DGIdb - PRKCA Gene Record

PRKCA 5578 Druggable GenomeClinically Actionable

Alternate Names:

5578
PROTEIN KINASE C ALPHA
PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
176960
9393
ENSG00000154229
OTTHUMG00000179533
P17252
PROTEIN KINASE C ALPHA TYPE
KPCA_HUMAN
PKC-A
1482
NP_002728
NM_002737
PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252]
PKC
PA33759
T12808
PKCI+/-
PKCalpha

Gene Info:

Initial Gene Query	PKC alpha
Counted Citations from 1950-2000	2549
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Human Readable Name	KINASE
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Target Class	Enzymes
Target Subclass	EC:2.7.11.13
GuideToPharmacology Gene Category Name	Delta subfamily
GuideToPharmacology Gene Category ID	533
Gene Biotype	PROTEIN_CODING

(13 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett
Millward MJ et al., 2006, The multikinase inhibitor midostaurin (PKC412A) lacks activity in metastatic melanoma: a phase IIA clinical and biologic study., Br J Cancer
Song J et al., 2014, Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells., Bioorg Med Chem Lett
Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res
Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem
Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem
Lahn M et al., 2006, The role of protein kinase C-alpha in hematologic malignancies., Acta Haematol
Vansteenkiste J et al., 2005, Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer., Invest New Drugs
Wong L et al., 2009, Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases., J Med Chem
Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod

APRINOCARSEN PRKCA

Interaction Score: 8.7

Interaction Types & Directionality:

antisense oligonucleotide (inhibitory)

Interaction Info:

Notes

PMIDs:
16424642 15868384

Sources:
TALC
TRISMETHOXYRESVERATROL PRKCA

Interaction Score: 5.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21880495

Sources:
DTC
REDIOCIDE A PRKCA

Interaction Score: 2.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22650618

Sources:
DTC
DIMETHYLSPINGOSINE PRKCA

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19469544

Sources:
DTC
PHORBOL MYRISTATE ACETATE PRKCA

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
CHEMBL27768 PRKCA

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
BRYOSTATIN PRKCA

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial
ENZASTAURIN PRKCA

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology
ENOXOLONE PRKCA

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24461294

Sources:
DTC
RUBOXISTAURIN PRKCA

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
MIDOSTAURIN PRKCA

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
16969355

Sources:
MyCancerGenome ChemblInteractions
CHEMBL1236539 PRKCA

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
BALANOL PRKCA

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
BEVACIZUMAB PRKCA

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29871907

Sources:
PharmGKB
CEP-2563 PRKCA

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
UCN-01 PRKCA

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GSK-690693 PRKCA

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CI-1040 PRKCA

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RESVERATROL PRKCA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21880495

Sources:
DTC
SOTRASTAURIN PRKCA

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
HYDROCHLOROTHIAZIDE PRKCA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
QUERCETIN PRKCA

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome

Ensembl: ENSG00000154229
- Version: 101_38
Alternate Names:

PRKCA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: PRKCA
- Version: February-2014
Alternate Names:

5578 Entrez Gene ID

Gene Info:

Initial Gene Query PKC alpha

Counted Citations from 1950-2000 2549

Gene Categories:

KINASE

Publications:
RussLampel: ENSG00000154229
- Version: 26-July-2011
Alternate Names:

PRKCA Display Id

PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252] Description

ENSG00000154229 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P17252
- Version: January-2014
Alternate Names:

PRKCA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Publications:
HopkinsGroom: P17252
- Version: 11-September-2012
Alternate Names:

ENSG00000154229 Ensembl Gene Id

5578 Entrez Gene Id

PRKCA Uniprot Gene Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5578
- Version: 29-September-2020
Alternate Names:

9393 HUGO Gene ID

9393 HUGO Gene Symbol

protein kinase C alpha HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Delta subfamily

GuideToPharmacology Gene Category ID 533

Gene Categories:

ENZYME

Publications:

PharmGKB: PRKCA

Version: 18-August-2020

Alternate Names:

PA33759 PharmGKB ID

Gene Info:

Publications:

Li M et al., 2018, Identification of a Genomic Region between <i>SLC29A1</i> and <i>HSP90AB1</i> Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)., Clin Cancer Res

DTC: PRKCA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod

Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem

Das J et al., 2011, Chemical modifications of resveratrol for improved protein kinase C alpha activity., Bioorg Med Chem

TALC: PKCA
- Version: 12-May-2016
Alternate Names:

PKCA Gene Symbol

Gene Info:

Publications:
MyCancerGenome: PRKCA
- Version: 20-Jun-2017
Alternate Names:

5578 Entrez Gene Id

PRKCA MyCancerGenome Gene Symbol

PKC-alpha MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000154229
- Version: 31-May-2017
Alternate Names:

ENSG00000154229 Gene Symbol

PRKCA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PKCA
- Version: chembl_23
Alternate Names:

PKCA GENE_SYMBOL

PRKACA GENE_SYMBOL

PRKCA GENE_SYMBOL

Gene Info:

Publications:
dGene: PRKCA
- Version: 27-Jun-2013
Alternate Names:

5578 Gene ID

AAG6 dGene Synonym

PKC-alpha dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Protein kinase C alpha
- Version: 2020.06.01
Alternate Names:

PRKCA TTD Gene Abbreviation

T12808 TTD Target ID

Gene Info:

Publications:
GO: PRKCA
- Version: 01-May-2021
Alternate Names:

PKCA GO Gene Synonym

PRKACA GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Pharos: PRKCA
- Version: 01-May-2021
Alternate Names:

Protein kinase C alpha type Gene Name

P17252 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
CarisMolecularIntelligence: PRKCA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Mechanism of Interaction	Protein kinase C (PKC) inhibitor
Direct Interaction	yes

PRKCA	Display Id
PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.37) (PKC-ALPHA) (PKC-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P17252]	Description
ENSG00000154229	Ensembl Gene Id

9393	HUGO Gene ID
9393	HUGO Gene Symbol
protein kinase C alpha	HUGO Gene Name

5578	Entrez Gene Id
PRKCA	MyCancerGenome Gene Symbol
PKC-alpha	MyCancerGenome Reported Gene Name

Trial Name	Bryostatin
Novel drug target	Established target

antagonist (inhibitory)
inhibitor (inhibitory)

PRKCA Gene Record

PRKCA 5578 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antisense oligonucleotide (inhibitory)

Interaction Info: Notes

PMIDs: 16424642 15868384

Sources: TALC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21880495

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22650618

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19469544

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Bryostatin Novel drug target Established target

PMIDs: 22579485

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: MyCancerGenome GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24461294

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: 16969355

Sources: MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29871907

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antisense oligonucleotide (inhibitory)

Interaction Info:

Notes

PMIDs:
16424642 15868384

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
21880495

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22650618

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19469544

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
24461294

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
16969355

Sources:
MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
29871907

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21880495

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Alternate Names:

PRKCA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5578 Entrez Gene ID