DGIdb - PTGS1 Gene Record

PTGS1 5742 Druggable Genome

Alternate Names:

5742
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1
PTGS1
COX1
COX3
PCOX1
PES-1
PGG/HS
PGHS-1
PGHS1
PHS1
PTGHS
176805
9604
ENSG00000095303
OTTHUMG00000020605
PA24346
Prostaglandin G/H synthase 1
Cyclooxygenase-1
Prostaglandin H2 synthase 1
COX-1
PGH synthase 1
PHS 1
P23219
PGH1_HUMAN
1375
PROSTAGLANDIN G/H SYNTHASE 1 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 1) (COX-1) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1) (PROSTAGLANDIN H2 SYNTHASE 1) (PGH SYNTHASE 1) (PGHS-1) (PHS 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23219]
T60529

Gene Info:

Target Subclass	1.14.99.1
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:1.14.99.1
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002007
Interpro Short Name	Haem_peroxidase_animal
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Name	Haem peroxidase, animal
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Cyclooxygenase
GuideToPharmacology Gene Category ID	269

(9 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Sinning C et al., 2008, New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide., J Med Chem
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hinz et al., 2008, Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man., FASEB J.
Allgayer, 2003, Review article: mechanisms of action of mesalazine in preventing colorectal carcinoma in inflammatory bowel disease., Aliment. Pharmacol. Ther.
Bender et al., 2007, Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure., ChemMedChem
Llorens et al., 2002, Differential binding mode of diverse cyclooxygenase inhibitors., J. Mol. Graph. Model.
Loll et al., 1996, Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site., Biochemistry
Warner et al., 1999, Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis., Proc. Natl. Acad. Sci. U.S.A.
Beretta et al., 2005, COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis., Pharmacol. Res.
Morton et al., 2005, Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis., Res. Vet. Sci.
Zitova et al., 2010, Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system., Anal. Biochem.
Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem
Gupta et al., 2004, Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors., Bioorg. Med. Chem. Lett.
Yu et al., 2013, Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro., Biopharm Drug Dispos
Martić et al., 2004, Synthesis, biological activity and molecular modeling studies of novel COX-1 inhibitors., Eur J Med Chem
Chavez et al., 2003, Valdecoxib: a review., Clin Ther
Patrignani, 2003, Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease., Thromb. Res.
Hillarp, 2004, [Acetylsalicylic acid resistance--clinical diagnosis with unclear mechanism]., Lakartidningen
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Verschuren JJ et al., 2013, Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction., Int J Cardiol
Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
Higuchi et al., 2004, Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach., Drugs Exp Clin Res
Moth et al., 2005, Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1., J. Med. Chem.
Bobadilla L et al., 2005, Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5-hydroxytryptamine-induced contractions in rat isolated thoracic and abdominal aorta., Clin. Exp. Pharmacol. Physiol.
Kundu et al., 2005, Cyclooxygenase inhibitors modulate NK activities that control metastatic disease., Cancer Immunol. Immunother.
Fornai et al., 2005, Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice., Gut
Christ AN et al., 2010, Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases., J Med Chem
Hanna MM, 2012, New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies., Eur J Med Chem
Blanco et al., 1999, Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes., J. Rheumatol.
Ottonello et al., 2009, Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway., Br. J. Pharmacol.
Kawai, 1998, Cyclooxygenase selectivity and the risk of gastro-intestinal complications of various non-steroidal anti-inflammatory drugs: a clinical consideration., Inflamm. Res.
Kean, 2004, Oxaprozin: kinetic and dynamic profile in the treatment of pain., Curr Med Res Opin
Yood et al., 2006, The impact of NSAID or COX-2 inhibitor use on the initiation of antihypertensive therapy., Pharmacoepidemiol Drug Saf
Zhou et al., 2009, Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug., Biol. Pharm. Bull.
Gamache et al., 2000, Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy., Inflammation
Chen et al., 2005, Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors., Bioorg. Med. Chem.
Young et al., 1996, Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production., Inflamm. Res.
Cappon et al., 2003, Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure., Birth Defects Res. B Dev. Reprod. Toxicol.
James et al., 2007, Selective COX-2 inhibitors, eicosanoid synthesis and clinical outcomes: a case study of system failure., Lipids
Brutzkus JC et al., 2020, Naproxen,
Stevenson, 2004, Aspirin and NSAID sensitivity., Immunol Allergy Clin North Am
Schmidt et al., 1991, Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F)., J. Biol. Chem.
Josephs et al., 1999, Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility., J. Surg. Res.
Poggi et al., 2006, Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus., J Clin Pharmacol
Wang H et al., 1999, Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries., J Nat Prod
Wiggins et al., 2009, Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis., Expert Opin Drug Metab Toxicol
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Takeuchi et al., 2006, Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease., Clin. Gastroenterol. Hepatol.
Bensen et al., 1998, Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis., Can Fam Physician
Giuliano et al., 2001, Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation., Eur. J. Pharmacol.
Cipollone et al., 1995, Effects of nabumetone on prostanoid biosynthesis in humans., Clin. Pharmacol. Ther.
Panara et al., 1999, Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects., J. Pharmacol. Exp. Ther.
Gates BJ et al., 2005, Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety., Expert Opin Pharmacother
Bekker A et al., 2018, Meloxicam in the management of post-operative pain: Narrative review., J Anaesthesiol Clin Pharmacol
Wilson et al., 2004, Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs., Am. J. Vet. Res.
Hirate et al., 2006, Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors., Neurosci. Res.
Riendeau et al., 1997, Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor., Br. J. Pharmacol.
Glaser et al., 1995, Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1., Eur. J. Pharmacol.
Campbell et al., 2002, The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon., Equine Vet. J.
Bugajski et al., 2001, Involvement of constitutive (COX-1) and inducible cyclooxygenase (COX-2) in the adrenergic-induced ACTH and corticosterone secretion., J. Physiol. Pharmacol.
Veiga et al., 2004, Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats., Life Sci.
Raju et al., 2002, Differential modulation of transforming growth factor-betas and cyclooxygenases in the platelet lysates of male F344 rats by dietary lipids and piroxicam., Mol. Cell. Biochem.
Fackovcova et al., 2000, Renal damage induced by the treatment with non-opioid analgesics--theoretical assumption or clinical significance., Bratisl Lek Listy
Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem
Kurahashi et al., 2001, Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites., J. Cardiovasc. Pharmacol.
Klegeris et al., Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity., Neurobiol. Aging
Dröge et al., Alternative splicing of cyclooxygenase-1 mRNA in the human iris., Ophthalmic Res.
Basselin et al., 2007, Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats., Neurochem. Res.
Rieke et al., 1999, The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors., J. Biol. Chem.
Nivsarkar et al., Cyclooxygenase inhibitors: a novel direction for Alzheimer's management., Pharmacol Rep
Hewett et al., 2000, Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture., J. Pharmacol. Exp. Ther.
Waterbury et al., 2006, Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium., Curr Med Res Opin
Giuliano et al., 1999, Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs., Br. J. Pharmacol.
Lim et al., 1999, Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines., Biochem. Pharmacol.
Cheng et al., 2003, Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27)., Eur. J. Pharmacol.
Soriano et al., 1999, Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines., Cancer Res.
Cheng et al., 2002, Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene., J. Physiol. Pharmacol.
Yamada et al., 1997, Prostaglandin E2 production dependent upon cyclooxygenase-1 and cyclooxygenase-2 and its contradictory modulation by auranofin in rat peritoneal macrophages., J. Pharmacol. Exp. Ther.
Lúcio et al., 2006, Interactions between oxicams and membrane bilayers: an explanation for their different COX selectivity., Med Chem
Ozgocmen et al., 2005, In vivo effect of celecoxib and tenoxicam on oxidant/ anti-oxidant status of patients with knee osteoarthritis., Ann. Clin. Lab. Sci.
Lora et al., 1997, Expression of recombinant human cyclooxygenase isoenzymes in transfected COS-7 cells in vitro and inhibition by tenoxicam, indomethacin and aspirin., Prostaglandins Leukot. Essent. Fatty Acids
Kothekar et al., Recognition of cyclooxygenase-2 (COX-2) active site by NSAIDs: a computer modelling study., Indian J. Biochem. Biophys.
Parsadaniantz et al., 2000, Effects of the inhibition of cyclo-oxygenase 1 or 2 or 5-lipoxygenase on the activation of the hypothalamic-pituitary-adrenal axis induced by interleukin-1beta in the male Rat., J. Neuroendocrinol.
Levoin et al., 2004, Elucidation of the mechanism of inhibition of cyclooxygenases by acyl-coenzyme A and acylglucuronic conjugates of ketoprofen., Biochem. Pharmacol.
Zúñiga et al., 2003, Effects of steroidal and non steroidal drugs on the neovascularization response induced by tumoral TA3 supernatant on CAM from chick embryo., Biol. Res.
Lashbrook et al., 1999, Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats., Pain
Uzan, 2005, The unexpected side effects of new nonsteroidal anti-inflammatory drugs., Expert Opin Emerg Drugs
Dionne et al., Analgesia and COX-2 inhibition., Clin. Exp. Rheumatol.
Blais et al., 2005, Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli., J. Neurochem.
Bosch-Marcè et al., 1999, Selective inhibition of cyclooxygenase 2 spares renal function and prostaglandin synthesis in cirrhotic rats with ascites., Gastroenterology
Kämpfer et al., 2003, Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair., J. Invest. Dermatol.
Calkin et al., 2002, Rapid potentiation of endothelium-dependent vasodilation by estradiol in postmenopausal women is mediated via cyclooxygenase 2., J. Clin. Endocrinol. Metab.
Hinz et al., 2003, Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac., Clin. Pharmacol. Ther.
Kirchheiner et al., 2003, Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans., Br J Clin Pharmacol
Nurtjahja-Tjendraputra et al., 2003, Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger., Thromb. Res.
Burdan et al., 2005, Skeletal developmental effects of selective and nonselective cyclooxygenase-2 inhibitors administered through organogenesis and fetogenesis in Wistar CRL:(WI)WUBR rats., Toxicology
Capasso et al., 1997, Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum., Eur. J. Pharmacol.
Capasso, 1999, Further studies on the involvement of the arachidonic acid cascade in the acute dependence produced by mu, kappa and delta opioid agonists in isolated tissues., Neuropharmacology
Kennedy et al., 2003, Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility., Reprod. Biol. Endocrinol.
Ringbom T et al., 1998, Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis., J Nat Prod
Sinniah et al., 2001, Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid., Clin. Nephrol.
Cryer et al., 1998, Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs., Am. J. Med.
Joo et al., 2006, Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models., Mol. Pharmacol.
Laudanno et al., 1998, [In vivo selectivity of nonsteroidal anti-inflammatory drugs on COX-1-COX-2 and gastrointestinal ulcers, in rats]., Acta Gastroenterol. Latinoam.
Gierse et al., 1995, Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase., Biochem. J.
Kammerl et al., 2001, Inhibition of COX-2 counteracts the effects of diuretics in rats., Kidney Int.
Gao LC et al., 2015, Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients., Eur J Clin Pharmacol

