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PRKCA Gene Record

  • Summary
  • Interactions
  • Claims
  • PRKCA 5578 Druggable GenomeClinically Actionable

    Alternate Names:

    5578
    PROTEIN KINASE C ALPHA
    PRKCA
    AAG6
    PKC-alpha
    PKCA
    PRKACA
    176960
    9393
    ENSG00000154229
    OTTHUMG00000179533
    BE0004895
    P17252
    PROTEIN KINASE C ALPHA TYPE
    KPCA_HUMAN
    PKC-A
    BE0001132
    1482
    NP_002728
    NM_002737
    PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252]
    PKC
    PA33759
    T12808

    Gene Info:

    Initial Gene Query PKC alpha
    Counted Citations from 1950-2000 2549
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Target Class Enzymes
    Target Subclass EC:2.7.11.13
    GuideToPharmacology Gene Category Name Delta subfamily
    GuideToPharmacology Gene Category ID 533
    Gene Biotype PROTEIN_CODING
    (15 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Radin DP et al., 2016, Delineating the molecular mechanisms of tamoxifen's oncolytic actions in estrogen receptor-negative cancers., Eur J Pharmacol
    O'Brian et al., 1985, Inhibition of protein kinase C by tamoxifen., Cancer Res.
    Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett
    Millward MJ et al., 2006, The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study., Br J Cancer
    Song J et al., 2014, Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells., Bioorg Med Chem Lett
    Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res
    Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem
    Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
    Vansteenkiste J et al., 2005, Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer., Invest New Drugs
    Lahn M et al., 2006, The role of protein kinase C-alpha in hematologic malignancies., Acta Haematol
    Wong L et al., 2009, Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases., J Med Chem
    Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod
    Azzi et al., 1997, Alpha-tocopherol as a modulator of smooth muscle cell proliferation., Prostaglandins Leukot. Essent. Fatty Acids
    Sylvester et al., 2001, Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation., Cell Prolif.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Huang et al., 2002, Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes., Diabetes Res. Clin. Pract.
    Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs
    López-Andreo et al., 2005, Retinoic acid as a modulator of the activity of protein kinase Calpha., Biochemistry
    Rodríguez-Alfaro et al., 2004, Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha., J. Mol. Biol.
    Corbin et al., 2007, Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity., Biochemistry
    Yu et al., 2002, Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C., Biochemistry
    Wang et al., 1998, Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol., Planta Med.
  • APRINOCARSEN   PRKCA

    Interaction Score: 7.84

    Interaction Types & Directionality:
    antisense oligonucleotide (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    15868384 16424642


    Sources:
    DrugBank TALC

  • TRISMETHOXYRESVERATROL   PRKCA

    Interaction Score: 3.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21880495


    Sources:
    DTC

  • REDIOCIDE A   PRKCA

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22650618


    Sources:
    DTC

  • TOCOPHEROL ACETATE   PRKCA

    Interaction Score: 1.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430404 11736999 17139284 17016423 11850093


    Sources:
    DrugBank

  • (+)-ALPHA-TOCOPHERYL SUCCINATE   PRKCA

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430404 11736999 17139284 17016423 11850093


    Sources:
    DrugBank

  • DIMETHYLSPINGOSINE   PRKCA

    Interaction Score: 1.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19469544


    Sources:
    DTC

  • PHOSPHATIDYL SERINE   PRKCA

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16114872 14698304 17367165 12269833


    Sources:
    DrugBank

  • PHORBOL MYRISTATE ACETATE   PRKCA

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24794745


    Sources:
    DTC

  • CHEMBL27768   PRKCA

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24794745


    Sources:
    DTC

  • PERIFOSINE   PRKCA

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16528479


    Sources:
    DrugBank

  • VITAMIN E   PRKCA

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430404 11736999 17139284 17016423 11850093


    Sources:
    DrugBank

  • BRYOSTATIN   PRKCA

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Bryostatin
    Novel drug target Established target

    PMIDs:
    22579485


    Sources:
    DTC TdgClinicalTrial

  • ENOXOLONE   PRKCA

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24461294


    Sources:
    DTC

  • MIDOSTAURIN   PRKCA

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    16969355


    Sources:
    DrugBank MyCancerGenome ChemblInteractions

  • RUBOXISTAURIN   PRKCA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ENZASTAURIN   PRKCA

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    MyCancerGenome GuideToPharmacology

