DGIdb - RHEB Gene Record

RHEB 6009 Clinically ActionableDrug Resistance

Alternate Names:

6009
RAS HOMOLOG, MTORC1 BINDING
RHEB
RHEB2
601293
10011
ENSG00000106615
OTTHUMG00000157330
4868
Q15382
GTP-binding protein Rheb

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
DRUG RESISTANCE
CLINICALLY ACTIONABLE

Publications:

Schöpel M et al., 2013, Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists., J Med Chem
Ghosh AP et al., 2015, Point mutations of the mTOR-RHEB pathway in renal cell carcinoma., Oncotarget

CHEMBL76398 RHEB

Interaction Score: 61.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24266771

Sources:
DTC
SIROLIMUS RHEB

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26255626

Sources:
CIViC

Ensembl: ENSG00000106615
- Version: 101_38
Alternate Names:

RHEB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
CIViC: RHEB
- Version: 14-September-2020
Alternate Names:

6009 Entrez Gene ID

4868 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Ghosh AP et al., 2015, Point mutations of the mTOR-RHEB pathway in renal cell carcinoma., Oncotarget
DTC: RHEB
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Schöpel M et al., 2013, Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists., J Med Chem
GO: RHEB
- Version: 01-February-2022
Alternate Names:

RHEB2 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:
Pharos: RHEB
- Version: 01-February-2022
Alternate Names:

GTP-binding protein Rheb Gene Name

Q15382 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
Oncomine: RHEB
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

RHEB Gene Record

RHEB 6009 Clinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL76398 RHEB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24266771

Sources: DTC

SIROLIMUS RHEB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26255626

Sources: CIViC

Ensembl: ENSG00000106615

Alternate Names: RHEB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

CIViC: RHEB

Alternate Names: 6009 Entrez Gene ID 4868 CIViC Gene ID

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications: Ghosh AP et al., 2015, Point mutations of the mTOR-RHEB pathway in renal cell carcinoma., Oncotarget

DTC: RHEB

Alternate Names:

Gene Info:

Publications: Schöpel M et al., 2013, Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists., J Med Chem

GO: RHEB

Alternate Names: RHEB2 GO Gene Synonym

Gene Info:

Gene Categories: TUMOR SUPPRESSOR

Publications:

Pharos: RHEB

Alternate Names: GTP-binding protein Rheb Gene Name Q15382 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

Oncomine: RHEB

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
24266771

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26255626

Sources:
CIViC

Alternate Names:

RHEB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

6009 Entrez Gene ID

4868 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Publications:

Ghosh AP et al., 2015, Point mutations of the mTOR-RHEB pathway in renal cell carcinoma., Oncotarget

Publications:

Schöpel M et al., 2013, Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists., J Med Chem

Alternate Names:

RHEB2 GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR

Alternate Names:

GTP-binding protein Rheb Gene Name

Q15382 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE