DGIdb - PRKAB1 Gene Record

PRKAB1 5564 Druggable Genome

Alternate Names:

5564
PROTEIN KINASE AMP-ACTIVATED NON-CATALYTIC SUBUNIT BETA 1
PRKAB1
AMPK
HAMPKb
602740
9378
ENSG00000111725
OTTHUMG00000168954
Q9Y478
AAKB1_HUMAN
PA33746
5'-AMP-activated protein kinase subunit beta-1

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.11.1
Target Main Class	Enzymes
Target Subclass	2.7.11.1
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Vucicevic et al., 2009, AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C., Biochem. Pharmacol.
Ruderman et al., 2003, Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity., Endocrinology
Kovacic et al., 2003, Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart., J. Biol. Chem.
Towler et al., 2007, AMP-activated protein kinase in metabolic control and insulin signaling., Circ. Res.
Leverve et al., 2003, Mitochondrial metabolism and type-2 diabetes: a specific target of metformin., Diabetes Metab.
Musi et al., 2002, Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes., Diabetes
Hardie, 2003, Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status., Endocrinology
Leclerc et al., 2004, Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion., Am. J. Physiol. Endocrinol. Metab.
Tosca et al., 2005, Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells., Endocrinology
Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.
Yamaguchi et al., 2005, Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes., Am. J. Physiol. Endocrinol. Metab.

METFORMIN PRKAB1

Interaction Score: 4.56

Interaction Types & Directionality:

activator (activating)

inducer (activating)

Interaction Info:

Trial Name glyburide + metformin,Glucovance

Novel drug target Established target

Trial Name metformin GR,Glumetza

PMIDs:
26471090 22722338 19428322 14500570 12890675 17307971 14502105 12086935 12960015 14871885

Sources:
DTC TdgClinicalTrial TEND PharmGKB
SAPONARIN PRKAB1

Interaction Score: 3.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26471090

Sources:
DTC
PROPYLTHIOURACIL PRKAB1

Interaction Score: 1.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12433937

Sources:
NCI
WORTMANNIN PRKAB1

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15928020

Sources:
NCI
PROGESTERONE PRKAB1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16020477

Sources:
NCI

Ensembl: ENSG00000111725
- Version: 101_38
Alternate Names:

PRKAB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9Y478
- Version: January-2014
Alternate Names:

PRKAB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:
TEND: Q9Y478
- Version: 01-August-2011
Alternate Names:

ENSG00000111725 Ensembl Gene Id

5564 Entrez Gene Id

PRKAB1 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 2.7.11.1

Publications:
PharmGKB: PRKAB1
- Version: 18-August-2020
Alternate Names:

PA33746 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

NCI: PRKAB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Leverve et al., 2003, Mitochondrial metabolism and type-2 diabetes: a specific target of metformin., Diabetes Metab.

Tosca et al., 2005, Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells., Endocrinology

Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.

DTC: PRKAB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000111725
- Version: 31-May-2017
Alternate Names:

ENSG00000111725 Gene Symbol

PRKAB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: PRKAB1
- Version: 01-February-2022
Alternate Names:

5'-AMP-activated protein kinase subunit beta-1 Gene Name

Q9Y478 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:
ClearityFoundationClinicalTrial: PRKAB1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Trial Name	glyburide + metformin,Glucovance
Novel drug target	Established target
Trial Name	metformin GR,Glumetza

ENSG00000111725	Ensembl Gene Id
5564	Entrez Gene Id
PRKAB1	Gene Symbol

5'-AMP-activated protein kinase subunit beta-1	Gene Name
Q9Y478	UniProt ID

activator (activating)
inducer (activating)

PRKAB1 Gene Record

PRKAB1 5564 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

METFORMIN PRKAB1

Interaction Types & Directionality: activator (activating) inducer (activating)

Interaction Info: Trial Name glyburide + metformin,Glucovance Novel drug target Established target Trial Name metformin GR,Glumetza

PMIDs: 26471090 22722338 19428322 14500570 12890675 17307971 14502105 12086935 12960015 14871885

Sources: DTC TdgClinicalTrial TEND PharmGKB

SAPONARIN PRKAB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26471090

Sources: DTC

PROPYLTHIOURACIL PRKAB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12433937

Sources: NCI

WORTMANNIN PRKAB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15928020

Sources: NCI

PROGESTERONE PRKAB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16020477

Sources: NCI

Ensembl: ENSG00000111725

Alternate Names: PRKAB1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q9Y478

Alternate Names: PRKAB1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.11.1

Publications:

TEND: Q9Y478

Alternate Names: ENSG00000111725 Ensembl Gene Id 5564 Entrez Gene Id PRKAB1 Gene Symbol

Gene Info: Target Main Class Enzymes Target Subclass 2.7.11.1

Publications:

PharmGKB: PRKAB1

Alternate Names: PA33746 PharmGKB ID

Gene Info:

Publications: Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

NCI: PRKAB1

Alternate Names:

Gene Info:

DTC: PRKAB1

Alternate Names:

Gene Info:

Publications: Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000111725

Alternate Names: ENSG00000111725 Gene Symbol PRKAB1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: PRKAB1

Alternate Names: 5'-AMP-activated protein kinase subunit beta-1 Gene Name Q9Y478 UniProt ID

Gene Info:

Gene Categories: KINASE, ENZYME

Publications:

ClearityFoundationClinicalTrial: PRKAB1

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

activator (activating)

inducer (activating)

Interaction Info:

Trial Name glyburide + metformin,Glucovance

Novel drug target Established target

Trial Name metformin GR,Glumetza

PMIDs:
26471090 22722338 19428322 14500570 12890675 17307971 14502105 12086935 12960015 14871885

Sources:
DTC TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26471090

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12433937

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15928020

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16020477

Sources:
NCI

Alternate Names:

PRKAB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PRKAB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Alternate Names:

ENSG00000111725 Ensembl Gene Id

5564 Entrez Gene Id

PRKAB1 Gene Symbol

Gene Info:

Target Main Class Enzymes

Target Subclass 2.7.11.1

Alternate Names:

PA33746 PharmGKB ID

Publications:

Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Publications:

Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

Alternate Names:

ENSG00000111725 Gene Symbol

PRKAB1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5'-AMP-activated protein kinase subunit beta-1 Gene Name

Q9Y478 UniProt ID

Gene Categories:

KINASE, ENZYME