DGIdb - RXRA Gene Record

RXRA 6256 Druggable Genome

Alternate Names:

6256
RETINOID X RECEPTOR ALPHA
RXRA
NR2B1
180245
10477
ENSG00000186350
OTTHUMG00000020887
P19793
RXRA_HUMAN
RETINOIC ACID RECEPTOR RXR-ALPHA (RETINOID X RECEPTOR ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P19793]
RETINOIC ACID RECEPTOR RXR-ALPHA
Nuclear receptor subfamily 2 group B member 1
PA34890
T13726
RXR-alpha
RXRalpha

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	Nuclear receptor
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000536
Interpro Type	Domain
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Uniprot Status	Swiss-Prot
Initial Gene Query	NR2B1
Counted Citations from 1950-2000	1276
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem
Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett
Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
Zhelyaznik et al., 2006, Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury., Neuroscience
Bartholin et al., 2006, TGIF inhibits retinoid signaling., Mol. Cell. Biol.
Calléja et al., 2006, Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes., Genes Dev.
Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
Fukasawa et al., 2006, [Retinoid therapy for autoimmune diseases]., Nihon Rinsho Meneki Gakkai Kaishi
Mizuguchi et al., 2006, Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60., Biol. Pharm. Bull.
Kotani H et al., 2010, Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor., J Nat Prod
de Urquiza AM et al., 2000, Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain., Science
German OL et al., 2013, Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors., J Lipid Res
Wagner CE et al., 2009, Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)., J Med Chem
Ohsawa F et al., 2013, Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency., J Med Chem
Yen et al., 2005, The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma., Mol. Cancer Ther.
Lalloyer et al., 2006, The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia., Arterioscler. Thromb. Vasc. Biol.
Yen et al., 2006, A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours., Br. J. Cancer
Rigas et al., 2005, Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene., Oncologist
Rizvi et al., 2001, Placebo-controlled trial of bexarotene, a retinoid x receptor agonist, as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell lung cancer., Clin Lung Cancer
Farol et al., 2004, Bexarotene: a clinical review., Expert Rev Anticancer Ther
Tooker et al., 2007, Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification., Cancer Res.
Lowe et al., Bexarotene., Am J Clin Dermatol
Tsai et al., 2008, A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia., Clin. Cancer Res.
Wang ZG et al., 2013, Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation., Eur J Med Chem
Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol
Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
Bernard, 1993, Adapalene, a new chemical entity with retinoid activity., Skin Pharmacol.
Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry
Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
Wada A et al., 2008, Preparation and biological evaluation of 5-substituted retinoic acids., Bioorg Med Chem
Wada A et al., 2010, Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives., Bioorg Med Chem
Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.

CHEMBL451158 RXRA

Interaction Score: 2.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18760926 20673632

Sources:
DTC
PHYTANIC ACID RXRA

Interaction Score: 1.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20695472

Sources:
DTC
BEXAROTENE RXRA

Interaction Score: 1.6

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name bexarotene,Targretin

Notes

PMIDs:
19791803 23391145 15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 18765556

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TEND TTD
ALITRETINOIN RXRA

Interaction Score: 1.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489

Sources:
DTC ChemblInteractions TEND TTD
OCTADECYLAMINE RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIMETHYLFORMAMIDE RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ADAPALENE RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10651997 8142113 19929446 9204085 31273085

Sources:
TdgClinicalTrial TEND
PHENOXYETHANOL RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORHEXIDINE DIACETATE RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METRIBUZIN RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEMETON S RXRA

Interaction Score: 0.85

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOCONEXENT RXRA

Interaction Score: 0.56

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
20695472 11118147 23723389

Sources:
DTC
ETRETINATE RXRA

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9298126 8301142 9074840

Sources:
ChemblInteractions
ANTHRAQUINONE RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SDX-101 RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Retinoid X receptor alpha modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BROMETHALIN RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FERBAM RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BIPHENYL RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFLUBENZURON RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINOXYFEN RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MESOTRIONE RXRA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HONOKIOL RXRA

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20695472

Sources:
DTC
AZINPHOS-ETHYL RXRA

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IRX-4204 RXRA

Interaction Score: 0.28

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid X receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUDIOXONIL RXRA

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ABAMECTIN RXRA

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL118417 RXRA

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BROMOXYNIL RXRA

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROPARGITE RXRA

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIBUTYLCHLOROSTANNANE RXRA

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORFENAPYR RXRA

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOROPHENE RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PYRACLOSTROBIN RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFENOCONAZOLE RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIPHENYLSTANNANOL RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIBUTYLTIN-OXIDE RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBUTYLDICHLOROSTANNANE RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
2-PHENYLPHENOL RXRA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN RXRA

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9153406 9074840

Sources:
ChemblInteractions
IMIPRAMINE HYDROCHLORIDE RXRA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOFAROTENE RXRA

Interaction Score: 0.14

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Retinoid receptor modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
STANOLONE RXRA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUTYLATED HYDROXYTOLUENE RXRA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICLOSAN RXRA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SAQUINAVIR MESYLATE RXRA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRICLOCARBAN RXRA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULINDAC RXRA

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
23434637

Sources:
DTC
BENZO(K)FLUORANTHENE RXRA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL329673 RXRA

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
T091317 RXRA

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLOROTHALONIL RXRA

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AFIMOXIFENE RXRA

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL275311 RXRA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROTENONE RXRA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRETINOIN RXRA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16946489

Sources:
DTC
CHEMBL297304 RXRA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZETHONIUM CHLORIDE RXRA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTINOMYCIN RXRA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICHLOROPHEN RXRA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RALOXIFENE HYDROCHLORIDE RXRA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIMEROSAL RXRA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIRAM RXRA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BITHIONOL RXRA

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE RXRA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICLOSAMIDE RXRA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HOMIDIUM BROMIDE RXRA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW7647 RXRA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HYDROCHLORIDE RXRA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN HYDROCHLORIDE RXRA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TESTOSTERONE RXRA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOCETAXEL RXRA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24193570

Sources:
PharmGKB
GENISTEIN RXRA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROGESTERONE RXRA

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000186350
- Version: 101_38
Alternate Names:

RXRA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: RXRA
- Version: February-2014
Alternate Names:

6256 Entrez Gene ID

Gene Info:

Initial Gene Query NR2B1

Counted Citations from 1950-2000 1276

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
HopkinsGroom: P19793
- Version: 11-September-2012
Alternate Names:

ENSG00000186350 Ensembl Gene Id

RETINOIC ACID RECEPTOR RXR-ALPHA Uniprot Protein Name

6256 Entrez Gene Id

Gene Info:

Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000536

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000186350
- Version: 26-July-2011
Alternate Names:

RXRA Display Id

ENSG00000186350 Ensembl Gene Id

RETINOIC ACID RECEPTOR RXR-ALPHA (RETINOID X RECEPTOR ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P19793] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P19793
- Version: January-2014
Alternate Names:

RXRA Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:
TEND: P19793
- Version: 01-August-2011
Alternate Names:

RXRA_HUMAN Uniprot Id

6256 Entrez Gene Id

ENSG00000186350 Ensembl Gene Id

Gene Info:

Target Main Class Receptors

Target Subclass Nuclear receptor

Publications:

PharmGKB: RXRA

Version: 18-August-2020

Alternate Names:

PA34890 PharmGKB ID

Gene Info:

Publications:

Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol

DTC: RXRA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem

Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett

Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod

TALC: RXRA
- Version: 12-May-2016
Alternate Names:

RXRA Gene Symbol

Gene Info:

Publications:
ChemblInteractions: NR2B1
- Version: chembl_23
Alternate Names:

NR2B1 GENE_SYMBOL

RXRA GENE_SYMBOL

Retinoic acid receptor RXR-alpha UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000186350
- Version: 31-May-2017
Alternate Names:

ENSG00000186350 Gene Symbol

RXRA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: RXRA
- Version: 01-February-2022
Alternate Names:

NR2B1 GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

Publications:
Tempus: RXRA
- Version: 11-November-2018
Alternate Names:

RXRA Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: RXRA
- Version: 27-Jun-2013
Alternate Names:

6256 Gene ID

NR2B1 dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TTD: Retinoic acid receptor RXR-alpha
- Version: 2020.06.01
Alternate Names:

RXRA TTD Gene Abbreviation

T13726 TTD Target ID

Gene Info:

Publications:
Pharos: RXRA
- Version: 01-February-2022
Alternate Names:

Retinoic acid receptor RXR-alpha Gene Name

P19793 UniProt ID

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

Publications:

Novel drug target	Established target
Trial Name	bexarotene,Targretin
Notes

Mechanism of Interaction	Retinoid receptor agonist
Direct Interaction	yes

Mechanism of Interaction	Retinoid X receptor alpha modulator
Direct Interaction	yes

Mechanism of Interaction	Retinoid X receptor agonist
Direct Interaction	yes

Mechanism of Interaction	Retinoid receptor modulator
Direct Interaction	yes

ENSG00000186350	Ensembl Gene Id
RETINOIC ACID RECEPTOR RXR-ALPHA	Uniprot Protein Name
6256	Entrez Gene Id

RXRA	Display Id
ENSG00000186350	Ensembl Gene Id
RETINOIC ACID RECEPTOR RXR-ALPHA (RETINOID X RECEPTOR ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P19793]	Description

RXRA_HUMAN	Uniprot Id
6256	Entrez Gene Id
ENSG00000186350	Ensembl Gene Id

NR2B1	GENE_SYMBOL
RXRA	GENE_SYMBOL
Retinoic acid receptor RXR-alpha	UNIPROT

activator (activating)
agonist (activating)

RXRA Gene Record

RXRA 6256 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18760926 20673632

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20695472

Sources: DTC

Interaction Types & Directionality: activator (activating) agonist (activating)

Interaction Info: Novel drug target Established target Trial Name bexarotene,Targretin Notes

PMIDs: 19791803 23391145 15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 18765556

Sources: TALC DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489

Sources: DTC ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10651997 8142113 19929446 9204085 31273085

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 20695472 11118147 23723389

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 9298126 8301142 9074840

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Retinoid X receptor alpha modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
18760926 20673632

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20695472

Sources:
DTC

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name bexarotene,Targretin

Notes

PMIDs:
19791803 23391145 15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 18765556

Sources:
TALC DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489

Sources:
DTC ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10651997 8142113 19929446 9204085 31273085

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

activator (activating)

PMIDs:
20695472 11118147 23723389

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9298126 8301142 9074840

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Retinoid X receptor alpha modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20695472

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid X receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found