DGIdb - PLAT Gene Record

PLAT 5327 Druggable Genome

Alternate Names:

5327
PLASMINOGEN ACTIVATOR, TISSUE TYPE
PLAT
T-PA
TPA
173370
9051
ENSG00000104368
OTTHUMG00000164072
INN=Reteplase
Tissue-type plasminogen activator
Tissue-type plasminogen activator chain A
Tissue-type plasminogen activator chain B
INN=Alteplase
t-plasminogen activator
TPA_HUMAN
P00750
TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750]
T45299

Gene Info:

Interpro Acc	IPR001254
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	PROTEASE
Interpro Short Name	Peptidase_S1_S6
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Target Subclass	3.4.21.68
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:3.4.21.68
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

CELL SURFACE
PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Merryman et al., 1997, Fibrinolytic and coagulant responses to regional limb perfusions of tumor necrosis factor, interferon-gamma, and/or melphalan., Thromb. Haemost.
Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
Barthwal et al., 1991, Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta)., Adv Contracept
Wells et al., 2003, Intrapleural fibrinolysis for parapneumonic effusion and empyema in children., Radiology
Stief et al., 2003, In vitro simulation of therapeutic plasmatic fibrinolysis., Clin. Appl. Thromb. Hemost.
Lindholt et al., 2003, Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms., Eur J Vasc Endovasc Surg
Chang et al., Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells., Cell Commun. Adhes.
Alemán et al., 2003, Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions., Clin. Sci.
Gündüz et al., 1999, Effects of recombinant human erythropoietin on fibrinolytic system in children on continuous ambulatory peritoneal dialysis., Adv Perit Dial
Goicoechea et al., 2006, Effects of atorvastatin on inflammatory and fibrinolytic parameters in patients with chronic kidney disease., J. Am. Soc. Nephrol.
Ozeren et al., 2005, The effects of short-term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI-1., Acta Obstet Gynecol Scand

UROKINASE PLAT

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name urokinase for injection,Kinlytic

Novel drug target Established target

PMIDs:
12893898 14507109 12787697 12745435 12826021

Sources:
TdgClinicalTrial
AMINOCAPROIC ACID PLAT

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tissue-type plasminogen activator inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAPROXEN PLAT

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1908176

Sources:
NCI
EPOETIN BETA PLAT

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10682118

Sources:
NCI
MELPHALAN PLAT

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9031449

Sources:
NCI
RALOXIFENE PLAT

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16167916

Sources:
NCI
ATORVASTATIN PLAT

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17130267

Sources:
NCI
BORTEZOMIB PLAT

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20875739

Sources:
DTC

Ensembl: ENSG00000104368
- Version: 101_38
Alternate Names:

PLAT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P00750
- Version: January-2014
Alternate Names:

PLAT Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.68

Publications:
HopkinsGroom: P00750
- Version: 11-September-2012
Alternate Names:

TPA_HUMAN Uniprot Id

TISSUE-TYPE PLASMINOGEN ACTIVATOR CHAIN B Uniprot Protein Name

5327 Entrez Gene Id

Gene Info:

Interpro Acc IPR001254

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000104368

Version: 26-July-2011

Alternate Names:

PLAT Display Id

ENSG00000104368 Ensembl Gene Id

TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P00750
- Version: 01-August-2011
Alternate Names:

P00750 Uniprot Accession

TPA_HUMAN Uniprot Id

PLAT Gene Symbol

Gene Info:

Target Subclass 3.4.21.68

Target Main Class Enzymes

Publications:

NCI: PLAT

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Merryman et al., 1997, Fibrinolytic and coagulant responses to regional limb perfusions of tumor necrosis factor, interferon-gamma, and/or melphalan., Thromb. Haemost.

Gündüz et al., 1999, Effects of recombinant human erythropoietin on fibrinolytic system in children on continuous ambulatory peritoneal dialysis., Adv Perit Dial

Wang et al., 1995, T-cell lymphokines, interleukin-4 and gamma interferon, modulate the induction of vascular smooth muscle cell tissue plasminogen activator and migration by serum and platelet-derived growth factor., Circ. Res.

DTC: PLAT

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

ChemblInteractions: PLAT
- Version: chembl_23
Alternate Names:

PLAT GENE_SYMBOL

Tissue-type plasminogen activator UNIPROT

Tissue-type plasminogen activator chain A UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000104368
- Version: 31-May-2017
Alternate Names:

ENSG00000104368 Gene Symbol

PLAT Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: PLAT
- Version: 27-Jun-2013
Alternate Names:

5327 Gene ID

T-PA dGene Synonym

TPA dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Tissue-type plasminogen activator
- Version: 2020.06.01
Alternate Names:

PLAT TTD Gene Abbreviation

T45299 TTD Target ID

Gene Info:

Publications:
Pharos: PLAT
- Version: 01-February-2022
Alternate Names:

Tissue-type plasminogen activator Gene Name

P00750 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: PLAT
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Trial Name	urokinase for injection,Kinlytic
Novel drug target	Established target

Mechanism of Interaction	Tissue-type plasminogen activator inhibitor
Direct Interaction	yes

TPA_HUMAN	Uniprot Id
TISSUE-TYPE PLASMINOGEN ACTIVATOR CHAIN B	Uniprot Protein Name
5327	Entrez Gene Id

PLAT	Display Id
ENSG00000104368	Ensembl Gene Id
TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750]	Description

PLAT	GENE_SYMBOL
Tissue-type plasminogen activator	UNIPROT
Tissue-type plasminogen activator chain A	UNIPROT

PLAT Gene Record

PLAT 5327 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name urokinase for injection,Kinlytic Novel drug target Established target

PMIDs: 12893898 14507109 12787697 12745435 12826021

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tissue-type plasminogen activator inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1908176

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10682118

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9031449

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16167916

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17130267

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20875739

Sources: DTC

Ensembl: ENSG00000104368

Alternate Names: PLAT Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P00750

Alternate Names: PLAT Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.21.68

Publications:

HopkinsGroom: P00750

Alternate Names: TPA_HUMAN Uniprot Id TISSUE-TYPE PLASMINOGEN ACTIVATOR CHAIN B Uniprot Protein Name 5327 Entrez Gene Id

Gene Info: Interpro Acc IPR001254 Uniprot Evidence 1: Evidence at protein level Human Readable Name DRUGGABLE GENOME

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000104368

Alternate Names: PLAT Display Id ENSG00000104368 Ensembl Gene Id TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P00750

Alternate Names: P00750 Uniprot Accession TPA_HUMAN Uniprot Id PLAT Gene Symbol

Gene Info: Target Subclass 3.4.21.68 Target Main Class Enzymes

Publications:

NCI: PLAT

Alternate Names:

Gene Info:

DTC: PLAT

Alternate Names:

Gene Info:

Publications: Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

ChemblInteractions: PLAT

Alternate Names: PLAT GENE_SYMBOL Tissue-type plasminogen activator UNIPROT Tissue-type plasminogen activator chain A UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000104368

Alternate Names: ENSG00000104368 Gene Symbol PLAT Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

dGene: PLAT

Alternate Names: 5327 Gene ID T-PA dGene Synonym TPA dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name urokinase for injection,Kinlytic

Novel drug target Established target

PMIDs:
12893898 14507109 12787697 12745435 12826021

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tissue-type plasminogen activator inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
1908176

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10682118

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9031449

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16167916

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17130267

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20875739

Sources:
DTC

Alternate Names:

PLAT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PLAT Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.68

Alternate Names:

TPA_HUMAN Uniprot Id

TISSUE-TYPE PLASMINOGEN ACTIVATOR CHAIN B Uniprot Protein Name

5327 Entrez Gene Id

Gene Info:

Interpro Acc IPR001254

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

PLAT Display Id

ENSG00000104368 Ensembl Gene Id

TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P00750 Uniprot Accession

TPA_HUMAN Uniprot Id

PLAT Gene Symbol

Gene Info:

Target Subclass 3.4.21.68

Target Main Class Enzymes

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

Alternate Names:

PLAT GENE_SYMBOL

Tissue-type plasminogen activator UNIPROT

Tissue-type plasminogen activator chain A UNIPROT

Alternate Names:

ENSG00000104368 Gene Symbol

PLAT Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5327 Gene ID

T-PA dGene Synonym

TPA dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

PLAT TTD Gene Abbreviation

T45299 TTD Target ID

Alternate Names:

Tissue-type plasminogen activator Gene Name

P00750 UniProt ID

Gene Categories:

ENZYME

Gene Categories:

CELL SURFACE