DGIdb - SELE Gene Record

SELE 6401 Druggable Genome

Alternate Names:

6401
SELECTIN E
SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
131210
10718
ENSG00000007908
OTTHUMG00000034851
P16581
ELAM-1
LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 2
ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1
E-SELECTIN
CD_antigen=CD62E
CD62 antigen-like family member E
BE0001074
PA35640
T72835

Gene Info:

Target Class	Receptors
Target Subclass	Receptors
Target Subclass	Selectin
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood
Chen et al., 2004, Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells., Arterioscler. Thromb. Vasc. Biol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

RIVIPANSEL SELE

Interaction Score: 6.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Selectin E antagonist

Trial Name GMI-1070

PMIDs:
20508165

Sources:
TdgClinicalTrial ChemblInteractions TTD
SIALYL LEWIS X SELE

Interaction Score: 5.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
UPROLESELAN SELE

Interaction Score: 5.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BIMOSIAMOSE SELE

Interaction Score: 5.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name bimosiamose, TBC 1269

Novel drug target Novel Target

Mechanism of Interaction Selectin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
CHEMBL1234621 SELE

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17016423 17139284

Sources:
DrugBank
ENDOSTATIN SELE

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
LEUCOVORIN SELE

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB
CARVEDILOL SELE

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15374848

Sources:
DrugBank
CAPECITABINE SELE

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB
OXALIPLATIN SELE

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB
FLUOROURACIL SELE

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB

Ensembl: ENSG00000007908
- Version: 101_38
Alternate Names:

SELE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P16581
- Version: January-2014
Alternate Names:

SELE Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Selectin

Publications:

PharmGKB: SELE

Version: 18-August-2020

Alternate Names:

PA35640 PharmGKB ID

Gene Info:

Publications:

Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

DrugBank: BE0001074

Version: 5.1.7

Alternate Names:

SELE DrugBank Gene Name

P16581 UniProt Accession

6401 Entrez Gene Id

Gene Info:

Publications:

Chen et al., 2004, Carvedilol inhibits tumor necrosis factor-alpha-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells., Arterioscler. Thromb. Vasc. Biol.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

TTD: E-selectin
- Version: 2020.06.01
Alternate Names:

SELE TTD Gene Abbreviation

T72835 TTD Target ID

Gene Info:

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood
HingoraniCasas: ENSG00000007908
- Version: 31-May-2017
Alternate Names:

ENSG00000007908 Gene Symbol

SELE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ELAM1
- Version: chembl_23
Alternate Names:

ELAM1 GENE_SYMBOL

SELE GENE_SYMBOL

E-selectin UNIPROT

Gene Info:

Publications:
DTC: SELE
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Selectin E antagonist
Trial Name	GMI-1070

Trial Name	bimosiamose, TBC 1269
Novel drug target	Novel Target
Mechanism of Interaction	Selectin inhibitor

SELE	DrugBank Gene Name
P16581	UniProt Accession
6401	Entrez Gene Id

SELE Gene Record

SELE 6401 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Selectin E antagonist Trial Name GMI-1070

PMIDs: 20508165

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name bimosiamose, TBC 1269 Novel drug target Novel Target Mechanism of Interaction Selectin inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17016423 17139284

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15374848

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Ensembl: ENSG00000007908

Alternate Names: SELE Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P16581

Alternate Names: SELE Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass Selectin

Publications:

PharmGKB: SELE

Alternate Names: PA35640 PharmGKB ID

Gene Info:

Publications: Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

DrugBank: BE0001074

Alternate Names: SELE DrugBank Gene Name P16581 UniProt Accession 6401 Entrez Gene Id

Gene Info:

TTD: E-selectin

Alternate Names: SELE TTD Gene Abbreviation T72835 TTD Target ID

Gene Info:

Publications: Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

HingoraniCasas: ENSG00000007908

Alternate Names: ENSG00000007908 Gene Symbol SELE Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ELAM1

Alternate Names: ELAM1 GENE_SYMBOL SELE GENE_SYMBOL E-selectin UNIPROT

Gene Info:

Publications:

DTC: SELE

Alternate Names:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Selectin E antagonist

Trial Name GMI-1070

PMIDs:
20508165

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name bimosiamose, TBC 1269

Novel drug target Novel Target

Mechanism of Interaction Selectin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
17016423 17139284

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15374848

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Alternate Names:

SELE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SELE Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Selectin

Alternate Names:

PA35640 PharmGKB ID

Publications:

Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

Alternate Names:

SELE DrugBank Gene Name

P16581 UniProt Accession

6401 Entrez Gene Id

Alternate Names:

SELE TTD Gene Abbreviation

T72835 TTD Target ID

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

Alternate Names:

ENSG00000007908 Gene Symbol

SELE Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ELAM1 GENE_SYMBOL

SELE GENE_SYMBOL

E-selectin UNIPROT