DGIdb - PSEN2 Gene Record

PSEN2 5664 Druggable Genome

Alternate Names:

5664
PRESENILIN 2
PSEN2
AD3L
AD4
CMD1V
PS2
STM2
600759
9509
ENSG00000143801
OTTHUMG00000037563
P49810
Gamma-secretase
T99204
PSNL2
Presenilin-2

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.4.23.-
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem
Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem
Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

CHEMBL392068 PSEN2

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23181502 19443228

Sources:
DTC
SEMAGACESTAT PSEN2

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name LY-450139

PMIDs:
19443228

Sources:
DTC TdgClinicalTrial
IC261 PSEN2

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20350806

Sources:
DTC
GSI-136 PSEN2

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL247471 PSEN2

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name BMS-299897

PMIDs:
None found

Sources:
TdgClinicalTrial
AVAGACESTAT PSEN2

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-708163

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Ensembl: ENSG00000143801
- Version: 101_38
Alternate Names:

PSEN2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P49810
- Version: January-2014
Alternate Names:

PSEN2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.-

Publications:

DTC: PSEN2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem

Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem

MyCancerGenome: PSEN2
- Version: 20-Jun-2017
Alternate Names:

5664 Entrez Gene Id

PSEN2 MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000143801
- Version: 31-May-2017
Alternate Names:

ENSG00000143801 Gene Symbol

PSEN2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: PSEN2
- Version: 19.3
Alternate Names:

ENSG00000143801 Ensembl Gene ID

AD3L Human Protein Atlas Gene Synonym

AD4 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER, ENZYME

Publications:
GO: PSEN2
- Version: 01-February-2022
Alternate Names:

AD4 GO Gene Synonym

PS2 GO Gene Synonym

PSNL2 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
dGene: PSEN2
- Version: 27-Jun-2013
Alternate Names:

5664 Gene ID

AD3L dGene Synonym

AD4 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Presenilin 2
- Version: 2020.06.01
Alternate Names:

PSEN2 TTD Gene Abbreviation

T99204 TTD Target ID

Gene Info:

Publications:
Pharos: PSEN2
- Version: 01-February-2022
Alternate Names:

Presenilin-2 Gene Name

P49810 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

5664	Entrez Gene Id
PSEN2	MyCancerGenome Gene Symbol
Gamma-secretase	MyCancerGenome Reported Gene Name

ENSG00000143801	Ensembl Gene ID
AD3L	Human Protein Atlas Gene Synonym
AD4	Human Protein Atlas Gene Synonym

Novel drug target	Novel Target
Trial Name	LY-450139

Trial Name	GSI-136
Novel drug target	Novel Target

Novel drug target	Novel Target
Trial Name	BMS-299897

Trial Name	BMS-708163
Novel drug target	Novel Target

PSEN2 Gene Record

PSEN2 5664 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL392068 PSEN2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23181502 19443228

Sources: DTC

SEMAGACESTAT PSEN2

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name LY-450139

PMIDs: 19443228

Sources: DTC TdgClinicalTrial

IC261 PSEN2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20350806

Sources: DTC

GSI-136 PSEN2

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GSI-136 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

CHEMBL247471 PSEN2

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name BMS-299897

PMIDs: None found

Sources: TdgClinicalTrial

AVAGACESTAT PSEN2

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-708163 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Ensembl: ENSG00000143801

Alternate Names: PSEN2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P49810

Alternate Names: PSEN2 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.23.-

Publications:

DTC: PSEN2

Alternate Names:

Gene Info:

MyCancerGenome: PSEN2

Alternate Names: 5664 Entrez Gene Id PSEN2 MyCancerGenome Gene Symbol Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:

HingoraniCasas: ENSG00000143801

Alternate Names: ENSG00000143801 Gene Symbol PSEN2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: PSEN2

Alternate Names: ENSG00000143801 Ensembl Gene ID AD3L Human Protein Atlas Gene Synonym AD4 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: TRANSPORTER, ENZYME

Publications:

GO: PSEN2

Alternate Names: AD4 GO Gene Synonym PS2 GO Gene Synonym PSNL2 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

dGene: PSEN2

Alternate Names: 5664 Gene ID AD3L dGene Synonym AD4 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

TTD: Presenilin 2

Alternate Names: PSEN2 TTD Gene Abbreviation T99204 TTD Target ID

Gene Info:

Publications:

Pharos: PSEN2

Alternate Names: Presenilin-2 Gene Name P49810 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23181502 19443228

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name LY-450139

PMIDs:
19443228

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
20350806

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name BMS-299897

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-708163

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Alternate Names:

PSEN2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PSEN2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.-

Alternate Names:

5664 Entrez Gene Id

PSEN2 MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Alternate Names:

ENSG00000143801 Gene Symbol

PSEN2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000143801 Ensembl Gene ID

AD3L Human Protein Atlas Gene Synonym

AD4 Human Protein Atlas Gene Synonym

Gene Categories:

TRANSPORTER, ENZYME

Alternate Names:

AD4 GO Gene Synonym

PS2 GO Gene Synonym

PSNL2 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

5664 Gene ID

AD3L dGene Synonym

AD4 dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

PSEN2 TTD Gene Abbreviation

T99204 TTD Target ID

Alternate Names:

Presenilin-2 Gene Name

P49810 UniProt ID

Gene Categories:

ENZYME