DGIdb - PPARG Gene Record

PPARG 5468 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

5468
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
601487
9236
ENSG00000132170
OTTHUMG00000129764
P37231
Peroxisome proliferator-activated receptor gamma
PPAR-gamma
Nuclear receptor subfamily 1 group C member 3
PA281
PPARG_HUMAN
595
NP_056953\|NP_619725
Peroxisome proliferator-activated receptor-γ
PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231]
T58921
NM_015869\|NM_138712\|NM_138711\|NM_005037
PPARG5

Gene Info:

Target Class	Receptors
Target Subclass	Nuclear receptor
Initial Gene Query	NR1C3
Counted Citations from 1950-2000	8212
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Target Main Class	Receptors
GuideToPharmacology Gene Category Name	1C. Peroxisome proliferator-activated receptors
GuideToPharmacology Gene Category ID	86
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000536
Interpro Type	Domain
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Uniprot Status	Swiss-Prot
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(16 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
TRANSCRIPTION FACTOR BINDING
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Kuroda M et al., 2010, Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity., Bioorg Med Chem
Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
Fuhr L et al., 2015, Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties., J Nat Prod
Chang F et al., 2007, Evolution of peroxisome proliferator-activated receptor agonists., Ann Pharmacother
Rousseaux et al., 2005, Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma., J. Exp. Med.
Linard et al., 2008, Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist., J. Pharmacol. Exp. Ther.
Desreumaux et al., 2006, Review article: mode of action and delivery of 5-aminosalicylic acid - new evidence., Aliment. Pharmacol. Ther.
Schwab et al., 2008, PPARgamma is involved in mesalazine-mediated induction of apoptosis and inhibition of cell growth in colon cancer cells., Carcinogenesis
Iacucci et al., 2010, Mesalazine in inflammatory bowel disease: a trendy topic once again?, Can. J. Gastroenterol.
Tursi, 2009, Balsalazide in treating colonic diseases., Expert Opin Drug Metab Toxicol
Piemontese L et al., 2015, Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175., Eur J Med Chem
Choi J et al., 2010, 1,3-Diphenyl-1H-pyrazole derivatives as a new series of potent PPARγ partial agonists., Bioorg Med Chem
Xiao B et al., 2012, Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists., Bioorg Med Chem
Gathiaka S et al., 2013, Design, development and evaluation of novel dual PPARδ/PPARγ agonists., Bioorg Med Chem Lett
Kharbanda C et al., 2014, Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents., Bioorg Med Chem Lett
Nazreen S et al., 2014, Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression., Bioorg Med Chem Lett
Festa C et al., 2012, Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ., J Med Chem
Usui S et al., 2005, Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2., Bioorg Med Chem Lett
Kharbanda C et al., 2015, Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect., Bioorg Med Chem Lett
Liu W et al., 2011, Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators., J Med Chem
Gorczynski MJ et al., 2009, Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation., J Med Chem
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Kameda et al., 2000, [Rosiglitazone (BRL-49653)]., Nippon Rinsho
Rieusset et al., 1999, Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes., Biochem. Biophys. Res. Commun.
Johnson et al., 2000, Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation., J. Mol. Biol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Su et al., 1999, Use of a PPAR gamma-specific monoclonal antibody to demonstrate thiazolidinediones induce PPAR gamma receptor expression in vitro., Hybridoma
Camp et al., 2000, Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone., Diabetes
Bhurruth-Alcor Y et al., 2010, Novel phospholipid analogues of pan-PPAR activator tetradecylthioacetic acid are more PPAR alpha selective., Bioorg Med Chem Lett
Blüher M et al., 2003, Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes., Diabetes Care
Sugii et al., 2009, PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization., Proc. Natl. Acad. Sci. U.S.A.
Spiegelman, 1998, PPAR-gamma: adipogenic regulator and thiazolidinedione receptor., Diabetes
Willson et al., 1996, The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones., J. Med. Chem.
Miyazaki et al., 2004, Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients., J. Clin. Endocrinol. Metab.
Lehmann et al., 1995, An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)., J. Biol. Chem.
Sato A et al., 2013, Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists., Bioorg Med Chem Lett
Mora FD et al., 2006, Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-gamma (PPARgamma): the marine sponge metabolite psammaplin A activates PPARgamma and induces apoptosis in human breast tumor cells., J Nat Prod
Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem
Wick M et al., 2002, Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth., Mol Pharmacol
Hiep NT et al., 2012, Polyhydroxylated macrolides from Seimatosporium discosioides and their effects on the activation of peroxisome proliferator-activated receptor gamma., J Nat Prod
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Hoang MH et al., 2012, Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells., Bioorg Med Chem Lett
Nhiem NX et al., 2011, Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway., Bioorg Med Chem Lett
Petrova et al., 1999, Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2., Proc. Natl. Acad. Sci. U.S.A.
Kitamura et al., 1999, Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells., Jpn. J. Cancer Res.
Demetri et al., 1999, Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma., Proc. Natl. Acad. Sci. U.S.A.
Satoh et al., 1999, Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells., Biochem. Biophys. Res. Commun.
Camp et al., 1999, PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes., FEBS Lett.
Baek et al., 2003, Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity., J. Biol. Chem.
Hong SS et al., 2012, Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes., Bioorg Med Chem Lett
Egerod FL et al., 2005, Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urothelium in vivo., Biomarkers
Chakrabarti et al., 2003, Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models., Br. J. Pharmacol.
Lehmann et al., 1997, Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs., J. Biol. Chem.
Cho et al., 2003, A simple ELISA for screening ligands of peroxisome proliferator-activated receptor-gamma., J. Biochem. Mol. Biol.
Cavender et al., 2010, Therapeutic potential of aleglitazar, a new dual PPAR-α/γ agonist: implications for cardiovascular disease in patients with diabetes mellitus., Am J Cardiovasc Drugs
Kasuga J et al., 2008, SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail., Bioorg Med Chem Lett
Tenenbaum et al., 2005, Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons., Cardiovasc Diabetol
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Durgam GG et al., 2006, Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands., Bioorg Med Chem Lett
Lallemand B et al., 2011, N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activity., J Med Chem
Li JL et al., 2012, PPAR-γ agonistic metabolites from the ascidian Herdmania momus., J Nat Prod
Pferschy-Wenzig EM et al., 2014, Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma., J Nat Prod
Ubukata M et al., 2007, Mycophenolic acid as a latent agonist of PPARgamma., Bioorg Med Chem Lett
Iio A et al., 2012, Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages., J Nat Prod
Herken H et al., 2009, The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia., DNA Cell Biol
Konno H et al., 2013, Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males: A Randomized Controlled Study., Evid Based Complement Alternat Med
Lee JH et al., 2015, Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats., J Pharm Sci

MBX-2044 PPARG

Interaction Score: 1.39

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name MBX-2044

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
NETOGLITAZONE PPARG

Interaction Score: 1.39

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology TTD
CLX-0921 PPARG

Interaction Score: 1.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
RAGAGLITAZAR PPARG

Interaction Score: 1.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
16240504 12970088 10592235

Sources:
GuideToPharmacology TTD
CHEMBL2178583 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934537

Sources:
DTC
LICOFLAVANONE A PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
SHINFLAVANONE PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
GLABRONE PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
CHEMBL2208197 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189988

Sources:
DTC
CHEMBL2178586 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934537

Sources:
DTC
ECHINATIN PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
OMS405 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL2057864 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22819190

Sources:
DTC
GANCAONIN L PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
CHEMBL2208196 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189988

Sources:
DTC
CHEMBL599165 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
CHEMBL2208195 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189988

Sources:
DTC
CHEMBL202243 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16263282

Sources:
DTC
CHEMBL1833984 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21889336

Sources:
DTC
ATX08-001 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
BALAGLITAZONE PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHEMBL2178596 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22934537

Sources:
DTC
ALEGLITAZAR PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name aleglitazar, R1439

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
10592235 20653327

Sources:
TdgClinicalTrial ChemblInteractions
KANZONOL X PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
EFATUTAZONE HYDROCHLORIDE PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name CS-7017

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RIVOGLITAZONE PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
ELATOSIDE D PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21889336

Sources:
DTC
CHEMBL1834951 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21889336

Sources:
DTC
SEIMATOPOLIDE A PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22424300

Sources:
DTC
KANZONOL W PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
INT131 PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

partial agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name INT-131, AMG-131, T131

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
SHINPTEROCARPIN PPARG

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
TESAGLITAZAR PPARG

Interaction Score: 0.69

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
16168052

Sources:
ChemblInteractions TTD
DB959 PPARG

Interaction Score: 0.69

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name DB-959

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
NAVEGLITAZAR PPARG

Interaction Score: 0.69

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name LY519818 , LY818

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
ARHALOFENATE PPARG

Interaction Score: 0.69

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
17519293

Sources:
ChemblInteractions TTD
BALSALAZIDE PPARG

Interaction Score: 0.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name balsalazide disodium,Colazal, Giazo

Novel drug target Established target

PMIDs:
16939423 20151072 18077625 19708827

Sources:
TdgClinicalTrial
PIOGLITAZONE PPARG

Interaction Score: 0.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12610044 21030263 24890090 15745794 16680159 20018750 9568680 8576907 11752352 15356026 7768881

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD
LOBEGLITAZONE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
25648999

Sources:
TTD
EFATUTAZONE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
THIAZOLIDINEDIONE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GLITAZONE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METAGLIDASEN PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name metaglidasen, JNJ-39659100, MBX-102

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TECNAZENE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
L-165461 PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
GLABROL PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20022509

Sources:
DTC
IMIGLITAZAR PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
GW501516 PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GW501516

Novel drug target Established target

PMIDs:
23566516

Sources:
DTC TdgClinicalTrial
IPRODIONE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TIROTUNDIN PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring PPARγ transactivation in response to compound binding directly to the receptor's ligand binding domain.

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

FENOFIBRIC ACID PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22579484 23566516

Sources:
DTC
CIGLITAZONE PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
23566516 16643023 20170185 12391285

Sources:
DTC GuideToPharmacology
FARGLITAZAR PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology TTD
GW7845 PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MK-0533 PPARG

Interaction Score: 0.46

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
None found

Sources:
ChemblInteractions
ROSIGLITAZONE PPARG

Interaction Score: 0.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
25497132 21030263 22819190 23273519 25442322 24890090 22934537 15745794 26384286 22070604 19719236 16680159 10707565 10548525 10764590 11752352 10475242 10871190

Sources:
DTC TdgClinicalTrial TEND GuideToPharmacology
ISOSILYBIN A PPARG

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24597776

Sources:
DTC
PROSTAGLANDIN D2 PPARG

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23566516

Sources:
DTC
INDEGLITAZAR PPARG

Interaction Score: 0.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

PMIDs:
10592235

Sources:
ChemblInteractions
ABIETIC ACID PPARG

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24799257

Sources:
DTC
TROGLITAZONE PPARG

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
10200320 10076568 10097144 10222233 10214942 11752352 12475986 22342624 16680159 22579484 22424300

Sources:
DTC ChemblInteractions GuideToPharmacology TTD
PHENAMIPHOS PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MITOGLITAZONE PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MSDC-0160

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL410478 PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL166112 PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MK-0767 PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
EDAGLITAZONE PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measuring agonist-induced cofactor recruitment.

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
L-796449 PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
ETALOCIB PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MURAGLITAZAR PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Trial Name muraglitazar, BMS-298585

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
REGLITAZAR PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
LY-510929 PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
AVE0847 PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
None found

Sources:
ChemblInteractions
AMORFRUTIN A PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25938459

Sources:
DTC
OXEGLITAZAR PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BENSULIDE PPARG

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL434063 PPARG

Interaction Score: 0.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
16680159

Sources:
DTC GuideToPharmacology
MESALAMINE PPARG

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name MAX-002

Direct Interaction? True

PMIDs:
15824083 18077625 16939423 18544567

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology
ROSIGLITAZONE MALEATE PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BARDOXOLONE PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PIOGLITAZONE HYDROCHLORIDE PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCHLORAZ PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SODELGLITAZAR PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALDICARB PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIFLOXYSTROBIN PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GSK-9578 PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DIMETHENAMID PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUORODIFEN PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUDIOXONIL PPARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLSALAZINE SODIUM PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLORFENAPYR PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MYCOPHENOLIC ACID PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17618115

Sources:
DTC
NALED PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BALSALAZIDE DISODIUM PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL375270 PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Irreversible inhibition

Endogenous Drug? False

PMIDs:
10592235

Sources:
GuideToPharmacology
FLUOXASTROBIN PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TETRADECYLTHIOACETIC ACID PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20036122

Sources:
DTC
BARDOXOLONE METHYL PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
TREPROSTINIL PPARG

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
HESPERETIN PPARG

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22429094

Sources:
DTC
SULFASALAZINE PPARG

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name sulfasalazine,Azulfidine, Salazopyrin

Novel drug target Established target

PMIDs:
15824083 18077625 16939423 18544567

Sources:
TdgClinicalTrial
2-PHENYLPHENOL PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPYLPARABEN PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENOXOLONE PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21888390

Sources:
DTC
METHOXYCHLOR PPARG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZOLEDRONIC ACID PPARG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PSAMMAPLIN A PPARG

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16643023

Sources:
DTC
PHENOLPHTHALEIN PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVOTHYROXINE PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLYBURIDE PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26384286

Sources:
DTC
3R14S-OCHRATOXIN A PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PATULIN PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BEXAROTENE PPARG

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measured using a TR-FRET competitive displacement assay.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
E319 PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPYLPYRAZOLETRIOL PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL312032 PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KEPONE PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INDOMETHACIN PPARG

Interaction Score: 0.04

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
9013583 12689521

Sources:
GuideToPharmacology
CHEMBL184450 PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROTENONE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW7647 PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18162399

Sources:
DTC
BENZBROMARONE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENOTHIAZINE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ZAFIRLUKAST PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
GuideToPharmacology
GENTIAN VIOLET PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLOROPHEN PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SPIRONOLACTONE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RALOXIFENE HYDROCHLORIDE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYLTHIONINIUM CHLORIDE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RESVERATROL PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
24454499

Sources:
GuideToPharmacology
DICLOFENAC PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
9,10-PHENANTHRENEQUINONE PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APIGENIN PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRADIOL PPARG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
OLANZAPINE PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19622037

Sources:
PharmGKB
ASPIRIN PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE PPARG

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000132170
- Version: 101_38
Alternate Names:

PPARG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P37231
- Version: January-2014
Alternate Names:

PPARG Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
BaderLabGenes: PPARG
- Version: February-2014
Alternate Names:

5468 Entrez Gene ID

Gene Info:

Initial Gene Query NR1C3

Counted Citations from 1950-2000 8212

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P37231
- Version: 11-September-2012
Alternate Names:

PPARG_HUMAN Uniprot Id

ENSG00000132170 Ensembl Gene Id

PPARG Uniprot Gene Name

Gene Info:

Interpro Acc IPR000536

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000132170
- Version: 26-July-2011
Alternate Names:

ENSG00000132170 Ensembl Gene Id

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPAR-GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P37231] Description

PPARG Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P37231
- Version: 01-August-2011
Alternate Names:

PPARG Gene Symbol

P37231 Uniprot Accession

ENSG00000132170 Ensembl Gene Id

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Publications:
GuideToPharmacology: 5468
- Version: 29-September-2020
Alternate Names:

9236 HUGO Gene ID

9236 HUGO Gene Symbol

peroxisome proliferator activated receptor gamma HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1C. Peroxisome proliferator-activated receptors

GuideToPharmacology Gene Category ID 86

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

PharmGKB: PPARG

Version: 18-August-2020

Alternate Names:

PA281 PharmGKB ID

Gene Info:

Publications:

Herken H et al., 2009, The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia., DNA Cell Biol

Blüher M et al., 2003, Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes., Diabetes Care

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

DTC: PPARG

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem

Li JL et al., 2012, PPAR-γ agonistic metabolites from the ascidian Herdmania momus., J Nat Prod

Xiao B et al., 2012, Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists., Bioorg Med Chem

TALC: PPARG
- Version: 12-May-2016
Alternate Names:

PPARG Gene Symbol

Gene Info:

Publications:
ChemblInteractions: NR1C3
- Version: chembl_23
Alternate Names:

NR1C3 GENE_SYMBOL

PPARG GENE_SYMBOL

Peroxisome proliferator-activated receptor gamma UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000132170
- Version: 31-May-2017
Alternate Names:

ENSG00000132170 Gene Symbol

PPARG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: PPARG
- Version: 11-November-2018
Alternate Names:

PPARG Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PPARG
- Version: 27-Jun-2013
Alternate Names:

5468 Gene ID

CIMT1 dGene Synonym

GLM1 dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Peroxisome proliferator-activated receptor gamma
- Version: 2020.06.01
Alternate Names:

PPAR-gamma TTD Gene Abbreviation

T58921 TTD Target ID

Gene Info:

Publications:
GO: PPARG
- Version: 01-May-2021
Alternate Names:

NR1C3 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE, TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR

Publications:
Pharos: PPARG
- Version: 01-May-2021
Alternate Names:

Peroxisome proliferator-activated receptor gamma Gene Name

P37231 UniProt ID

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
FoundationOneGenes: PPARG
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: PPARG
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: PPARG
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma modulator
Direct Interaction	yes
Trial Name	MBX-2044

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma modulator

Trial Name	aleglitazar, R1439
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist

Trial Name	DB-959
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist

Trial Name	LY519818 , LY818
Novel drug target	Established target
Mechanism of Interaction	Peroxisome proliferator-activated receptor gamma agonist

Trial Name	balsalazide disodium,Colazal, Giazo
Novel drug target	Established target

Trial Name	metaglidasen, JNJ-39659100, MBX-102
Novel drug target	Established target

Details of the Assay for Interaction	Measuring PPARγ transactivation in response to compound binding directly to the receptor's ligand binding domain.
Specific Action of the Ligand	Agonist
Endogenous Drug?	False

Details of the Assay for Interaction	Measuring agonist-induced cofactor recruitment.
Specific Action of the Ligand	Agonist
Endogenous Drug?	False

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Irreversible inhibition
Endogenous Drug?	False

Trial Name	sulfasalazine,Azulfidine, Salazopyrin
Novel drug target	Established target

Details of the Assay for Interaction	Measured using a TR-FRET competitive displacement assay.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

PPARG_HUMAN	Uniprot Id
ENSG00000132170	Ensembl Gene Id
PPARG	Uniprot Gene Name

PPARG	Gene Symbol
P37231	Uniprot Accession
ENSG00000132170	Ensembl Gene Id

9236	HUGO Gene ID
9236	HUGO Gene Symbol
peroxisome proliferator activated receptor gamma	HUGO Gene Name

NR1C3	GENE_SYMBOL
PPARG	GENE_SYMBOL
Peroxisome proliferator-activated receptor gamma	UNIPROT

Peroxisome proliferator-activated receptor gamma	Gene Name
P37231	UniProt ID

PPARG Gene Record

PPARG 5468 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator Direct Interaction yes Trial Name MBX-2044

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating) modulator

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist Direct Interaction yes Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: 16240504 12970088 10592235

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22934537

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23189988

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22934537

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22819190

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23189988

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20022509

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23189988

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16263282

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

Trial Name MBX-2044

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
16240504 12970088 10592235

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
22934537

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22934537

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
22819190

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16263282

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21889336

Sources:
DTC

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
22934537

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name aleglitazar, R1439

Novel drug target Established target

Mechanism of Interaction Peroxisome proliferator-activated receptor gamma agonist

PMIDs:
10592235 20653327

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20022509

Sources:
DTC