DGIdb - PTPN6 Gene Record

PTPN6 5777 Druggable GenomeClinically Actionable

Alternate Names:

5777
PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6
PTPN6
HCP
HCPH
HPTP1C
PTP-1C
SH-PTP1
SHP-1
SHP-1L
SHP1
176883
9658
ENSG00000111679
OTTHUMG00000168518
P29350
PTN6_HUMAN
TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6
PROTEIN-TYROSINE PHOSPHATASE SHP-1
TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1C) (PTP-1C) (HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE) (SH-PTP1) (PROTEIN-TYROSINE PHOSPHATASE SHP-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29350]
T98264
PROTEIN TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 6

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	Protein-tyrosine/Dual-specificity phosphatase
Interpro Type	Domain
Interpro Short Name	Tyr/Dual-specificity_Pase
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000387
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	PROTEIN PHOSPHATASE
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

PROTEIN PHOSPHATASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Hou S et al., 2014, Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6., J Med Chem
Chen KF et al., 2012, Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity., Eur J Med Chem
Yu WM et al., 2008, Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay., J Med Chem

CHEMBL510966 PTPN6

Interaction Score: 15.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19007293

Sources:
DTC
CHEMBL472004 PTPN6

Interaction Score: 5.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOFACITINIB PTPN6

Interaction Score: 3.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24978112

Sources:
DTC
SORAFENIB PTPN6

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22871485

Sources:
DTC

Ensembl: ENSG00000111679
- Version: 101_38
Alternate Names:

PTPN6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P29350
- Version: 11-September-2012
Alternate Names:

5777 Entrez Gene Id

PTN6_HUMAN Uniprot Id

TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Protein-tyrosine/Dual-specificity phosphatase

Interpro Type Domain

Gene Categories:

PROTEIN PHOSPHATASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000111679

Version: 26-July-2011

Alternate Names:

PTPN6 Display Id

ENSG00000111679 Ensembl Gene Id

TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1C) (PTP-1C) (HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE) (SH-PTP1) (PROTEIN-TYROSINE PHOSPHATASE SHP-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29350] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: PTPN6

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Cyster et al., 1995, Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection., Immunity

Huang et al., 2005, SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner., Cytokine

DTC: PTPN6

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Hou S et al., 2014, Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6., J Med Chem

Chen KF et al., 2012, Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity., Eur J Med Chem

Yu WM et al., 2008, Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay., J Med Chem

dGene: PTPN6
- Version: 27-Jun-2013
Alternate Names:

5777 Gene ID

HCP dGene Synonym

HCPH dGene Synonym

Gene Info:

Gene Categories:

PROTEIN PHOSPHATASE

Publications:
TTD: Protein-tyrosine phosphatase SHP-1
- Version: 2020.06.01
Alternate Names:

PTPN6 TTD Gene Abbreviation

T98264 TTD Target ID

Gene Info:

Publications:
FoundationOneGenes: PTPN6
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

5777	Entrez Gene Id
PTN6_HUMAN	Uniprot Id
TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6	Uniprot Protein Name

PTPN6	Display Id
ENSG00000111679	Ensembl Gene Id
TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1C) (PTP-1C) (HEMATOPOIETIC CELL PROTEIN-TYROSINE PHOSPHATASE) (SH-PTP1) (PROTEIN-TYROSINE PHOSPHATASE SHP-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29350]	Description

5777	Gene ID
HCP	dGene Synonym
HCPH	dGene Synonym

PTPN6	TTD Gene Abbreviation
T98264	TTD Target ID

PTPN6 Gene Record

PTPN6 5777 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL510966 PTPN6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19007293

Sources: DTC

CHEMBL472004 PTPN6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TOFACITINIB PTPN6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24978112

Sources: DTC

SORAFENIB PTPN6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22871485

Sources: DTC

Ensembl: ENSG00000111679

Alternate Names: PTPN6 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P29350

Alternate Names: 5777 Entrez Gene Id PTN6_HUMAN Uniprot Id TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 Uniprot Protein Name

Gene Info: Human Readable Name DRUGGABLE GENOME Interpro Name Protein-tyrosine/Dual-specificity phosphatase Interpro Type Domain

Gene Categories: PROTEIN PHOSPHATASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000111679

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: PTPN6

Alternate Names:

Gene Info:

DTC: PTPN6

Alternate Names:

Gene Info:

dGene: PTPN6

Alternate Names: 5777 Gene ID HCP dGene Synonym HCPH dGene Synonym

Gene Info:

Gene Categories: PROTEIN PHOSPHATASE

Publications:

TTD: Protein-tyrosine phosphatase SHP-1

Alternate Names: PTPN6 TTD Gene Abbreviation T98264 TTD Target ID

Gene Info:

Publications:

FoundationOneGenes: PTPN6

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
19007293

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
24978112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22871485

Sources:
DTC

Alternate Names:

PTPN6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5777 Entrez Gene Id

PTN6_HUMAN Uniprot Id

TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 6 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Protein-tyrosine/Dual-specificity phosphatase

Interpro Type Domain

Gene Categories:

PROTEIN PHOSPHATASE, DRUGGABLE GENOME

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5777 Gene ID

HCP dGene Synonym

HCPH dGene Synonym

Gene Categories:

PROTEIN PHOSPHATASE

Alternate Names:

PTPN6 TTD Gene Abbreviation

T98264 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE