ROCK1 Gene Record

  • ROCK1 6093 Druggable Genome

    Alternate Names:

    6093
    RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE 1
    ROCK1
    P160ROCK
    ROCK-I
    601702
    10251
    ENSG00000067900
    OTTHUMG00000131723
    ROCK1_HUMAN
    Q13464
    p160 ROCK-1
    Rho-associated, coiled-coil-containing protein kinase I
    Rho-associated, coiled-coil-containing protein kinase 1
    Renal carcinoma antigen NY-REN-35
    Rho-associated protein kinase 1
    ROCK
    RHO-ASSOCIATED PROTEIN KINASE
    RHO-ASSOCIATED PROTEIN KINASE 1 (EC 2.7.1.37) (RHO-ASSOCIATED, COILED- COIL CONTAINING PROTEIN KINASE 1) (P160 ROCK-1) (P160ROCK). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13464]
    T84726
    T51282

    Gene Info:

    Human Readable Name KINASE
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME

    Publications:

  • VEROSUDIL   ROCK1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Rho-associated protein kinase inhibitor
    Direct Interaction yes
    Trial Name AR-12286

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • NETARSUDIL DIMESYLATE   ROCK1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NETARSUDIL   ROCK1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SAR-407899   ROCK1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Rho-associated protein kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • Y-39983   ROCK1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Rho-associated protein kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • AMA0076   ROCK1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Rho-associated protein kinase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DE-104   ROCK1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Rho-associated protein kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AT-13148   ROCK1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Rho-associated protein kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • VX-702   ROCK1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL365617   ROCK1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2005186   ROCK1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FASUDIL   ROCK1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DTC TTD

  • CI-1040   ROCK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LAUROGUADINE   ROCK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL546797   ROCK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL541400   ROCK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1997335   ROCK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GO-6976   ROCK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KENPAULLONE   ROCK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JNJ-7706621   ROCK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALSTERPAULLONE   ROCK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   ROCK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   ROCK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LINIFANIB   ROCK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   ROCK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   ROCK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   ROCK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   ROCK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   ROCK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   ROCK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000067900

    • Version: 101_38

    Alternate Names:
    ROCK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000067900

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000067900 Ensembl Gene Id
    ROCK1 Display Id
    RHO-ASSOCIATED PROTEIN KINASE 1 (EC 2.7.1.37) (RHO-ASSOCIATED, COILED- COIL CONTAINING PROTEIN KINASE 1) (P160 ROCK-1) (P160ROCK). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13464] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q13464

    • Version: 11-September-2012

    Alternate Names:
    Q13464 Uniprot Accession
    ENSG00000067900 Ensembl Gene Id
    6093 Entrez Gene Id

    Gene Info:
    Human Readable Name KINASE
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Type Domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q13464

    • Version: January-2014

    Alternate Names:
    ROCK1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • ChemblInteractions: ROCK1

    • Version: chembl_23

    Alternate Names:
    ROCK1 GENE_SYMBOL
    Rho-associated protein kinase 1 UNIPROT
    Renal carcinoma antigen NY-REN-35 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000067900

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000067900 Gene Symbol
    ROCK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: ROCK1

    • Version: 27-Jun-2013

    Alternate Names:
    6093 Gene ID
    P160ROCK dGene Synonym
    ROCK-I dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Rho-associated protein kinase 1

    • Version: 2020.06.01

    Alternate Names:
    ROCK1 TTD Gene Abbreviation
    T51282 TTD Target ID

    Gene Info:

    Publications:

  • TTD: Rho-associated protein kinase

    • Version: 2020.06.01

    Alternate Names:
    ROCK TTD Gene Abbreviation
    T84726 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: ROCK1

    • Version: 01-February-2022

    Alternate Names:
    Rho-associated protein kinase 1 Gene Name
    Q13464 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • DTC: ROCK1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: ROCK1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications: