DGIdb - PSMB8 Gene Record

PSMB8 5696 Druggable Genome

Alternate Names:

5696
PROTEASOME SUBUNIT BETA 8
PSMB8
ALDD
D6S216
D6S216E
JMP
LMP7
NKJO
PSMB5i
RING10
177046
9545
ENSG00000204264
OTTHUMG00000031285
Y2
P28062
Macropain subunit C13
Really interesting new gene 10 protein
Low molecular mass protein 7
Multicatalytic endopeptidase complex subunit C13
Proteasome subunit beta type-8
Proteasome component C13
Proteasome subunit beta-5i
Proteasome
2408
NP_004150\|NP_683720
NM_004159\|NM_148919
proteasome 20S subunit beta 8
PRAAS1

Gene Info:

GuideToPharmacology Gene Category Name	T1: Proteasome
GuideToPharmacology Gene Category ID	752
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood
Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
Kawamura S et al., 2013, Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action., J Med Chem

LACTACYSTIN PSMB8

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23547757

Sources:
DTC
BELACTOSIN A PSMB8

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23547757

Sources:
DTC

KZR-616 PSMB8

Interaction Score: 1.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cells using the ProCISE ELISA.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

CARFILZOMIB PSMB8

Interaction Score: 0.7

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome ChemblInteractions
MARIZOMIB PSMB8

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BORTEZOMIB PSMB8

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
IXAZOMIB CITRATE PSMB8

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OPROZOMIB PSMB8

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000204264
- Version: 101_38
Alternate Names:

PSMB8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 5696
- Version: 29-September-2020
Alternate Names:

9545 HUGO Gene ID

9545 HUGO Gene Symbol

proteasome 20S subunit beta 8 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name T1: Proteasome

GuideToPharmacology Gene Category ID 752

Gene Categories:

ENZYME

Publications:

DTC: PSMB8

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

Kawamura S et al., 2013, Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action., J Med Chem

MyCancerGenome: PSMB8
- Version: 20-Jun-2017
Alternate Names:

5696 Entrez Gene Id

PSMB8 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000204264
- Version: 31-May-2017
Alternate Names:

ENSG00000204264 Gene Symbol

PSMB8 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: LMP7
- Version: chembl_23
Alternate Names:

PSMB5i GENE_SYMBOL

RING10 GENE_SYMBOL

Y2 GENE_SYMBOL

Gene Info:

Publications:
dGene: PSMB8
- Version: 27-Jun-2013
Alternate Names:

5696 Gene ID

ALDD dGene Synonym

D6S216 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Details of the Assay for Interaction	Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cells using the ProCISE ELISA.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Mechanism of Interaction	26S proteosome inhibitor
Direct Interaction	yes

Mechanism of Interaction	20S Proteasome inhibitor
Direct Interaction	yes

9545	HUGO Gene ID
9545	HUGO Gene Symbol
proteasome 20S subunit beta 8	HUGO Gene Name

5696	Entrez Gene Id
PSMB8	MyCancerGenome Gene Symbol
Proteasome	MyCancerGenome Reported Gene Name

PSMB5i	GENE_SYMBOL
RING10	GENE_SYMBOL
Y2	GENE_SYMBOL

PSMB8 Gene Record

PSMB8 5696 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23547757

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23547757

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cells using the ProCISE ELISA. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 17591945 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 20S Proteasome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000204264

Alternate Names: PSMB8 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 5696

Alternate Names: 9545 HUGO Gene ID 9545 HUGO Gene Symbol proteasome 20S subunit beta 8 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name T1: Proteasome GuideToPharmacology Gene Category ID 752

Gene Categories: ENZYME

Publications:

DTC: PSMB8

Alternate Names:

Gene Info:

MyCancerGenome: PSMB8

Alternate Names: 5696 Entrez Gene Id PSMB8 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

HingoraniCasas: ENSG00000204264

Alternate Names: ENSG00000204264 Gene Symbol PSMB8 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: LMP7

Alternate Names: PSMB5i GENE_SYMBOL RING10 GENE_SYMBOL Y2 GENE_SYMBOL

Gene Info:

Publications:

dGene: PSMB8

Alternate Names: 5696 Gene ID ALDD dGene Synonym D6S216 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23547757

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23547757

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cells using the ProCISE ELISA.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
17591945 24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PSMB8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

9545 HUGO Gene ID

9545 HUGO Gene Symbol

proteasome 20S subunit beta 8 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name T1: Proteasome

GuideToPharmacology Gene Category ID 752

Gene Categories:

ENZYME

Alternate Names:

5696 Entrez Gene Id

PSMB8 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

ENSG00000204264 Gene Symbol

PSMB8 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PSMB5i GENE_SYMBOL

RING10 GENE_SYMBOL

Y2 GENE_SYMBOL

Alternate Names:

5696 Gene ID

ALDD dGene Synonym

D6S216 dGene Synonym

Gene Categories:

PROTEASE