DGIdb - PLD1 Gene Record

PLD1 5337 Druggable Genome

Alternate Names:

5337
PHOSPHOLIPASE D1
PLD1
CVDD
602382
9067
ENSG00000075651
OTTHUMG00000156947
BE0002181
Q13393
1433
T38996

Gene Info:

GuideToPharmacology Gene Category Name	Phosphatidylcholine-specific phospholipase D
GuideToPharmacology Gene Category ID	276
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Lee et al., 2005, Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity., J. Cell. Sci.
Eisen et al., 2002, Selective estrogen receptor (ER) modulators differentially regulate phospholipase D catalytic activity in ER-negative breast cancer cells., Mol. Pharmacol.
Scott SA et al., 2009, Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness., Nat Chem Biol

HALOPEMIDE PLD1

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHOLINE SALICYLATE PLD1

Interaction Score: 3.25

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
16179605

Sources:
DrugBank
CHOLINE PLD1

Interaction Score: 2.84

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
16179605

Sources:
DrugBank
AFIMOXIFENE PLD1

Interaction Score: 1.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19136975

Sources:
DTC
TAMOXIFEN PLD1

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12237338 19136975

Sources:
DTC NCI

Ensembl: ENSG00000075651
- Version: 101_38
Alternate Names:

PLD1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 5337
- Version: 29-September-2020
Alternate Names:

9067 HUGO Gene ID

9067 HUGO Gene Symbol

phospholipase D1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Phosphatidylcholine-specific phospholipase D

GuideToPharmacology Gene Category ID 276

Gene Categories:

ENZYME

Publications:
DrugBank: BE0002181
- Version: 5.1.7
Alternate Names:

PLD1 DrugBank Gene Name

Q13393 UniProt Accession

5337 Entrez Gene Id

Gene Info:

Publications:

Lee et al., 2005, Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity., J. Cell. Sci.

NCI: PLD1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Eisen et al., 2002, Selective estrogen receptor (ER) modulators differentially regulate phospholipase D catalytic activity in ER-negative breast cancer cells., Mol. Pharmacol.

Kim et al., 1999, Phospholipase D1 is located and activated by protein kinase C alpha in the plasma membrane in 3Y1 fibroblast cell., Biochim. Biophys. Acta

DTC: PLD1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Scott SA et al., 2009, Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness., Nat Chem Biol
HingoraniCasas: ENSG00000075651
- Version: 31-May-2017
Alternate Names:

ENSG00000075651 Gene Symbol

PLD1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: PLD1
- Version: 19.3
Alternate Names:

ENSG00000075651 Ensembl Gene ID

Phospholipase D1 Human Protein Atlas Gene Description

Q13393 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: PLD1
- Version: 03-September-2020
Alternate Names:

Phospholipase D1 Gene Name

Q13393 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Phospholipase D1
- Version: 2020.06.01
Alternate Names:

PLD1 TTD Gene Abbreviation

T38996 TTD Target ID

Gene Info:

Publications:

9067	HUGO Gene ID
9067	HUGO Gene Symbol
phospholipase D1	HUGO Gene Name

PLD1	DrugBank Gene Name
Q13393	UniProt Accession
5337	Entrez Gene Id

ENSG00000075651	Ensembl Gene ID
Phospholipase D1	Human Protein Atlas Gene Description
Q13393	UniProt ID

PLD1 Gene Record

PLD1 5337 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

HALOPEMIDE PLD1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

CHOLINE SALICYLATE PLD1

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 16179605

Sources: DrugBank

CHOLINE PLD1

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 16179605

Sources: DrugBank

AFIMOXIFENE PLD1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19136975

Sources: DTC

TAMOXIFEN PLD1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12237338 19136975

Sources: DTC NCI

Ensembl: ENSG00000075651

Alternate Names: PLD1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 5337

Alternate Names: 9067 HUGO Gene ID 9067 HUGO Gene Symbol phospholipase D1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Phosphatidylcholine-specific phospholipase D GuideToPharmacology Gene Category ID 276

Gene Categories: ENZYME

Publications:

DrugBank: BE0002181

Alternate Names: PLD1 DrugBank Gene Name Q13393 UniProt Accession 5337 Entrez Gene Id

Gene Info:

Publications: Lee et al., 2005, Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity., J. Cell. Sci.

NCI: PLD1

Alternate Names:

Gene Info:

DTC: PLD1

Alternate Names:

Gene Info:

Publications: Scott SA et al., 2009, Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness., Nat Chem Biol

HingoraniCasas: ENSG00000075651

Alternate Names: ENSG00000075651 Gene Symbol PLD1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: PLD1

Alternate Names: ENSG00000075651 Ensembl Gene ID Phospholipase D1 Human Protein Atlas Gene Description Q13393 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: PLD1

Alternate Names: Phospholipase D1 Gene Name Q13393 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

TTD: Phospholipase D1

Alternate Names: PLD1 TTD Gene Abbreviation T38996 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

product of

PMIDs:
16179605

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
16179605

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19136975

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12237338 19136975

Sources:
DTC NCI

Alternate Names:

PLD1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

9067 HUGO Gene ID

9067 HUGO Gene Symbol

phospholipase D1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Phosphatidylcholine-specific phospholipase D

GuideToPharmacology Gene Category ID 276

Gene Categories:

ENZYME

Alternate Names:

PLD1 DrugBank Gene Name

Q13393 UniProt Accession

5337 Entrez Gene Id

Publications:

Lee et al., 2005, Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity., J. Cell. Sci.

Publications:

Scott SA et al., 2009, Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness., Nat Chem Biol

Alternate Names:

ENSG00000075651 Gene Symbol

PLD1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000075651 Ensembl Gene ID

Phospholipase D1 Human Protein Atlas Gene Description

Q13393 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

Phospholipase D1 Gene Name

Q13393 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

PLD1 TTD Gene Abbreviation

T38996 TTD Target ID