• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

RORA Gene Record

  • Summary
  • Interactions
  • Claims
  • RORA 6095 Druggable Genome

    Alternate Names:

    6095
    RAR RELATED ORPHAN RECEPTOR A
    RORA
    NR1F1
    ROR1
    ROR2
    ROR3
    RZR-ALPHA
    RZRA
    600825
    10258
    ENSG00000069667
    OTTHUMG00000132769
    P35398
    NUCLEAR RECEPTOR ROR-ALPHA
    RORA_HUMAN
    NUCLEAR RECEPTOR ROR-ALPHA (NUCLEAR RECEPTOR RZR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P35398]
    PA34630
    T43206
    IDDECA

    Gene Info:

    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Acc IPR000536
    Uniprot Status Swiss-Prot
    Initial Gene Query NR1F1
    Counted Citations from 1950-2000 336
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    KINASE
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Garriock HA et al., 2010, A genomewide association study of citalopram response in major depressive disorder., Biol Psychiatry
    Schräder et al., 1996, Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers., J. Biol. Chem.
    Winczyk et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer., Tumour Biol.
  • MELATONIN   RORA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8702678 12595746


    Sources:
    NCI

  • T091317   RORA

    Interaction Score: 1.72

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CITALOPRAM   RORA

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19846067


    Sources:
    PharmGKB

  • Ensembl: ENSG00000069667

    • Version: 101_38

    Alternate Names:
    RORA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000069667

    • Version: 26-July-2011

    Alternate Names:
    NUCLEAR RECEPTOR ROR-ALPHA (NUCLEAR RECEPTOR RZR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P35398] Description
    RORA Display Id
    ENSG00000069667 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P35398

    • Version: 11-September-2012

    Alternate Names:
    6095 Entrez Gene Id
    RORA Uniprot Gene Name
    NUCLEAR RECEPTOR ROR-ALPHA Uniprot Protein Name

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: RORA

    • Version: February-2014

    Alternate Names:
    6095 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1F1
    Counted Citations from 1950-2000 336

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • PharmGKB: RORA

    • Version: 18-August-2020

    Alternate Names:
    PA34630 PharmGKB ID

    Gene Info:

    Publications:
    Ayatollahi SA et al., 2020, The efficacy of interferon-beta therapy in multiple sclerosis patients: investigation of the RORA gene as a predictive biomarker., Pharmacogenomics J
    Garriock HA et al., 2010, A genomewide association study of citalopram response in major depressive disorder., Biol Psychiatry

  • NCI: RORA

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Schräder et al., 1996, Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers., J. Biol. Chem.
    Winczyk et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer., Tumour Biol.

  • HingoraniCasas: ENSG00000069667

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000069667 Gene Symbol
    RORA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: RORA

    • Version: 01-February-2022

    Alternate Names:
    NR1F1 GO Gene Synonym
    RZRA GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • dGene: RORA

    • Version: 27-Jun-2013

    Alternate Names:
    6095 Gene ID
    NR1F1 dGene Synonym
    ROR1 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Nuclear receptor ROR-alpha

    • Version: 2020.06.01

    Alternate Names:
    RORA TTD Gene Abbreviation
    T43206 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: RORA

    • Version: 01-February-2022

    Alternate Names:
    Nuclear receptor ROR-alpha Gene Name
    P35398 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, NUCLEAR HORMONE RECEPTOR

    Publications:

  • DTC: RORA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21