DGIdb - SCN1A Gene Record

SCN1A 6323 Druggable Genome

Alternate Names:

6323
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 1
SCN1A
EIEE6
FEB3
FEB3A
FHM3
GEFSP2
HBSCI
NAC1
Nav1.1
SCN1
SMEI
182389
10585
ENSG00000144285
OTTHUMG00000044173
SCN1A_HUMAN
P35498
578
Na<sub>v</sub>1.1
Sodium channel protein brain I subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.1
Sodium channel protein type I subunit alpha
Sodium channel protein type 1 subunit alpha
PA301
NP_008851\|NP_001159435\|NP_001159436
NM_006920\|NM_001165963\|NM_001165964\|NM_001202435
SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]
DEE6
DRVT

Gene Info:

Initial Gene Query	Nav1.1
Counted Citations from 1950-2000	398
Target Class	Transporters
Target Subclass	TC:1.A.1.10.7
Interpro Short Name	Ion_trans_dom
Interpro Acc	IPR005821
Human Readable Name	ION CHANNEL
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Ion transport domain
Target Subclass	Voltage_gated_ion_channels
Target Main Class	Transporters
Target Subclass	Channels
Transmembrane Helix Count	24
Target Subclass	SodiumChannels
GuideToPharmacology Gene Category Name	Voltage-gated sodium channels
GuideToPharmacology Gene Category ID	82
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
Ceulemans et al., 2004, "Severe myoclonic epilepsy in infancy". Relevance for the clinician of severe epilepsy starting in infancy., Acta Neurol Belg
Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol
Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.
Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.
Korff et al., 2007, Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients., J. Child Neurol.
Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Tate et al., 2006, A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose., Pharmacogenet. Genomics
Mantegazza et al., 2010, Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders., Lancet Neurol
Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.
Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
Wong et al., 1986, Conformational analysis of clinically active anticonvulsant drugs., J. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
McLean et al., 1988, Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture., J. Pharmacol. Exp. Ther.
Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol
Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res
Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One
Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther
Shorvon S, 2000, Oxcarbazepine: a review., Seizure
Schmidt D et al., 2000, Oxcarbazepine for Treatment of Partial Epilepsy: A Review and Recommendations for Clinical Use., Epilepsy Behav
Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain
Ma CL et al., 2015, Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy., Pharmacogenomics
Zhou BT et al., 2012, Comprehensive analysis of the association of SCN1A gene polymorphisms with the retention rate of carbamazepine following monotherapy for new-onset focal seizures in the Chinese Han population., Clin Exp Pharmacol Physiol
Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
Manna I et al., 2011, A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy., Epilepsia
Schlachter K et al., 2009, A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures., Neurology
Yang et al., 2002, Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker., Mol. Pharmacol.
Lipkind et al., 2010, Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore., Mol. Pharmacol.
Rogawski et al., 2004, The neurobiology of antiepileptic drugs., Nat. Rev. Neurosci.
Yang et al., 2010, Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels., Anesthesiology
Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.

ETHOSUXIMIDE SCN1A

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB
LEVETIRACETAM SCN1A

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB
PHENACEMIDE SCN1A

Interaction Score: 0.72

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
3959032 17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND
OXCARBAZEPINE SCN1A

Interaction Score: 0.57

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 26555147 25155934 23859570 22591328 21747585 10845729 12737829 28842369

Sources:
ChemblInteractions PharmGKB
ZONISAMIDE SCN1A

Interaction Score: 0.49

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19948168 15511691 14704463 18433351 20001433 11752352 20025128 19557119

Sources:
TdgClinicalTrial ChemblInteractions TEND
CARBAMAZEPINE SCN1A

Interaction Score: 0.37

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 26555147 26314341 25155934 23859570 22591328 22292851 22188362 21747585 21561445 19289736 12391287 20643904 15208697 20526191

Sources:
ChemblInteractions PharmGKB
TETRODOTOXIN SCN1A

Interaction Score: 0.34

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

Specific Action of the Ligand Pore blocker

PMIDs:
17663442

Sources:
TdgClinicalTrial GuideToPharmacology
TETRACAINE SCN1A

Interaction Score: 0.28

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
22053156 23888118

Sources:
ChemblInteractions
LAMOTRIGINE SCN1A

Interaction Score: 0.28

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 25155934 23859570 21747585 16174788

Sources:
ChemblInteractions PharmGKB
SAXITOXIN SCN1A

Interaction Score: 0.26

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

PMIDs:
None found

Sources:
GuideToPharmacology
VERATRIDINE SCN1A

Interaction Score: 0.26

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Activation

PMIDs:
None found

Sources:
GuideToPharmacology
CLOBAZAM SCN1A

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB
TOPIRAMATE SCN1A

Interaction Score: 0.19

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name topiramate controlled release,Trokesa

PMIDs:
15508261 12861512 11948006 15526956 17621480

Sources:
TdgClinicalTrial ChemblInteractions TEND
PHENYTOIN SCN1A

Interaction Score: 0.18

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
17001291 20298965 15805193

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB
NITRAZEPAM SCN1A

Interaction Score: 0.15

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2450203

Sources:
TdgClinicalTrial TEND
PROPOXYCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINAMIDE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE SULFATE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE POLYGALACTURONATE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EVENAMIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSPHENYTOIN SODIUM SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETIDOCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPARACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDECAINIDE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MERETHOXYLLINE PROCAINE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOCAINIDE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HEXYLCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEXILETINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPIVACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE GLUCONATE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE ACETATE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ARTICAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROPIVACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
CHLOROPROCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SODIUM SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
NKTR-171 SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DISOPYRAMIDE PHOSPHATE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENOXINATE HYDROCHLORIDE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERLOSAMIDE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MORICIZINE HYDROCHLORIDE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENYTOIN SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IRAMPANEL SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPAFENONE HYDROCHLORIDE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SAFINAMIDE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DYCLONINE HYDROCHLORIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENAZOPYRIDINE HYDROCHLORIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE HYDROCHLORIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RALFINAMIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN1A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRIMIDONE SCN1A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE SCN1A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000144285
- Version: 101_38
Alternate Names:

SCN1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P35498
- Version: January-2014
Alternate Names:

SCN1A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10.7

Publications:
TEND: P35498
- Version: 01-August-2011
Alternate Names:

SCN1A Gene Symbol

SCN1A_HUMAN Uniprot Id

ENSG00000144285 Ensembl Gene Id

Gene Info:

Target Subclass Voltage_gated_ion_channels

Target Main Class Transporters

Target Subclass Channels

Publications:

RussLampel: ENSG00000144285

Version: 26-July-2011

Alternate Names:

SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498] Description

ENSG00000144285 Ensembl Gene Id

SCN1A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: SCN1A
- Version: February-2014
Alternate Names:

6323 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.1

Counted Citations from 1950-2000 398

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: P35498
- Version: 11-September-2012
Alternate Names:

SCN1A Uniprot Gene Name

SCN1A_HUMAN Uniprot Id

ENSG00000144285 Ensembl Gene Id

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Acc IPR005821

Human Readable Name ION CHANNEL

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 6323
- Version: 29-September-2020
Alternate Names:

10585 HUGO Gene ID

10585 HUGO Gene Symbol

sodium voltage-gated channel alpha subunit 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Voltage-gated sodium channels

GuideToPharmacology Gene Category ID 82

Gene Categories:

ION CHANNEL

Publications:

PharmGKB: SCN1A

Version: 18-August-2020

Alternate Names:

PA301 PharmGKB ID

Gene Info:

Publications:

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

HingoraniCasas: ENSG00000144285
- Version: 31-May-2017
Alternate Names:

ENSG00000144285 Gene Symbol

SCN1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NAC1
- Version: chembl_23
Alternate Names:

SCN1 GENE_SYMBOL

SCN1A GENE_SYMBOL

Sodium channel protein type 1 subunit alpha UNIPROT

Gene Info:

Publications:
Pharos: SCN1A
- Version: 01-May-2021
Alternate Names:

Sodium channel protein type 1 subunit alpha Gene Name

P35498 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Sodium channel alpha subunit blocker

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

Trial Name	zonisamide,Zonegran, Trerief
Trial Name	OREX-003, olanzapine plus zonisamide SR
Novel drug target	Established target

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Pore blocker

SCN1A	Gene Symbol
SCN1A_HUMAN	Uniprot Id
ENSG00000144285	Ensembl Gene Id

SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]	Description
ENSG00000144285	Ensembl Gene Id
SCN1A	Display Id

SCN1A	Uniprot Gene Name
SCN1A_HUMAN	Uniprot Id
ENSG00000144285	Ensembl Gene Id

10585	HUGO Gene ID
10585	HUGO Gene Symbol
sodium voltage-gated channel alpha subunit 1	HUGO Gene Name

SCN1	GENE_SYMBOL
SCN1A	GENE_SYMBOL
Sodium channel protein type 1 subunit alpha	UNIPROT

Sodium channel protein type 1 subunit alpha	Gene Name
P35498	UniProt ID

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

SCN1A Gene Record

SCN1A 6323 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28753467 25155934 23859570 21747585

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28753467 25155934 23859570 21747585

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 3959032 17016423 17139284 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 28753467 26555147 25155934 23859570 22591328 21747585 10845729 12737829 28842369

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name zonisamide,Zonegran, Trerief Trial Name OREX-003, olanzapine plus zonisamide SR Novel drug target Established target

PMIDs: 19948168 15511691 14704463 18433351 20001433 11752352 20025128 19557119

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 28753467 26555147 26314341 25155934 23859570 22591328 22292851 22188362 21747585 21561445 19289736 12391287 20643904 15208697 20526191

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name tetrodotoxin,Tectin, Tetrodin Specific Action of the Ligand Pore blocker

PMIDs: 17663442

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 22053156 23888118

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 28753467 25155934 23859570 21747585 16174788

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Pore blocker

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Activation

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28753467 25155934 23859570 21747585

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes Trial Name topiramate controlled release,Trokesa

PMIDs: 15508261 12861512 11948006 15526956 17621480

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 17001291 20298965 15805193

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2450203

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
3959032 17016423 17139284 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 26555147 25155934 23859570 22591328 21747585 10845729 12737829 28842369

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19948168 15511691 14704463 18433351 20001433 11752352 20025128 19557119

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 26555147 26314341 25155934 23859570 22591328 22292851 22188362 21747585 21561445 19289736 12391287 20643904 15208697 20526191

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

Specific Action of the Ligand Pore blocker

PMIDs:
17663442

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
22053156 23888118

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
28753467 25155934 23859570 21747585 16174788

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Activation

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
28753467 25155934 23859570 21747585

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name topiramate controlled release,Trokesa

PMIDs:
15508261 12861512 11948006 15526956 17621480

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
17001291 20298965 15805193

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2450203

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found