DGIdb - PRKCA Gene Record

PRKCA 5578 Druggable GenomeClinically Actionable

Alternate Names:

5578
PROTEIN KINASE C ALPHA
PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
176960
9393
ENSG00000154229
OTTHUMG00000179533
BE0004895
P17252
PROTEIN KINASE C ALPHA TYPE
KPCA_HUMAN
PKC-A
BE0001132
1482
NP_002728
NM_002737
PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252]
PKC
PA33759
T12808

Gene Info:

Initial Gene Query	PKC alpha
Counted Citations from 1950-2000	2549
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Human Readable Name	KINASE
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Target Class	Enzymes
Target Subclass	EC:2.7.11.13
GuideToPharmacology Gene Category Name	Delta subfamily
GuideToPharmacology Gene Category ID	533
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Radin DP et al., 2016, Delineating the molecular mechanisms of tamoxifen's oncolytic actions in estrogen receptor-negative cancers., Eur J Pharmacol
O'Brian et al., 1985, Inhibition of protein kinase C by tamoxifen., Cancer Res.
Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett
Millward MJ et al., 2006, The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study., Br J Cancer
Song J et al., 2014, Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells., Bioorg Med Chem Lett
Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res
Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem
Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
Vansteenkiste J et al., 2005, Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer., Invest New Drugs
Lahn M et al., 2006, The role of protein kinase C-alpha in hematologic malignancies., Acta Haematol
Wong L et al., 2009, Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases., J Med Chem
Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod
Azzi et al., 1997, Alpha-tocopherol as a modulator of smooth muscle cell proliferation., Prostaglandins Leukot. Essent. Fatty Acids
Sylvester et al., 2001, Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation., Cell Prolif.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Huang et al., 2002, Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes., Diabetes Res. Clin. Pract.
Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs
López-Andreo et al., 2005, Retinoic acid as a modulator of the activity of protein kinase Calpha., Biochemistry
Rodríguez-Alfaro et al., 2004, Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha., J. Mol. Biol.
Corbin et al., 2007, Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity., Biochemistry
Yu et al., 2002, Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C., Biochemistry
Wang et al., 1998, Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol., Planta Med.

APRINOCARSEN PRKCA

Interaction Score: 7.84

Interaction Types & Directionality:

antisense oligonucleotide (inhibitory)

Interaction Info:

Notes

PMIDs:
15868384 16424642

Sources:
DrugBank TALC
TRISMETHOXYRESVERATROL PRKCA

Interaction Score: 3.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21880495

Sources:
DTC
REDIOCIDE A PRKCA

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22650618

Sources:
DTC
TOCOPHEROL ACETATE PRKCA

Interaction Score: 1.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank
(+)-ALPHA-TOCOPHERYL SUCCINATE PRKCA

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank
DIMETHYLSPINGOSINE PRKCA

Interaction Score: 1.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19469544

Sources:
DTC
PHOSPHATIDYL SERINE PRKCA

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16114872 14698304 17367165 12269833

Sources:
DrugBank
PHORBOL MYRISTATE ACETATE PRKCA

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
CHEMBL27768 PRKCA

Interaction Score: 0.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
PERIFOSINE PRKCA

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16528479

Sources:
DrugBank
VITAMIN E PRKCA

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank
BRYOSTATIN PRKCA

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial
ENOXOLONE PRKCA

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24461294

Sources:
DTC
MIDOSTAURIN PRKCA

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
16969355

Sources:
DrugBank MyCancerGenome ChemblInteractions
RUBOXISTAURIN PRKCA

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ENZASTAURIN PRKCA

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology
CHEMBL1236539 PRKCA

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
BALANOL PRKCA

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CEP-2563 PRKCA

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
UCN-01 PRKCA

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BEVACIZUMAB PRKCA

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29871907

Sources:
PharmGKB
GSK-690693 PRKCA

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TAMOXIFEN PRKCA

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
27083550 3157445

Sources:
DrugBank
ELLAGIC ACID PRKCA

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9581512

Sources:
DrugBank
CI-1040 PRKCA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SOTRASTAURIN PRKCA

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
RESVERATROL PRKCA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21880495

Sources:
DTC
HYDROCHLOROTHIAZIDE PRKCA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
QUERCETIN PRKCA

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome

Ensembl: ENSG00000154229
- Version: 101_38
Alternate Names:

PRKCA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: PRKCA
- Version: February-2014
Alternate Names:

5578 Entrez Gene ID

Gene Info:

Initial Gene Query PKC alpha

Counted Citations from 1950-2000 2549

Gene Categories:

KINASE

Publications:
RussLampel: ENSG00000154229
- Version: 26-July-2011
Alternate Names:

