DGIdb - PLA2G2A Gene Record

PLA2G2A 5320 Druggable Genome

Alternate Names:

5320
PHOSPHOLIPASE A2 GROUP IIA
PLA2G2A
MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
172411
9031
ENSG00000188257
OTTHUMG00000002699
P14555
PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE) (GROUP IIA PHOSPHOLIPASE A2) (GIIC SPLA2) (NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2) (NPS-PLA2). [SOURCE:UNIPROT/SWISSPROT;ACC:P14555]
NPS-PLA2
Phosphatidylcholine 2-acylhydrolase 2A
Non-pancreatic secretory phospholipase A2
Group IIA phospholipase A2
GIIC sPLA2
Phospholipase A2, membrane associated
RASF-A
PA2GA_HUMAN
GIIA sPLA2
T19160

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	PHOSPHOLIPASE
Interpro Name	Phospholipase A2, eukaryotic
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR001211
Interpro Short Name	PLipase_A2_euk
Target Class	Enzymes
Target Subclass	EC:3.1.1.4
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

PHOSPHOLIPASE
DRUGGABLE GENOME
ENZYME

Publications:

Halberg et al., 2000, Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers., Proc. Natl. Acad. Sci. U.S.A.
Burstein et al., 1994, Phospholipase participation in cannabinoid-induced release of free arachidonic acid., Biochem. Pharmacol.
Martínez-Salgado et al., 1997, Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation., Am. J. Physiol.
Kimura et al., 1987, Calcium-dependent regulation of phospholipase A2 and its inhibitors, including tetracaine, for acetylcholine receptor cluster formation in mouse myotubes co-cultured with spinal cord explant., Int. J. Dev. Neurosci.
Nakamura et al., 1995, Heparin-enhanced plasma phospholipase A2 activity and prostacyclin synthesis in patients undergoing cardiac surgery., J. Clin. Invest.

VARESPLADIB PLA2G2A

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name varespladib sodium, A-001

Novel drug target Novel Target

Trial Name varespladib, A-002

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CORTISONE PLA2G2A

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3503494

Sources:
NCI
VARESPLADIB METHYL PLA2G2A

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phospholipase A2 group IIA inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DRONABINOL PLA2G2A

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7945419

Sources:
NCI
PIROXICAM PLA2G2A

Interaction Score: 1.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10716720

Sources:
NCI
GENTAMICIN PLA2G2A

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9249592

Sources:
NCI
HEPARIN PLA2G2A

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7883954

Sources:
NCI

Ensembl: ENSG00000188257
- Version: 101_38
Alternate Names:

PLA2G2A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P14555
- Version: 11-September-2012
Alternate Names:

PLA2G2A Uniprot Gene Name

5320 Entrez Gene Id

PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED Uniprot Protein Name

Gene Info:

Human Readable Name PHOSPHOLIPASE

Interpro Name Phospholipase A2, eukaryotic

Interpro Type Family

Gene Categories:

PHOSPHOLIPASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000188257

Version: 26-July-2011

Alternate Names:

PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE) (GROUP IIA PHOSPHOLIPASE A2) (GIIC SPLA2) (NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2) (NPS-PLA2). [SOURCE:UNIPROT/SWISSPROT;ACC:P14555] Description

ENSG00000188257 Ensembl Gene Id

PLA2G2A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P14555
- Version: January-2014
Alternate Names:

PLA2G2A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.4

Publications:

NCI: PLA2G2A

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Crowl et al., 1991, Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response., J. Biol. Chem.

Roshak et al., 1996, Suppression of human synovial fibroblast 85 kDa phospholipase A2 by antisense reduces interleukin-1 beta induced prostaglandin E2., J. Rheumatol.

Burstein et al., 1994, Phospholipase participation in cannabinoid-induced release of free arachidonic acid., Biochem. Pharmacol.

HingoraniCasas: ENSG00000188257
- Version: 31-May-2017
Alternate Names:

ENSG00000188257 Gene Symbol

PLA2G2A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PLA2B
- Version: chembl_23
Alternate Names:

PLA2L GENE_SYMBOL

RASF-A GENE_SYMBOL

PLA2G2A GENE_SYMBOL

Gene Info:

Publications:
TTD: Group IIA phospholipase A2
- Version: 2020.06.01
Alternate Names:

GIIA sPLA2 TTD Gene Abbreviation

T19160 TTD Target ID

Gene Info:

Publications:
Pharos: PLA2G2A
- Version: 01-February-2022
Alternate Names:

Phospholipase A2, membrane associated Gene Name

P14555 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Trial Name	varespladib sodium, A-001
Novel drug target	Novel Target
Trial Name	varespladib, A-002

Direct Interaction	yes
Mechanism of Interaction	Phospholipase A2 group IIA inhibitor

PLA2G2A	Uniprot Gene Name
5320	Entrez Gene Id
PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED	Uniprot Protein Name

PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED PRECURSOR (EC 3.1.1.4) (PHOSPHATIDYLCHOLINE 2-ACYLHYDROLASE) (GROUP IIA PHOSPHOLIPASE A2) (GIIC SPLA2) (NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2) (NPS-PLA2). [SOURCE:UNIPROT/SWISSPROT;ACC:P14555]	Description
ENSG00000188257	Ensembl Gene Id
PLA2G2A	Display Id

Phospholipase A2, membrane associated	Gene Name
P14555	UniProt ID

PLA2L	GENE_SYMBOL
RASF-A	GENE_SYMBOL
PLA2G2A	GENE_SYMBOL

PLA2G2A Gene Record

PLA2G2A 5320 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

VARESPLADIB PLA2G2A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name varespladib sodium, A-001 Novel drug target Novel Target Trial Name varespladib, A-002

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

CORTISONE PLA2G2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3503494

Sources: NCI

VARESPLADIB METHYL PLA2G2A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phospholipase A2 group IIA inhibitor

PMIDs: None found

Sources: ChemblInteractions

DRONABINOL PLA2G2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7945419

Sources: NCI

PIROXICAM PLA2G2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10716720

Sources: NCI

GENTAMICIN PLA2G2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9249592

Sources: NCI

HEPARIN PLA2G2A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7883954

Sources: NCI

Ensembl: ENSG00000188257

Alternate Names: PLA2G2A Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P14555

Alternate Names: PLA2G2A Uniprot Gene Name 5320 Entrez Gene Id PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED Uniprot Protein Name

Gene Info: Human Readable Name PHOSPHOLIPASE Interpro Name Phospholipase A2, eukaryotic Interpro Type Family

Gene Categories: PHOSPHOLIPASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000188257

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P14555

Alternate Names: PLA2G2A Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.1.1.4

Publications:

NCI: PLA2G2A

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000188257

Alternate Names: ENSG00000188257 Gene Symbol PLA2G2A Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: PLA2B

Alternate Names: PLA2L GENE_SYMBOL RASF-A GENE_SYMBOL PLA2G2A GENE_SYMBOL

Gene Info:

Publications:

TTD: Group IIA phospholipase A2

Alternate Names: GIIA sPLA2 TTD Gene Abbreviation T19160 TTD Target ID

Gene Info:

Publications:

Pharos: PLA2G2A

Alternate Names: Phospholipase A2, membrane associated Gene Name P14555 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name varespladib sodium, A-001

Novel drug target Novel Target

Trial Name varespladib, A-002

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
3503494

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phospholipase A2 group IIA inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
7945419

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10716720

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9249592

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7883954

Sources:
NCI

Alternate Names:

PLA2G2A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PLA2G2A Uniprot Gene Name

5320 Entrez Gene Id

PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED Uniprot Protein Name

Gene Info:

Human Readable Name PHOSPHOLIPASE

Interpro Name Phospholipase A2, eukaryotic

Interpro Type Family

Gene Categories:

PHOSPHOLIPASE, DRUGGABLE GENOME

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PLA2G2A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.4

Alternate Names:

ENSG00000188257 Gene Symbol

PLA2G2A Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PLA2L GENE_SYMBOL

RASF-A GENE_SYMBOL

PLA2G2A GENE_SYMBOL

Alternate Names:

GIIA sPLA2 TTD Gene Abbreviation

T19160 TTD Target ID

Alternate Names:

Phospholipase A2, membrane associated Gene Name

P14555 UniProt ID

Gene Categories:

ENZYME