DGIdb - RAC1 Gene Record

RAC1 5879 Clinically ActionableDrug Resistance

Alternate Names:

5879
RAC FAMILY SMALL GTPASE 1
RAC1
MIG5
Rac-1
TC-25
p21-Rac1
602048
9801
ENSG00000136238
OTTHUMG00000023540
P63000
4753
MRD48
Ras-related C3 botulinum toxin substrate 1

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

KINASE
DRUG RESISTANCE
CLINICALLY ACTIONABLE

Publications:

Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem
Watson et al., 2014, The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF., Cancer Res.
Van Allen et al., 2014, The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma., Cancer Discov
Lionarons DA et al., 2019, RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance., Cancer Cell

CHEMBL257119 RAC1

Interaction Score: 15.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
CHEMBL554475 RAC1

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
CHEMBL562095 RAC1

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
CHEMBL579882 RAC1

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL563777 RAC1

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19527032

Sources:
DTC
PLX-4720 RAC1

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31257073

Sources:
CIViC
DABRAFENIB RAC1

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25056119 24265153

Sources:
CIViC
VEMURAFENIB RAC1

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25056119 24265153

Sources:
CIViC

Ensembl: ENSG00000136238
- Version: 101_38
Alternate Names:

RAC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

CIViC: RAC1

Version: 14-September-2020

Alternate Names:

5879 Entrez Gene ID

4753 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Watson et al., 2014, The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF., Cancer Res.

Van Allen et al., 2014, The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma., Cancer Discov

Lionarons DA et al., 2019, RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance., Cancer Cell

DTC: RAC1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem
Tempus: RAC1
- Version: 11-November-2018
Alternate Names:

RAC1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: RAC1
- Version: 01-May-2021
Alternate Names:

Ras-related C3 botulinum toxin substrate 1 Gene Name

P63000 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: RAC1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: RAC1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: RAC1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: RAC1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Ras-related C3 botulinum toxin substrate 1	Gene Name
P63000	UniProt ID

RAC1 Gene Record

RAC1 5879 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19527032

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31257073

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25056119 24265153

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25056119 24265153

Sources: CIViC

Ensembl: ENSG00000136238

Alternate Names: RAC1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: RAC1

Alternate Names: 5879 Entrez Gene ID 4753 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

DTC: RAC1

Alternate Names:

Gene Info:

Publications: Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem

Tempus: RAC1

Alternate Names: RAC1 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: RAC1

Alternate Names: Ras-related C3 botulinum toxin substrate 1 Gene Name P63000 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

MskImpact: RAC1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: RAC1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: RAC1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Oncomine: RAC1

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19527032

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
31257073

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
25056119 24265153

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
25056119 24265153

Sources:
CIViC

Alternate Names:

RAC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5879 Entrez Gene ID

4753 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem

Alternate Names:

RAC1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Ras-related C3 botulinum toxin substrate 1 Gene Name

P63000 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE