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RHEB Gene Record

  • Summary
  • Interactions
  • Claims
  • RHEB 6009 Clinically ActionableDrug Resistance

    Alternate Names:

    6009
    RAS HOMOLOG, MTORC1 BINDING
    RHEB
    RHEB2
    601293
    10011
    ENSG00000106615
    OTTHUMG00000157330
    4868
    Q15382
    GTP-binding protein Rheb

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    DRUG RESISTANCE
    CLINICALLY ACTIONABLE

    Publications:

    Schöpel M et al., 2013, Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists., J Med Chem
    Ghosh AP et al., 2015, Point mutations of the mTOR-RHEB pathway in renal cell carcinoma., Oncotarget
  • CHEMBL76398   RHEB

    Interaction Score: 61.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24266771


    Sources:
    DTC

  • SIROLIMUS   RHEB

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26255626


    Sources:
    CIViC

  • Ensembl: ENSG00000106615

    • Version: 101_38

    Alternate Names:
    RHEB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: RHEB

    • Version: 14-September-2020

    Alternate Names:
    6009 Entrez Gene ID
    4868 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Ghosh AP et al., 2015, Point mutations of the mTOR-RHEB pathway in renal cell carcinoma., Oncotarget

  • DTC: RHEB

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Schöpel M et al., 2013, Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists., J Med Chem

  • GO: RHEB

    • Version: 01-February-2022

    Alternate Names:
    RHEB2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

  • Pharos: RHEB

    • Version: 01-February-2022

    Alternate Names:
    GTP-binding protein Rheb Gene Name
    Q15382 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • Oncomine: RHEB

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21