DGIdb - SCN10A Gene Record

SCN10A 6336 Druggable Genome

Alternate Names:

6336
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 10
SCN10A
FEPS2
Nav1.8
PN3
SNS
hPN3
604427
10582
ENSG00000185313
OTTHUMG00000048245
Q9Y5Y9
SCNAA_HUMAN
SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA
VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.8
SODIUM CHANNEL PROTEIN TYPE X SUBUNIT ALPHA
PERIPHERAL NERVE SODIUM CHANNEL 3
SODIUM CHANNEL PROTEIN TYPE X ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.8) (PERIPHERAL NERVE SODIUM CHANNEL 3) (HPN3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y9]
PA35000
Voltage-gated sodium channel alpha Nav1.8
T43739

Gene Info:

Target Main Class	Transporters
Transmembrane Helix Count	23
Target Subclass	Voltage_gated_ion_channels
Target Subclass	SodiumChannels
Target Subclass	Channels
Target Class	Transporters
Target Subclass	TC:1.A.1.10
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ion_trans_dom
Interpro Acc	IPR005821
Uniprot Status	Swiss-Prot
Interpro Name	Ion transport domain
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Initial Gene Query	Nav1.8
Counted Citations from 1950-2000	298
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Roghani et al., Evaluating the efficacy of commonly used topical anesthetics., Pediatr Dent
Tella et al., 1998, Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine., Pharmacol. Biochem. Behav.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Sheets et al., 2010, Sodium channel molecular conformations and antiarrhythmic drug affinity., Trends Cardiovasc. Med.
Hung et al., 2009, Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats., Neurosci. Lett.
Ahern et al., 2008, Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels., Circ. Res.
Hanck et al., 2009, Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity., Circ. Res.
Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.
Liu et al., 2000, The effects of ropivacaine on sodium currents in dorsal horn neurons of neonatal rats., Anesth. Analg.
Louro et al., 1998, Carboxyl groups at the membrane interface as molecular targets for local anesthetics., Biophys. Chem.
Ryan et al., 1996, Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study., J. Biol. Chem.
Muroi et al., 2009, Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel., J. Gen. Physiol.
Ekberg et al., 2006, muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits., Proc. Natl. Acad. Sci. U.S.A.
Karoly et al., 2010, Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study., PLoS Comput. Biol.
Chevrier P et al., 2004, Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine., Br J Pharmacol
Leffler et al., 2010, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites., Eur. J. Pharmacol.
He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
Wong et al., 1993, On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve., Anesth. Analg.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Ueta et al., In vitro antagonism of recombinant ligand-gated ion-channel receptors by stereospecific enantiomers of bupivacaine., Reg Anesth Pain Med
Vladimirov et al., 2000, Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies., Anesthesiology
Bräu et al., 2000, Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics., Anesth. Analg.
Katalymov, 1995, [The effect of inhibitors of sodium permeability (novocaine and tetrodotoxin) on the trace depolarization of myelinated nerve fibers]., Fiziol Zh Im I M Sechenova
Bräu et al., 1998, Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve., Anesth. Analg.
Creveling et al., 1990, Procaine isothiocyanate: an irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels., Neurochem. Res.

PROCAINE SCN10A

Interaction Score: 2.85

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8581044 9768788 2167458 17016423 17139284

Sources:
TdgClinicalTrial TEND
BENZOCAINE SCN10A

Interaction Score: 2.85

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17967784 17016423 17139284 19661462 16174788

Sources:
TdgClinicalTrial TEND
PROPARACAINE SCN10A

Interaction Score: 2.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9476974 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
HEXYLCAINE SCN10A

Interaction Score: 2.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17139284 17016423 15148257

Sources:
TdgClinicalTrial TEND
LEVOBUPIVACAINE SCN10A

Interaction Score: 1.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16418020 10969308 17016423 17139284 11094008

Sources:
TdgClinicalTrial TEND
BENOXINATE SCN10A

Interaction Score: 1.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 19429093

Sources:
TdgClinicalTrial TEND
ROPIVACAINE SCN10A

Interaction Score: 1.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ropivacaine HCl,Naropin

Novel drug target Established target

PMIDs:
17016423 17139284 10781449

Sources:
TdgClinicalTrial TEND TTD
CHLOROPROCAINE SCN10A

Interaction Score: 1.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8418714 17016423 17139284

Sources:
TdgClinicalTrial TEND
DSP-2230 SCN10A

Interaction Score: 0.81

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
RILPIVIRINE SCN10A

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PF-04531083 SCN10A

Interaction Score: 0.81

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIBUCAINE SCN10A

Interaction Score: 0.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9742684 17016423 17139284 8798723

Sources:
TdgClinicalTrial TEND
MEPIVACAINE SCN10A

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name APF 112, mepivacaine sustained-release

Novel drug target Established target

PMIDs:
20044988 17016423 17139284

Sources:
TdgClinicalTrial TEND
DYCLONINE SCN10A

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10355012 9476974 17016423 17139284

Sources:
TdgClinicalTrial TEND
BUPIVACAINE SCN10A

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Durect

Trial Name DUR-843,Eladur, Transdur-Bupivacaine

Trial Name DepoBupivacaine, bupivacaine,Exparel

PMIDs:
20685573 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
TIAPRIDE SCN10A

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LIDOCAINE SCN10A

Interaction Score: 0.31

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name ALGRX 3268,Zingo

Novel drug target Established target

Trial Name lidocaine hydrochloride, piroxicam, AK1015,Akten

PMIDs:
19088384 17077153 20585544

Sources:
TdgClinicalTrial ChemblInteractions TEND
CONATUMUMAB SCN10A

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIBUCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.16

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
COCAINE SCN10A

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
TETRACAINE SCN10A

Interaction Score: 0.15

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions TTD
ERLOSAMIDE SCN10A

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions
AFACIFENACIN SCN10A

Interaction Score: 0.12

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRODOTOXIN SCN10A

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name tetrodotoxin,Tectin, Tetrodin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TETRACAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NKTR-171 SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENACEMIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE SULFATE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINAMIDE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDECAINIDE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE POLYGALACTURONATE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETIDOCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE ACETATE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLOROPROCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
MEPIVACAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPARACAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EVENAMIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOCAINIDE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
MEXILETINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SODIUM SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PROPOXYCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MERETHOXYLLINE PROCAINE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE GLUCONATE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ROPIVACAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HEXYLCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
FOSPHENYTOIN SODIUM SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ARTICAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENOXINATE HYDROCHLORIDE SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE HYDROCHLORIDE SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DISOPYRAMIDE PHOSPHATE SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
MORICIZINE HYDROCHLORIDE SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENYTOIN SCN10A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
IRAMPANEL SCN10A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPAFENONE HYDROCHLORIDE SCN10A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENAZOPYRIDINE HYDROCHLORIDE SCN10A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE HYDROCHLORIDE SCN10A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN10A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DYCLONINE HYDROCHLORIDE SCN10A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RALFINAMIDE SCN10A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN10A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE SCN10A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE SCN10A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZONISAMIDE SCN10A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE SCN10A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PRIMIDONE SCN10A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CARBOPLATIN SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26194361

Sources:
PharmGKB
TOPIRAMATE SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CARBAMAZEPINE SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000185313
- Version: 101_38
Alternate Names:

SCN10A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q9Y5Y9
- Version: 01-August-2011
Alternate Names:

6336 Entrez Gene Id

SCNAA_HUMAN Uniprot Id

SCN10A Gene Symbol

Gene Info:

Target Main Class Transporters

Transmembrane Helix Count 23

Target Subclass Voltage_gated_ion_channels

Publications:
TdgClinicalTrial: Q9Y5Y9
- Version: January-2014
Alternate Names:

SCN10A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10

Publications:
HopkinsGroom: Q9Y5Y9
- Version: 11-September-2012
Alternate Names:

SCNAA_HUMAN Uniprot Id

SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA Uniprot Protein Name

SCN10A Uniprot Gene Name

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Acc IPR005821

Uniprot Status Swiss-Prot

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000185313

Version: 26-July-2011

Alternate Names:

SODIUM CHANNEL PROTEIN TYPE X ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.8) (PERIPHERAL NERVE SODIUM CHANNEL 3) (HPN3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y9] Description

SCN10A Display Id

ENSG00000185313 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: SCN10A
- Version: February-2014
Alternate Names:

6336 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.8

Counted Citations from 1950-2000 298

Gene Categories:

ION CHANNEL

Publications:
PharmGKB: SCN10A
- Version: 18-August-2020
Alternate Names:

PA35000 PharmGKB ID

Gene Info:

Publications:

He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
TTD: Voltage-gated sodium channel alpha Nav1.8
- Version: 2020.06.01
Alternate Names:

SCN10A TTD Gene Abbreviation

T43739 TTD Target ID

Gene Info:

Publications:

Shields SD et al., 2015, Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis., PLoS One
HingoraniCasas: ENSG00000185313
- Version: 31-May-2017
Alternate Names:

ENSG00000185313 Gene Symbol

SCN10A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: SCN10A
- Version: chembl_23
Alternate Names:

SCN10A GENE_SYMBOL

Sodium channel protein type 10 subunit alpha UNIPROT

Peripheral nerve sodium channel 3 UNIPROT

Gene Info:

Publications:
Pharos: SCN10A
- Version: 01-February-2022
Alternate Names:

Sodium channel protein type 10 subunit alpha Gene Name

Q9Y5Y9 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	ropivacaine HCl,Naropin
Novel drug target	Established target

Mechanism of Interaction	Sodium channel protein type X alpha subunit blocker
Direct Interaction	yes

Trial Name	APF 112, mepivacaine sustained-release
Novel drug target	Established target

Trial Name	Durect
Trial Name	DUR-843,Eladur, Transdur-Bupivacaine
Trial Name	DepoBupivacaine, bupivacaine,Exparel

Trial Name	ALGRX 3268,Zingo
Novel drug target	Established target
Trial Name	lidocaine hydrochloride, piroxicam, AK1015,Akten

Direct Interaction	yes
Mechanism of Interaction	Sodium channel alpha subunit blocker

Trial Name	tetrodotoxin,Tectin, Tetrodin
Novel drug target	Established target

SCNAA_HUMAN	Uniprot Id
SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA	Uniprot Protein Name
SCN10A	Uniprot Gene Name

SODIUM CHANNEL PROTEIN TYPE X ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.8) (PERIPHERAL NERVE SODIUM CHANNEL 3) (HPN3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y9]	Description
SCN10A	Display Id
ENSG00000185313	Ensembl Gene Id

SCN10A	GENE_SYMBOL
Sodium channel protein type 10 subunit alpha	UNIPROT
Peripheral nerve sodium channel 3	UNIPROT

blocker (inhibitory)
inhibitor (inhibitory)

Sodium channel protein type 10 subunit alpha	Gene Name
Q9Y5Y9	UniProt ID

SCN10A Gene Record

SCN10A 6336 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8581044 9768788 2167458 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17967784 17016423 17139284 19661462 16174788

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9476974 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17139284 17016423 15148257

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16418020 10969308 17016423 17139284 11094008

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 19429093

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ropivacaine HCl,Naropin Novel drug target Established target

PMIDs: 17016423 17139284 10781449

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8418714 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel protein type X alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel protein type X alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9742684 17016423 17139284 8798723

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name APF 112, mepivacaine sustained-release Novel drug target Established target

PMIDs: 20044988 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10355012 9476974 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Durect Trial Name DUR-843,Eladur, Transdur-Bupivacaine Trial Name DepoBupivacaine, bupivacaine,Exparel

PMIDs: 20685573 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name ALGRX 3268,Zingo Novel drug target Established target Trial Name lidocaine hydrochloride, piroxicam, AK1015,Akten

PMIDs: 19088384 17077153 20585544

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8581044 9768788 2167458 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17967784 17016423 17139284 19661462 16174788

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9476974 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17139284 17016423 15148257

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16418020 10969308 17016423 17139284 11094008

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 19429093

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ropivacaine HCl,Naropin

Novel drug target Established target

PMIDs:
17016423 17139284 10781449

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8418714 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9742684 17016423 17139284 8798723

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name APF 112, mepivacaine sustained-release

Novel drug target Established target

PMIDs:
20044988 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10355012 9476974 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Durect

Trial Name DUR-843,Eladur, Transdur-Bupivacaine

Trial Name DepoBupivacaine, bupivacaine,Exparel

PMIDs:
20685573 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name ALGRX 3268,Zingo

Novel drug target Established target

Trial Name lidocaine hydrochloride, piroxicam, AK1015,Akten

PMIDs:
19088384 17077153 20585544

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found