DGIdb - PIK3CG Gene Record

PIK3CG 5294 Druggable GenomeClinically Actionable

Alternate Names:

5294
PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA
PIK3CG
PI3CG
PI3K
PI3Kgamma
PIK3
p110gamma
p120-PI3K
601232
8978
ENSG00000105851
OTTHUMG00000157641
P48736
PtdIns-3-kinase subunit p110-gamma
PtdIns-3-kinase subunit gamma
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
PI3K-gamma
Phosphoinositide-3-kinase catalytic gamma polypeptide
PI3-kinase subunit gamma
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
Serine/threonine protein kinase PIK3CG
PK3CG_HUMAN
PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM (EC 2.7.1.153) (PI3-KINASE P110 SUBUNIT GAMMA) (PTDINS- 3-KINASE P110) (PI3K) (PI3KGAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P48736]
PI3-kinase gamma
T95913

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.1.153
Interpro Name	Phosphatidylinositol 3-/4-kinase, catalytic domain
Interpro Acc	IPR000403
Interpro Short Name	PI3/4_kinase_cat_dom
Interpro Type	Domain
Human Readable Name	PHOSPHATIDYLINOSITOL 3 KINASE
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(13 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
PHOSPHATIDYLINOSITOL 3 KINASE
CLINICALLY ACTIONABLE

Publications:

Palanki et al., 2007, Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction., J. Med. Chem.
Olsen et al., 2007, Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action., Int. J. Biochem. Cell Biol.
Boyle DL et al., 2014, Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis., J Pharmacol Exp Ther
Vangapandu HV et al., 2017, Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia., Expert Opin Investig Drugs
Lampson BL et al., 2017, PI3Kδ-selective and PI3Kα/δ-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma., Expert Opin Investig Drugs
Isakoff et al., 1995, The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake., Proc. Natl. Acad. Sci. U.S.A.
Pereira et al., 2005, Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes., Metab. Clin. Exp.
Collier et al., 2004, Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells., Biochem. Biophys. Res. Commun.
Ma et al., 2004, Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha., Endocrinology
Yakes et al., 2002, Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action., Cancer Res.
Berry et al., 2006, Heparin localization and fine structure regulate Burkitt's lymphoma growth., Biochem. Biophys. Res. Commun.
Duca et al., 2005, Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts., Mol. Pharmacol.
Wen PY et al., 2012, Current clinical development of PI3K pathway inhibitors in glioblastoma., Neuro Oncol
Simoncini et al., 2002, Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene., Circulation
Bläser et al., 2006, In vitro studies on the signal transduction of thyroidal uptake of 18F-FDG and 131I-Iodide., J. Nucl. Med.
Barragán et al., 2002, Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells., Blood
Andreu et al., 2005, BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells., Cancer Res.
Iwama et al., 1995, Effect of lovastatin and fluoromevalonate on phosphatidylinositol 3-kinase activity stimulated with PDGF., Clin Exp Pharmacol Physiol Suppl
Prasad et al., 2005, Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction., J. Neurochem.
Fischer et al., 1996, Signals mediating stimulation of cardiomyocyte glucose transport by the alpha-adrenergic agonist phenylephrine., Am. J. Physiol.
Budzyn et al., 2005, Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension., J. Pharmacol. Exp. Ther.
McCallum et al., 2005, Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats., J. Hypertens.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Perrino et al., 2005, Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression., J. Am. Coll. Cardiol.
James et al., 2004, Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes., J. Biol. Chem.
Conus et al., 1998, Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k., J. Biol. Chem.
Wang et al., 2006, Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling., Endocrinology
Kang et al., 2004, The effects of clozapine on the GSK-3-mediated signaling pathway., FEBS Lett.
Salatino et al., 2006, Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation., Oncogene
Wu et al., 2005, Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cells., Mol. Endocrinol.
Cui et al., 2003, Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2., Oncogene
Lampinen et al., 2006, Albumin stimulation of eosinophil migration involves PI3-kinases and is associated with diminished eosinophil CD49d and CD49f expression., Int. Arch. Allergy Immunol.
Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
Mabuchi et al., 2002, Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel., J. Biol. Chem.
Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.
Park et al., 2005, Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity., Immunology
Kwak et al., 2000, Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells., Circulation
Urbich et al., 2005, FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells., FASEB J.
Fuhrer et al., 1996, Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11., Exp. Hematol.
Veerasingham et al., 2005, Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat., Circ. Res.
Chen et al., 2004, Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity., Biochem. Biophys. Res. Commun.
Lee et al., 2006, Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis., Biochim. Biophys. Acta
Lakkakorpi et al., 1997, Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading., Exp. Cell Res.
Lee et al., 2004, Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection., Circulation
Fujiwara et al., 2007, Blockade of the phosphatidylinositol-3-kinase-Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated., Mol. Cancer Ther.
Shingu et al., 2003, Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells., Cancer Res.
Hiroi et al., 2006, Rapid nongenomic actions of thyroid hormone., Proc. Natl. Acad. Sci. U.S.A.
Theodoropoulou et al., 2006, Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression., Cancer Res.
Jakubíková et al., 2005, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells., Biochem. Pharmacol.
Jiang et al., 2002, Syk regulation of phosphoinositide 3-kinase-dependent NK cell function., J. Immunol.
Hunter et al., 1998, Phosphatidylinositol 3'-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the granulocyte colony-stimulating factor receptor., J. Immunol.
Afaq et al., 2004, Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin., Toxicol. Appl. Pharmacol.
Patel et al., 2005, Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma)., Cell. Signal.
Ciprés et al., 1999, An IL-2 receptor beta subdomain that controls Bcl-X(L) expression and cell survival., Eur. J. Immunol.
Weylie et al., 2006, Phosphatidylinositide 3-kinase is important in late-stage fibroblast growth factor-1-mediated angiogenesis in vivo., J. Vasc. Res.
Ito et al., 2005, Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action., J. Lipid Res.

DUVELISIB PIK3CG

Interaction Score: 1.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

PMIDs:
24244039 28388280 28945111

Sources:
ChemblInteractions TTD
NM-404 PIK3CG

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IPI-549 PIK3CG

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FIBROBLAST GROWTH FACTOR-1 PIK3CG

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16272825 15627653

Sources:
NCI
TG100-115 PIK3CG

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

Direct Interaction yes

PMIDs:
17685602

Sources:
ChemblInteractions TTD
HERCEPTIN PIK3CG

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12124352

Sources:
NCI
RP-6530 PIK3CG

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
UMBRALISIB TOSYLATE PIK3CG

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CAL-263 PIK3CG

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
GDC-0077 PIK3CG

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
NEOMYCIN PIK3CG

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15024008

Sources:
NCI
BIMIRALISIB PIK3CG

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
BGT-226 PIK3CG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OPRELVEKIN PIK3CG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8641341

Sources:
NCI
MANNITOL PIK3CG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10811601

Sources:
NCI
FLUDEOXYGLUCOSE-F18 PIK3CG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16883020

Sources:
NCI
RG-7666 PIK3CG

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
22619466

Sources:
ChemblInteractions TTD
SULFORAPHANE PIK3CG

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15896333

Sources:
NCI
PHENYLEPHRINE PIK3CG

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8928748 15743931 15662223

Sources:
NCI
LACTOSE, ANHYDROUS PIK3CG

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15653554

Sources:
NCI
SONOLISIB PIK3CG

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD
ESTRONE PIK3CG

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16860831

Sources:
NCI
GLUCAGON PIK3CG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15530428

Sources:
NCI
IONOMYCIN PIK3CG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9468542

Sources:
NCI
FILGRASTIM PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9590246

Sources:
NCI
OCTREOTIDE PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16452215

Sources:
NCI
PERIFOSINE PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IMATINIB MESYLATE PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15833859

Sources:
NCI
AZD-8186 PIK3CG

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
TASELISIB PIK3CG

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase class I inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
COPANLISIB PIK3CG

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial
PF-04691502 PIK3CG

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD
VOXTALISIB PIK3CG

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD
DS-7423 PIK3CG

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
PA-799 PIK3CG

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
VS-5584 PIK3CG

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase class I inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
OMIPALISIB PIK3CG

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial TTD
CAPTOPRIL PIK3CG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15662030

Sources:
NCI
PILARALISIB PIK3CG

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase class I inhibitor

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD
GEDATOLISIB PIK3CG

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD
ALBUMIN HUMAN PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16569934

Sources:
NCI
GSK-1059615 PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
WX-037 PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZSTK-474 PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RECILISIB PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase class I inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BUPARLISIB PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD
ENZASTAURIN PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SF-1126 PIK3CG

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BERZOSERTIB PIK3CG

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
BGT-226 PIK3CG

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PWT-33587 PIK3CG

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RIGOSERTIB PIK3CG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ALTEPLASE PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15020199

Sources:
NCI
DAIDZEIN PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16108819

Sources:
NCI
FLUDARABINE PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11929788

Sources:
NCI
SAMOTOLISIB PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7479761 16311098 15485656 15297437

Sources:
NCI
PICEATANNOL PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11907067

Sources:
NCI
APITOLISIB PIK3CG

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions
PUQUITINIB PIK3CG

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase class I inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DACTOLISIB PIK3CG

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD
ROSIGLITAZONE PIK3CG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16777975

Sources:
NCI
PANULISIB PIK3CG

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD-6482 PIK3CG

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TROGLITAZONE PIK3CG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15993751

Sources:
NCI
ALDESLEUKIN PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10229082

Sources:
NCI
MELATONIN PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16313502

Sources:
NCI
EMODIN PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17018259

Sources:
NCI
ISOPROTERENOL PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15936620

Sources:
NCI
LOVASTATIN PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9072409 15953363

Sources:
NCI
RALOXIFENE PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11901050

Sources:
NCI
HEPARIN PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16904641

Sources:
NCI
LIOTHYRONINE SODIUM PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16966610

Sources:
NCI
PICTILISIB PIK3CG

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions
GSK-2636771 PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
ALPELISIB PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome MyCancerGenomeClinicalTrial
PROGESTERONE PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16799639 15528272 14534541

Sources:
NCI
FIMEPINOSTAT PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
PI-103 PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
VINCRISTINE PIK3CG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17363506 12874004

Sources:
NCI
INFIGRATINIB PIK3CG

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
COLCHICINE PIK3CG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9434625

Sources:
NCI
SIMVASTATIN PIK3CG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15337692

Sources:
NCI
CLOZAPINE PIK3CG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14988008

Sources:
NCI
ATORVASTATIN PIK3CG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15824087

Sources:
NCI
QUERCETIN PIK3CG

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235

Sources:
MyCancerGenome
DOXORUBICIN PIK3CG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16905201

Sources:
NCI
PACLITAXEL PIK3CG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12087097

Sources:
NCI

Ensembl: ENSG00000105851
- Version: 101_38
Alternate Names:

PIK3CG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P48736
- Version: January-2014
Alternate Names:

PIK3CG Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.1.153

Publications:
HopkinsGroom: P48736
- Version: 11-September-2012
Alternate Names:

PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM Uniprot Protein Name

ENSG00000105851 Ensembl Gene Id

PIK3CG Uniprot Gene Name

Gene Info:

Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain

Interpro Acc IPR000403

Interpro Short Name PI3/4_kinase_cat_dom

Gene Categories:

DRUGGABLE GENOME, PHOSPHATIDYLINOSITOL 3 KINASE

Publications:

RussLampel: ENSG00000105851

Version: 26-July-2011

Alternate Names:

ENSG00000105851 Ensembl Gene Id

PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM (EC 2.7.1.153) (PI3-KINASE P110 SUBUNIT GAMMA) (PTDINS- 3-KINASE P110) (PI3K) (PI3KGAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P48736] Description

PIK3CG Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TTD: PI3-kinase gamma
- Version: 2020.06.01
Alternate Names:

PIK3CG TTD Gene Abbreviation

T95913 TTD Target ID

Gene Info:

Publications:

Wen PY et al., 2012, Current clinical development of PI3K pathway inhibitors in glioblastoma., Neuro Oncol

NCI: PIK3CG

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Olsen et al., 2007, Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action., Int. J. Biochem. Cell Biol.

Collier et al., 2004, Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells., Biochem. Biophys. Res. Commun.

Isakoff et al., 1995, The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake., Proc. Natl. Acad. Sci. U.S.A.

ChemblInteractions: PIK3CG

Version: chembl_23

Alternate Names:

PIK3CG GENE_SYMBOL

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform UNIPROT

Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000105851
- Version: 31-May-2017
Alternate Names:

ENSG00000105851 Gene Symbol

PIK3CG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: PIK3CG
- Version: 20-Jun-2017
Alternate Names:

5294 Entrez Gene Id

PIK3CG MyCancerGenome Gene Symbol

PI3K MyCancerGenome Reported Gene Name

Gene Info:

Publications:
Tempus: PIK3CG
- Version: 11-November-2018
Alternate Names:

PIK3CG Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PIK3CG
- Version: 27-Jun-2013
Alternate Names:

5294 Gene ID

PI3CG dGene Synonym

PI3K dGene Synonym

Gene Info:

Gene Categories:

KINASE, PHOSPHATIDYLINOSITOL 3 KINASE

Publications:
Pharos: PIK3CG
- Version: 01-February-2022
Alternate Names:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Gene Name

P48736 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MyCancerGenomeClinicalTrial: PIK3CG
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
MskImpact: PIK3CG
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: PIK3CG
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: PIK3CG
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: PIK3CG
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	PI3-kinase p110-gamma subunit inhibitor

Mechanism of Interaction	PI3-kinase class I inhibitor
Direct Interaction	yes

PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM	Uniprot Protein Name
ENSG00000105851	Ensembl Gene Id
PIK3CG	Uniprot Gene Name

PIK3CG	GENE_SYMBOL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	UNIPROT
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma	UNIPROT

5294	Entrez Gene Id
PIK3CG	MyCancerGenome Gene Symbol
PI3K	MyCancerGenome Reported Gene Name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Gene Name
P48736	UniProt ID

PIK3CG Gene Record

PIK3CG 5294 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

PMIDs: 24244039 28388280 28945111

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16272825 15627653

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor Direct Interaction yes

PMIDs: 17685602

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12124352

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15024008

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8641341

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10811601

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16883020

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction PI3-kinase class I inhibitor Direct Interaction yes

PMIDs: 22619466

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15896333

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

PMIDs:
24244039 28388280 28945111

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16272825 15627653

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

Direct Interaction yes

PMIDs:
17685602

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
12124352

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
15024008

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8641341

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10811601

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16883020

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
22619466

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
15896333

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8928748 15743931 15662223

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15653554

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction PI3-kinase class I inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
16860831

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15530428

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9468542

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9590246