DGIdb - SELE Gene Record

SELE 6401 Druggable Genome

Alternate Names:

6401
SELECTIN E
SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
131210
10718
ENSG00000007908
OTTHUMG00000034851
P16581
ELAM-1
LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 2
ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1
E-SELECTIN
CD_antigen=CD62E
CD62 antigen-like family member E
PA35640
T72835

Gene Info:

Target Class	Receptors
Target Subclass	Receptors
Target Subclass	Selectin
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther
Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

RIVIPANSEL SELE

Interaction Score: 10.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Selectin E antagonist

Trial Name GMI-1070

PMIDs:
20508165

Sources:
TdgClinicalTrial ChemblInteractions TTD
SIALYL LEWIS X SELE

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
UPROLESELAN SELE

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BIMOSIAMOSE SELE

Interaction Score: 7.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name bimosiamose, TBC 1269

Novel drug target Novel Target

Mechanism of Interaction Selectin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
LEUCOVORIN SELE

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB
CAPECITABINE SELE

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB
OXALIPLATIN SELE

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB
FLUOROURACIL SELE

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24980946

Sources:
PharmGKB

Ensembl: ENSG00000007908
- Version: 101_38
Alternate Names:

SELE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P16581
- Version: January-2014
Alternate Names:

SELE Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Selectin

Publications:

PharmGKB: SELE

Version: 18-August-2020

Alternate Names:

PA35640 PharmGKB ID

Gene Info:

Publications:

Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

TTD: E-selectin
- Version: 2020.06.01
Alternate Names:

SELE TTD Gene Abbreviation

T72835 TTD Target ID

Gene Info:

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood
HingoraniCasas: ENSG00000007908
- Version: 31-May-2017
Alternate Names:

ENSG00000007908 Gene Symbol

SELE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ELAM1
- Version: chembl_23
Alternate Names:

ELAM1 GENE_SYMBOL

SELE GENE_SYMBOL

E-selectin UNIPROT

Gene Info:

Publications:
GO: SELE
- Version: 01-February-2022
Alternate Names:

ELAM1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
DTC: SELE
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Selectin E antagonist
Trial Name	GMI-1070

Trial Name	bimosiamose, TBC 1269
Novel drug target	Novel Target
Mechanism of Interaction	Selectin inhibitor

ELAM1	GENE_SYMBOL
SELE	GENE_SYMBOL
E-selectin	UNIPROT

SELE Gene Record

SELE 6401 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Selectin E antagonist Trial Name GMI-1070

PMIDs: 20508165

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name bimosiamose, TBC 1269 Novel drug target Novel Target Mechanism of Interaction Selectin inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24980946

Sources: PharmGKB

Ensembl: ENSG00000007908

Alternate Names: SELE Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P16581

Alternate Names: SELE Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass Selectin

Publications:

PharmGKB: SELE

Alternate Names: PA35640 PharmGKB ID

Gene Info:

Publications: Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

TTD: E-selectin

Alternate Names: SELE TTD Gene Abbreviation T72835 TTD Target ID

Gene Info:

Publications: Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

HingoraniCasas: ENSG00000007908

Alternate Names: ENSG00000007908 Gene Symbol SELE Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ELAM1

Alternate Names: ELAM1 GENE_SYMBOL SELE GENE_SYMBOL E-selectin UNIPROT

Gene Info:

Publications:

GO: SELE

Alternate Names: ELAM1 GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

DTC: SELE

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Selectin E antagonist

Trial Name GMI-1070

PMIDs:
20508165

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name bimosiamose, TBC 1269

Novel drug target Novel Target

Mechanism of Interaction Selectin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24980946

Sources:
PharmGKB

Alternate Names:

SELE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SELE Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass Selectin

Alternate Names:

PA35640 PharmGKB ID

Publications:

Custodio A et al., 2014, Pharmacogenetic predictors of outcome in patients with stage II and III colon cancer treated with oxaliplatin and fluoropyrimidine-based adjuvant chemotherapy., Mol Cancer Ther

Alternate Names:

SELE TTD Gene Abbreviation

T72835 TTD Target ID

Publications:

Chang J et al., 2010, GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice., Blood

Alternate Names:

ENSG00000007908 Gene Symbol

SELE Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ELAM1 GENE_SYMBOL

SELE GENE_SYMBOL

E-selectin UNIPROT

Alternate Names:

ELAM1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE