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PIK3CG Gene Record

  • Summary
  • Interactions
  • Claims
  • PIK3CG 5294 Druggable GenomeClinically Actionable

    Alternate Names:

    5294
    PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA
    PIK3CG
    PI3CG
    PI3K
    PI3Kgamma
    PIK3
    p110gamma
    p120-PI3K
    601232
    8978
    ENSG00000105851
    OTTHUMG00000157641
    P48736
    PtdIns-3-kinase subunit p110-gamma
    PtdIns-3-kinase subunit gamma
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    PI3K-gamma
    Phosphoinositide-3-kinase catalytic gamma polypeptide
    PI3-kinase subunit gamma
    Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
    Serine/threonine protein kinase PIK3CG
    PK3CG_HUMAN
    PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM (EC 2.7.1.153) (PI3-KINASE P110 SUBUNIT GAMMA) (PTDINS- 3-KINASE P110) (PI3K) (PI3KGAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P48736]
    PI3-kinase gamma
    T95913

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.1.153
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Interpro Acc IPR000403
    Interpro Short Name PI3/4_kinase_cat_dom
    Interpro Type Domain
    Human Readable Name PHOSPHATIDYLINOSITOL 3 KINASE
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (13 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    PHOSPHATIDYLINOSITOL 3 KINASE
    CLINICALLY ACTIONABLE

    Publications:

    Palanki et al., 2007, Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction., J. Med. Chem.
    Olsen et al., 2007, Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action., Int. J. Biochem. Cell Biol.
    Boyle DL et al., 2014, Novel phosphoinositide 3-kinase δ,γ inhibitor: potent anti-inflammatory effects and joint protection in models of rheumatoid arthritis., J Pharmacol Exp Ther
    Vangapandu HV et al., 2017, Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia., Expert Opin Investig Drugs
    Lampson BL et al., 2017, PI3Kδ-selective and PI3Kα/δ-combinatorial inhibitors in clinical development for B-cell non-Hodgkin lymphoma., Expert Opin Investig Drugs
    Isakoff et al., 1995, The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake., Proc. Natl. Acad. Sci. U.S.A.
    Pereira et al., 2005, Inhibition of the phosphatidylinositol 3'-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes., Metab. Clin. Exp.
    Collier et al., 2004, Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells., Biochem. Biophys. Res. Commun.
    Ma et al., 2004, Mechanisms of hemorrhage-induced hepatic insulin resistance: role of tumor necrosis factor-alpha., Endocrinology
    Yakes et al., 2002, Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action., Cancer Res.
    Berry et al., 2006, Heparin localization and fine structure regulate Burkitt's lymphoma growth., Biochem. Biophys. Res. Commun.
    Duca et al., 2005, Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts., Mol. Pharmacol.
    Wen PY et al., 2012, Current clinical development of PI3K pathway inhibitors in glioblastoma., Neuro Oncol
    Simoncini et al., 2002, Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene., Circulation
    Bläser et al., 2006, In vitro studies on the signal transduction of thyroidal uptake of 18F-FDG and 131I-Iodide., J. Nucl. Med.
    Barragán et al., 2002, Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells., Blood
    Andreu et al., 2005, BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells., Cancer Res.
    Iwama et al., 1995, Effect of lovastatin and fluoromevalonate on phosphatidylinositol 3-kinase activity stimulated with PDGF., Clin Exp Pharmacol Physiol Suppl
    Prasad et al., 2005, Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction., J. Neurochem.
    Fischer et al., 1996, Signals mediating stimulation of cardiomyocyte glucose transport by the alpha-adrenergic agonist phenylephrine., Am. J. Physiol.
    Budzyn et al., 2005, Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension., J. Pharmacol. Exp. Ther.
    McCallum et al., 2005, Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats., J. Hypertens.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Perrino et al., 2005, Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression., J. Am. Coll. Cardiol.
    James et al., 2004, Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes., J. Biol. Chem.
    Conus et al., 1998, Differential regulation by calcium reveals distinct signaling requirements for the activation of Akt and p70S6k., J. Biol. Chem.
    Wang et al., 2006, Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling., Endocrinology
    Kang et al., 2004, The effects of clozapine on the GSK-3-mediated signaling pathway., FEBS Lett.
    Salatino et al., 2006, Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation., Oncogene
    Wu et al., 2005, Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cells., Mol. Endocrinol.
    Cui et al., 2003, Progesterone crosstalks with insulin-like growth factor signaling in breast cancer cells via induction of insulin receptor substrate-2., Oncogene
    Lampinen et al., 2006, Albumin stimulation of eosinophil migration involves PI3-kinases and is associated with diminished eosinophil CD49d and CD49f expression., Int. Arch. Allergy Immunol.
    Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
    Mabuchi et al., 2002, Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel., J. Biol. Chem.
    Lee et al., 2006, Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus., J. Pineal Res.
    Park et al., 2005, Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity., Immunology
    Kwak et al., 2000, Angiopoietin-1 inhibits irradiation- and mannitol-induced apoptosis in endothelial cells., Circulation
    Urbich et al., 2005, FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells., FASEB J.
    Fuhrer et al., 1996, Activation of Src-family protein tyrosine kinases and phosphatidylinositol 3-kinase in 3T3-L1 mouse preadipocytes by interleukin-11., Exp. Hematol.
    Veerasingham et al., 2005, Increased PI3-kinase in presympathetic brain areas of the spontaneously hypertensive rat., Circ. Res.
    Chen et al., 2004, Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity., Biochem. Biophys. Res. Commun.
    Lee et al., 2006, Interplay between PI3K/Akt and MAPK signaling pathways in DNA-damaging drug-induced apoptosis., Biochim. Biophys. Acta
    Lakkakorpi et al., 1997, Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading., Exp. Cell Res.
    Lee et al., 2004, Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection., Circulation
    Fujiwara et al., 2007, Blockade of the phosphatidylinositol-3-kinase-Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated., Mol. Cancer Ther.
    Shingu et al., 2003, Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells., Cancer Res.
    Hiroi et al., 2006, Rapid nongenomic actions of thyroid hormone., Proc. Natl. Acad. Sci. U.S.A.
    Theodoropoulou et al., 2006, Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression., Cancer Res.
    Jakubíková et al., 2005, Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells., Biochem. Pharmacol.
    Jiang et al., 2002, Syk regulation of phosphoinositide 3-kinase-dependent NK cell function., J. Immunol.
    Hunter et al., 1998, Phosphatidylinositol 3'-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the granulocyte colony-stimulating factor receptor., J. Immunol.
    Afaq et al., 2004, Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin., Toxicol. Appl. Pharmacol.
    Patel et al., 2005, Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma)., Cell. Signal.
    Ciprés et al., 1999, An IL-2 receptor beta subdomain that controls Bcl-X(L) expression and cell survival., Eur. J. Immunol.
    Weylie et al., 2006, Phosphatidylinositide 3-kinase is important in late-stage fibroblast growth factor-1-mediated angiogenesis in vivo., J. Vasc. Res.
    Ito et al., 2005, Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action., J. Lipid Res.
  • DUVELISIB   PIK3CG

