• PRKCI 5584 Druggable GenomeClinically Actionable

    Alternate Names:

    5584
    PROTEIN KINASE C IOTA
    PRKCI
    DXS1179E
    PKCI
    nPKC-iota
    600539
    9404
    ENSG00000163558
    OTTHUMG00000150214
    P41743
    1490
    NP_002731
    NM_002740
    PKC
    BE0003889
    KPCI_HUMAN
    aPKC-lambda/iota
    PRKC-lambda/iota
    Atypical protein kinase C-lambda/iota
    Protein kinase C iota type
    PROTEIN KINASE C, IOTA TYPE (EC 2.7.1.37) (NPKC-IOTA) (ATYPICAL PROTEIN KINASE C-LAMBDA/IOTA) (APKC-LAMBDA/IOTA) (PRKC-LAMBDA/IOTA). [SOURCE:UNIPROT/SWISSPROT;ACC:P41743]

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.13
    GuideToPharmacology Gene Category Name Iota subfamily
    GuideToPharmacology Gene Category ID 535
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE
    Interpro Acc IPR002290
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C (PKC) inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

    • Version: 101_38

    Alternate Names:
    PRKCI Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    PRKCI Uniprot Gene Name
    PROTEIN KINASE C IOTA TYPE Uniprot Protein Name
    ENSG00000163558 Ensembl Gene Id

    Gene Info:
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    PRKCI Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.13

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000163558 Ensembl Gene Id
    PRKCI Display Id
    PROTEIN KINASE C, IOTA TYPE (EC 2.7.1.37) (NPKC-IOTA) (ATYPICAL PROTEIN KINASE C-LAMBDA/IOTA) (APKC-LAMBDA/IOTA) (PRKC-LAMBDA/IOTA). [SOURCE:UNIPROT/SWISSPROT;ACC:P41743] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    9404 HUGO Gene ID
    9404 HUGO Gene Symbol
    protein kinase C iota HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Iota subfamily
    GuideToPharmacology Gene Category ID 535

    Gene Categories:
    ENZYME

    Publications:

    • Version: 5.1.7
    • Version: chembl_23

    Alternate Names:
    DXS1179E GENE_SYMBOL
    PRKCI GENE_SYMBOL
    Protein kinase C iota type UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000163558 Gene Symbol
    PRKCI Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 20-Jun-2017

    Alternate Names:
    5584 Entrez Gene Id
    PRKCI MyCancerGenome Gene Symbol
    PKC MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

    • Version: 03-September-2020

    Alternate Names:
    Protein kinase C iota type Gene Name
    P41743 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 05-September-2020

    Alternate Names:
    DXS1179E GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    5584 Gene ID
    DXS1179E dGene Synonym
    PKCI dGene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE, KINASE

    Publications:

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: