulator

Interaction Info: Mechanism of Interaction Progesterone receptor modulator Direct Interaction yes

PMIDs: 15714390 15857972

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Progesterone receptor agonist Direct Interaction yes Novel drug target Established target

PMIDs: 1324557 8384965 17107221 11752352 7750291

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Direct Interaction yes

PMIDs: 3139361 11041225 6645495 10601100 11752352 7750284

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Progesterone receptor agonist Trial Name drospirenone plus estradiol,Angeliq

PMIDs: 15493951 16157482 17000933 11024226 16291771 8922878 7625729

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name norelgestromin/ethinyl estradiol,Ortho Evra Novel drug target Established target Mechanism of Interaction Progesterone receptor agonist

PMIDs: 1324557 7750291 19962254 8384965 17107221

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Progesterone receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name etonogestrel implant,Implanon Novel drug target Established target Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs: 11041225 15063480 10601100 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Progesterone receptor agonist Direct Interaction yes

PMIDs: 858280 11752352 166800

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Warner Novel drug target Established target Trial Name -

PMIDs: 15189034 16084894 11752352 10494488 15261304 7711211 15063480

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Progesterone receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Progesterone receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name estradiol valerate + dienogest,Natazia, Qlaira Novel drug target Established target

PMIDs: 18061638

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name oral contraceptive,Pill-Plus Novel drug target Established target

Interaction Types & Directionality:

modulator

Interaction Info:

Trial Name Ulipristal

Novel drug target Established target

Mechanism of Interaction Progesterone receptor modulator

PMIDs:
23437846

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
436795 16045524 6827166 11752352 15128769 8486204

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

binder

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name SOH-075,NorLevo

PMIDs:
16157482 17484506 16084894 17531625 17077229 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Progesterone receptor modulator

Direct Interaction yes

PMIDs:
15714390 15857972

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
1324557 8384965 17107221 11752352 7750291

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Direct Interaction yes

PMIDs:
3139361 11041225 6645495 10601100 11752352 7750284

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name drospirenone plus estradiol,Angeliq

PMIDs:
15493951 16157482 17000933 11024226 16291771 8922878 7625729

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name norelgestromin/ethinyl estradiol,Ortho Evra

Novel drug target Established target

Mechanism of Interaction Progesterone receptor agonist

PMIDs:
1324557 7750291 19962254 8384965 17107221

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name etonogestrel implant,Implanon

Novel drug target Established target

Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs:
11041225 15063480 10601100 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Progesterone receptor agonist

Direct Interaction yes

PMIDs:
858280 11752352 166800

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Warner

Novel drug target Established target

Trial Name -

PMIDs:
15189034 16084894 11752352 10494488 15261304 7711211 15063480

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Progesterone receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name estradiol valerate + dienogest,Natazia, Qlaira

Novel drug target Established target

PMIDs:
18061638

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name oral contraceptive,Pill-Plus

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

activator (activating)

binder

Interaction Info:

Trial Name contraceptive patch, ethinylestradiol + gestodene,FC Patch Fidencia

Novel drug target Established target

PMIDs:
15697108

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor modulator