DGIdb - RELA Gene Record

RELA 5970 Druggable GenomeClinically Actionable

Alternate Names:

5970
RELA PROTO-ONCOGENE, NF-KB SUBUNIT
RELA
NFKB3
p65
164014
9955
ENSG00000173039
OTTHUMG00000166566
Q04206
TF65_HUMAN
TRANSCRIPTION FACTOR P65
TRANSCRIPTION FACTOR P65 (NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q04206]
PA296
CMCU

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Short Name	NF_Rel_dor
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Name	NF-kappa-B/Rel/dorsal
Interpro Acc	IPR000451
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Sharma RK et al., 2006, Biological evaluation, chelation, and molecular modeling studies of novel metal-chelating inhibitors of NF-kappaB-DNA binding: structure activity relationships., J Med Chem
Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett
Feldman M et al., 2011, Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential., J Nat Prod
Dandawate P et al., 2012, Synthesis, characterization, molecular docking and cytotoxic activity of novel plumbagin hydrazones against breast cancer cells., Bioorg Med Chem Lett
Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem
Simitsopoulou M et al., 2008, Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors., Antimicrob Agents Chemother
Zelová H et al., 2014, Evaluation of anti-inflammatory activity of prenylated substances isolated from Morus alba and Morus nigra., J Nat Prod
Yamamoto M et al., 2008, Inactivation of NF-kappaB components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues., J Med Chem
Okorji UP et al., 2014, A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFNγ-activated BV2 microglia., Bioorg Med Chem
Chen HW et al., 2011, Inhibition of TNF-α-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway., J Nat Prod
Tamura R et al., 2012, Eudesmane-type sesquiterpene lactones inhibit multiple steps in the NF-κB signaling pathway induced by inflammatory cytokines., Bioorg Med Chem Lett
Tanaka YT et al., 2013, Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B., Bioorg Med Chem Lett
Maccari R et al., 2014, Structure-activity relationships and molecular modelling of new 5-arylidene-4-thiazolidinone derivatives as aldose reductase inhibitors and potential anti-inflammatory agents., Eur J Med Chem
Michelini FM et al., 2013, Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog., Bioorg Med Chem
Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

BROMOPYROGALLOL RED RELA

Interaction Score: 2.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16759101

Sources:
DTC
MULBERROFURAN H RELA

Interaction Score: 2.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24901948

Sources:
DTC
CYNAROPICRIN RELA

Interaction Score: 2.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23232059

Sources:
DTC
PYROCATECHOL VIOLET RELA

Interaction Score: 2.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16759101

Sources:
DTC
MORUSINOL RELA

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24901948

Sources:
DTC
CHEMBL1940084 RELA

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22153345

Sources:
DTC
DEHYDROXYMETHYLEPOXYQUINOMICIN RELA

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18729348

Sources:
DTC
CUDRAFLAVONE B RELA

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24901948

Sources:
DTC
ISORHAMNETIN RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
CHRYSOERIOL RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
QUERCETAGETIN RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
SORBINIL RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24819954

Sources:
DTC
TAMARIXETIN RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
ANDROGRAPHOLIDE RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22026410

Sources:
DTC
DIOSMETIN RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
KAEMPFERIDE RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
PARTHENOLIDE RELA

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
CHEMBL8483 RELA

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18566250

Sources:
DTC
VORICONAZOLE RELA

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18625774

Sources:
DTC
ARTESUNATE RELA

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25074847

Sources:
DTC
CHEMBL1405979 RELA

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPETIN RELA

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
RUTIN RELA

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25496805

Sources:
DTC
PECTOLINARIGENIN RELA

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOLIQUIRITIGENIN RELA

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21866899

Sources:
DTC
PLUMBAGIN RELA

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22483392

Sources:
DTC
FRENTIZOLE RELA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACACETIN RELA

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
CHEMBL502774 RELA

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL406557 RELA

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL260560 RELA

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KAEMPFEROL RELA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
6,4'-DIMETHOXYFLAVONE RELA

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL85826 RELA

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
4',7-DIMETHOXY-5-HYDROXYGENISTEIN RELA

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL201325 RELA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INDOPROFEN RELA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2094789 RELA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL602718 RELA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL408850 RELA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYROGALLOL RED RELA

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16759101

Sources:
DTC
APIGENIN RELA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
PYRROLIDINE DITHIOCARBAMATE RELA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL528694 RELA

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL428789 RELA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL84010 RELA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LUTEOLIN RELA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
GEFITINIB RELA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31664190

Sources:
PharmGKB
QUERCETIN RELA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25190466

Sources:
DTC
DEXAMETHASONE RELA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23219855

Sources:
DTC
RESVERATROL RELA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000173039
- Version: 101_38
Alternate Names:

RELA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000173039
- Version: 26-July-2011
Alternate Names:

ENSG00000173039 Ensembl Gene Id

TRANSCRIPTION FACTOR P65 (NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q04206] Description

RELA Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: Q04206
- Version: 11-September-2012
Alternate Names:

TRANSCRIPTION FACTOR P65 Uniprot Protein Name

5970 Entrez Gene Id

ENSG00000173039 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Family

Interpro Short Name NF_Rel_dor

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: RELA
- Version: 18-August-2020
Alternate Names:

PA296 PharmGKB ID

Gene Info:

Publications:

Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

NCI: RELA

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Benimetskaya et al., 1997, Formation of a G-tetrad and higher order structures correlates with biological activity of the RelA (NF-kappaB p65) 'antisense' oligodeoxynucleotide., Nucleic Acids Res.

Perez et al., 1994, Regulation of adhesion and growth of fibrosarcoma cells by NF-kappa B RelA involves transforming growth factor beta., Mol. Cell. Biol.

DTC: RELA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Feldman M et al., 2011, Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential., J Nat Prod

Amrutha K et al., 2014, Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study., Bioorg Med Chem Lett

Baldisserotto A et al., 2015, Design, synthesis and biological activity of a novel Rutin analogue with improved lipid soluble properties., Bioorg Med Chem

HingoraniCasas: ENSG00000173039
- Version: 31-May-2017
Alternate Names:

ENSG00000173039 Gene Symbol

RELA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: RELA
- Version: 01-February-2022
Alternate Names:

NFKB3 GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX

Publications:
Pharos: RELA
- Version: 01-February-2022
Alternate Names:

Transcription factor p65 Gene Name

Q04206 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
CarisMolecularIntelligence: RELA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: RELA
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

ENSG00000173039	Ensembl Gene Id
TRANSCRIPTION FACTOR P65 (NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q04206]	Description
RELA	Display Id

TRANSCRIPTION FACTOR P65	Uniprot Protein Name
5970	Entrez Gene Id
ENSG00000173039	Ensembl Gene Id

RELA Gene Record

RELA 5970 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16759101

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24901948

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23232059

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16759101

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24901948

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22153345

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18729348

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24901948

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24819954

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22026410

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25190466

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18566250

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
16759101

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24901948

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23232059

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16759101

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24901948

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22153345

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18729348

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24901948

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24819954

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22026410

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18566250

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18625774

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25074847

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25190466

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25496805

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21866899

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22483392

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found