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PLAT Gene Record

  • Summary
  • Interactions
  • Claims
  • PLAT 5327 Druggable Genome

    Alternate Names:

    5327
    PLASMINOGEN ACTIVATOR, TISSUE TYPE
    PLAT
    T-PA
    TPA
    173370
    9051
    ENSG00000104368
    OTTHUMG00000164072
    INN=Reteplase
    Tissue-type plasminogen activator
    Tissue-type plasminogen activator chain A
    Tissue-type plasminogen activator chain B
    INN=Alteplase
    t-plasminogen activator
    TPA_HUMAN
    P00750
    TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750]
    T45299

    Gene Info:

    Interpro Acc IPR001254
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name PROTEASE
    Interpro Short Name Peptidase_S1_S6
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Target Subclass 3.4.21.68
    Target Main Class Enzymes
    Target Class Enzymes
    Target Subclass EC:3.4.21.68
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Merryman et al., 1997, Fibrinolytic and coagulant responses to regional limb perfusions of tumor necrosis factor, interferon-gamma, and/or melphalan., Thromb. Haemost.
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Barthwal et al., 1991, Management of IUD-associated menorrhagia in female rhesus monkeys (Macaca mulatta)., Adv Contracept
    Wells et al., 2003, Intrapleural fibrinolysis for parapneumonic effusion and empyema in children., Radiology
    Stief et al., 2003, In vitro simulation of therapeutic plasmatic fibrinolysis., Clin. Appl. Thromb. Hemost.
    Lindholt et al., 2003, Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms., Eur J Vasc Endovasc Surg
    Chang et al., Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells., Cell Commun. Adhes.
    Alemán et al., 2003, Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions., Clin. Sci.
    Gündüz et al., 1999, Effects of recombinant human erythropoietin on fibrinolytic system in children on continuous ambulatory peritoneal dialysis., Adv Perit Dial
    Goicoechea et al., 2006, Effects of atorvastatin on inflammatory and fibrinolytic parameters in patients with chronic kidney disease., J. Am. Soc. Nephrol.
    Ozeren et al., 2005, The effects of short-term raloxifene therapy on fibrinolysis markers: TAFI, tPA, and PAI-1., Acta Obstet Gynecol Scand
  • UROKINASE   PLAT

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name urokinase for injection,Kinlytic
    Novel drug target Established target

    PMIDs:
    12893898 14507109 12787697 12745435 12826021


    Sources:
    TdgClinicalTrial

  • AMINOCAPROIC ACID   PLAT

    Interaction Score: 3.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tissue-type plasminogen activator inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NAPROXEN   PLAT

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1908176


    Sources:
    NCI

  • EPOETIN BETA   PLAT

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10682118


    Sources:
    NCI

  • MELPHALAN   PLAT

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9031449


    Sources:
    NCI

  • RALOXIFENE   PLAT

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16167916


    Sources:
    NCI

  • ATORVASTATIN   PLAT

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17130267


    Sources:
    NCI

  • BORTEZOMIB   PLAT

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • Ensembl: ENSG00000104368

    • Version: 101_38

    Alternate Names:
    PLAT Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P00750

    • Version: January-2014

    Alternate Names:
    PLAT Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.68

    Publications:

  • HopkinsGroom: P00750

    • Version: 11-September-2012

    Alternate Names:
    TPA_HUMAN Uniprot Id
    TISSUE-TYPE PLASMINOGEN ACTIVATOR CHAIN B Uniprot Protein Name
    5327 Entrez Gene Id

    Gene Info:
    Interpro Acc IPR001254
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000104368

    • Version: 26-July-2011

    Alternate Names:
    PLAT Display Id
    ENSG00000104368 Ensembl Gene Id
    TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR (EC 3.4.21.68) (TPA) (T- PA) (T-PLASMINOGEN ACTIVATOR) (ALTEPLASE) (RETEPLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00750] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P00750

    • Version: 01-August-2011

    Alternate Names:
    P00750 Uniprot Accession
    TPA_HUMAN Uniprot Id
    PLAT Gene Symbol

    Gene Info:
    Target Subclass 3.4.21.68
    Target Main Class Enzymes

    Publications:

  • NCI: PLAT

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Merryman et al., 1997, Fibrinolytic and coagulant responses to regional limb perfusions of tumor necrosis factor, interferon-gamma, and/or melphalan., Thromb. Haemost.
    Gündüz et al., 1999, Effects of recombinant human erythropoietin on fibrinolytic system in children on continuous ambulatory peritoneal dialysis., Adv Perit Dial
    Wang et al., 1995, T-cell lymphokines, interleukin-4 and gamma interferon, modulate the induction of vascular smooth muscle cell tissue plasminogen activator and migration by serum and platelet-derived growth factor., Circ. Res.

  • DTC: PLAT

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • ChemblInteractions: PLAT

    • Version: chembl_23

    Alternate Names:
    PLAT GENE_SYMBOL
    Tissue-type plasminogen activator UNIPROT
    Tissue-type plasminogen activator chain A UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000104368

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000104368 Gene Symbol
    PLAT Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: PLAT

    • Version: 27-Jun-2013

    Alternate Names:
    5327 Gene ID
    T-PA dGene Synonym
    TPA dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Tissue-type plasminogen activator

    • Version: 2020.06.01

    Alternate Names:
    PLAT TTD Gene Abbreviation
    T45299 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: PLAT

    • Version: 01-February-2022

    Alternate Names:
    Tissue-type plasminogen activator Gene Name
    P00750 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: PLAT

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21