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PSMD4 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSMD4 5710

    Alternate Names:

    5710
    PROTEASOME 26S SUBUNIT, NON-ATPASE 4
    PSMD4
    AF
    AF-1
    ASF
    MCB1
    Rpn10
    S5A
    pUB-R5
    601648
    9561
    ENSG00000159352
    OTTHUMG00000012349
    Multiubiquitin chain-binding protein
    26S proteasome regulatory subunit S5A
    26S proteasome regulatory subunit RPN10
    26S proteasome non-ATPase regulatory subunit 4
    Antisecretory factor 1
    4630
    Proteasome
    PROTEASOME 26S SUBUNIT UBIQUITIN RECEPTOR, NON-ATPASE 4

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    Publications:

    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
    Lin PL et al., 2016, Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4., Free Radic Biol Med
    Fejzo et al., 2017, Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi., Genes Chromosomes Cancer
  • TALAZOPARIB   PSMD4

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28316110


    Sources:
    CIViC

  • CARFILZOMIB   PSMD4

    Interaction Score: 1.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    24524217 27033953


    Sources:
    DTC MyCancerGenome ChemblInteractions CIViC

  • BORTEZOMIB   PSMD4

    Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • IXAZOMIB CITRATE   PSMD4

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OPROZOMIB   PSMD4

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000159352

    • Version: 101_38

    Alternate Names:
    PSMD4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: PSMD4

    • Version: 14-September-2020

    Alternate Names:
    5710 Entrez Gene ID
    4630 CIViC Gene ID

    Gene Info:

    Publications:
    Fejzo et al., 2017, Proteasome ubiquitin receptor PSMD4 is an amplification target in breast cancer and may predict sensitivity to PARPi., Genes Chromosomes Cancer
    Lin PL et al., 2016, Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4., Free Radic Biol Med

  • NCI: PSMD4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lundgren et al., 2005, Identification and characterization of a Drosophila proteasome regulatory network., Mol. Cell. Biol.

  • DTC: PSMD4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

  • MyCancerGenome: PSMD4

    • Version: 20-Jun-2017

    Alternate Names:
    5710 Entrez Gene Id
    PSMD4 MyCancerGenome Gene Symbol
    Proteasome MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: MCB1

    • Version: chembl_23

    Alternate Names:
    MCB1 GENE_SYMBOL
    PSMD4 GENE_SYMBOL
    26S proteasome non-ATPase regulatory subunit 4 UNIPROT

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21