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RXRA Gene Record

  • Summary
  • Interactions
  • Claims
  • RXRA 6256 Druggable Genome

    Alternate Names:

    6256
    RETINOID X RECEPTOR ALPHA
    RXRA
    NR2B1
    180245
    10477
    ENSG00000186350
    OTTHUMG00000020887
    P19793
    RXRA_HUMAN
    RETINOIC ACID RECEPTOR RXR-ALPHA (RETINOID X RECEPTOR ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P19793]
    RETINOIC ACID RECEPTOR RXR-ALPHA
    Nuclear receptor subfamily 2 group B member 1
    PA34890
    T13726
    RXR-alpha
    RXRalpha

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    Target Subclass Nuclear receptor
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000536
    Interpro Type Domain
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Initial Gene Query NR2B1
    Counted Citations from 1950-2000 1276
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem
    Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
    Zhelyaznik et al., 2006, Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury., Neuroscience
    Bartholin et al., 2006, TGIF inhibits retinoid signaling., Mol. Cell. Biol.
    Calléja et al., 2006, Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes., Genes Dev.
    Garnock-Jones et al., 2009, Alitretinoin: in severe chronic hand eczema., Drugs
    Fukasawa et al., 2006, [Retinoid therapy for autoimmune diseases]., Nihon Rinsho Meneki Gakkai Kaishi
    Mizuguchi et al., 2006, Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60., Biol. Pharm. Bull.
    Kotani H et al., 2010, Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor., J Nat Prod
    de Urquiza AM et al., 2000, Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain., Science
    German OL et al., 2013, Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors., J Lipid Res
    Wagner CE et al., 2009, Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene)., J Med Chem
    Ohsawa F et al., 2013, Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency., J Med Chem
    Yen et al., 2005, The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma., Mol. Cancer Ther.
    Lalloyer et al., 2006, The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia., Arterioscler. Thromb. Vasc. Biol.
    Yen et al., 2006, A selective retinoid X receptor agonist bexarotene (LGD1069, targretin) inhibits angiogenesis and metastasis in solid tumours., Br. J. Cancer
    Rigas et al., 2005, Emerging role of rexinoids in non-small cell lung cancer: focus on bexarotene., Oncologist
    Rizvi et al., 2001, Placebo-controlled trial of bexarotene, a retinoid x receptor agonist, as maintenance therapy for patients treated with chemotherapy for advanced non-small-cell lung cancer., Clin Lung Cancer
    Farol et al., 2004, Bexarotene: a clinical review., Expert Rev Anticancer Ther
    Tooker et al., 2007, Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification., Cancer Res.
    Lowe et al., Bexarotene., Am J Clin Dermatol
    Tsai et al., 2008, A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia., Clin. Cancer Res.
    Wang ZG et al., 2013, Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation., Eur J Med Chem
    Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol
    Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
    Bernard, 1993, Adapalene, a new chemical entity with retinoid activity., Skin Pharmacol.
    Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
    Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
    Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry
    Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
    Wada A et al., 2008, Preparation and biological evaluation of 5-substituted retinoic acids., Bioorg Med Chem
    Wada A et al., 2010, Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives., Bioorg Med Chem
    Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
    Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
  • CHEMBL451158   RXRA

    Interaction Score: 2.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18760926 20673632


    Sources:
    DTC

  • PHYTANIC ACID   RXRA

    Interaction Score: 1.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20695472


    Sources:
    DTC

  • BEXAROTENE   RXRA

    Interaction Score: 1.6

    Interaction Types & Directionality:
    activator (activating)
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name bexarotene,Targretin
    Notes

    PMIDs:
    19791803 23391145 15897247 17008586 16495926 15632250 14700480 15056048 17483357 11702369 18765556


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • ALITRETINOIN   RXRA

    Interaction Score: 1.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    21489804 25057340 7807131 18321241 16782282 16428452 16751185 19678713 16819260 16946489


    Sources:
    DTC ChemblInteractions TEND TTD

  • OCTADECYLAMINE   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIMETHYLFORMAMIDE   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ADAPALENE   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10651997 8142113 19929446 9204085 31273085


    Sources:
    TdgClinicalTrial TEND

  • PHENOXYETHANOL   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORHEXIDINE DIACETATE   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • METRIBUZIN   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEMETON S   RXRA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOCONEXENT   RXRA

    Interaction Score: 0.56

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    20695472 11118147 23723389


    Sources:
    DTC

  • ETRETINATE   RXRA

    Interaction Score: 0.48

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    9298126 8301142 9074840


    Sources:
    ChemblInteractions

  • ANTHRAQUINONE   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SDX-101   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Retinoid X receptor alpha modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BROMETHALIN   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FERBAM   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BIPHENYL   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIFLUBENZURON   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUINOXYFEN   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MESOTRIONE   RXRA

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HONOKIOL   RXRA

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20695472


    Sources:
    DTC

  • AZINPHOS-ETHYL   RXRA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IRX-4204   RXRA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid X receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLUDIOXONIL   RXRA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ABAMECTIN   RXRA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL118417   RXRA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BROMOXYNIL   RXRA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROPARGITE   RXRA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIBUTYLCHLOROSTANNANE   RXRA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORFENAPYR   RXRA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOROPHENE   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PYRACLOSTROBIN   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIFENOCONAZOLE   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIPHENYLSTANNANOL   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIBUTYLTIN-OXIDE   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIBUTYLDICHLOROSTANNANE   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 2-PHENYLPHENOL   RXRA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACITRETIN   RXRA

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    9153406 9074840


    Sources:
    ChemblInteractions

  • IMIPRAMINE HYDROCHLORIDE   RXRA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MOFAROTENE   RXRA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Retinoid receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • STANOLONE   RXRA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BUTYLATED HYDROXYTOLUENE   RXRA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICLOSAN   RXRA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SAQUINAVIR MESYLATE   RXRA

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRICLOCARBAN   RXRA

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SULINDAC   RXRA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    23434637


    Sources:
    DTC

  • BENZO(K)FLUORANTHENE   RXRA

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL329673   RXRA

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • T091317   RXRA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLOROTHALONIL   RXRA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AFIMOXIFENE   RXRA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL275311   RXRA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ROTENONE   RXRA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRETINOIN   RXRA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16946489


    Sources:
    DTC

  • CHEMBL297304   RXRA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BENZETHONIUM CHLORIDE   RXRA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTINOMYCIN   RXRA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICHLOROPHEN   RXRA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RALOXIFENE HYDROCHLORIDE   RXRA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIMEROSAL   RXRA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIRAM   RXRA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BITHIONOL   RXRA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PIMOZIDE   RXRA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICLOSAMIDE   RXRA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HOMIDIUM BROMIDE   RXRA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW7647   RXRA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DAUNORUBICIN HYDROCHLORIDE   RXRA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN HYDROCHLORIDE   RXRA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TESTOSTERONE   RXRA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOCETAXEL   RXRA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24193570


    Sources:
    PharmGKB

  • GENISTEIN   RXRA

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROGESTERONE   RXRA

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000186350

    • Version: 101_38

    Alternate Names:
    RXRA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: RXRA

    • Version: February-2014

    Alternate Names:
    6256 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR2B1
    Counted Citations from 1950-2000 1276

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • HopkinsGroom: P19793

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000186350 Ensembl Gene Id
    RETINOIC ACID RECEPTOR RXR-ALPHA Uniprot Protein Name
    6256 Entrez Gene Id

    Gene Info:
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000536

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000186350

    • Version: 26-July-2011

    Alternate Names:
    RXRA Display Id
    ENSG00000186350 Ensembl Gene Id
    RETINOIC ACID RECEPTOR RXR-ALPHA (RETINOID X RECEPTOR ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P19793] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P19793

    • Version: January-2014

    Alternate Names:
    RXRA Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • TEND: P19793

    • Version: 01-August-2011

    Alternate Names:
    RXRA_HUMAN Uniprot Id
    6256 Entrez Gene Id
    ENSG00000186350 Ensembl Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • PharmGKB: RXRA

    • Version: 18-August-2020

    Alternate Names:
    PA34890 PharmGKB ID

    Gene Info:

    Publications:
    Chew SC et al., 2014, Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients., Eur J Clin Pharmacol

  • DTC: RXRA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Okitsu T et al., 2011, Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity., Bioorg Med Chem
    Chen F et al., 2014, Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site., ACS Med Chem Lett
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod

  • TALC: RXRA

    • Version: 12-May-2016

    Alternate Names:
    RXRA Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: NR2B1

    • Version: chembl_23

    Alternate Names:
    NR2B1 GENE_SYMBOL
    RXRA GENE_SYMBOL
    Retinoic acid receptor RXR-alpha UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000186350

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000186350 Gene Symbol
    RXRA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: RXRA

    • Version: 01-February-2022

    Alternate Names:
    NR2B1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, NUCLEAR HORMONE RECEPTOR

    Publications:

  • Tempus: RXRA

    • Version: 11-November-2018

    Alternate Names:
    RXRA Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: RXRA

    • Version: 27-Jun-2013

    Alternate Names:
    6256 Gene ID
    NR2B1 dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Retinoic acid receptor RXR-alpha

    • Version: 2020.06.01

    Alternate Names:
    RXRA TTD Gene Abbreviation
    T13726 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: RXRA

    • Version: 01-February-2022

    Alternate Names:
    Retinoic acid receptor RXR-alpha Gene Name
    P19793 UniProt ID

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21