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PTPN6 Gene Record

  • Summary
  • Interactions
  • Claims
  • PTPN6 5777 Druggable GenomeClinically Actionable

    Alternate Names:

    5777
    PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6
    PTPN6
    HCP
    HCPH
    HPTP1C
    PTP-1C
    SH-PTP1
    SHP-1
    SHP-1L
    SHP1
    176883
    9658
    ENSG00000111679
    OTTHUMG00000168518
    P29350
    PTN6_HUMAN
    TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
    PROTEIN-TYROSINE PHOSPHATASE SHP-1
    TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1C) (PTP-1C) (HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE) (SH-PTP1) (PROTEIN-TYROSINE PHOSPHATASE SHP-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29350]
    T98264
    PROTEIN TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 6

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name Protein-tyrosine/Dual-specificity phosphatase
    Interpro Type Domain
    Interpro Short Name Tyr/Dual-specificity_Pase
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000387
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name PROTEIN PHOSPHATASE
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    PROTEIN PHOSPHATASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Hou S et al., 2014, Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6., J Med Chem
    Chen KF et al., 2012, Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity., Eur J Med Chem
    Yu WM et al., 2008, Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay., J Med Chem
  • CHEMBL510966   PTPN6

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19007293


    Sources:
    DTC

  • CHEMBL472004   PTPN6

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TOFACITINIB   PTPN6

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24978112


    Sources:
    DTC

  • SORAFENIB   PTPN6

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22871485


    Sources:
    DTC

  • Ensembl: ENSG00000111679

    • Version: 101_38

    Alternate Names:
    PTPN6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P29350

    • Version: 11-September-2012

    Alternate Names:
    5777 Entrez Gene Id
    PTN6_HUMAN Uniprot Id
    TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Protein-tyrosine/Dual-specificity phosphatase
    Interpro Type Domain

    Gene Categories:
    PROTEIN PHOSPHATASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000111679

    • Version: 26-July-2011

    Alternate Names:
    PTPN6 Display Id
    ENSG00000111679 Ensembl Gene Id
    TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1C) (PTP-1C) (HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE) (SH-PTP1) (PROTEIN-TYROSINE PHOSPHATASE SHP-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29350] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: PTPN6

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Cyster et al., 1995, Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection., Immunity
    Huang et al., 2005, SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner., Cytokine

  • DTC: PTPN6

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Hou S et al., 2014, Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6., J Med Chem
    Chen KF et al., 2012, Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity., Eur J Med Chem
    Yu WM et al., 2008, Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay., J Med Chem

  • dGene: PTPN6

    • Version: 27-Jun-2013

    Alternate Names:
    5777 Gene ID
    HCP dGene Synonym
    HCPH dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEIN PHOSPHATASE

    Publications:

  • TTD: Protein-tyrosine phosphatase SHP-1

    • Version: 2020.06.01

    Alternate Names:
    PTPN6 TTD Gene Abbreviation
    T98264 TTD Target ID

    Gene Info:

    Publications:

  • FoundationOneGenes: PTPN6

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21