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RARG Gene Record

  • Summary
  • Interactions
  • Claims
  • RARG 5916 Druggable Genome

    Alternate Names:

    5916
    RETINOIC ACID RECEPTOR GAMMA
    RARG
    NR1B3
    RARC
    180190
    9866
    ENSG00000172819
    OTTHUMG00000048077
    P13631
    RARG_HUMAN
    RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P22932]
    RAR-gamma
    Nuclear receptor subfamily 1 group B member 3
    PA34227
    T82146
    RARgamma

    Gene Info:

    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000536
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Type Domain
    Target Class Receptors
    Target Subclass Nuclear receptor
    Initial Gene Query NR1B3
    Counted Citations from 1950-2000 597
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Reddy et al., 1992, Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system., Biochem. J.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kamei et al., 1993, Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes., Biochem. J.
    Borger et al., 2000, Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-beta., Virology
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Layton A, 2009, The use of isotretinoin in acne., Dermatoendocrinol
    Arechalde et al., 2000, Management of psoriasis: the position of retinoid drugs., BioDrugs
    Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol
    Li et al., 2006, Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis., Proc. Natl. Acad. Sci. U.S.A.
    Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
    Parrella et al., 2006, Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways., Mol. Pharmacol.
    Dzhagalov et al., 2007, Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma., J. Immunol.
    Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
    Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem
    Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
    Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
    Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem
  • TRIFAROTENE   RARG

    Interaction Score: 7.73

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    29974453


    Sources:
    TTD

  • PALOVAROTENE   RARG

    Interaction Score: 7.73

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoic acid receptor gamma agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • ADAPALENE   RARG

    Interaction Score: 5.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    10592235 17016423 17139284 19929446 10651997 9204085 31273085


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TAZAROTENE   RARG

    Interaction Score: 4.35

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name tazarotene,Tazorac
    Novel drug target Established target
    Mechanism of Interaction Retinoic acid receptor agonist

    PMIDs:
    10592235 18034539 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHEMBL472172   RARG

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18702457 19216008


    Sources:
    DTC

  • ALITRETINOIN   RARG

    Interaction Score: 3.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    16880407 19678713 16788091 10592235 17277115


    Sources:
    ChemblInteractions TEND TTD

  • ETRETINATE   RARG

    Interaction Score: 2.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    10592235 17016423 17139284


    Sources:
    ChemblInteractions

  • TRETINOIN   RARG

    Interaction Score: 1.47

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name tretinoin microsponge,Retin-A

    PMIDs:
    10592235 1332684 11752352 8394693 10792999 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • IRX4310   RARG

    Interaction Score: 1.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ACITRETIN   RARG

    Interaction Score: 0.97

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    10592235 17016423 17139284


    Sources:
    ChemblInteractions

  • ISOTRETINOIN   RARG

    Interaction Score: 0.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes

    PMIDs:
    20436884


    Sources:
    ChemblInteractions

  • MOFAROTENE   RARG

    Interaction Score: 0.64

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoid receptor modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL275311   RARG

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18951029


    Sources:
    DTC

  • FENRETINIDE   RARG

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name fenretinide, RT-101

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DAUNORUBICIN   RARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   RARG

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000172819

    • Version: 101_38

    Alternate Names:
    RARG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P13631

    • Version: 01-August-2011

    Alternate Names:
    5916 Entrez Gene Id
    RARG_HUMAN Uniprot Id
    P13631 Uniprot Accession

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • HopkinsGroom: P13631

    • Version: 11-September-2012

    Alternate Names:
    5916 Entrez Gene Id
    RARG_HUMAN Uniprot Id
    RETINOIC ACID RECEPTOR GAMMA Uniprot Protein Name

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000536

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000172819

    • Version: 26-July-2011

    Alternate Names:
    RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P22932] Description
    ENSG00000172819 Ensembl Gene Id
    RARG Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P13631

    • Version: January-2014

    Alternate Names:
    RARG Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • BaderLabGenes: RARG

    • Version: February-2014

    Alternate Names:
    5916 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1B3
    Counted Citations from 1950-2000 597

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • NCI: RARG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Thacher et al., 1999, Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes., Cell Growth Differ.
    Bernard et al., 1992, Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma., Biochem. Biophys. Res. Commun.

  • DTC: RARG

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem
    Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

  • HingoraniCasas: ENSG00000172819

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000172819 Gene Symbol
    RARG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NR1B3

    • Version: chembl_23

    Alternate Names:
    NR1B3 GENE_SYMBOL
    RARG GENE_SYMBOL
    Retinoic acid receptor gamma UNIPROT

    Gene Info:

    Publications:

  • PharmGKB: RARG

    • Version: 18-August-2020

    Alternate Names:
    PA34227 PharmGKB ID

    Gene Info:

    Publications:

  • GO: RARG

    • Version: 01-February-2022

    Alternate Names:
    NR1B3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: RARG

    • Version: 27-Jun-2013

    Alternate Names:
    5916 Gene ID
    NR1B3 dGene Synonym
    RARC dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Retinoic acid receptor gamma

    • Version: 2020.06.01

    Alternate Names:
    RARG TTD Gene Abbreviation
    T82146 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21