DGIdb - PPARG Gene Record

PPARG 5468 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

5468
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
601487
9236
ENSG00000132170
OTTHUMG00000129764
P37231
Peroxisome proliferator-activated receptor gamma
PPAR-gamma
Nuclear receptor subfamily 1 group C member 3
PA281
BE0000215
PPARG_HUMAN
595
NP_056953\|NP_619725
Peroxisome proliferator-activated receptor-γ
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231]
T58921
NM_015869\|NM_138712\|NM_138711\|NM_005037

Gene Info:

Target Class	Receptors
Target Subclass	Nuclear receptor
Initial Gene Query	NR1C3
Counted Citations from 1950-2000	8212
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Target Main Class	Receptors
GuideToPharmacology Gene Category Name	1C. Peroxisome proliferator-activated receptors
GuideToPharmacology Gene Category ID	86
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000536
Interpro Type	Domain
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Uniprot Status	Swiss-Prot
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(17 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
TRANSCRIPTION FACTOR BINDING
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Kuroda M et al., 2010, Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity., Bioorg Med Chem
Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
Fuhr L et al., 2015, Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties., J Nat Prod
Chang F et al., 2007, Evolution of peroxisome proliferator-activated receptor agonists., Ann Pharmacother
Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
Rousseaux et al., 2005, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma., J. Exp. Med.
Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.
Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
Iacucci et al., 2010, Mesalazine in inflammatory bowel disease: a trendy topic once again?, Can. J. Gastroenterol.
Tursi, 2009, Balsalazide in treating colonic diseases., Expert Opin Drug Metab Toxicol
Su et al., 1999, Use of a PPAR gamma-specific monoclonal antibody to demonstrate thiazolidinediones induce PPAR gamma receptor expression in vitro., Hybridoma
Xiao B et al., 2012, Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists., Bioorg Med Chem
Festa C et al., 2012, Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ., J Med Chem
Nazreen S et al., 2014, Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression., Bioorg Med Chem Lett
Kharbanda C et al., 2015, Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect., Bioorg Med Chem Lett
Johnson et al., 2000, Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation., J. Mol. Biol.
Liu W et al., 2011, Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators., J Med Chem
Camp et al., 2000, Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone., Diabetes
Kameda et al., 2000, [Rosiglitazone (BRL-49653)]., Nippon Rinsho
Gorczynski MJ et al., 2009, Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation., J Med Chem
Kharbanda C et al., 2014, Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents., Bioorg Med Chem Lett
Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett
Usui S et al., 2005, Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2., Bioorg Med Chem Lett
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Choi J et al., 2010, 1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists., Bioorg Med Chem
Rieusset et al., 1999, Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes., Biochem. Biophys. Res. Commun.
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Piemontese L et al., 2015, Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175., Eur J Med Chem
Bhurruth-Alcor Y et al., 2010, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective., Bioorg Med Chem Lett
Blüher M et al., 2003, Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes., Diabetes Care
Lehmann et al., 1995, An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)., J. Biol. Chem.
Miyazaki et al., 2004, Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients., J. Clin. Endocrinol. Metab.
Willson et al., 1996, The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones., J. Med. Chem.
Spiegelman, 1998, PPAR-gamma: adipogenic regulator and thiazolidinedione receptor., Diabetes
Sugii et al., 2009, PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization., Proc. Natl. Acad. Sci. U.S.A.
Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem
Wick M et al., 2002, Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth., Mol Pharmacol
Mora FD et al., 2006, Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells., J Nat Prod
Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
Hiep NT et al., 2012, Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma., J Nat Prod
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
Nhiem NX et al., 2011, Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway., Bioorg Med Chem Lett
Kitamura et al., 1999, Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells., Jpn. J. Cancer Res.
Satoh et al., 1999, Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells., Biochem. Biophys. Res. Commun.
Hong SS et al., 2012, Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes., Bioorg Med Chem Lett
Petrova et al., 1999, Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2., Proc. Natl. Acad. Sci. U.S.A.
Baek et al., 2003, Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity., J. Biol. Chem.
Demetri et al., 1999, Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma., Proc. Natl. Acad. Sci. U.S.A.
Camp et al., 1999, PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes., FEBS Lett.
Chakrabarti et al., 2003, Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models., Br. J. Pharmacol.
Egerod FL et al., 2005, Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urothelium in vivo., Biomarkers
Lehmann et al., 1997, Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs., J. Biol. Chem.
Cho et al., 2003, A simple ELISA for screening ligands of peroxisome proliferator-activated receptor-gamma., J. Biochem. Mol. Biol.
Cavender et al., 2010, Therapeutic potential of aleglitazar, a new dual PPAR-α/γ agonist: implications for cardiovascular disease in patients with diabetes mellitus., Am J Cardiovasc Drugs
Kasuga J et al., 2008, SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail., Bioorg Med Chem Lett
Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Durgam GG et al., 2006, Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands., Bioorg Med Chem Lett
Lallemand B et al., 2011, N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activity., J Med Chem
Li JL et al., 2012, PPAR-γ agonistic metabolites from the ascidian Herdmania momus., J Nat Prod
Dill et al., 2010, A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons., J. Neurosci.
Pferschy-Wenzig EM et al., 2014, Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma., J Nat Prod
Ubukata M et al., 2007, Mycophenolic acid as a latent agonist of PPARgamma., Bioorg Med Chem Lett
Iio A et al., 2012, Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages., J Nat Prod
Scarsi et al., 2007, Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach., Mol. Pharmacol.
Herken H et al., 2009, The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia., DNA Cell Biol
Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med
Yamagishi et al., 2005, Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property., Med. Hypotheses
Tagami et al., 2009, A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones., Endocrinology
Imayama et al., 2006, Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma., Cardiovasc. Res.
Yamagishi et al., 2006, Role of insulin-sensitizing property of telmisartan, a commercially available angiotensin II type 1 receptor blocker in preventing the development of atrial fibrillation., Med. Hypotheses
Yamagishi et al., 2007, Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders., Curr. Mol. Med.
Kurtz, 2005, Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator., Acta Diabetol
Kurtz, 2008, Beyond the classic angiotensin-receptor-blocker profile., Nat Clin Pract Cardiovasc Med
Lee JH et al., 2015, Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats., J Pharm Sci
Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.
Ramakers et al., 2007, Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells., Lipids
Chambrier et al., 2002, Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma., Obes. Res.
Selvaraj et al., 2006, Lutein and eicosapentaenoic acid interact to modify iNOS mRNA levels through the PPARgamma/RXR pathway in chickens and HD11 cell lines., J. Nutr.
Horia et al., 2007, Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells., Carcinogenesis
Edwards IJ et al., 2008, Omega-3 Fatty Acids and PPARgamma in Cancer., PPAR Res
Varga T et al., 2011, PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation., Biochim Biophys Acta
Inoue et al., 2002, Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB., Biochem. Biophys. Res. Commun.
Erbe DV et al., 2005, Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms., Mol Pharmacol
Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci
Fang M et al., 2015, Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust., Environ Health Perspect
Nishiyama T et al., 2005, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice., J Agric Food Chem
Rodríguez-Cruz M et al., 2017, Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors., Nutrition
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
Mezei O et al., 2003, Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells., J Nutr
Szalowska E et al., 2014, Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices., PLoS One
Song M et al., 2011, Phospholipidosis induced by PPARγ signaling in human bronchial epithelial (BEAS-2B) cells exposed to amiodarone., Toxicol Sci
Hulin B et al., 1992, Novel thiazolidine-2,4-diones as potent euglycemic agents., J Med Chem
Kumar H et al., 2020, Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells., Haematologica
Scuderi C et al., 2014, Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPARγ involvement., Phytother Res
Zhang L et al., 2014, Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ., Toxicol Appl Pharmacol
Sarath Josh MK et al., 2014, Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach., J Appl Toxicol

CLX-0921 PPARG

Interaction Score: 1.28

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions
MBX-2044 PPARG

Interaction Score: 0.96

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name MBX-2044

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
NETOGLITAZONE PPARG

Interaction Score: 0.96

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
None found

Sources:
TTD GuideToPharmacology ChemblInteractions
RAGAGLITAZAR PPARG

Interaction Score: 0.96

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
12970088 16240504 10592235

Sources:
TTD DrugBank GuideToPharmacology
INT131 PPARG

Interaction Score: 0.96

Interaction Types & Directionality:

partial agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name INT-131, AMG-131, T131

PMIDs:
None found

Sources:
TdgClinicalTrial DrugBank ChemblInteractions
CHEMBL1210221 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL364748 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1230670 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL86658 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL451721 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL200495 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL378160 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL191060 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL191275 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL2178583 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934537

Sources:
DTC
LICOFLAVANONE A PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
SHINFLAVANONE PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
GLABRONE PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
CHEMBL2208197 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189988

Sources:
DTC
CHEMBL2178586 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934537

Sources:
DTC
ECHINATIN PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
OMS405 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
CHEMBL2057864 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22819190

Sources:
DTC
GANCAONIN L PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
CHEMBL2208196 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189988

Sources:
DTC
CHEMBL599165 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
CHEMBL2208195 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189988

Sources:
DTC
CHEMBL202243 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16263282

Sources:
DTC
CHEMBL1833984 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21889336

Sources:
DTC
ATX08-001 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
BALAGLITAZONE PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
TESAGLITAZAR PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
16168052

Sources:
TTD DrugBank ChemblInteractions
CHEMBL2178596 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934537

Sources:
DTC
NAVEGLITAZAR PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name LY519818 , LY818

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions
KANZONOL X PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
EFATUTAZONE HYDROCHLORIDE PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name CS-7017

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RIVOGLITAZONE PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TTD ChemblInteractions
ELATOSIDE D PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21889336

Sources:
DTC
CHEMBL1834951 PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21889336

Sources:
DTC
SEIMATOPOLIDE A PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22424300

Sources:
DTC
ARHALOFENATE PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
17519293

Sources:
TTD DrugBank ChemblInteractions
KANZONOL W PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
SHINPTEROCARPIN PPARG

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
ALEGLITAZAR PPARG

Interaction Score: 0.53

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name aleglitazar, R1439

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
20653327 10592235

Sources:
TdgClinicalTrial DrugBank ChemblInteractions
LOBEGLITAZONE PPARG

Interaction Score: 0.48

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
25648999

Sources:
TTD DrugBank
DB959 PPARG

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DB-959

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions
BALSALAZIDE PPARG

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name balsalazide disodium,Colazal, Giazo

Novel drug target Established target

PMIDs:
18077625 20151072 16939423 19708827

Sources:
TdgClinicalTrial DrugBank
CIGLITAZONE PPARG

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
20170185 12391285 16643023 23566516

Sources:
DTC DrugBank GuideToPharmacology
PIOGLITAZONE PPARG

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12610044 7768881 24890090 15356026 8576907 9568680 15745794 11752352 21030263 20018750 16680159

Sources:
TEND DTC PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology
CHEMBL201880 PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
DARGLITAZONE PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
1588563

Sources:
DrugBank
TELMISARTAN PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
15617852 19147680 16938288 16154710 17691961 15868121 18580862

Sources:
DrugBank
EFATUTAZONE PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
THIAZOLIDINEDIONE PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GLITAZONE PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METAGLIDASEN PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name metaglidasen, JNJ-39659100, MBX-102

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TECNAZENE PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
L-165461 PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
GLABROL PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
IMIGLITAZAR PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
GW501516 PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GW501516

Novel drug target Established target

PMIDs:
23566516

Sources:
DTC TdgClinicalTrial
IPRODIONE PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TIROTUNDIN PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring PPARγ transactivation in response to compound binding directly to the receptor's ligand binding domain.

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

FENOFIBRIC ACID PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22579484 23566516

Sources:
DTC
REGLITAZAR PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
DrugBank GuideToPharmacology
FARGLITAZAR PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
TTD GuideToPharmacology ChemblInteractions
GW7845 PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MK-0533 PPARG

Interaction Score: 0.32

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
None found

Sources:
ChemblInteractions
INDEGLITAZAR PPARG

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

PMIDs:
10592235

Sources:
DrugBank ChemblInteractions
ROSIGLITAZONE PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
10475242 22819190 22934537 24890090 26384286 10764590 22070604 10871190 10707565 19719236 25442322 23273519 15745794 11752352 21030263 10548525 16680159 25497132

Sources:
TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology
CHEMBL1204498 PPARG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CLINOFIBRATE PPARG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11779144

Sources:
DrugBank
ISOSILYBIN A PPARG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24597776

Sources:
DTC
MURAGLITAZAR PPARG

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Trial Name muraglitazar, BMS-298585

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions
ABIETIC ACID PPARG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24799257

Sources:
DTC
DECANOIC ACID PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
24998974

Sources:
DrugBank
ERTIPROTAFIB PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15475571

Sources:
DrugBank
PHENAMIPHOS PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MITOGLITAZONE PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MSDC-0160

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ICOSAPENT PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11552681 17610002 12055328 16702329 17052999

Sources:
DrugBank
CHEMBL410478 PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL166112 PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MK-0767 PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
EDAGLITAZONE PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring agonist-induced cofactor recruitment.

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MITIGLINIDE PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17082235

Sources:
DrugBank
L-796449 PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
ETALOCIB PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LY-510929 PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
AVE0847 PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
ChemblInteractions
AMORFRUTIN A PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25938459

Sources:
DTC
OXEGLITAZAR PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BENSULIDE PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TROGLITAZONE PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
22579484 10076568 10222233 22342624 22424300 10200320 12475986 10097144 11752352 10214942 16680159

Sources:
DTC TTD DrugBank GuideToPharmacology ChemblInteractions
ELAIDIC ACID PPARG

Interaction Score: 0.13

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
24998974

Sources:
DrugBank
FENOPROFEN PPARG

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9013583

Sources:
DrugBank
ISOFLAVONE PPARG

Interaction Score: 0.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
12730403

Sources:
DrugBank
PROSTAGLANDIN D2 PPARG

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23566516

Sources:
DTC
MESALAMINE PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name MAX-002

Direct Interaction? True

PMIDs:
18544567 15824083 18077625 16939423

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
CHEMBL434063 PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
16680159

Sources:
DTC GuideToPharmacology
ELAFIBRANOR PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ROSIGLITAZONE MALEATE PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIOGLITAZONE HYDROCHLORIDE PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCHLORAZ PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SODELGLITAZAR PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALDICARB PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIFLOXYSTROBIN PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-9578 PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DIMETHENAMID PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUORODIFEN PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUDIOXONIL PPARG

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL375270 PPARG

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Irreversible inhibition

Endogenous Drug? False

PMIDs:
10592235

Sources:
DrugBank GuideToPharmacology
CLOFAZIMINE PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
31371410

Sources:
DrugBank
BEZAFIBRATE PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16168052

Sources:
DrugBank
DOCONEXENT PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
18769551 21382489

Sources:
DrugBank
OLSALAZINE SODIUM PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BARDOXOLONE PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
GLIPIZIDE PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17082235

Sources:
DrugBank
CHLORFENAPYR PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MYCOPHENOLIC ACID PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17618115

Sources:
DTC
NALED PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BALSALAZIDE DISODIUM PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUOXASTROBIN PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TETRADECYLTHIOACETIC ACID PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20036122

Sources:
DTC
BARDOXOLONE METHYL PPARG

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
TREPROSTINIL PPARG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
SULFASALAZINE PPARG

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name sulfasalazine,Azulfidine, Salazopyrin

Novel drug target Established target

PMIDs:
18544567 15824083 18077625 16939423

Sources:
TdgClinicalTrial DrugBank
PHTHALIC ACID PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23843199

Sources:
DrugBank
FLUFENAMIC ACID PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
9013583

Sources:
DrugBank
FISH OIL TRIGLYCERIDES PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28760435

Sources:
DrugBank
TRICLOSAN PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25314719

Sources:
DrugBank
2-PHENYLPHENOL PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPYLPARABEN PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENOXOLONE PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21888390

