5743 |
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2 |
PTGS2 |
COX-2 |
COX2 |
GRIPGHS |
PGG/HS |
PGHS-2 |
PHS-2 |
hCox-2 |
600262 |
9605 |
ENSG00000073756 |
OTTHUMG00000035473 |
P35354 |
PA293 |
PGH2_HUMAN |
PROSTAGLANDIN G/H SYNTHASE 2 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 2) (COX-2) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2) (PROSTAGLANDIN H2 SYNTHASE 2) (PGH SYNTHASE 2) (PGHS-2) (PHS II). [SOURCE:UNIPROT/SWISSPROT;ACC:P35354] |
Prostaglandin G/H synthase 2 |
Cyclooxygenase-2 |
PHS II |
Prostaglandin H2 synthase 2 |
PGH synthase 2 |
4659 |
T66665 |
Target Class | Enzymes |
Target Subclass | EC:1.14.99.1 |
Target Subclass | 1.14.99.1 |
Target Main Class | Enzymes |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Interpro Acc | IPR002007 |
Interpro Name | Haem peroxidase, animal |
Interpro Short Name | Haem_peroxidase_animal |
Uniprot Evidence | 1: Evidence at protein level |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Trial Name | etoricoxib, MK-663,Arcoxia |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase-2 inhibitor |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase-2 inhibitor |
Direct Interaction | yes |
Trial Name | - |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase-2 inhibitor |
Direct Interaction | yes |
Trial Name | apricoxib, TG01,Capoxigem |
n/a |
Novel drug target | Established target |
Trial Name | Cimicoxib |
inhibitor (inhibitory) |
Trial Name | intranasal ketorolac tromethamine, ROX-888,Sprix |
Novel drug target | Established target |
Trial Name | ketorolac tromethamine ophthalmic solution,Acuvail |
inhibitor (inhibitory) |
Trial Name | Bromfenac |
Novel drug target | Established target |
Trial Name | ISV-101 |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Trial Name | CRx-401 |
inhibitor (inhibitory) |
Trial Name | ketoprofen in Transfersome gel, IDEA-033,Diractin |
Novel drug target | Established target |
Trial Name | ketoprofen transdermal patch, EN3269 |
inhibitor (inhibitory) |
Trial Name | rofecoxib,Vioxx |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase-2 inhibitor |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | HCT 1026, NO-flurbiprofen |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | - |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase-2 inhibitor |
Direct Interaction | yes |
Trial Name | - |
inhibitor (inhibitory) |
Trial Name | MT 100 |
Novel drug target | Established target |
Trial Name | MT 400,Treximet |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase-2 inhibitor |
Trial Name | CG100649 |
inhibitor (inhibitory) |
Trial Name | parecoxib sodium,Dynastat |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | licofelone, ML3000 |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | lidocaine hydrochloride, piroxicam, AK1015,Akten |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | Naproxcinod |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | VB-201 |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Trial Name | Cerimon |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Trial Name | HZT-501, ibuprofen + famotidine,Duexa |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Trial Name | MAX-002 |
Novel drug target | Established target |
Trial Name | mesalamine,Pentasa, Canasa, Asacol |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | sulfasalazine,Azulfidine, Salazopyrin |
Novel drug target | Established target |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | dersalazine sodium |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Notes | |
Novel drug target | Established target |
Trial Name | celecoxib,Celebrex, Celecox |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
Trial Name | PTI-701 |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclooxygenase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclooxygenase inhibitor |
Direct Interaction | yes |
PTGS2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
PGH2_HUMAN | Uniprot Id |
PROSTAGLANDIN G/H SYNTHASE 2 | Uniprot Protein Name |
5743 | Entrez Gene Id |
Uniprot Status | Swiss-Prot |
Interpro Type | Family |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PROSTAGLANDIN G/H SYNTHASE 2 PRECURSOR (EC 1.14.99.1) (CYCLOOXYGENASE- 2) (COX-2) (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2) (PROSTAGLANDIN H2 SYNTHASE 2) (PGH SYNTHASE 2) (PGHS-2) (PHS II). [SOURCE:UNIPROT/SWISSPROT;ACC:P35354] | Description |
ENSG00000073756 | Ensembl Gene Id |
PTGS2 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PTGS2 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:1.14.99.1 |
PGH2_HUMAN | Uniprot Id |
5743 | Entrez Gene Id |
P35354 | Uniprot Accession |
Target Subclass | 1.14.99.1 |
Target Main Class | Enzymes |
PA293 | PharmGKB ID |
5743 | Entrez Gene ID |
4659 | CIViC Gene ID |
ENSG00000073756 | Gene Symbol |
PTGS2 | Ensembl Id |
DRUGGABLE GENOME |
PTGS2 | Gene Symbol |
COX-2 | Gene Symbol |
COX2 | GENE_SYMBOL |
PTGS2 | GENE_SYMBOL |
Prostaglandin G/H synthase 2 | UNIPROT |
COX-2 | TTD Gene Abbreviation |
T66665 | TTD Target ID |
Prostaglandin G/H synthase 2 | Gene Name |
P35354 | UniProt ID |
ENZYME |