DGIdb - RARG Gene Record

RARG 5916 Druggable Genome

Alternate Names:

5916
RETINOIC ACID RECEPTOR GAMMA
RARG
NR1B3
RARC
180190
9866
ENSG00000172819
OTTHUMG00000048077
P13631
RARG_HUMAN
RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P22932]
RAR-gamma
Nuclear receptor subfamily 1 group B member 3
PA34227
T82146
RARgamma

Gene Info:

Human Readable Name	NUCLEAR HORMONE RECEPTOR
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR000536
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Interpro Type	Domain
Target Class	Receptors
Target Subclass	Nuclear receptor
Initial Gene Query	NR1B3
Counted Citations from 1950-2000	597
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Reddy et al., 1992, Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system., Biochem. J.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kamei et al., 1993, Retinoic acid receptor gamma 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes., Biochem. J.
Borger et al., 2000, Retinoic acid resistance at late stages of human papillomavirus type 16-mediated transformation of human keratinocytes arises despite intact retinoid signaling and is due to a loss of sensitivity to transforming growth factor-beta., Virology
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Layton A, 2009, The use of isotretinoin in acne., Dermatoendocrinol
Arechalde et al., 2000, Management of psoriasis: the position of retinoid drugs., BioDrugs
Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol
Li et al., 2006, Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis., Proc. Natl. Acad. Sci. U.S.A.
Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
Parrella et al., 2006, Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamma and retinoid-independent pathways., Mol. Pharmacol.
Dzhagalov et al., 2007, Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma., J. Immunol.
Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem
Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

TRIFAROTENE RARG

Interaction Score: 7.73

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
29974453

Sources:
TTD
PALOVAROTENE RARG

Interaction Score: 7.73

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoic acid receptor gamma agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
ADAPALENE RARG

Interaction Score: 5.52

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
10592235 17016423 17139284 19929446 10651997 9204085 31273085

Sources:
TdgClinicalTrial ChemblInteractions TEND
TAZAROTENE RARG

Interaction Score: 4.35

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name tazarotene,Tazorac

Novel drug target Established target

Mechanism of Interaction Retinoic acid receptor agonist

PMIDs:
10592235 18034539 17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
CHEMBL472172 RARG

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18702457 19216008

Sources:
DTC
ALITRETINOIN RARG

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
16880407 19678713 16788091 10592235 17277115

Sources:
ChemblInteractions TEND TTD
ETRETINATE RARG

Interaction Score: 2.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
10592235 17016423 17139284

Sources:
ChemblInteractions
TRETINOIN RARG

Interaction Score: 1.47

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name tretinoin microsponge,Retin-A

PMIDs:
10592235 1332684 11752352 8394693 10792999 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
IRX4310 RARG

Interaction Score: 1.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACITRETIN RARG

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
10592235 17016423 17139284

Sources:
ChemblInteractions
ISOTRETINOIN RARG

Interaction Score: 0.7

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
20436884

Sources:
ChemblInteractions
MOFAROTENE RARG

Interaction Score: 0.64

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL275311 RARG

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18951029

Sources:
DTC
FENRETINIDE RARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name fenretinide, RT-101

PMIDs:
None found

Sources:
TdgClinicalTrial
DAUNORUBICIN RARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DOXORUBICIN RARG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000172819
- Version: 101_38
Alternate Names:

RARG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P13631
- Version: 01-August-2011
Alternate Names:

5916 Entrez Gene Id

RARG_HUMAN Uniprot Id

P13631 Uniprot Accession

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Publications:
HopkinsGroom: P13631
- Version: 11-September-2012
Alternate Names:

5916 Entrez Gene Id

RARG_HUMAN Uniprot Id

RETINOIC ACID RECEPTOR GAMMA Uniprot Protein Name

Gene Info:

Interpro Name Nuclear hormone receptor, ligand-binding, core

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000536

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000172819
- Version: 26-July-2011
Alternate Names:

RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P22932] Description

ENSG00000172819 Ensembl Gene Id

RARG Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P13631
- Version: January-2014
Alternate Names:

RARG Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
BaderLabGenes: RARG
- Version: February-2014
Alternate Names:

5916 Entrez Gene ID

Gene Info:

Initial Gene Query NR1B3

Counted Citations from 1950-2000 597

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:

NCI: RARG

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Thacher et al., 1999, Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: divergent effects from agonist at retinoic acid receptor gamma in human keratinocytes., Cell Growth Differ.

Bernard et al., 1992, Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma., Biochem. Biophys. Res. Commun.

DTC: RARG

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pérez-Rodríguez S et al., 2009, Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles., Eur J Med Chem

Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem

Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

HingoraniCasas: ENSG00000172819
- Version: 31-May-2017
Alternate Names:

ENSG00000172819 Gene Symbol

RARG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NR1B3
- Version: chembl_23
Alternate Names:

NR1B3 GENE_SYMBOL

RARG GENE_SYMBOL

Retinoic acid receptor gamma UNIPROT

Gene Info:

Publications:
PharmGKB: RARG
- Version: 18-August-2020
Alternate Names:

PA34227 PharmGKB ID

Gene Info:

Publications:
GO: RARG
- Version: 01-February-2022
Alternate Names:

NR1B3 GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

Publications:
dGene: RARG
- Version: 27-Jun-2013
Alternate Names:

5916 Gene ID

NR1B3 dGene Synonym

RARC dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Retinoic acid receptor gamma
- Version: 2020.06.01
Alternate Names:

RARG TTD Gene Abbreviation

T82146 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Retinoic acid receptor gamma agonist

Mechanism of Interaction	Retinoic acid receptor agonist
Direct Interaction	yes
Trial Name	-

Trial Name	tazarotene,Tazorac
Novel drug target	Established target
Mechanism of Interaction	Retinoic acid receptor agonist

Mechanism of Interaction	Retinoid receptor agonist
Direct Interaction	yes

Mechanism of Interaction	Retinoic acid receptor antagonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Retinoid receptor modulator

5916	Entrez Gene Id
RARG_HUMAN	Uniprot Id
P13631	Uniprot Accession

RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P22932]	Description
ENSG00000172819	Ensembl Gene Id
RARG	Display Id

NR1B3	GENE_SYMBOL
RARG	GENE_SYMBOL
Retinoic acid receptor gamma	UNIPROT

RARG Gene Record

RARG 5916 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 29974453

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoic acid receptor gamma agonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes Trial Name -

PMIDs: 10592235 17016423 17139284 19929446 10651997 9204085 31273085

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name tazarotene,Tazorac Novel drug target Established target Mechanism of Interaction Retinoic acid receptor agonist

PMIDs: 10592235 18034539 17016423 17139284 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18702457 19216008

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 16880407 19678713 16788091 10592235 17277115

Sources: ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 10592235 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes Trial Name tretinoin microsponge,Retin-A

PMIDs: 10592235 1332684 11752352 8394693 10792999 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Retinoic acid receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 10592235 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes

PMIDs: 20436884

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18951029

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name fenretinide, RT-101

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000172819

Alternate Names: RARG Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P13631

Alternate Names: 5916 Entrez Gene Id RARG_HUMAN Uniprot Id P13631 Uniprot Accession

Gene Info: Target Subclass Nuclear receptor Target Main Class Receptors

Publications:

HopkinsGroom: P13631

Alternate Names: 5916 Entrez Gene Id RARG_HUMAN Uniprot Id RETINOIC ACID RECEPTOR GAMMA Uniprot Protein Name

Interaction Types & Directionality:

agonist (activating)

PMIDs:
29974453

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoic acid receptor gamma agonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name -

PMIDs:
10592235 17016423 17139284 19929446 10651997 9204085 31273085

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name tazarotene,Tazorac

Novel drug target Established target

Mechanism of Interaction Retinoic acid receptor agonist

PMIDs:
10592235 18034539 17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
18702457 19216008

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
16880407 19678713 16788091 10592235 17277115

Sources:
ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
10592235 17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name tretinoin microsponge,Retin-A

PMIDs:
10592235 1332684 11752352 8394693 10792999 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
10592235 17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
20436884

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
18951029

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name fenretinide, RT-101

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

RARG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5916 Entrez Gene Id

RARG_HUMAN Uniprot Id

P13631 Uniprot Accession

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Alternate Names:

5916 Entrez Gene Id

RARG_HUMAN Uniprot Id

RETINOIC ACID RECEPTOR GAMMA Uniprot Protein Name

Gene Info:

Interpro Name Nuclear hormone receptor, ligand-binding, core

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR000536

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Alternate Names:

RETINOIC ACID RECEPTOR GAMMA-2 (RAR-GAMMA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P22932] Description

ENSG00000172819 Ensembl Gene Id

RARG Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

RARG Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Alternate Names:

5916 Entrez Gene ID

Gene Info:

Initial Gene Query NR1B3

Counted Citations from 1950-2000 597

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

ENSG00000172819 Gene Symbol

RARG Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NR1B3 GENE_SYMBOL

RARG GENE_SYMBOL

Retinoic acid receptor gamma UNIPROT

Alternate Names:

PA34227 PharmGKB ID

Alternate Names:

NR1B3 GO Gene Synonym

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR