DGIdb - RAC1 Gene Record

RAC1 5879 Clinically ActionableDrug Resistance

Alternate Names:

5879
RAC FAMILY SMALL GTPASE 1
RAC1
MIG5
Rac-1
TC-25
p21-Rac1
602048
9801
ENSG00000136238
OTTHUMG00000023540
BE0001109
P63000
4753
Ras-related C3 botulinum toxin substrate 1

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

KINASE
DRUG RESISTANCE
CLINICALLY ACTIONABLE

Publications:

Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem
Watson et al., 2014, The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF., Cancer Res.
Van Allen et al., 2014, The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma., Cancer Discov
Lionarons DA et al., 2019, RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance., Cancer Cell
Tiede I et al., 2003, CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes., J Clin Invest

CHEMBL257119 RAC1

Interaction Score: 11.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
CHEMBL554475 RAC1

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
CHEMBL562095 RAC1

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
CHEMBL579882 RAC1

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL563777 RAC1

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
PLX-4720 RAC1

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31257073

Sources:
CIViC
DABRAFENIB RAC1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25056119 24265153

Sources:
CIViC
VEMURAFENIB RAC1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25056119 24265153

Sources:
CIViC
AZATHIOPRINE RAC1

Interaction Score: 0.44

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
12697733

Sources:
DrugBank
CHEMBL384759 RAC1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank

Ensembl: ENSG00000136238
- Version: 101_38
Alternate Names:

RAC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: RAC1

Version: 14-September-2020

Alternate Names:

5879 Entrez Gene ID

4753 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Watson et al., 2014, The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF., Cancer Res.

Van Allen et al., 2014, The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma., Cancer Discov

Lionarons DA et al., 2019, RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance., Cancer Cell

DrugBank: BE0001109
- Version: 5.1.7
Alternate Names:

RAC1 DrugBank Gene Name

P63000 UniProt Accession

5879 Entrez Gene Id

Gene Info:

Publications:

Tiede I et al., 2003, CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes., J Clin Invest
DTC: RAC1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem
Pharos: RAC1
- Version: 03-September-2020
Alternate Names:

Ras-related C3 botulinum toxin substrate 1 Gene Name

P63000 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
Tempus: RAC1
- Version: 11-November-2018
Alternate Names:

RAC1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
MskImpact: RAC1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: RAC1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: RAC1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: RAC1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

RAC1	DrugBank Gene Name
P63000	UniProt Accession
5879	Entrez Gene Id

Ras-related C3 botulinum toxin substrate 1	Gene Name
P63000	UniProt ID

RAC1 Gene Record

RAC1 5879 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31257073

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25056119 24265153

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25056119 24265153

Sources: CIViC

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 12697733

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Ensembl: ENSG00000136238

Alternate Names: RAC1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: RAC1

Alternate Names: 5879 Entrez Gene ID 4753 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

DrugBank: BE0001109

Alternate Names: RAC1 DrugBank Gene Name P63000 UniProt Accession 5879 Entrez Gene Id

Gene Info:

Publications: Tiede I et al., 2003, CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes., J Clin Invest

DTC: RAC1

Alternate Names:

Gene Info:

Publications: Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem

Pharos: RAC1

Alternate Names: Ras-related C3 botulinum toxin substrate 1 Gene Name P63000 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

Tempus: RAC1

Alternate Names: RAC1 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

MskImpact: RAC1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: RAC1

Alternate Names:

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
31257073

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
25056119 24265153

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
25056119 24265153

Sources:
CIViC

Interaction Types & Directionality:

modulator

PMIDs:
12697733

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Alternate Names:

RAC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5879 Entrez Gene ID

4753 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

RAC1 DrugBank Gene Name

P63000 UniProt Accession

5879 Entrez Gene Id

Publications:

Tiede I et al., 2003, CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes., J Clin Invest

Publications:

Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem

Alternate Names:

Ras-related C3 botulinum toxin substrate 1 Gene Name

P63000 UniProt ID

Gene Categories:

KINASE

Alternate Names:

RAC1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE