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PLA2G1B Gene Record

  • Summary
  • Interactions
  • Claims
  • PLA2G1B 5319 Druggable Genome

    Alternate Names:

    5319
    PHOSPHOLIPASE A2 GROUP IB
    PLA2G1B
    PLA2
    PLA2A
    PPLA2
    172410
    9030
    ENSG00000170890
    OTTHUMG00000169343
    P04054
    PHOSPHOLIPASE A2
    PHOSPHOLIPASE A2 PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2- ACYLHYDROLASE) (GROUP IB PHOSPHOLIPASE A2). [SOURCE:UNIPROT/SWISSPROT;ACC:P04054]
    PA21B_HUMAN
    T31479

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:3.1.1.4
    Interpro Name Phospholipase A2, eukaryotic
    Interpro Type Family
    Human Readable Name PHOSPHOLIPASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001211
    Uniprot Status Swiss-Prot
    Interpro Short Name PLipase_A2_euk
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PHOSPHOLIPASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Seiler et al., 1995, Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist., Biochem. Pharmacol.
    Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod
    Ottlecz et al., 1999, Effect of ranitidine bismuth citrate on the phospholipase A2 activity of Naja naja venom and Helicobacter pylori: a biochemical analysis., Aliment. Pharmacol. Ther.
    Zhang et al., 1998, Regulation of membrane release in apoptosis., Biochem. J.
    Mustonen et al., 1991, Activation of phospholipase A2 by adriamycin in vitro. Role of drug-lipid interactions., J. Biol. Chem.
    Kucia et al., Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex., Pol J Pharmacol
  • DEOXY CHOLATE   PLA2G1B

    Interaction Score: 5.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19102680


    Sources:
    DTC

  • CHOLIC ACID   PLA2G1B

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19102680


    Sources:
    DTC

  • CONTEZOLID ACEFOSAMIL   PLA2G1B

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MANOALIDE   PLA2G1B

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLOCORTOLONE   PLA2G1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL605084   PLA2G1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIFLORASONE   PLA2G1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RILAPLADIB   PLA2G1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHENODIOL   PLA2G1B

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19102680


    Sources:
    DTC

  • CLOBETASOL   PLA2G1B

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MILTEFOSINE   PLA2G1B

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AMITRIPTYLINE   PLA2G1B

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12856820


    Sources:
    NCI

  • CHEMBL528181   PLA2G1B

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RANITIDINE   PLA2G1B

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10383521


    Sources:
    NCI

  • TOLFENAMIC ACID   PLA2G1B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ADRIAMYCIN   PLA2G1B

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2007582


    Sources:
    NCI

  • BIFONAZOLE   PLA2G1B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CETYLPYRIDINIUM BROMIDE   PLA2G1B

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALEXIDINE HYDROCHLORIDE   PLA2G1B

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FENTICLOR   PLA2G1B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETOPOSIDE   PLA2G1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9716508


    Sources:
    NCI

  • PROGESTERONE   PLA2G1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7872957


    Sources:
    NCI

  • Ensembl: ENSG00000170890

    • Version: 101_38

    Alternate Names:
    PLA2G1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000170890

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000170890 Ensembl Gene Id
    PLA2G1B Display Id
    PHOSPHOLIPASE A2 PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2- ACYLHYDROLASE) (GROUP IB PHOSPHOLIPASE A2). [SOURCE:UNIPROT/SWISSPROT;ACC:P04054] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P04054

    • Version: January-2014

    Alternate Names:
    PLA2G1B Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.1.4

    Publications:

  • HopkinsGroom: P04054

    • Version: 11-September-2012

    Alternate Names:
    PA21B_HUMAN Uniprot Id
    ENSG00000170890 Ensembl Gene Id
    5319 Entrez Gene Id

    Gene Info:
    Interpro Name Phospholipase A2, eukaryotic
    Interpro Type Family
    Human Readable Name PHOSPHOLIPASE

    Gene Categories:
    PHOSPHOLIPASE, DRUGGABLE GENOME

    Publications:

  • NCI: PLA2G1B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Rosenthal et al., 2001, Developmental maturation of primate placental trophoblast: placental cytosolic and secretory phospholipase A2 expression after estrogen suppression of baboons., Prostaglandins Other Lipid Mediat.
    Mustonen et al., 1991, Activation of phospholipase A2 by adriamycin in vitro. Role of drug-lipid interactions., J. Biol. Chem.
    Seiler et al., 1995, Inhibition of thrombin and SFLLR-peptide stimulation of platelet aggregation, phospholipase A2 and Na+/H+ exchange by a thrombin receptor antagonist., Biochem. Pharmacol.

  • DTC: PLA2G1B

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Yu BZ et al., 2009, Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia., J Nat Prod

  • HingoraniCasas: ENSG00000170890

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000170890 Gene Symbol
    PLA2G1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: PLA2G1B

    • Version: 01-February-2022

    Alternate Names:
    PLA2 GO Gene Synonym
    PLA2A GO Gene Synonym
    PPLA2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • TTD: Phospholipase A2

    • Version: 2020.06.01

    Alternate Names:
    PLA2G1B TTD Gene Abbreviation
    T31479 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: PLA2G1B

    • Version: 01-February-2022

    Alternate Names:
    Phospholipase A2 Gene Name
    P04054 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21