SCN4A Gene Record

  • LANPERISONE   SCN4A

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LEVOBUPIVACAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.98

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUPIVACAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.98

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONISAMIDE   SCN4A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes
    Trial Name Empatic

    PMIDs:
    19948168 15511691 14704463 18433351 20001433 20025128 19557119


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FOSPROPOFOL   SCN4A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • RANOLAZINE   SCN4A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIDOCAINE   SCN4A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    14662728


    Sources:
    ChemblInteractions

  • TETRODOTOXIN   SCN4A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name tetrodotoxin,Tectin, Tetrodin
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PROPOFOL   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name propofol lingual spray
    Novel drug target Established target
    Trial Name propofol,Diprivan

    PMIDs:
    18574460


    Sources:
    TdgClinicalTrial TEND

  • MEXILETINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPIVACAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARTICAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINAMIDE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUPIVACAINE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLOROPROCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EVENAMIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE ACETATE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETHOTOIN   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE SULFATE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROPIVACAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIDOCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPARACAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDECAINIDE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENACEMIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE GLUCONATE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOCAINIDE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSPHENYTOIN SODIUM   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN SODIUM   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE POLYGALACTURONATE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NKTR-171   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEXYLCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETIDOCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRACAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MERETHOXYLLINE PROCAINE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPOXYCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE   SCN4A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRACAINE   SCN4A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE   SCN4A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DISOPYRAMIDE PHOSPHATE   SCN4A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RUFINAMIDE   SCN4A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENOXINATE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERLOSAMIDE   SCN4A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPHENYTOIN   SCN4A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MORICIZINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IRAMPANEL   SCN4A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPAFENONE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAFINAMIDE   SCN4A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Safinamide

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RILUZOLE   SCN4A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DRONEDARONE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENAZOPYRIDINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DYCLONINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RALFINAMIDE   SCN4A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE HYDROCHLORIDE   SCN4A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXCARBAZEPINE   SCN4A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE CITRATE   SCN4A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LAMOTRIGINE   SCN4A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN4A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN   SCN4A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOPIRAMATE   SCN4A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CARBAMAZEPINE   SCN4A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NERISPIRDINE   SCN4A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000007314

    • Version: 101_38

    Alternate Names:
    SCN4A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P35499

    • Version: 01-August-2011

    Alternate Names:
    SCN4A_HUMAN Uniprot Id
    SCN4A Gene Symbol
    6329 Entrez Gene Id

    Gene Info:
    Transmembrane Helix Count 24
    Target Subclass Voltage_gated_ion_channels
    Target Subclass Channels

    Publications:

  • BaderLabGenes: SCN4A

    • Version: February-2014

    Alternate Names:
    6329 Entrez Gene ID

    Gene Info:
    Initial Gene Query Nav1.4
    Counted Citations from 1950-2000 496

    Gene Categories:
    ION CHANNEL

    Publications:

  • RussLampel: ENSG00000007314

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000007314 Ensembl Gene Id
    SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.4) (SODIUM CHANNEL PROTEIN, SKELETAL MUSCLE ALPHA-SUBUNIT) (SKM1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35499] Description
    SCN4A Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P35499

    • Version: 11-September-2012

    Alternate Names:
    SCN4A_HUMAN Uniprot Id
    ENSG00000007314 Ensembl Gene Id
    P35499 Uniprot Accession

    Gene Info:
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Ion transport domain

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P35499

    • Version: January-2014

    Alternate Names:
    SCN4A Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.10.4

    Publications:

  • ChemblInteractions: SCN4A

    • Version: chembl_23

    Alternate Names:
    SCN4A GENE_SYMBOL
    Sodium channel protein type 4 subunit alpha UNIPROT
    SkM1 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000007314

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000007314 Gene Symbol
    SCN4A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Voltage-gated sodium channel alpha Nav1.4

    • Version: 2020.06.01

    Alternate Names:
    SCN4A TTD Gene Abbreviation
    T02546 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SCN4A

    • Version: 01-February-2022

    Alternate Names:
    Sodium channel protein type 4 subunit alpha Gene Name
    P35499 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: