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SELE Gene Record

  • Summary
  • Interactions
  • Claims
  • SELE 6401 Druggable Genome

    Alternate Names:

    6401
    SELECTIN E
    SELE
    CD62E
    ELAM
    ELAM1
    ESEL
    LECAM2
    131210
    10718
    ENSG00000007908
    OTTHUMG00000034851
    P16581
    ELAM-1
    LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 2
    ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1
    E-SELECTIN
    CD_antigen=CD62E
    CD62 antigen-like family member E
    PA35640
    T72835

    Gene Info:

    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Selectin
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther
    Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood
  • RIVIPANSEL   SELE

    Interaction Score: 10.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Selectin E antagonist
    Trial Name GMI-1070

    PMIDs:
    20508165


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • SIALYL LEWIS X   SELE

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • UPROLESELAN   SELE

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BIMOSIAMOSE   SELE

    Interaction Score: 7.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name bimosiamose, TBC 1269
    Novel drug target Novel Target
    Mechanism of Interaction Selectin inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • LEUCOVORIN   SELE

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24980946


    Sources:
    PharmGKB

  • CAPECITABINE   SELE

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24980946


    Sources:
    PharmGKB

  • OXALIPLATIN   SELE

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24980946


    Sources:
    PharmGKB

  • FLUOROURACIL   SELE

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24980946


    Sources:
    PharmGKB

  • Ensembl: ENSG00000007908

    • Version: 101_38

    Alternate Names:
    SELE Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P16581

    • Version: January-2014

    Alternate Names:
    SELE Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Selectin

    Publications:

  • PharmGKB: SELE

    • Version: 18-August-2020

    Alternate Names:
    PA35640 PharmGKB ID

    Gene Info:

    Publications:
    Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

  • TTD: E-selectin

    • Version: 2020.06.01

    Alternate Names:
    SELE TTD Gene Abbreviation
    T72835 TTD Target ID

    Gene Info:

    Publications:
    Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

  • HingoraniCasas: ENSG00000007908

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000007908 Gene Symbol
    SELE Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ELAM1

    • Version: chembl_23

    Alternate Names:
    ELAM1 GENE_SYMBOL
    SELE GENE_SYMBOL
    E-selectin UNIPROT

    Gene Info:

    Publications:

  • GO: SELE

    • Version: 01-February-2022

    Alternate Names:
    ELAM1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • DTC: SELE

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21