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PPARG Gene Record

  • Summary
  • Interactions
  • Claims
  • PPARG 5468 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    5468
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
    PPARG
    CIMT1
    GLM1
    NR1C3
    PPARG1
    PPARG2
    PPARgamma
    601487
    9236
    ENSG00000132170
    OTTHUMG00000129764
    P37231
    Peroxisome proliferator-activated receptor gamma
    PPAR-gamma
    Nuclear receptor subfamily 1 group C member 3
    PA281
    BE0000215
    PPARG_HUMAN
    595
    NP_056953|NP_619725
    Peroxisome proliferator-activated receptor-γ
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231]
    T58921
    NM_015869|NM_138712|NM_138711|NM_005037

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    Initial Gene Query NR1C3
    Counted Citations from 1950-2000 8212
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Target Main Class Receptors
    GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors
    GuideToPharmacology Gene Category ID 86
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000536
    Interpro Type Domain
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Status Swiss-Prot
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (17 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    TRANSCRIPTION FACTOR BINDING
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Kuroda M et al., 2010, Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity., Bioorg Med Chem
    Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
    Fuhr L et al., 2015, Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties., J Nat Prod
    Chang F et al., 2007, Evolution of peroxisome proliferator-activated receptor agonists., Ann Pharmacother
    Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
    Rousseaux et al., 2005, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma., J. Exp. Med.
    Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.
    Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
    Iacucci et al., 2010, Mesalazine in inflammatory bowel disease: a trendy topic once again?, Can. J. Gastroenterol.
    Tursi, 2009, Balsalazide in treating colonic diseases., Expert Opin Drug Metab Toxicol
    Su et al., 1999, Use of a PPAR gamma-specific monoclonal antibody to demonstrate thiazolidinediones induce PPAR gamma receptor expression in vitro., Hybridoma
    Xiao B et al., 2012, Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists., Bioorg Med Chem
    Festa C et al., 2012, Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ., J Med Chem
    Nazreen S et al., 2014, Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression., Bioorg Med Chem Lett
    Kharbanda C et al., 2015, Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect., Bioorg Med Chem Lett
    Johnson et al., 2000, Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation., J. Mol. Biol.
    Liu W et al., 2011, Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators., J Med Chem
    Camp et al., 2000, Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone., Diabetes
    Kameda et al., 2000, [Rosiglitazone (BRL-49653)]., Nippon Rinsho
    Gorczynski MJ et al., 2009, Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation., J Med Chem
    Kharbanda C et al., 2014, Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents., Bioorg Med Chem Lett
    Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett
    Usui S et al., 2005, Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2., Bioorg Med Chem Lett
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Choi J et al., 2010, 1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists., Bioorg Med Chem
    Rieusset et al., 1999, Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes., Biochem. Biophys. Res. Commun.
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    Piemontese L et al., 2015, Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175., Eur J Med Chem
    Bhurruth-Alcor Y et al., 2010, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective., Bioorg Med Chem Lett
    Blüher M et al., 2003, Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes., Diabetes Care
    Lehmann et al., 1995, An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)., J. Biol. Chem.
    Miyazaki et al., 2004, Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients., J. Clin. Endocrinol. Metab.
    Willson et al., 1996, The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones., J. Med. Chem.
    Spiegelman, 1998, PPAR-gamma: adipogenic regulator and thiazolidinedione receptor., Diabetes
    Sugii et al., 2009, PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization., Proc. Natl. Acad. Sci. U.S.A.
    Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem
    Wick M et al., 2002, Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth., Mol Pharmacol
    Mora FD et al., 2006, Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells., J Nat Prod
    Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
    Hiep NT et al., 2012, Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma., J Nat Prod
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
    Nhiem NX et al., 2011, Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway., Bioorg Med Chem Lett
    Kitamura et al., 1999, Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells., Jpn. J. Cancer Res.
    Satoh et al., 1999, Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells., Biochem. Biophys. Res. Commun.
    Hong SS et al., 2012, Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes., Bioorg Med Chem Lett
    Petrova et al., 1999, Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2., Proc. Natl. Acad. Sci. U.S.A.
    Baek et al., 2003, Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity., J. Biol. Chem.
    Demetri et al., 1999, Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma., Proc. Natl. Acad. Sci. U.S.A.
    Camp et al., 1999, PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes., FEBS Lett.
    Chakrabarti et al., 2003, Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models., Br. J. Pharmacol.
    Egerod FL et al., 2005, Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urothelium in vivo., Biomarkers
    Lehmann et al., 1997, Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs., J. Biol. Chem.
    Cho et al., 2003, A simple ELISA for screening ligands of peroxisome proliferator-activated receptor-gamma., J. Biochem. Mol. Biol.
    Cavender et al., 2010, Therapeutic potential of aleglitazar, a new dual PPAR-α/γ agonist: implications for cardiovascular disease in patients with diabetes mellitus., Am J Cardiovasc Drugs
    Kasuga J et al., 2008, SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail., Bioorg Med Chem Lett
    Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Durgam GG et al., 2006, Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands., Bioorg Med Chem Lett
    Lallemand B et al., 2011, N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activity., J Med Chem
    Li JL et al., 2012, PPAR-γ agonistic metabolites from the ascidian Herdmania momus., J Nat Prod
    Dill et al., 2010, A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons., J. Neurosci.
    Pferschy-Wenzig EM et al., 2014, Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma., J Nat Prod
    Ubukata M et al., 2007, Mycophenolic acid as a latent agonist of PPARgamma., Bioorg Med Chem Lett
    Iio A et al., 2012, Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages., J Nat Prod
    Scarsi et al., 2007, Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach., Mol. Pharmacol.
    Herken H et al., 2009, The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia., DNA Cell Biol
    Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med
    Yamagishi et al., 2005, Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property., Med. Hypotheses
    Tagami et al., 2009, A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones., Endocrinology
    Imayama et al., 2006, Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma., Cardiovasc. Res.
    Yamagishi et al., 2006, Role of insulin-sensitizing property of telmisartan, a commercially available angiotensin II type 1 receptor blocker in preventing the development of atrial fibrillation., Med. Hypotheses
    Yamagishi et al., 2007, Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders., Curr. Mol. Med.
    Kurtz, 2005, Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator., Acta Diabetol
    Kurtz, 2008, Beyond the classic angiotensin-receptor-blocker profile., Nat Clin Pract Cardiovasc Med
    Lee JH et al., 2015, Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats., J Pharm Sci
    Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.
    Ramakers et al., 2007, Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells., Lipids
    Chambrier et al., 2002, Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma., Obes. Res.
    Selvaraj et al., 2006, Lutein and eicosapentaenoic acid interact to modify iNOS mRNA levels through the PPARgamma/RXR pathway in chickens and HD11 cell lines., J. Nutr.
    Horia et al., 2007, Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells., Carcinogenesis
    Edwards IJ et al., 2008, Omega-3 Fatty Acids and PPARgamma in Cancer., PPAR Res
    Varga T et al., 2011, PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation., Biochim Biophys Acta
    Inoue et al., 2002, Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB., Biochem. Biophys. Res. Commun.
    Erbe DV et al., 2005, Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms., Mol Pharmacol
    Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci
    Fang M et al., 2015, Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust., Environ Health Perspect
    Nishiyama T et al., 2005, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice., J Agric Food Chem
    Rodríguez-Cruz M et al., 2017, Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors., Nutrition
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Mezei O et al., 2003, Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells., J Nutr
    Szalowska E et al., 2014, Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices., PLoS One
    Song M et al., 2011, Phospholipidosis induced by PPARγ signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone., Toxicol Sci
    Hulin B et al., 1992, Novel thiazolidine-2,4-diones as potent euglycemic agents., J Med Chem
    Kumar H et al., 2020, Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells., Haematologica
    Scuderi C et al., 2014, Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPARγ involvement., Phytother Res
    Zhang L et al., 2014, Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ., Toxicol Appl Pharmacol
    Sarath Josh MK et al., 2014, Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach., J Appl Toxicol
  • CLX-0921   PPARG

    Interaction Score: 1.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • MBX-2044   PPARG

    Interaction Score: 0.96

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator
    Direct Interaction yes
    Trial Name MBX-2044

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • NETOGLITAZONE   PPARG

    Interaction Score: 0.96

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology ChemblInteractions

  • RAGAGLITAZAR   PPARG

    Interaction Score: 0.96

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    12970088 16240504 10592235


    Sources:
    TTD DrugBank GuideToPharmacology

  • INT131   PPARG

    Interaction Score: 0.96

    Interaction Types & Directionality:
    partial agonist (activating)
    modulator

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator
    Direct Interaction yes
    Trial Name INT-131, AMG-131, T131

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial DrugBank ChemblInteractions

  • CHEMBL1210221   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL364748   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1230670   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL86658   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL451721   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL200495   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL378160   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL191060   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL191275   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL2178583   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22934537


    Sources:
    DTC

  • LICOFLAVANONE A   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • SHINFLAVANONE   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • GLABRONE   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • CHEMBL2208197   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23189988


    Sources:
    DTC

  • CHEMBL2178586   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22934537


    Sources:
    DTC

  • ECHINATIN   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • OMS405   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • CHEMBL2057864   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22819190


    Sources:
    DTC

  • GANCAONIN L   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • CHEMBL2208196   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23189988


    Sources:
    DTC

  • CHEMBL599165   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • CHEMBL2208195   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23189988


    Sources:
    DTC

  • CHEMBL202243   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16263282


    Sources:
    DTC

  • CHEMBL1833984   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21889336


    Sources:
    DTC

  • ATX08-001   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • BALAGLITAZONE   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma partial agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • TESAGLITAZAR   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    16168052


    Sources:
    TTD DrugBank ChemblInteractions

  • CHEMBL2178596   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22934537


    Sources:
    DTC

  • NAVEGLITAZAR   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name LY519818 , LY818
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • KANZONOL X   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • EFATUTAZONE HYDROCHLORIDE   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name CS-7017
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • RIVOGLITAZONE   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • ELATOSIDE D   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21889336


    Sources:
    DTC

  • CHEMBL1834951   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21889336


    Sources:
    DTC

  • SEIMATOPOLIDE A   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22424300


    Sources:
    DTC

  • ARHALOFENATE   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

    PMIDs:
    17519293


    Sources:
    TTD DrugBank ChemblInteractions

  • KANZONOL W   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • SHINPTEROCARPIN   PPARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • ALEGLITAZAR   PPARG

    Interaction Score: 0.53

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name aleglitazar, R1439
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    20653327 10592235


    Sources:
    TdgClinicalTrial DrugBank ChemblInteractions

  • LOBEGLITAZONE   PPARG

    Interaction Score: 0.48

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    25648999


    Sources:
    TTD DrugBank

  • DB959   PPARG

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name DB-959
    Novel drug target Established target
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD ChemblInteractions

  • BALSALAZIDE   PPARG

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name balsalazide disodium,Colazal, Giazo
    Novel drug target Established target

    PMIDs:
    18077625 20151072 16939423 19708827


    Sources:
    TdgClinicalTrial DrugBank

  • CIGLITAZONE   PPARG

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    20170185 12391285 16643023 23566516


    Sources:
    DTC DrugBank GuideToPharmacology

  • PIOGLITAZONE   PPARG

    Interaction Score: 0.34

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    12610044 7768881 24890090 15356026 8576907 9568680 15745794 11752352 21030263 20018750 16680159


    Sources:
    TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • CHEMBL201880   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • DARGLITAZONE   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    1588563


    Sources:
    DrugBank

  • TELMISARTAN   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    15617852 19147680 16938288 16154710 17691961 15868121 18580862


    Sources:
    DrugBank

  • EFATUTAZONE   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • THIAZOLIDINEDIONE   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GLITAZONE   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • METAGLIDASEN   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name metaglidasen, JNJ-39659100, MBX-102
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TECNAZENE   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • L-165461   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLABROL   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20022509


    Sources:
    DTC

  • IMIGLITAZAR   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • GW501516   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GW501516
    Novel drug target Established target

    PMIDs:
    23566516


    Sources:
    DTC TdgClinicalTrial

  • IPRODIONE   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TIROTUNDIN   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Measuring PPARγ transactivation in response to compound binding directly to the receptor's ligand binding domain.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FENOFIBRIC ACID   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22579484 23566516


    Sources:
    DTC

  • REGLITAZAR   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    DrugBank GuideToPharmacology

  • FARGLITAZAR   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology ChemblInteractions

  • GW7845   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • MK-0533   PPARG

    Interaction Score: 0.32

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDEGLITAZAR   PPARG

    Interaction Score: 0.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

    PMIDs:
    10592235


    Sources:
    DrugBank ChemblInteractions

  • ROSIGLITAZONE   PPARG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    10475242 22819190 22934537 24890090 26384286 10764590 22070604 10871190 10707565 19719236 25442322 23273519 15745794 11752352 21030263 10548525 16680159 25497132


    Sources:
    TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology

  • CHEMBL1204498   PPARG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CLINOFIBRATE   PPARG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11779144


    Sources:
    DrugBank

  • ISOSILYBIN A   PPARG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24597776


    Sources:
    DTC

  • MURAGLITAZAR   PPARG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes
    Trial Name muraglitazar, BMS-298585

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • ABIETIC ACID   PPARG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24799257


    Sources:
    DTC

  • DECANOIC ACID   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    24998974


    Sources:
    DrugBank

  • ERTIPROTAFIB   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15475571


    Sources:
    DrugBank

  • PHENAMIPHOS   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MITOGLITAZONE   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name MSDC-0160
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ICOSAPENT   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    11552681 17610002 12055328 16702329 17052999


    Sources:
    DrugBank

  • CHEMBL410478   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL166112   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MK-0767   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • EDAGLITAZONE   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction Measuring agonist-induced cofactor recruitment.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • MITIGLINIDE   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17082235


    Sources:
    DrugBank

  • L-796449   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ETALOCIB   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LY-510929   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AVE0847   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMORFRUTIN A   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25938459


    Sources:
    DTC

  • OXEGLITAZAR   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BENSULIDE   PPARG

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TROGLITAZONE   PPARG

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    22579484 10076568 10222233 22342624 22424300 10200320 12475986 10097144 11752352 10214942 16680159


    Sources:
    DTC TTD DrugBank GuideToPharmacology ChemblInteractions

  • ELAIDIC ACID   PPARG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    24998974


    Sources:
    DrugBank

  • FENOPROFEN   PPARG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9013583


    Sources:
    DrugBank

  • ISOFLAVONE   PPARG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    12730403


    Sources:
    DrugBank

  • PROSTAGLANDIN D2   PPARG

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23566516


    Sources:
    DTC

  • MESALAMINE   PPARG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name MAX-002
    Direct Interaction? True

    PMIDs:
    18544567 15824083 18077625 16939423


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL434063   PPARG

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    16680159


    Sources:
    DTC GuideToPharmacology

  • ELAFIBRANOR   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ROSIGLITAZONE MALEATE   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIOGLITAZONE HYDROCHLORIDE   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCHLORAZ   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SODELGLITAZAR   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALDICARB   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIFLOXYSTROBIN   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GSK-9578   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DIMETHENAMID   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUORODIFEN   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUDIOXONIL   PPARG

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL375270   PPARG

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Irreversible inhibition
    Endogenous Drug? False

    PMIDs:
    10592235


    Sources:
    DrugBank GuideToPharmacology

  • CLOFAZIMINE   PPARG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    31371410


    Sources:
    DrugBank

  • BEZAFIBRATE   PPARG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16168052


    Sources:
    DrugBank

  • DOCONEXENT   PPARG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    18769551 21382489


    Sources:
    DrugBank

  • OLSALAZINE SODIUM   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BARDOXOLONE   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLIPIZIDE   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17082235


    Sources:
    DrugBank

  • CHLORFENAPYR   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MYCOPHENOLIC ACID   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17618115


    Sources:
    DTC

  • NALED   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BALSALAZIDE DISODIUM   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUOXASTROBIN   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TETRADECYLTHIOACETIC ACID   PPARG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20036122


    Sources:
    DTC

  • BARDOXOLONE METHYL   PPARG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • TREPROSTINIL   PPARG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • SULFASALAZINE   PPARG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name sulfasalazine,Azulfidine, Salazopyrin
    Novel drug target Established target

    PMIDs:
    18544567 15824083 18077625 16939423


    Sources:
    TdgClinicalTrial DrugBank

  • PHTHALIC ACID   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23843199


    Sources:
    DrugBank

  • FLUFENAMIC ACID   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    9013583


    Sources:
    DrugBank

  • FISH OIL TRIGLYCERIDES   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28760435


    Sources:
    DrugBank

  • TRICLOSAN   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25314719


    Sources:
    DrugBank

  • 2-PHENYLPHENOL   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPYLPARABEN   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENOXOLONE   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21888390


    Sources:
    DTC

  • METHOXYCHLOR   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NATEGLINIDE   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17082235


    Sources:
    DrugBank

  • ZOLEDRONIC ACID   PPARG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DEXIBUPROFEN   PPARG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    20089905


    Sources:
    DrugBank

  • PSAMMAPLIN A   PPARG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16643023


    Sources:
    DTC

  • HESPERETIN   PPARG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22429094


    Sources:
    DTC

  • REPAGLINIDE   PPARG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17082235


    Sources:
    DrugBank

  • AMIODARONE   PPARG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    24489787 21123845


    Sources:
    DrugBank

  • 3R14S-OCHRATOXIN A   PPARG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PATULIN   PPARG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BEXAROTENE   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured using a TR-FRET competitive displacement assay.
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • INDOMETHACIN   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    activator (activating)
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    9013583 12689521


    Sources:
    DrugBank GuideToPharmacology

  • LEVOTHYROXINE   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • E319   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPYLPYRAZOLETRIOL   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL312032   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GLYBURIDE   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26384286


    Sources:
    DTC

  • PHENOLPHTHALEIN   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KEPONE   PPARG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL184450   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ROTENONE   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CANNABIDIOL   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    24288245 26264914


    Sources:
    DrugBank

  • GW7647   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18162399


    Sources:
    DTC

  • LINOLENIC ACID   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16731579


    Sources:
    DrugBank

  • BENZBROMARONE   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENOTHIAZINE   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZAFIRLUKAST   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GENTIAN VIOLET   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICHLOROPHEN   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IBUPROFEN   PPARG

    Interaction Score: 0.02

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    20089905


    Sources:
    DrugBank

  • NABIXIMOLS   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • RALOXIFENE HYDROCHLORIDE   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RESVERATROL   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    24454499


    Sources:
    DrugBank GuideToPharmacology

  • METHYLTHIONINIUM CHLORIDE   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICLOFENAC   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SPIRONOLACTONE   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 9,10-PHENANTHRENEQUINONE   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • APIGENIN   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CELECOXIB   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • ESTRADIOL   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OLANZAPINE   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19622037


    Sources:
    PharmGKB

  • CURCUMIN   PPARG

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15713005


    Sources:
    DrugBank

  • ASPIRIN   PPARG

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHOTREXATE   PPARG

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000132170

    • Version: 101_38

    Alternate Names:
    PPARG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P37231

    • Version: January-2014

    Alternate Names:
    PPARG Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • BaderLabGenes: PPARG

    • Version: February-2014

    Alternate Names:
    5468 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1C3
    Counted Citations from 1950-2000 8212

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: P37231

    • Version: 11-September-2012

    Alternate Names:
    PPARG_HUMAN Uniprot Id
    ENSG00000132170 Ensembl Gene Id
    PPARG Uniprot Gene Name

    Gene Info:
    Interpro Acc IPR000536
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000132170

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000132170 Ensembl Gene Id
    PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231] Description
    PPARG Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P37231

    • Version: 01-August-2011

    Alternate Names:
    PPARG Gene Symbol
    P37231 Uniprot Accession
    ENSG00000132170 Ensembl Gene Id

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • GuideToPharmacology: 5468

    • Version: 29-September-2020

    Alternate Names:
    9236 HUGO Gene ID
    9236 HUGO Gene Symbol
    peroxisome proliferator activated receptor gamma HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors
    GuideToPharmacology Gene Category ID 86

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • PharmGKB: PPARG

    • Version: 18-August-2020

    Alternate Names:
    PA281 PharmGKB ID

    Gene Info:

    Publications:
    Herken H et al., 2009, The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia., DNA Cell Biol
    Blüher M et al., 2003, Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes., Diabetes Care
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • DrugBank: BE0000215

    • Version: 5.1.7

    Alternate Names:
    PPARG DrugBank Gene Name
    P37231 UniProt Accession
    5468 Entrez Gene Id

    Gene Info:

    Publications:
    Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci
    Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.
    Ramakers et al., 2007, Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells., Lipids

  • DTC: PPARG

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
    Li JL et al., 2012, PPAR-γ agonistic metabolites from the ascidian Herdmania momus., J Nat Prod
    Xiao B et al., 2012, Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists., Bioorg Med Chem

  • TALC: PPARG

    • Version: 12-May-2016

    Alternate Names:
    PPARG Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: NR1C3

    • Version: chembl_23

    Alternate Names:
    NR1C3 GENE_SYMBOL
    PPARG GENE_SYMBOL
    Peroxisome proliferator-activated receptor gamma UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000132170

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000132170 Gene Symbol
    PPARG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: PPARG

    • Version: 03-September-2020

    Alternate Names:
    Peroxisome proliferator-activated receptor gamma Gene Name
    P37231 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • GO: PPARG

    • Version: 05-September-2020

    Alternate Names:
    NR1C3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR

    Publications:

  • Tempus: PPARG

    • Version: 11-November-2018

    Alternate Names:
    PPARG Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: PPARG

    • Version: 27-Jun-2013

    Alternate Names:
    5468 Gene ID
    CIMT1 dGene Synonym
    GLM1 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Peroxisome proliferator-activated receptor gamma

    • Version: 2020.06.01

    Alternate Names:
    PPAR-gamma TTD Gene Abbreviation
    T58921 TTD Target ID

    Gene Info:

    Publications:

  • FoundationOneGenes: PPARG

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: PPARG

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: PPARG

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21