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PSMB8 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSMB8 5696 Druggable Genome

    Alternate Names:

    5696
    PROTEASOME SUBUNIT BETA 8
    PSMB8
    ALDD
    D6S216
    D6S216E
    JMP
    LMP7
    NKJO
    PSMB5i
    RING10
    177046
    9545
    ENSG00000204264
    OTTHUMG00000031285
    Y2
    Macropain subunit C13
    Really interesting new gene 10 protein
    Low molecular mass protein 7
    Multicatalytic endopeptidase complex subunit C13
    Proteasome subunit beta type-8
    Proteasome component C13
    Proteasome subunit beta-5i
    Proteasome
    proteasome 20S subunit beta 8
    PRAAS1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
    Kawamura S et al., 2013, Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action., J Med Chem
  • LACTACYSTIN   PSMB8

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23547757


    Sources:
    DTC

  • BELACTOSIN A   PSMB8

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23547757


    Sources:
    DTC

  • CARFILZOMIB   PSMB8

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    17591945 24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • MARIZOMIB   PSMB8

    Interaction Score: 0.44

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 20S Proteasome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BORTEZOMIB   PSMB8

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • IXAZOMIB CITRATE   PSMB8

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OPROZOMIB   PSMB8

    Interaction Score: 0.23

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000204264

    • Version: 101_38

    Alternate Names:
    PSMB8 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • DTC: PSMB8

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
    Kawamura S et al., 2013, Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action., J Med Chem

  • MyCancerGenome: PSMB8

    • Version: 20-Jun-2017

    Alternate Names:
    5696 Entrez Gene Id
    PSMB8 MyCancerGenome Gene Symbol
    Proteasome MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000204264

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000204264 Gene Symbol
    PSMB8 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: LMP7

    • Version: chembl_23

    Alternate Names:
    PSMB5i GENE_SYMBOL
    RING10 GENE_SYMBOL
    Y2 GENE_SYMBOL

    Gene Info:

    Publications:

  • dGene: PSMB8

    • Version: 27-Jun-2013

    Alternate Names:
    5696 Gene ID
    ALDD dGene Synonym
    D6S216 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21