  • CHEMBL1236539   PRKCA

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BALANOL   PRKCA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CEP-2563   PRKCA

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • UCN-01   PRKCA

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BEVACIZUMAB   PRKCA

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29871907


    Sources:
    PharmGKB

  • GSK-690693   PRKCA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TAMOXIFEN   PRKCA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    27083550 3157445


    Sources:
    DrugBank

  • ELLAGIC ACID   PRKCA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9581512


    Sources:
    DrugBank

  • CI-1040   PRKCA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SOTRASTAURIN   PRKCA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • RESVERATROL   PRKCA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21880495


    Sources:
    DTC

  • HYDROCHLOROTHIAZIDE   PRKCA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • QUERCETIN   PRKCA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • Ensembl: ENSG00000154229

    • Version: 101_38

    Alternate Names:
    PRKCA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: PRKCA

    • Version: February-2014

    Alternate Names:
    5578 Entrez Gene ID

    Gene Info:
    Initial Gene Query PKC alpha
    Counted Citations from 1950-2000 2549

    Gene Categories:
    KINASE

    Publications:

  • RussLampel: ENSG00000154229

    • Version: 26-July-2011

    Alternate Names:
    PRKCA Display Id
    PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252] Description
    ENSG00000154229 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P17252

    • Version: January-2014

    Alternate Names:
    PRKCA Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.13

    Publications:

  • HopkinsGroom: P17252

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000154229 Ensembl Gene Id
    5578 Entrez Gene Id
    PRKCA Uniprot Gene Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5578

    • Version: 29-September-2020

    Alternate Names:
    9393 HUGO Gene ID
    9393 HUGO Gene Symbol
    protein kinase C alpha HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Delta subfamily
    GuideToPharmacology Gene Category ID 533

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: PRKCA

    • Version: 18-August-2020

    Alternate Names:
    PA33759 PharmGKB ID

    Gene Info:

    Publications:
    Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res

  • DrugBank: BE0004895

    • Version: 5.1.7

    Alternate Names:
    PRKCA DrugBank Gene Name
    P17252 UniProt Accession
    5578 Entrez Gene Id

    Gene Info:

    Publications:
    Radin DP et al., 2016, Delineating the molecular mechanisms of tamoxifen's oncolytic actions in estrogen receptor-negative cancers., Eur J Pharmacol
    O'Brian et al., 1985, Inhibition of protein kinase C by tamoxifen., Cancer Res.

  • DrugBank: BE0001132

    • Version: 5.1.7

    Alternate Names:
    PRKCA DrugBank Gene Name
    P17252 UniProt Accession
    5578 Entrez Gene Id

    Gene Info:

    Publications:
    López-Andreo et al., 2005, Retinoic acid as a modulator of the activity of protein kinase Calpha., Biochemistry
    Rodríguez-Alfaro et al., 2004, Role of the lysine-rich cluster of the C2 domain in the phosphatidylserine-dependent activation of PKCalpha., J. Mol. Biol.
    Corbin et al., 2007, Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity., Biochemistry

  • DTC: PRKCA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod
    Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem
    Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

  • TALC: PKCA

    • Version: 12-May-2016

    Alternate Names:
    PKCA Gene Symbol

    Gene Info:

    Publications:

  • MyCancerGenome: PRKCA

    • Version: 20-Jun-2017

    Alternate Names:
    5578 Entrez Gene Id
    PRKCA MyCancerGenome Gene Symbol
    PKC-alpha MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000154229

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000154229 Gene Symbol
    PRKCA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: PKCA

    • Version: chembl_23

    Alternate Names:
    PKCA GENE_SYMBOL
    PRKACA GENE_SYMBOL
    PRKCA GENE_SYMBOL

    Gene Info:

    Publications:

  • Pharos: PRKCA

    • Version: 03-September-2020

    Alternate Names:
    Protein kinase C alpha type Gene Name
    P17252 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: PRKCA

    • Version: 05-September-2020

    Alternate Names:
    PKCA GO Gene Synonym
    PRKACA GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: PRKCA

    • Version: 27-Jun-2013

    Alternate Names:
    5578 Gene ID
    AAG6 dGene Synonym
    PKC-alpha dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Protein kinase C alpha

    • Version: 2020.06.01

    Alternate Names:
    PRKCA TTD Gene Abbreviation
    T12808 TTD Target ID

    Gene Info:

    Publications:

  • CarisMolecularIntelligence: PRKCA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13