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RAC1 Gene Record

  • Summary
  • Interactions
  • Claims
  • RAC1 5879 Clinically ActionableDrug Resistance

    Alternate Names:

    5879
    RAC FAMILY SMALL GTPASE 1
    RAC1
    MIG5
    Rac-1
    TC-25
    p21-Rac1
    602048
    9801
    ENSG00000136238
    OTTHUMG00000023540
    4753
    MRD48
    Ras-related C3 botulinum toxin substrate 1
    P63000

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUG RESISTANCE
    CLINICALLY ACTIONABLE

    Publications:

    Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem
    Watson et al., 2014, The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF., Cancer Res.
    Van Allen et al., 2014, The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma., Cancer Discov
    Lionarons DA et al., 2019, RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance., Cancer Cell
  • CHEMBL257119   RAC1

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19527032


    Sources:
    DTC

  • CHEMBL554475   RAC1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19527032


    Sources:
    DTC

  • CHEMBL562095   RAC1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19527032


    Sources:
    DTC

  • CHEMBL579882   RAC1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL563777   RAC1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19527032


    Sources:
    DTC

  • PLX-4720   RAC1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31257073


    Sources:
    CIViC

  • DABRAFENIB   RAC1

    Interaction Score: 1.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25056119 24265153


    Sources:
    CIViC

  • VEMURAFENIB   RAC1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25056119 24265153


    Sources:
    CIViC

  • Ensembl: ENSG00000136238

    • Version: 101_38

    Alternate Names:
    RAC1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: RAC1

    • Version: 14-September-2020

    Alternate Names:
    5879 Entrez Gene ID
    4753 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Watson et al., 2014, The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF., Cancer Res.
    Van Allen et al., 2014, The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma., Cancer Discov
    Lionarons DA et al., 2019, RAC1<sup>P29S</sup> Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance., Cancer Cell

  • DTC: RAC1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Ferri N et al., 2009, Virtual screening approach for the identification of new Rac1 inhibitors., J Med Chem

  • Tempus: RAC1

    • Version: 11-November-2018

    Alternate Names:
    RAC1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: RAC1

    • Version: 01-February-2022

    Alternate Names:
    Ras-related C3 botulinum toxin substrate 1 Gene Name
    P63000 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: RAC1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: RAC1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: RAC1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: RAC1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21