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RARB 5915 Druggable Genome
Alternate Names:
5915 RETINOIC ACID RECEPTOR BETA RARB HAP MCOPS12 NR1B2 RARbeta1 RRB2 180220 9865 ENSG00000077092 OTTHUMG00000130480 HBV-activated protein Nuclear receptor subfamily 1 group B member 2 RAR-epsilon RAR-beta 51401 RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826] P10826 RARB_HUMAN 591 NP_000956|NP_057236 NM_016152 Retinoic acid receptor-β T61657 Gene Info:
Initial Gene Query NR1B2 Counted Citations from 1950-2000 1251 Human Readable Name DRUGGABLE GENOME Target Main Class Receptors Target Subclass Nuclear receptor Target Class Receptors GuideToPharmacology Gene Category Name 1B. Retinoic acid receptors GuideToPharmacology Gene Category ID 85 Human Readable Name NUCLEAR HORMONE RECEPTOR Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Interpro Type Domain Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core Interpro Acc IPR000536 Interpro Name Nuclear hormone receptor, ligand-binding, core Gene Biotype PROTEIN_CODING Gene Categories: Category Details
NUCLEAR HORMONE RECEPTOR DRUGGABLE GENOME Publications:
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Interaction Score: 8.51
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Trial Name Tamibarotene, Z-208, INNO-507 Novel drug target Established target Direct Interaction? False -
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Trial Name - Novel drug target Established target Mechanism of Interaction Retinoic acid receptor agonist -
Interaction Score: 4.73
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes Specific Action of the Ligand Agonist
Sources:
ChemblInteractions TEND GuideToPharmacology TTD -
Interaction Score: 4.25
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Interaction Score: 4.25
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Direct Interaction yes Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction? True
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Interaction Score: 2.84
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Details of the Assay for Interaction In a reported assay measuring activation mediated by agonist binding to the RARβ ligand-binding domain. Specific Action of the Ligand Agonist Endogenous Drug? False -
Interaction Score: 2.13
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Interaction Score: 1.82
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Retinoic acid receptor antagonist Direct Interaction yes -
Interaction Score: 1.22
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Interaction Types & Directionality:
agonist (activating) Interaction Info:
Direct Interaction yes Mechanism of Interaction Retinoid receptor agonist -
Interaction Score: 0.71
Interaction Types & Directionality:
modulator Interaction Info:
Direct Interaction yes Mechanism of Interaction Retinoid receptor modulator -
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Specific Action of the Ligand Agonist Endogenous Drug? True Direct Interaction? True -
Interaction Score: 0.39
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes -
Interaction Score: 0.16
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name fenretinide, RT-101 Novel drug target Established target
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- Version: 101_38
Alternate Names:
RARB Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
5915 Entrez Gene Id ENSG00000077092 Ensembl Gene Id RARB_HUMAN Uniprot Id Gene Info:
Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Interpro Type Domain Gene Categories:
NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
RARB Gene Symbol Gene Info:
Target Class Receptors Target Subclass Nuclear receptor Publications:
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- Version: 26-July-2011
Alternate Names:
ENSG00000077092 Ensembl Gene Id RARB Display Id RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826] Description Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
5915 Entrez Gene Id RARB Gene Symbol RARB_HUMAN Uniprot Id Gene Info:
Target Main Class Receptors Target Subclass Nuclear receptor Publications:
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- Version: February-2014
Alternate Names:
51401 Entrez Gene ID Gene Info:
Initial Gene Query NR1B2 Counted Citations from 1950-2000 1251 Gene Categories:
NUCLEAR HORMONE RECEPTOR Publications:
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- Version: 29-September-2020
Alternate Names:
9865 HUGO Gene ID 9865 HUGO Gene Symbol retinoic acid receptor beta HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name 1B. Retinoic acid receptors GuideToPharmacology Gene Category ID 85 Gene Categories:
NUCLEAR HORMONE RECEPTOR Publications:
-
Alternate Names:
Gene Info:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000077092 Gene Symbol RARB Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
NR1B2 GENE_SYMBOL RARB GENE_SYMBOL Retinoic acid receptor beta UNIPROT Gene Info:
Publications:
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Alternate Names:
5915 Gene ID HAP dGene Synonym NR1B2 dGene Synonym Gene Info:
Gene Categories:
NUCLEAR HORMONE RECEPTOR Publications:
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- Version: 2020.06.01
Alternate Names:
RARB TTD Gene Abbreviation T61657 TTD Target ID Gene Info:
Publications:
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Alternate Names:
HAP GO Gene Synonym NR1B2 GO Gene Synonym Gene Info:
Gene Categories:
NUCLEAR HORMONE RECEPTOR Publications: