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PTH Gene Record

  • Summary
  • Interactions
  • Claims
  • PTH 5741 Druggable Genome

    Alternate Names:

    5741
    PARATHYROID HORMONE
    PTH
    PTH1
    168450
    9606
    ENSG00000152266
    OTTHUMG00000165785
    T98708
    FIH1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Tebb et al., 2005, Canine hyperadrenocorticism: effects of trilostane on parathyroid hormone, calcium and phosphate concentrations., J Small Anim Pract
    Mizokuchi et al., 1992, Possible mechanism of impaired calcium and vitamin D metabolism in nephrotic rats., Kidney Int.
    Kayser et al., 1989, Changes in serum phosphate during beta-blockade in healthy men are not due to changes in the renal handling of phosphate., J. Intern. Med.
    Vargas et al., 1987, Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones., J. Bone Miner. Res.
    Lorenzo et al., 1983, DNA synthesis is not necessary for osteoclastic responses to parathyroid hormone in cultured fetal rat long bones., J. Clin. Invest.
    Lorenzo et al., 1986, Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long-bone cultures., J. Clin. Invest.
    Fiore et al., 1985, Long-term effects of histamine H2-receptor antagonists on serum parathyroid hormone in chronic renal failure., Clin. Endocrinol. (Oxf)
    Biagi et al., 1985, [Effects of H2 blockers on blood levels of parathormones and calcitonin in normal subjects]., Minerva Med.
    Gur et al., 2005, Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?, BMC Gastroenterol
    Goulding et al., 1990, Effects of clomiphene and tamoxifen in vivo on the bone-resorbing effects of parathyroid hormone and of high oral doses of calcitriol (1,25(OH)2D3) in rats with intact ovarian function consuming low calcium diet., Bone Miner
    Rao et al., 2003, Lycopene I--effect on osteoclasts: lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures., J Med Food
    Nieszporek et al., 1990, [Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A]., Pol. Arch. Med. Wewn.
    Kawashima et al., 1985, Aspirin inhibition of 1 alpha-hydroxyvitamin D3 or parathyroid hormone induced hypercalcemia in vivo in rats. A mechanism independent of prostaglandin biosynthesis inhibition., Biochem. Pharmacol.
    Imanaka et al., 1988, Effect of estrogens on renal responsiveness to parathyroid hormone in elderly female subjects., Endocrinol. Jpn.
    Bergner et al., 2005, High bone-binding capacity of ibandronate in hemodialysis patients., Int J Clin Pharmacol Res
    Sippel et al., 2004, Does propofol anesthesia affect intraoperative parathyroid hormone levels? A randomized, prospective trial., Surgery
    Rico et al., 1992, Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin., Eur. Neurol.
    Hansen et al., 1979, Small cell carcinoma of the lung: relation of calcitonin to bone marrow metastases, parathormone and gastrin., Acta Med Scand
  • IBANDRONIC ACID   PTH

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16366420


    Sources:
    NCI

  • PREMARIN   PTH

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2850907


    Sources:
    NCI

  • CLOMIPHENE   PTH

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2322693


    Sources:
    NCI

  • TERIPARATIDE   PTH

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CALCITONIN   PTH

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    227233


    Sources:
    NCI

  • TRILOSTANE   PTH

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16300115


    Sources:
    NCI

  • PENICILLAMINE   PTH

    Interaction Score: 1.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3137774


    Sources:
    NCI

  • LYCOPENE   PTH

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12935316


    Sources:
    NCI

  • PUROMYCIN   PTH

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1328752


    Sources:
    NCI

  • RANITIDINE   PTH

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3878237 2864665


    Sources:
    NCI

  • HYDROXYUREA   PTH

    Interaction Score: 0.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6643680 3086384


    Sources:
    NCI

  • AZATHIOPRINE   PTH

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2216934


    Sources:
    NCI

  • LAMIVUDINE   PTH

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16171525


    Sources:
    NCI

  • ATENOLOL   PTH

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2649632


    Sources:
    NCI

  • PHENOBARBITAL   PTH

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1490499


    Sources:
    NCI

  • MIDAZOLAM   PTH

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15657568


    Sources:
    NCI

  • ASPIRIN   PTH

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4004906


    Sources:
    NCI

  • Ensembl: ENSG00000152266

    • Version: 101_38

    Alternate Names:
    PTH Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: PTH

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Tebb et al., 2005, Canine hyperadrenocorticism: effects of trilostane on parathyroid hormone, calcium and phosphate concentrations., J Small Anim Pract
    Vargas et al., 1987, Comparison of the effects of auranofin, gold sodium thiomalate, and penicillamine on resorption of cultured fetal rat long bones., J. Bone Miner. Res.
    Lorenzo et al., 1986, Effects of DNA and prostaglandin synthesis inhibitors on the stimulation of bone resorption by epidermal growth factor in fetal rat long-bone cultures., J. Clin. Invest.

  • HingoraniCasas: ENSG00000152266

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000152266 Gene Symbol
    PTH Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Parathyroid hormone

    • Version: 2020.06.01

    Alternate Names:
    PTH TTD Gene Abbreviation
    T98708 TTD Target ID

    Gene Info:

    Publications:

  • GO: PTH

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21