PRKCA Display Id

PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252] Description

ENSG00000154229 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P17252
- Version: January-2014
Alternate Names:

PRKCA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Publications:
HopkinsGroom: P17252
- Version: 11-September-2012
Alternate Names:

ENSG00000154229 Ensembl Gene Id

5578 Entrez Gene Id

PRKCA Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5578
- Version: 29-September-2020
Alternate Names:

9393 HUGO Gene ID

9393 HUGO Gene Symbol

protein kinase C alpha HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Delta subfamily

GuideToPharmacology Gene Category ID 533

Gene Categories:

ENZYME

Publications:

PharmGKB: PRKCA

Version: 18-August-2020

Alternate Names:

PA33759 PharmGKB ID

Gene Info:

Publications:

Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res

DrugBank: BE0004895

Version: 5.1.7

Alternate Names:

PRKCA DrugBank Gene Name

P17252 UniProt Accession

5578 Entrez Gene Id

Gene Info:

Publications:

Radin DP et al., 2016, Delineating the molecular mechanisms of tamoxifen's oncolytic actions in estrogen receptor-negative cancers., Eur J Pharmacol

O'Brian et al., 1985, Inhibition of protein kinase C by tamoxifen., Cancer Res.

DrugBank: BE0001132

Version: 5.1.7

Alternate Names:

PRKCA DrugBank Gene Name

P17252 UniProt Accession

5578 Entrez Gene Id

Gene Info:

Publications:

López-Andreo et al., 2005, Retinoic acid as a modulator of the activity of protein kinase Calpha., Biochemistry

Rodríguez-Alfaro et al., 2004, Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha., J. Mol. Biol.

Corbin et al., 2007, Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity., Biochemistry

DTC: PRKCA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod

Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem

Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

TALC: PKCA
- Version: 12-May-2016
Alternate Names:

PKCA Gene Symbol

Gene Info:

Publications:
MyCancerGenome: PRKCA
- Version: 20-Jun-2017
Alternate Names:

5578 Entrez Gene Id

PRKCA MyCancerGenome Gene Symbol

PKC-alpha MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000154229
- Version: 31-May-2017
Alternate Names:

ENSG00000154229 Gene Symbol

PRKCA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PKCA
- Version: chembl_23
Alternate Names:

PKCA GENE_SYMBOL

PRKACA GENE_SYMBOL

PRKCA GENE_SYMBOL

Gene Info:

Publications:
Pharos: PRKCA
- Version: 03-September-2020
Alternate Names:

Protein kinase C alpha type Gene Name

P17252 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: PRKCA
- Version: 05-September-2020
Alternate Names:

PKCA GO Gene Synonym

PRKACA GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: PRKCA
- Version: 27-Jun-2013
Alternate Names:

5578 Gene ID

AAG6 dGene Synonym

PKC-alpha dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Protein kinase C alpha
- Version: 2020.06.01
Alternate Names:

PRKCA TTD Gene Abbreviation

T12808 TTD Target ID

Gene Info:

Publications:
CarisMolecularIntelligence: PRKCA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Protein kinase C (PKC) inhibitor
Direct Interaction	yes

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

PRKCA	Display Id
PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252]	Description
ENSG00000154229	Ensembl Gene Id

9393	HUGO Gene ID
9393	HUGO Gene Symbol
protein kinase C alpha	HUGO Gene Name

PRKCA	DrugBank Gene Name
P17252	UniProt Accession
5578	Entrez Gene Id

Trial Name	Bryostatin
Novel drug target	Established target

antagonist (inhibitory)
inhibitor (inhibitory)

PRKCA Gene Record

PRKCA 5578 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antisense oligonucleotide (inhibitory)

Interaction Info: Notes

PMIDs: 15868384 16424642

Sources: DrugBank TALC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21880495

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22650618

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9430404 11736999 17139284 17016423 11850093

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9430404 11736999 17139284 17016423 11850093

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19469544

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16114872 14698304 17367165 12269833

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16528479

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9430404 11736999 17139284 17016423 11850093

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Bryostatin Novel drug target Established target

PMIDs: 22579485

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24461294

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: 16969355

Sources: DrugBank MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: MyCancerGenome GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

Interaction Types & Directionality:

antisense oligonucleotide (inhibitory)

Interaction Info:

Notes

PMIDs:
15868384 16424642

Sources:
DrugBank TALC

Interaction Types & Directionality:

n/a

PMIDs:
21880495

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22650618

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19469544

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16114872 14698304 17367165 12269833

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16528479

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9430404 11736999 17139284 17016423 11850093

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24461294

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
16969355

Sources:
DrugBank MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
29871907

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
27083550 3157445

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)