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SCNN1B Gene Record

  • Summary
  • Interactions
  • Claims
  • SCNN1B 6338 Druggable Genome

    Alternate Names:

    6338
    SODIUM CHANNEL EPITHELIAL 1 BETA SUBUNIT
    SCNN1B
    BESC1
    ENaCb
    ENaCbeta
    SCNEB
    600760
    10600
    ENSG00000168447
    OTTHUMG00000131608
    P51168
    SCNNB_HUMAN
    AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA
    Nonvoltage-gated sodium channel 1 subunit beta
    Beta-ENaC
    Epithelial Na(+) channel subunit beta
    Beta-NaCH
    PA306
    AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT (EPITHELIAL NA+ CHANNEL BETA SUBUNIT) (BETA ENAC) (NONVOLTAGE-GATED SODIUM CHANNEL 1 BETA SUBUNIT) (SCNEB) (BETA NACH) (ENACB). [SOURCE:UNIPROT/SWISSPROT;ACC:P51168]
    SODIUM CHANNEL EPITHELIAL 1 SUBUNIT BETA
    LIDLS1

    Gene Info:

    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name Na+channel_ASC
    Interpro Acc IPR001873
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name ION CHANNEL
    Interpro Name Na+ channel, amiloride-sensitive
    Transmembrane Helix Count 2
    Target Subclass Amiloride-sensitive Na+ channel
    Target Subclass Channels
    Target Main Class Transporters
    Target Class Transporters
    Target Subclass TC:1.A.6.1.1
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Busch et al., 1996, Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis., Pflugers Arch.
    Wagner et al., 2001, Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis., Cell. Physiol. Biochem.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
    Brooks et al., 2002, Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice., Hypertension
    Lebowitz et al., 2003, Effect of altered Na+ entry on expression of apical and basolateral transport proteins in A6 epithelia., Am. J. Physiol. Renal Physiol.
    Yamagata et al., The impact of phorbol ester on the regulation of amiloride-sensitive epithelial sodium channel in alveolar type ii epithelial cells., Exp. Lung Res.
    Planès et al., 2005, In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases., Am. J. Physiol. Lung Cell Mol. Physiol.
    Kamide et al., 2004, Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives., Hypertens. Res.
    Spraggs C et al., 2007, Genetic variants in the epithelial sodium channel associate with oedema in type 2 diabetic patients receiving the peroxisome proliferator-activated receptor gamma agonist farglitazar., Pharmacogenet Genomics
  • AMILORIDE   SCNN1B

    Interaction Score: 11.59

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name HTI-101
    Novel drug target Established target

    PMIDs:
    23788015 11882592 12746257 12396248 15681398 15198480


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • FARGLITAZAR   SCNN1B

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18004211


    Sources:
    PharmGKB

  • TRIAMTERENE   SCNN1B

    Interaction Score: 5.15

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker

    PMIDs:
    8772124 11509829 17016423 17139284 23788015


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • P-1037   SCNN1B

    Interaction Score: 3.43

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMILORIDE HYDROCHLORIDE   SCNN1B

    Interaction Score: 2.58

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Amiloride-sensitive sodium channel, ENaC blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GLYBURIDE   SCNN1B

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18004211


    Sources:
    PharmGKB

  • Ensembl: ENSG00000168447

    • Version: 101_38

    Alternate Names:
    SCNN1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000168447

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000168447 Ensembl Gene Id
    SCNN1B Display Id
    AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT (EPITHELIAL NA+ CHANNEL BETA SUBUNIT) (BETA ENAC) (NONVOLTAGE-GATED SODIUM CHANNEL 1 BETA SUBUNIT) (SCNEB) (BETA NACH) (ENACB). [SOURCE:UNIPROT/SWISSPROT;ACC:P51168] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P51168

    • Version: January-2014

    Alternate Names:
    SCNN1B Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.6.1.1

    Publications:

  • TEND: P51168

    • Version: 01-August-2011

    Alternate Names:
    6338 Entrez Gene Id
    SCNNB_HUMAN Uniprot Id
    ENSG00000168447 Ensembl Gene Id

    Gene Info:
    Transmembrane Helix Count 2
    Target Subclass Amiloride-sensitive Na+ channel
    Target Subclass Channels

    Publications:

  • HopkinsGroom: P51168

    • Version: 11-September-2012

    Alternate Names:
    6338 Entrez Gene Id
    AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA Uniprot Protein Name
    SCNN1B Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Interpro Short Name Na+channel_ASC

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • PharmGKB: SCNN1B

    • Version: 18-August-2020

    Alternate Names:
    PA306 PharmGKB ID

    Gene Info:

    Publications:
    Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
    Spraggs C et al., 2007, Genetic variants in the epithelial sodium channel associate with oedema in type 2 diabetic patients receiving the peroxisome proliferator-activated receptor gamma agonist farglitazar., Pharmacogenet Genomics

  • ChemblInteractions: SCNN1B

    • Version: chembl_23

    Alternate Names:
    SCNN1B GENE_SYMBOL
    Amiloride-sensitive sodium channel subunit beta UNIPROT
    Beta-NaCH UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000168447

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000168447 Gene Symbol
    SCNN1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: SCNN1B

    • Version: 01-February-2022

    Alternate Names:
    Amiloride-sensitive sodium channel subunit beta Gene Name
    P51168 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • GO: SCNN1B

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21