Sources:
DTC
METHOXYCHLOR PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NATEGLINIDE PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17082235

Sources:
DrugBank
ZOLEDRONIC ACID PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DEXIBUPROFEN PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
20089905

Sources:
DrugBank
PSAMMAPLIN A PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16643023

Sources:
DTC
HESPERETIN PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22429094

Sources:
DTC
REPAGLINIDE PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
17082235

Sources:
DrugBank
AMIODARONE PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
24489787 21123845

Sources:
DrugBank
3R14S-OCHRATOXIN A PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PATULIN PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BEXAROTENE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measured using a TR-FRET competitive displacement assay.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
INDOMETHACIN PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
9013583 12689521

Sources:
DrugBank GuideToPharmacology
LEVOTHYROXINE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
E319 PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPYLPYRAZOLETRIOL PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL312032 PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLYBURIDE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26384286

Sources:
DTC
PHENOLPHTHALEIN PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KEPONE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL184450 PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROTENONE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CANNABIDIOL PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
24288245 26264914

Sources:
DrugBank
GW7647 PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18162399

Sources:
DTC
LINOLENIC ACID PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16731579

Sources:
DrugBank
BENZBROMARONE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENOTHIAZINE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZAFIRLUKAST PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
GENTIAN VIOLET PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLOROPHEN PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IBUPROFEN PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
20089905

Sources:
DrugBank
NABIXIMOLS PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
RALOXIFENE HYDROCHLORIDE PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
24454499

Sources:
DrugBank GuideToPharmacology
METHYLTHIONINIUM CHLORIDE PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICLOFENAC PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SPIRONOLACTONE PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
9,10-PHENANTHRENEQUINONE PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APIGENIN PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
ESTRADIOL PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLANZAPINE PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19622037

Sources:
PharmGKB
CURCUMIN PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15713005

Sources:
DrugBank
ASPIRIN PPARG

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE PPARG

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000132170
- Version: 101_38
Alternate Names:

PPARG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P37231
- Version: January-2014
Alternate Names:

PPARG Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
BaderLabGenes: PPARG
- Version: February-2014
Alternate Names:

5468 Entrez Gene ID

Gene Info:

Initial Gene Query NR1C3

Counted Citations from 1950-2000 8212

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P37231
- Version: 11-September-2012
Alternate Names:

PPARG_HUMAN Uniprot Id

ENSG00000132170 Ensembl Gene Id

PPARG Uniprot Gene Name

Gene Info:

Interpro Acc IPR000536

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000132170
- Version: 26-July-2011
Alternate Names:

ENSG00000132170 Ensembl Gene Id

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231] Description

PPARG Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P37231
- Version: 01-August-2011
Alternate Names:

PPARG Gene Symbol

P37231 Uniprot Accession

ENSG00000132170 Ensembl Gene Id

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Publications:
GuideToPharmacology: 5468
- Version: 29-September-2020
Alternate Names:

9236 HUGO Gene ID

9236 HUGO Gene Symbol

peroxisome proliferator activated receptor gamma HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors

GuideToPharmacology Gene Category ID 86

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

PharmGKB: PPARG

Version: 18-August-2020

Alternate Names:

PA281 PharmGKB ID

Gene Info:

Publications:

Herken H et al., 2009, The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia., DNA Cell Biol

Blüher M et al., 2003, Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes., Diabetes Care

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DrugBank: BE0000215

Version: 5.1.7

Alternate Names:

PPARG DrugBank Gene Name

P37231 UniProt Accession

5468 Entrez Gene Id

Gene Info:

Publications:

Vanden Heuvel JP et al., 2006, Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha., Toxicol Sci

Iwata et al., 2001, Interaction between peroxisome proliferator-activated receptor gamma and its agonists: docking study of oximes having 5-benzyl-2,4-thiazolidinedione., J. Mol. Graph. Model.

Ramakers et al., 2007, Arachidonic acid but not eicosapentaenoic acid (EPA) and oleic acid activates NF-kappaB and elevates ICAM-1 expression in Caco-2 cells., Lipids

DTC: PPARG

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem

Li JL et al., 2012, PPAR-γ agonistic metabolites from the ascidian Herdmania momus., J Nat Prod

Xiao B et al., 2012, Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists., Bioorg Med Chem

TALC: PPARG
- Version: 12-May-2016
Alternate Names:

PPARG Gene Symbol

Gene Info:

Publications:
ChemblInteractions: NR1C3
- Version: chembl_23
Alternate Names:

NR1C3 GENE_SYMBOL

PPARG GENE_SYMBOL

Peroxisome proliferator-activated receptor gamma UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000132170
- Version: 31-May-2017
Alternate Names:

ENSG00000132170 Gene Symbol

PPARG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: PPARG
- Version: 03-September-2020
Alternate Names:

Peroxisome proliferator-activated receptor gamma Gene Name

P37231 UniProt ID

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
GO: PPARG
- Version: 05-September-2020
Alternate Names:

NR1C3 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR

Publications:
Tempus: PPARG
- Version: 11-November-2018
Alternate Names:

PPARG Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PPARG
- Version: 27-Jun-2013
Alternate Names:

5468 Gene ID

CIMT1 dGene Synonym

GLM1 dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Peroxisome proliferator-activated receptor gamma
- Version: 2020.06.01
Alternate Names:

PPAR-gamma TTD Gene Abbreviation

T58921 TTD Target ID

Gene Info:

Publications:
FoundationOneGenes: PPARG
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: PPARG
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: PPARG
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist
Direct Interaction	yes
Novel drug target	Established target

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma modulator

Trial Name	LY519818 , LY818
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist

Trial Name	aleglitazar, R1439
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist

Trial Name	DB-959
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist

Trial Name	balsalazide disodium,Colazal, Giazo
Novel drug target	Established target

Trial Name	metaglidasen, JNJ-39659100, MBX-102
Novel drug target	Established target

Details of the Assay for Interaction	Measuring PPARγ transactivation in response to compound binding directly to the receptor's ligand binding domain.
Specific Action of the Ligand	Agonist
Endogenous Drug?	False

Details of the Assay for Interaction	Measuring agonist-induced cofactor recruitment.
Specific Action of the Ligand	Agonist
Endogenous Drug?	False

Specific Action of the Ligand	Irreversible inhibition
Endogenous Drug?	False

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False
Direct Interaction?	False

Trial Name	sulfasalazine,Azulfidine, Salazopyrin
Novel drug target	Established target

Details of the Assay for Interaction	Measured using a TR-FRET competitive displacement assay.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

PPARG_HUMAN	Uniprot Id
ENSG00000132170	Ensembl Gene Id
PPARG	Uniprot Gene Name

PPARG	Gene Symbol
P37231	Uniprot Accession
ENSG00000132170	Ensembl Gene Id

9236	HUGO Gene ID
9236	HUGO Gene Symbol
peroxisome proliferator activated receptor gamma	HUGO Gene Name

PPARG	DrugBank Gene Name
P37231	UniProt Accession
5468	Entrez Gene Id

NR1C3	GENE_SYMBOL
PPARG	GENE_SYMBOL
Peroxisome proliferator-activated receptor gamma	UNIPROT

Peroxisome proliferator-activated receptor gamma	Gene Name
P37231	UniProt ID

PPARG Gene Record

PPARG 5468 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist Direct Interaction yes Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator Direct Interaction yes Trial Name MBX-2044

PMIDs: None found

Sources: TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality: agonist (activating) modulator

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs: None found

Sources: TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: 12970088 16240504 10592235

Sources: TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: partial agonist (activating) modulator

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator Direct Interaction yes Trial Name INT-131, AMG-131, T131

PMIDs: None found

Sources: TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22934537

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name MBX-2044

PMIDs:
None found

Sources:
TdgClinicalTrial TTD ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
None found

Sources:
TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
12970088 16240504 10592235

Sources:
TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

partial agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name INT-131, AMG-131, T131

PMIDs:
None found

Sources:
TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22934537

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22934537

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22819190

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189988