    Interaction Score: 1.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

    PMIDs:
    24244039 28388280 28945111


    Sources:
    ChemblInteractions TTD

  • NM-404   PIK3CG

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • IPI-549   PIK3CG

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FIBROBLAST GROWTH FACTOR-1   PIK3CG

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16272825 15627653


    Sources:
    NCI

  • TG100-115   PIK3CG

    Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor
    Direct Interaction yes

    PMIDs:
    17685602


    Sources:
    ChemblInteractions TTD

  • HERCEPTIN   PIK3CG

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12124352


    Sources:
    NCI

  • RP-6530   PIK3CG

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • UMBRALISIB TOSYLATE   PIK3CG

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CAL-263   PIK3CG

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase p110-gamma subunit inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GDC-0077   PIK3CG

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NEOMYCIN   PIK3CG

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15024008


    Sources:
    NCI

  • BIMIRALISIB   PIK3CG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BGT-226   PIK3CG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OPRELVEKIN   PIK3CG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8641341


    Sources:
    NCI

  • MANNITOL   PIK3CG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10811601


    Sources:
    NCI

  • FLUDEOXYGLUCOSE-F18   PIK3CG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16883020


    Sources:
    NCI

  • RG-7666   PIK3CG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    22619466


    Sources:
    ChemblInteractions TTD

  • SULFORAPHANE   PIK3CG

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15896333


    Sources:
    NCI

  • PHENYLEPHRINE   PIK3CG

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8928748 15743931 15662223


    Sources:
    NCI

  • LACTOSE, ANHYDROUS   PIK3CG

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15653554


    Sources:
    NCI

  • SONOLISIB   PIK3CG

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD

  • ESTRONE   PIK3CG

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16860831


    Sources:
    NCI

  • GLUCAGON   PIK3CG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15530428


    Sources:
    NCI

  • IONOMYCIN   PIK3CG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9468542


    Sources:
    NCI

  • FILGRASTIM   PIK3CG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9590246


    Sources:
    NCI

  • OCTREOTIDE   PIK3CG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16452215


    Sources:
    NCI

  • PERIFOSINE   PIK3CG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • IMATINIB MESYLATE   PIK3CG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15833859


    Sources:
    NCI

  • AZD-8186   PIK3CG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TASELISIB   PIK3CG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • COPANLISIB   PIK3CG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial

  • PF-04691502   PIK3CG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions TTD

  • VOXTALISIB   PIK3CG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions TTD

  • DS-7423   PIK3CG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • PA-799   PIK3CG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • VS-5584   PIK3CG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • OMIPALISIB   PIK3CG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions MyCancerGenomeClinicalTrial TTD

  • CAPTOPRIL   PIK3CG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15662030


    Sources:
    NCI

  • PILARALISIB   PIK3CG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions TTD

  • GEDATOLISIB   PIK3CG

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD

  • ALBUMIN HUMAN   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16569934


    Sources:
    NCI

  • GSK-1059615   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • WX-037   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZSTK-474   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RECILISIB   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUPARLISIB   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions TTD

  • ENZASTAURIN   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SF-1126   PIK3CG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BERZOSERTIB   PIK3CG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BGT-226   PIK3CG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PWT-33587   PIK3CG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RIGOSERTIB   PIK3CG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ALTEPLASE   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15020199


    Sources:
    NCI

  • DAIDZEIN   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16108819


    Sources:
    NCI

  • FLUDARABINE   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11929788


    Sources:
    NCI

  • SAMOTOLISIB   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7479761 16311098 15485656 15297437


    Sources:
    NCI

  • PICEATANNOL   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11907067


    Sources:
    NCI

  • APITOLISIB   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • PUQUITINIB   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction PI3-kinase class I inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DACTOLISIB   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial TTD

  • ROSIGLITAZONE   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16777975


    Sources:
    NCI

  • PANULISIB   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AZD-6482   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TROGLITAZONE   PIK3CG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15993751


    Sources:
    NCI

  • ALDESLEUKIN   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10229082


    Sources:
    NCI

  • MELATONIN   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16313502


    Sources:
    NCI

  • EMODIN   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17018259


    Sources:
    NCI

  • ISOPROTERENOL   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15936620


    Sources:
    NCI

  • LOVASTATIN   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9072409 15953363


    Sources:
    NCI

  • RALOXIFENE   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11901050


    Sources:
    NCI

  • HEPARIN   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16904641


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16966610


    Sources:
    NCI

  • PICTILISIB   PIK3CG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction PI3-kinase class I inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • GSK-2636771   PIK3CG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • ALPELISIB   PIK3CG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome MyCancerGenomeClinicalTrial

  • PROGESTERONE   PIK3CG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16799639 15528272 14534541


    Sources:
    NCI

  • FIMEPINOSTAT   PIK3CG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PI-103   PIK3CG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • VINCRISTINE   PIK3CG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17363506 12874004


    Sources:
    NCI

  • INFIGRATINIB   PIK3CG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • COLCHICINE   PIK3CG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9434625


    Sources:
    NCI

  • SIMVASTATIN   PIK3CG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15337692


    Sources:
    NCI

  • CLOZAPINE   PIK3CG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14988008


    Sources:
    NCI

  • ATORVASTATIN   PIK3CG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15824087


    Sources:
    NCI

  • QUERCETIN   PIK3CG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    MyCancerGenome

  • DOXORUBICIN   PIK3CG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16905201


    Sources:
    NCI

  • PACLITAXEL   PIK3CG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12087097


    Sources:
    NCI

  • Ensembl: ENSG00000105851

    • Version: 101_38

    Alternate Names:
    PIK3CG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P48736

    • Version: January-2014

    Alternate Names:
    PIK3CG Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.1.153

    Publications:

  • HopkinsGroom: P48736

    • Version: 11-September-2012

    Alternate Names:
    PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM Uniprot Protein Name
    ENSG00000105851 Ensembl Gene Id
    PIK3CG Uniprot Gene Name

    Gene Info:
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Interpro Acc IPR000403
    Interpro Short Name PI3/4_kinase_cat_dom

    Gene Categories:
    DRUGGABLE GENOME, PHOSPHATIDYLINOSITOL 3 KINASE

    Publications:

  • RussLampel: ENSG00000105851

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000105851 Ensembl Gene Id
    PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM (EC 2.7.1.153) (PI3-KINASE P110 SUBUNIT GAMMA) (PTDINS- 3-KINASE P110) (PI3K) (PI3KGAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P48736] Description
    PIK3CG Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: PI3-kinase gamma

    • Version: 2020.06.01

    Alternate Names:
    PIK3CG TTD Gene Abbreviation
    T95913 TTD Target ID

    Gene Info:

    Publications:
    Wen PY et al., 2012, Current clinical development of PI3K pathway inhibitors in glioblastoma., Neuro Oncol

  • NCI: PIK3CG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Olsen et al., 2007, Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action., Int. J. Biochem. Cell Biol.
    Collier et al., 2004, Phosphatidylinositol 3-kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells., Biochem. Biophys. Res. Commun.
    Isakoff et al., 1995, The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake., Proc. Natl. Acad. Sci. U.S.A.

  • ChemblInteractions: PIK3CG

    • Version: chembl_23

    Alternate Names:
    PIK3CG GENE_SYMBOL
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform UNIPROT
    Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000105851

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105851 Gene Symbol
    PIK3CG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: PIK3CG

    • Version: 20-Jun-2017

    Alternate Names:
    5294 Entrez Gene Id
    PIK3CG MyCancerGenome Gene Symbol
    PI3K MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • Tempus: PIK3CG

    • Version: 11-November-2018

    Alternate Names:
    PIK3CG Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: PIK3CG

    • Version: 27-Jun-2013

    Alternate Names:
    5294 Gene ID
    PI3CG dGene Synonym
    PI3K dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, PHOSPHATIDYLINOSITOL 3 KINASE

    Publications:

  • Pharos: PIK3CG

    • Version: 01-February-2022

    Alternate Names:
    Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Gene Name
    P48736 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MyCancerGenomeClinicalTrial: PIK3CG

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: PIK3CG

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: PIK3CG

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: PIK3CG

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: PIK3CG

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21