DGIdb - RARB Gene Record

RARB 5915 Druggable Genome

Alternate Names:

5915
RETINOIC ACID RECEPTOR BETA
RARB
HAP
MCOPS12
NR1B2
RARbeta1
RRB2
180220
9865
ENSG00000077092
OTTHUMG00000130480
HBV-activated protein
Nuclear receptor subfamily 1 group B member 2
RAR-epsilon
RAR-beta
51401
RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826]
P10826
RARB_HUMAN
T61657
RARbeta

Gene Info:

Initial Gene Query	NR1B2
Counted Citations from 1950-2000	1251
Human Readable Name	DRUGGABLE GENOME
Target Main Class	Receptors
Target Subclass	Nuclear receptor
Target Class	Receptors
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Interpro Acc	IPR000536
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME

Publications:

Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
Miwako et al., 2007, Tamibarotene., Drugs Today
Sanda et al., 2005, Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis., Leukemia
Jimi et al., 2007, RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells., Int. J. Oncol.
2004, Tamibarotene: AM 80, retinobenzoic acid, Tamibaro., Drugs R D
Mizuiri et al., 2005, DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage., Cancer Sci.
Nalbandian et al., 2005, A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression., Differentiation
Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
Husson et al., 2006, Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats., Neurobiol. Dis.
Liu et al., 2005, 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells., Cancer Lett.
Jones et al., 2003, A phase 1 study of tazarotene in adults with advanced cancer., Br. J. Cancer
Orlandi et al., 2004, Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene., J. Invest. Dermatol.
Arechalde et al., 2000, Management of psoriasis: the position of retinoid drugs., BioDrugs
Chandraratna, 1996, Tazarotene--first of a new generation of receptor-selective retinoids., Br. J. Dermatol.
Berggren Söderlund et al., 1995, Expression of human all-trans-retinoic acid receptor beta and its ligand-binding domain in Escherichia coli., Biochem. J.
Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.
Zouboulis, Retinoids--which dermatological indications will benefit in the near future?, Skin Pharmacol. Appl. Skin Physiol.
Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)
Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
Lund BW et al., 2009, Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands., J Med Chem
Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem
Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Alvarez et al., 2004, 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists., Bioorg. Med. Chem. Lett.
Steidl U et al., 2005, Distinct gene expression pattern of malignant hematopoietic stem and progenitor cells in polycythemia vera., Ann N Y Acad Sci

TAMIBAROTENE RARB

Interaction Score: 10.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Tamibarotene, Z-208, INNO-507

Novel drug target Established target

PMIDs:
17925887 15843826 17611697 15563242

Sources:
TdgClinicalTrial TEND TTD
ADAPALENE RARB

Interaction Score: 6.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Retinoic acid receptor agonist

PMIDs:
9557255 9990413 11752352 9204085 31273085 19929446 10651997

Sources:
TdgClinicalTrial ChemblInteractions TEND
ALITRETINOIN RARB

Interaction Score: 4.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
16128742 16316409 19678713 16253547 16531051 16297713

Sources:
ChemblInteractions TEND TTD
CHEMBL472172 RARB

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19216008 18702457

Sources:
DTC
TAZAROTENE RARB

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoic acid receptor agonist

Novel drug target Established target

PMIDs:
12942109 15102095 18034539 9035701

Sources:
TdgClinicalTrial ChemblInteractions TEND
CHEMBL425027 RARB

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19239230

Sources:
DTC
ETRETINATE RARB

Interaction Score: 1.89

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9298126 8301142

Sources:
ChemblInteractions
IRX4310 RARB

Interaction Score: 1.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL275311 RARB

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18951029 10592235 15546741

Sources:
DTC
ACITRETIN RARB

Interaction Score: 1.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
7755585 19144697 11586072

Sources:
ChemblInteractions
MOFAROTENE RARB

Interaction Score: 0.74

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions
ISOTRETINOIN RARB

Interaction Score: 0.4

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRETINOIN RARB

Interaction Score: 0.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
15958702

Sources:
ChemblInteractions
FENRETINIDE RARB

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Ensembl: ENSG00000077092
- Version: 101_38
Alternate Names:

RARB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P10826
- Version: 11-September-2012
Alternate Names:

5915 Entrez Gene Id

ENSG00000077092 Ensembl Gene Id

RARB_HUMAN Uniprot Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P10826
- Version: January-2014
Alternate Names:

RARB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
RussLampel: ENSG00000077092
- Version: 26-July-2011
Alternate Names:

ENSG00000077092 Ensembl Gene Id

RARB Display Id

RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P10826
- Version: 01-August-2011
Alternate Names:

5915 Entrez Gene Id

RARB Gene Symbol

RARB_HUMAN Uniprot Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Publications:
BaderLabGenes: NR1B2
- Version: February-2014
Alternate Names:

51401 Entrez Gene ID

Gene Info:

Initial Gene Query NR1B2

Counted Citations from 1950-2000 1251

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
NCI: RARB
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Swift et al., 2006, Truncated RAR beta isoform enhances proliferation and retinoid resistance., J. Cell. Physiol.

DTC: RARB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lund BW et al., 2009, Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands., J Med Chem

Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem

Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem

HingoraniCasas: ENSG00000077092
- Version: 31-May-2017
Alternate Names:

ENSG00000077092 Gene Symbol

RARB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HAP
- Version: chembl_23
Alternate Names:

NR1B2 GENE_SYMBOL

RARB GENE_SYMBOL

Retinoic acid receptor beta UNIPROT

Gene Info:

Publications:
GO: RARB
- Version: 01-February-2022
Alternate Names:

HAP GO Gene Synonym

NR1B2 GO Gene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
dGene: RARB
- Version: 27-Jun-2013
Alternate Names:

5915 Gene ID

HAP dGene Synonym

NR1B2 dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Retinoic acid receptor beta
- Version: 2020.06.01
Alternate Names:

RARB TTD Gene Abbreviation

T61657 TTD Target ID

Gene Info:

Publications:

Trial Name	Tamibarotene, Z-208, INNO-507
Novel drug target	Established target

Mechanism of Interaction	Retinoid receptor agonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Retinoic acid receptor agonist
Novel drug target	Established target

Mechanism of Interaction	Retinoic acid receptor antagonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Retinoid receptor modulator

Trial Name	fenretinide, RT-101
Novel drug target	Established target

5915	Entrez Gene Id
ENSG00000077092	Ensembl Gene Id
RARB_HUMAN	Uniprot Id

NR1B2	GENE_SYMBOL
RARB	GENE_SYMBOL
Retinoic acid receptor beta	UNIPROT

RARB Gene Record

RARB 5915 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Tamibarotene, Z-208, INNO-507 Novel drug target Established target

PMIDs: 17925887 15843826 17611697 15563242

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Retinoic acid receptor agonist

PMIDs: 9557255 9990413 11752352 9204085 31273085 19929446 10651997

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 16128742 16316409 19678713 16253547 16531051 16297713

Sources: ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19216008 18702457

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoic acid receptor agonist Novel drug target Established target

PMIDs: 12942109 15102095 18034539 9035701

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19239230

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 9298126 8301142

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Retinoic acid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18951029 10592235 15546741

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor agonist

PMIDs: 7755585 19144697 11586072

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes

PMIDs: 15958702

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name fenretinide, RT-101 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Ensembl: ENSG00000077092

Alternate Names: RARB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P10826

Alternate Names: 5915 Entrez Gene Id ENSG00000077092 Ensembl Gene Id RARB_HUMAN Uniprot Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Interpro Type Domain

Gene Categories: NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P10826

Alternate Names: RARB Gene Symbol

Gene Info: Target Class Receptors Target Subclass Nuclear receptor

Publications:

RussLampel: ENSG00000077092

Alternate Names: ENSG00000077092 Ensembl Gene Id RARB Display Id RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Tamibarotene, Z-208, INNO-507

Novel drug target Established target

PMIDs:
17925887 15843826 17611697 15563242

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Retinoic acid receptor agonist

PMIDs:
9557255 9990413 11752352 9204085 31273085 19929446 10651997

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
16128742 16316409 19678713 16253547 16531051 16297713

Sources:
ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
19216008 18702457

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoic acid receptor agonist

Novel drug target Established target

PMIDs:
12942109 15102095 18034539 9035701

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
19239230

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9298126 8301142

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18951029 10592235 15546741

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
7755585 19144697 11586072

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
15958702

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Alternate Names:

RARB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5915 Entrez Gene Id

ENSG00000077092 Ensembl Gene Id

RARB_HUMAN Uniprot Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Alternate Names:

RARB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Alternate Names:

ENSG00000077092 Ensembl Gene Id

RARB Display Id

RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5915 Entrez Gene Id

RARB Gene Symbol

RARB_HUMAN Uniprot Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Alternate Names:

51401 Entrez Gene ID

Gene Info:

Initial Gene Query NR1B2

Counted Citations from 1950-2000 1251

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

Swift et al., 2006, Truncated RAR beta isoform enhances proliferation and retinoid resistance., J. Cell. Physiol.

Alternate Names:

ENSG00000077092 Gene Symbol

RARB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NR1B2 GENE_SYMBOL

RARB GENE_SYMBOL

Retinoic acid receptor beta UNIPROT

Alternate Names:

HAP GO Gene Synonym

NR1B2 GO Gene Synonym

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

5915 Gene ID

HAP dGene Synonym

NR1B2 dGene Synonym

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

RARB TTD Gene Abbreviation

T61657 TTD Target ID