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PRKAB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PRKAB1 5564 Druggable Genome

    Alternate Names:

    5564
    PROTEIN KINASE AMP-ACTIVATED NON-CATALYTIC SUBUNIT BETA 1
    PRKAB1
    AMPK
    HAMPKb
    602740
    9378
    ENSG00000111725
    OTTHUMG00000168954
    Q9Y478
    AAKB1_HUMAN
    PA33746
    5'-AMP-activated protein kinase subunit beta-1

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Target Main Class Enzymes
    Target Subclass 2.7.11.1
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Vucicevic et al., 2009, AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C., Biochem. Pharmacol.
    Ruderman et al., 2003, Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity., Endocrinology
    Kovacic et al., 2003, Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart., J. Biol. Chem.
    Towler et al., 2007, AMP-activated protein kinase in metabolic control and insulin signaling., Circ. Res.
    Leverve et al., 2003, Mitochondrial metabolism and type-2 diabetes: a specific target of metformin., Diabetes Metab.
    Musi et al., 2002, Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes., Diabetes
    Hardie, 2003, Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status., Endocrinology
    Leclerc et al., 2004, Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion., Am. J. Physiol. Endocrinol. Metab.
    Tosca et al., 2005, Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells., Endocrinology
    Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.
    Yamaguchi et al., 2005, Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes., Am. J. Physiol. Endocrinol. Metab.
  • METFORMIN   PRKAB1

    Interaction Score: 4.56

    Interaction Types & Directionality:
    activator (activating)
    inducer (activating)

    Interaction Info:
    Trial Name glyburide + metformin,Glucovance
    Novel drug target Established target
    Trial Name metformin GR,Glumetza

    PMIDs:
    26471090 22722338 19428322 14500570 12890675 17307971 14502105 12086935 12960015 14871885


    Sources:
    DTC TdgClinicalTrial TEND PharmGKB

  • SAPONARIN   PRKAB1

    Interaction Score: 3.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26471090


    Sources:
    DTC

  • PROPYLTHIOURACIL   PRKAB1

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12433937


    Sources:
    NCI

  • WORTMANNIN   PRKAB1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15928020


    Sources:
    NCI

  • PROGESTERONE   PRKAB1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16020477


    Sources:
    NCI

  • Ensembl: ENSG00000111725

    • Version: 101_38

    Alternate Names:
    PRKAB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q9Y478

    • Version: January-2014

    Alternate Names:
    PRKAB1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • TEND: Q9Y478

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000111725 Ensembl Gene Id
    5564 Entrez Gene Id
    PRKAB1 Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 2.7.11.1

    Publications:

  • PharmGKB: PRKAB1

    • Version: 18-August-2020

    Alternate Names:
    PA33746 PharmGKB ID

    Gene Info:

    Publications:
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

  • NCI: PRKAB1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Leverve et al., 2003, Mitochondrial metabolism and type-2 diabetes: a specific target of metformin., Diabetes Metab.
    Tosca et al., 2005, Adenosine 5'-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells., Endocrinology
    Park et al., 2002, Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle., J. Appl. Physiol.

  • DTC: PRKAB1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Seo WD et al., 2015, Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000111725

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111725 Gene Symbol
    PRKAB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: PRKAB1

    • Version: 01-February-2022

    Alternate Names:
    5'-AMP-activated protein kinase subunit beta-1 Gene Name
    Q9Y478 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

  • ClearityFoundationClinicalTrial: PRKAB1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21