• RIPK1 8737 Druggable Genome

    Alternate Names:

    8737
    RECEPTOR INTERACTING SERINE/THREONINE KINASE 1
    RIPK1
    RIP
    RIP-1
    RIP1
    603453
    10019
    ENSG00000137275
    OTTHUMG00000014134
    Q13546
    RIPK1_HUMAN
    RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 1
    2189
    NP_003795
    NM_003804
    RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE RIP) (CELL DEATH PROTEIN RIP) (RECEPTOR INTERACTING PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13546]
    Receptor-interacting protein 1
    T99340
    AIEFL
    IMD57

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name KINASE
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    GuideToPharmacology Gene Category Name Receptor interacting protein kinase (RIPK) family
    GuideToPharmacology Gene Category ID 613
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of cellular necrosis in TNFα-treated FADD-deficient Jurkat cells.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16116226


    Sources:
    NCI

  • Interaction Score: 0.79

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of recombinant RIPK1 in an <i>in vitro</i> ADP-Glo assay (Promega).
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    RIPK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    RIPK1 Display Id
    RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE RIP) (CELL DEATH PROTEIN RIP) (RECEPTOR INTERACTING PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13546] Description
    ENSG00000137275 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    RIPK1 Uniprot Gene Name
    ENSG00000137275 Ensembl Gene Id
    8737 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    10019 HUGO Gene ID
    10019 HUGO Gene Symbol
    receptor interacting serine/threonine kinase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Receptor interacting protein kinase (RIPK) family
    GuideToPharmacology Gene Category ID 613

    Gene Categories:
    ENZYME

    Publications:

    • Version: 14-September-2017
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137275 Gene Symbol
    RIPK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    8737 Gene ID
    RIP dGene Synonym
    RIP1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    RIPK1 TTD Gene Abbreviation
    T99340 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    RIP GO Gene Synonym
    RIP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Receptor-interacting serine/threonine-protein kinase 1 Gene Name
    Q13546 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications: