• PRKCH 5583 Druggable Genome

    Alternate Names:

    5583
    PROTEIN KINASE C ETA
    PRKCH
    PKC-L
    PKCL
    PRKCL
    nPKC-eta
    605437
    9403
    ENSG00000027075
    OTTHUMG00000152341
    PKC
    P24723
    KPCL_HUMAN
    PROTEIN KINASE C ETA TYPE
    PROTEIN KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA) (PKC-L). [SOURCE:UNIPROT/SWISSPROT;ACC:P24723]
    1487
    NM_006255
    NP_006246

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Target Class Enzymes
    Target Subclass EC:2.7.11.13
    GuideToPharmacology Gene Category Name Eta subfamily
    GuideToPharmacology Gene Category ID 534
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

  • Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Bryostatin
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Protein kinase C (PKC) inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Alteration PRKCH:amp;ABL1__BCR
    Drug family MEK inhibitor;BCR-ABL inhibitor 1st gen&KIT inhibitor
    combination therapy Trametinib;Imatinib

    PMIDs:
    None found


    Sources:
    CGI

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Trametinib;Imatinib
    Drug family MEK inhibitor;BCR-ABL inhibitor 1st gen&KIT inhibitor
    Alteration PRKCH:amp;ABL1__BCR

    PMIDs:
    None found


    Sources:
    CGI

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

    • Version: 101_38

    Alternate Names:
    PRKCH Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    PRKCH Uniprot Gene Name
    KPCL_HUMAN Uniprot Id
    P24723 Uniprot Accession

    Gene Info:
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000027075 Ensembl Gene Id
    PROTEIN KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA) (PKC-L). [SOURCE:UNIPROT/SWISSPROT;ACC:P24723] Description
    PRKCH Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    PRKCH Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.13

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    9403 HUGO Gene ID
    9403 HUGO Gene Symbol
    protein kinase C eta HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Eta subfamily
    GuideToPharmacology Gene Category ID 534

    Gene Categories:
    ENZYME

    Publications:

    • Version: 20-Jun-2017

    Alternate Names:
    5583 Entrez Gene Id
    PRKCH MyCancerGenome Gene Symbol
    PKC MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000027075 Gene Symbol
    PRKCH Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    PRKCL GENE_SYMBOL
    PRKCH GENE_SYMBOL
    Protein kinase C eta type UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000027075 Ensembl Gene ID
    PKC-L Human Protein Atlas Gene Synonym
    PKCL Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 03-September-2020

    Alternate Names:
    Protein kinase C eta type Gene Name
    P24723 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 05-September-2020

    Alternate Names:
    PKCL GO Gene Synonym
    PRKCL GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    5583 Gene ID
    PKC-L dGene Synonym
    PKCL dGene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE, KINASE

    Publications:

    • Version: 27-September-2017

    Alternate Names:

    Gene Info:

    Publications: