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PSEN2 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSEN2 5664 Druggable Genome

    Alternate Names:

    5664
    PRESENILIN 2
    PSEN2
    AD3L
    AD4
    CMD1V
    PS2
    STM2
    600759
    9509
    ENSG00000143801
    OTTHUMG00000037563
    P49810
    Gamma-secretase
    T99204
    PSNL2
    Presenilin-2

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:3.4.23.-
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    CELL SURFACE
    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem
    Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem
    Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett
  • CHEMBL392068   PSEN2

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23181502 19443228


    Sources:
    DTC

  • SEMAGACESTAT   PSEN2

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name LY-450139

    PMIDs:
    19443228


    Sources:
    DTC TdgClinicalTrial

  • IC261   PSEN2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20350806


    Sources:
    DTC

  • GSI-136   PSEN2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GSI-136
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CHEMBL247471   PSEN2

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name BMS-299897

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AVAGACESTAT   PSEN2

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name BMS-708163
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000143801

    • Version: 101_38

    Alternate Names:
    PSEN2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P49810

    • Version: January-2014

    Alternate Names:
    PSEN2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.23.-

    Publications:

  • DTC: PSEN2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett
    Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem
    Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem

  • MyCancerGenome: PSEN2

    • Version: 20-Jun-2017

    Alternate Names:
    5664 Entrez Gene Id
    PSEN2 MyCancerGenome Gene Symbol
    Gamma-secretase MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000143801

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000143801 Gene Symbol
    PSEN2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: PSEN2

    • Version: 19.3

    Alternate Names:
    ENSG00000143801 Ensembl Gene ID
    AD3L Human Protein Atlas Gene Synonym
    AD4 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER, ENZYME

    Publications:

  • GO: PSEN2

    • Version: 01-February-2022

    Alternate Names:
    AD4 GO Gene Synonym
    PS2 GO Gene Synonym
    PSNL2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • dGene: PSEN2

    • Version: 27-Jun-2013

    Alternate Names:
    5664 Gene ID
    AD3L dGene Synonym
    AD4 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Presenilin 2

    • Version: 2020.06.01

    Alternate Names:
    PSEN2 TTD Gene Abbreviation
    T99204 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: PSEN2

    • Version: 01-February-2022

    Alternate Names:
    Presenilin-2 Gene Name
    P49810 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21