SUPROFEN PTGS1

Interaction Score: 4.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
17477341 11752352 11885959 8652509 10377455

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
SALSALATE PTGS1

Interaction Score: 3.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15242723 1680855 11752352 10452868

Sources:
TdgClinicalTrial TEND TTD
BROMFENAC PTGS1

Interaction Score: 2.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Bromfenac

Novel drug target Established target

Trial Name ISV-101

PMIDs:
11752352 16846546

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
KETOROLAC PTGS1

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ketorolac tromethamine ophthalmic solution,Acuvail

Novel drug target Established target

Trial Name ROX-828

PMIDs:
10422661 16262557 11695255 16277613 10220509

Sources:
TdgClinicalTrial TEND GuideToPharmacology
ETODOLAC PTGS1

Interaction Score: 2.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name VT-122

Novel drug target Established target

PMIDs:
15198222 16473424 9146894 8566109 12358053

Sources:
TdgClinicalTrial TEND
OXAPROZIN PTGS1

Interaction Score: 2.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19338579 9831331 15324530 17024689 19952416

Sources:
ChemblInteractions GuideToPharmacology
TOLMETIN PTGS1

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16182428 9253954 10465690 14613550

Sources:
TdgClinicalTrial TEND
NEPAFENAC PTGS1

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10850857

Sources:
TdgClinicalTrial ChemblInteractions TEND
KETOPROFEN PTGS1

Interaction Score: 1.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ketoprofen in Transfersome gel, IDEA-033,Diractin

Novel drug target Established target

Trial Name ketoprofen transdermal patch, EN3269

PMIDs:
10929089 14987823 15476667 11811354 14513718

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
BALSALAZIDE PTGS1

Interaction Score: 1.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name balsalazide disodium,Colazal, Giazo

PMIDs:
12950415 19743890 17016423 17139284 11752352

Sources:
TdgClinicalTrial TTD
FLURBIPROFEN PTGS1

Interaction Score: 1.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources:
ChemblInteractions TEND GuideToPharmacology
TENOXICAM PTGS1

Interaction Score: 1.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9152412 17017983 15943176 9175172 11563332

Sources:
TdgClinicalTrial TEND
FENOPROFEN PTGS1

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Inhibition

PMIDs:
17050798

Sources:
TdgClinicalTrial TEND GuideToPharmacology
DIFLUNISAL PTGS1

Interaction Score: 1.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Trial Name CRx-401

PMIDs:
15755648 8737748 12852483

Sources:
TdgClinicalTrial ChemblInteractions TEND
(+)-EPICATECHIN PTGS1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NAPROXCINOD PTGS1

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology
GINGER PTGS1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14693173

Sources:
NCI
MELOXICAM PTGS1

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10381787 10381057 16197363 30774225

Sources:
GuideToPharmacology
E163 PTGS1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10075763

Sources:
DTC
NABUMETONE PTGS1

Interaction Score: 0.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16469680 9481468 11525777 7554708

Sources:
TdgClinicalTrial TEND
PIROXICAM PTGS1

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
11785774 15464832 11952155 11153163 10381057

Sources:
ChemblInteractions TEND GuideToPharmacology TTD
LATANOPROST PTGS1

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25339146

Sources:
PharmGKB
MEFENAMIC ACID PTGS1

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
11316248 9626023 16223958 9773153 7832763

Sources:
ChemblInteractions
NAPROXEN PTGS1

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Trial Name MT 100

PMIDs:
17541796 30247840

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
AMINOSALICYLATE SODIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IMRECOXIB PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DICLOFENAC EPOLAMINE PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VB-201 PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VB-201

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BROMFENAC SODIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FENOPROFEN CALCIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GW-406381 PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
FLURBIPROFEN SODIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FENBUFEN PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NAPROXEN ETEMESIL PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DICLOFENAC POTASSIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IBUPROFEN SODIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AMINOSALICYLATE POTASSIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SULINDAC PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
10372826 10484067 12586211 10626810 12512695

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
CURCUMIN PYRAZOLE PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24920381

Sources:
DTC
OXAPROZIN POTASSIUM PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IBUPROFEN LYSINE PTGS1

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IBUPROFEN PTGS1

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name HZT-501, ibuprofen + famotidine,Duexa

Novel drug target Established target

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
23651359 14741265 23536207 14987823 11752352 12852704 14592549 15575422 25502615

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology PharmGKB
DICLOFENAC PTGS1

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
12713596 12414874 12966366 11752352 12852704 12534640

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
PHENYLBUTAZONE PTGS1

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
15939622 15563928 19849999

Sources:
ChemblInteractions GuideToPharmacology
INDOMETHACIN PTGS1

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
15700751 15887968 15743404 15891886 15831902 20684598 22818041 23651359 10381057

Sources:
DTC ChemblInteractions TEND GuideToPharmacology
KETOROLAC TROMETHAMINE PTGS1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLMETIN SODIUM PTGS1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAPROXEN SODIUM PTGS1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
MESALAMINE PTGS1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MAX-002

Novel drug target Established target

Trial Name mesalamine,Pentasa, Canasa, Asacol

PMIDs:
12950415 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
OLSALAZINE SODIUM PTGS1

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SC-560 PTGS1

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
DERSALAZINE PTGS1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name dersalazine sodium

PMIDs:
None found

Sources:
TdgClinicalTrial
BISMUTH SUBSALICYLATE PTGS1

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BALSALAZIDE DISODIUM PTGS1

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ACETAMINOPHEN PTGS1

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
19053765 11752352 17884974

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
DICLOFENAC SODIUM PTGS1

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
URSOLIC ACID PTGS1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9784154

Sources:
DTC
MECLOFENAMATE SODIUM PTGS1

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
SULFASALAZINE PTGS1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Novel drug target Established target

PMIDs:
12950415

Sources:
TdgClinicalTrial ChemblInteractions
ASPIRIN PTGS1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
23651359 22940005 20938371 16493486

Sources:
DTC ChemblInteractions TEND GuideToPharmacology PharmGKB
CLOPIDOGREL PTGS1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22940005

Sources:
PharmGKB
OXYPHENBUTAZONE PTGS1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NIMESULIDE PTGS1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
HYDROCHLOROTHIAZIDE PTGS1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11703585

Sources:
NCI
CURCUMIN PTGS1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24920381

Sources:
DTC TTD
CELECOXIB PTGS1

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000095303
- Version: 101_38
Alternate Names:

PTGS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P23219
- Version: 01-August-2011
Alternate Names:

PGH1_HUMAN Uniprot Id

PTGS1 Gene Symbol

5742 Entrez Gene Id

Gene Info:

Target Subclass 1.14.99.1

Target Main Class Enzymes

Publications:

RussLampel: ENSG00000095303

Version: 26-July-2011

Alternate Names:

PROSTAGLANDIN G/H SYNTHASE 1 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 1) (COX-1) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1) (PROSTAGLANDIN H2 SYNTHASE 1) (PGH SYNTHASE 1) (PGHS-1) (PHS 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23219] Description

ENSG00000095303 Ensembl Gene Id

PTGS1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P23219
- Version: 11-September-2012
Alternate Names:

ENSG00000095303 Ensembl Gene Id

PTGS1 Uniprot Gene Name

PGH1_HUMAN Uniprot Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR002007

Interpro Short Name Haem_peroxidase_animal

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P23219
- Version: January-2014
Alternate Names:

PTGS1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.14.99.1

Publications:
GuideToPharmacology: 5742
- Version: 29-September-2020
Alternate Names:

9604 HUGO Gene ID

9604 HUGO Gene Symbol

prostaglandin-endoperoxide synthase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Cyclooxygenase

GuideToPharmacology Gene Category ID 269

Gene Categories:

ENZYME

Publications:

PharmGKB: PTGS1

Version: 18-August-2020

Alternate Names:

PA24346 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

St Germaine CG et al., 2010, Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs., Am J Cardiol

Gao LC et al., 2015, Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients., Eur J Clin Pharmacol

TTD: Prostaglandin G/H synthase 1
- Version: 2020.06.01
Alternate Names:

COX-1 TTD Gene Abbreviation

T60529 TTD Target ID

Gene Info:

Publications:

Cohen MP et al., 2013, Inhibiting Amadori-modified albumin formation improves biomarkers of podocyte damage in diabetic rats., Physiol Rep

NCI: PTGS1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kammerl et al., 2001, Inhibition of COX-2 counteracts the effects of diuretics in rats., Kidney Int.

Giannitrapani et al., 2007, Response to antiviral therapy and hepatic expression of cyclooxygenases in chronic hepatitis C., Eur J Gastroenterol Hepatol

Nurtjahja-Tjendraputra et al., 2003, Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger., Thromb. Res.

DTC: PTGS1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem

Wang H et al., 1999, Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries., J Nat Prod

Sinning C et al., 2008, New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide., J Med Chem

ChemblInteractions: COX1
- Version: chembl_23
Alternate Names:

COX1 GENE_SYMBOL

PTGS1 GENE_SYMBOL

Prostaglandin G/H synthase 1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000095303
- Version: 31-May-2017
Alternate Names:

ENSG00000095303 Gene Symbol

PTGS1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: PTGS1
- Version: 01-May-2021
Alternate Names:

Prostaglandin G/H synthase 1 Gene Name

P23219 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Mechanism of Interaction	Cyclooxygenase inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Trial Name	Bromfenac
Novel drug target	Established target
Trial Name	ISV-101

Trial Name	ketorolac tromethamine ophthalmic solution,Acuvail
Novel drug target	Established target
Trial Name	ROX-828

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Trial Name	ketoprofen in Transfersome gel, IDEA-033,Diractin
Novel drug target	Established target
Trial Name	ketoprofen transdermal patch, EN3269

Trial Name	HZT-501, ibuprofen + famotidine,Duexa
Novel drug target	Established target
Mechanism of Interaction	Cyclooxygenase inhibitor

Trial Name	MAX-002
Novel drug target	Established target
Trial Name	mesalamine,Pentasa, Canasa, Asacol

PROSTAGLANDIN G/H SYNTHASE 1 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 1) (COX-1) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1) (PROSTAGLANDIN H2 SYNTHASE 1) (PGH SYNTHASE 1) (PGHS-1) (PHS 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P23219]	Description
ENSG00000095303	Ensembl Gene Id
PTGS1	Display Id

9604	HUGO Gene ID
9604	HUGO Gene Symbol
prostaglandin-endoperoxide synthase 1	HUGO Gene Name

COX1	GENE_SYMBOL
PTGS1	GENE_SYMBOL
Prostaglandin G/H synthase 1	UNIPROT

PTGS1 Gene Record

PTGS1 5742 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 17477341 11752352 11885959 8652509 10377455

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 15242723 1680855 11752352 10452868

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Bromfenac Novel drug target Established target Trial Name ISV-101

PMIDs: 11752352 16846546

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ketorolac tromethamine ophthalmic solution,Acuvail Novel drug target Established target Trial Name ROX-828

PMIDs: 10422661 16262557 11695255 16277613 10220509

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name VT-122 Novel drug target Established target

PMIDs: 15198222 16473424 9146894 8566109 12358053

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: 19338579 9831331 15324530 17024689 19952416

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16182428 9253954 10465690 14613550

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Trial Name -

PMIDs: 10850857

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ketoprofen in Transfersome gel, IDEA-033,Diractin Novel drug target Established target Trial Name ketoprofen transdermal patch, EN3269

PMIDs: 10929089 14987823 15476667 11811354 14513718

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name balsalazide disodium,Colazal, Giazo

PMIDs: 12950415 19743890 17016423 17139284 11752352

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources: ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9152412 17017983 15943176 9175172 11563332

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Specific Action of the Ligand Inhibition

PMIDs: 17050798

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Trial Name CRx-401

PMIDs: 15755648 8737748 12852483

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14693173

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 10381787 10381057 16197363 30774225

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
17477341 11752352 11885959 8652509 10377455

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
15242723 1680855 11752352 10452868

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Bromfenac

Novel drug target Established target

Trial Name ISV-101

PMIDs:
11752352 16846546

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ketorolac tromethamine ophthalmic solution,Acuvail

Novel drug target Established target

Trial Name ROX-828

PMIDs:
10422661 16262557 11695255 16277613 10220509

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name VT-122

Novel drug target Established target

PMIDs:
15198222 16473424 9146894 8566109 12358053

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
19338579 9831331 15324530 17024689 19952416

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16182428 9253954 10465690 14613550

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
10850857

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ketoprofen in Transfersome gel, IDEA-033,Diractin

Novel drug target Established target

Trial Name ketoprofen transdermal patch, EN3269

PMIDs:
10929089 14987823 15476667 11811354 14513718

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name balsalazide disodium,Colazal, Giazo

PMIDs:
12950415 19743890 17016423 17139284 11752352

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources:
ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9152412 17017983 15943176 9175172 11563332

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Specific Action of the Ligand Inhibition

PMIDs:
17050798

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Trial Name CRx-401

PMIDs:
15755648 8737748 12852483

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
14693173

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
10381787 10381057 16197363 30774225

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10075763

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16469680 9481468 11525777 7554708

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
11785774 15464832 11952155 11153163 10381057