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RARB Gene Record

  • Summary
  • Interactions
  • Claims
  • RARB 5915 Druggable Genome

    Alternate Names:

    5915
    RETINOIC ACID RECEPTOR BETA
    RARB
    HAP
    MCOPS12
    NR1B2
    RARbeta1
    RRB2
    180220
    9865
    ENSG00000077092
    OTTHUMG00000130480
    HBV-activated protein
    Nuclear receptor subfamily 1 group B member 2
    RAR-epsilon
    RAR-beta
    51401
    RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826]
    P10826
    RARB_HUMAN
    T61657
    RARbeta

    Gene Info:

    Initial Gene Query NR1B2
    Counted Citations from 1950-2000 1251
    Human Readable Name DRUGGABLE GENOME
    Target Main Class Receptors
    Target Subclass Nuclear receptor
    Target Class Receptors
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Acc IPR000536
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
    Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
    Miwako et al., 2007, Tamibarotene., Drugs Today
    Sanda et al., 2005, Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis., Leukemia
    Jimi et al., 2007, RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells., Int. J. Oncol.
    2004, Tamibarotene: AM 80, retinobenzoic acid, Tamibaro., Drugs R D
    Mizuiri et al., 2005, DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage., Cancer Sci.
    Nalbandian et al., 2005, A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression., Differentiation
    Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
    Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
    Husson et al., 2006, Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats., Neurobiol. Dis.
    Liu et al., 2005, 5-Aza-2'-deoxycytidine induces retinoic acid receptor-beta(2) demethylation and growth inhibition in esophageal squamous carcinoma cells., Cancer Lett.
    Jones et al., 2003, A phase 1 study of tazarotene in adults with advanced cancer., Br. J. Cancer
    Orlandi et al., 2004, Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene., J. Invest. Dermatol.
    Arechalde et al., 2000, Management of psoriasis: the position of retinoid drugs., BioDrugs
    Chandraratna, 1996, Tazarotene--first of a new generation of receptor-selective retinoids., Br. J. Dermatol.
    Berggren Söderlund et al., 1995, Expression of human all-trans-retinoic acid receptor beta and its ligand-binding domain in Escherichia coli., Biochem. J.
    Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.
    Zouboulis, Retinoids--which dermatological indications will benefit in the near future?, Skin Pharmacol. Appl. Skin Physiol.
    Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)
    Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
    Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
    Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
    Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
    Lund BW et al., 2009, Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands., J Med Chem
    Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem
    Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Alvarez et al., 2004, 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists., Bioorg. Med. Chem. Lett.
    Steidl U et al., 2005, Distinct gene expression pattern of malignant hematopoietic stem and progenitor cells in polycythemia vera., Ann N Y Acad Sci
  • TAMIBAROTENE   RARB

    Interaction Score: 10.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Tamibarotene, Z-208, INNO-507
    Novel drug target Established target

    PMIDs:
    17925887 15843826 17611697 15563242


    Sources:
    TdgClinicalTrial TEND TTD

  • ADAPALENE   RARB

    Interaction Score: 6.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Retinoic acid receptor agonist

    PMIDs:
    9557255 9990413 11752352 9204085 31273085 19929446 10651997


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ALITRETINOIN   RARB

    Interaction Score: 4.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    16128742 16316409 19678713 16253547 16531051 16297713


    Sources:
    ChemblInteractions TEND TTD

  • CHEMBL472172   RARB

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19216008 18702457


    Sources:
    DTC

  • TAZAROTENE   RARB

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoic acid receptor agonist
    Novel drug target Established target

    PMIDs:
    12942109 15102095 18034539 9035701


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CHEMBL425027   RARB

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19239230


    Sources:
    DTC

  • ETRETINATE   RARB

    Interaction Score: 1.89

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    9298126 8301142


    Sources:
    ChemblInteractions

  • IRX4310   RARB

    Interaction Score: 1.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL275311   RARB

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18951029 10592235 15546741


    Sources:
    DTC

  • ACITRETIN   RARB

    Interaction Score: 1.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoid receptor agonist

    PMIDs:
    7755585 19144697 11586072


    Sources:
    ChemblInteractions

  • MOFAROTENE   RARB

    Interaction Score: 0.74

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoid receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOTRETINOIN   RARB

    Interaction Score: 0.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRETINOIN   RARB

    Interaction Score: 0.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes

    PMIDs:
    15958702


    Sources:
    ChemblInteractions

  • FENRETINIDE   RARB

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name fenretinide, RT-101
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000077092

    • Version: 101_38

    Alternate Names:
    RARB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P10826

    • Version: 11-September-2012

    Alternate Names:
    5915 Entrez Gene Id
    ENSG00000077092 Ensembl Gene Id
    RARB_HUMAN Uniprot Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P10826

    • Version: January-2014

    Alternate Names:
    RARB Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • RussLampel: ENSG00000077092

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000077092 Ensembl Gene Id
    RARB Display Id
    RETINOIC ACID RECEPTOR BETA (RAR-BETA) (RAR-EPSILON) (HBV-ACTIVATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P10826] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P10826

    • Version: 01-August-2011

    Alternate Names:
    5915 Entrez Gene Id
    RARB Gene Symbol
    RARB_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • BaderLabGenes: NR1B2

    • Version: February-2014

    Alternate Names:
    51401 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1B2
    Counted Citations from 1950-2000 1251

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • NCI: RARB

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Swift et al., 2006, Truncated RAR beta isoform enhances proliferation and retinoid resistance., J. Cell. Physiol.

  • DTC: RARB

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lund BW et al., 2009, Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands., J Med Chem
    Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem
    Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem

  • HingoraniCasas: ENSG00000077092

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000077092 Gene Symbol
    RARB Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HAP

    • Version: chembl_23

    Alternate Names:
    NR1B2 GENE_SYMBOL
    RARB GENE_SYMBOL
    Retinoic acid receptor beta UNIPROT

    Gene Info:

    Publications:

  • GO: RARB

    • Version: 01-February-2022

    Alternate Names:
    HAP GO Gene Synonym
    NR1B2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: RARB

    • Version: 27-Jun-2013

    Alternate Names:
    5915 Gene ID
    HAP dGene Synonym
    NR1B2 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Retinoic acid receptor beta

    • Version: 2020.06.01

    Alternate Names:
    RARB TTD Gene Abbreviation
    T61657 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21