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SERPINC1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SERPINC1 462 Druggable Genome

    Alternate Names:

    462
    SERPIN FAMILY C MEMBER 1
    SERPINC1
    AT3
    AT3D
    ATIII
    THPH7
    107300
    775
    ENSG00000117601
    OTTHUMG00000037276
    P01008
    ANT3_HUMAN
    ANTITHROMBIN-III
    Serpin C1
    ANTITHROMBIN-III PRECURSOR (ATIII). [SOURCE:UNIPROT/SWISSPROT;ACC:P01008]
    PA35026
    T73476
    ATIII-R2
    ATIII-T1
    ATIII-T2

    Gene Info:

    Target Main Class Other
    Target Subclass Enzyme Inhibitor
    Human Readable Name PROTEASE INHIBITOR
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Serpin_fam
    Interpro Acc IPR000215
    Interpro Type Family
    Interpro Name Serpin family
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Target Class Miscellaneous
    Target Subclass Enzyme regulator
    Target Class Other
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    PROTEASE INHIBITOR
    DRUGGABLE GENOME

    Publications:

    Chuang et al., 2001, Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin., J. Biol. Chem.
    Schedin-Weiss et al., 2010, Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes., Arch. Biochem. Biophys.
    Pappalardo et al., 2006, Anticoagulation management in patients undergoing open heart surgery by activated clotting time and whole blood heparin concentration., Perfusion
    Sun et al., 2007, A fluorescent polymeric heparin sensor., Chemistry
    Petitou et al., 1999, Synthesis of thrombin-inhibiting heparin mimetics without side effects., Nature
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Mirow et al., 2007, Plasma protein binding properties to immobilized heparin and heparin-albumin conjugate., Artif Organs
    Gettins et al., 2009, Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement., FEBS Lett.
    Cosmi et al., 2003, Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans., Thromb. Res.
    Harenberg, 1998, Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide., Med Res Rev
    Donat et al., 2002, The pharmacokinetics of fondaparinux sodium in healthy volunteers., Clin Pharmacokinet
    Cheng, 2002, Fondaparinux: a new antithrombotic agent., Clin Ther
    Dager et al., 2004, Special considerations with fondaparinux therapy: heparin-induced thrombocytopenia and wound healing., Pharmacotherapy
    Paolucci et al., 2002, Fondaparinux sodium mechanism of action: identification of specific binding to purified and human plasma-derived proteins., Clin Pharmacokinet
    Arbit E et al., 2006, Oral heparin: status review., Thromb J
    Bisio et al., 2009, Structural features of low-molecular-weight heparins affecting their affinity to antithrombin., Thromb. Haemost.
    Peng et al., 2005, [Effects of thrombolysis and anticoagulation on the functions of vascular endothelial cells and coagulation and fibrinolysis in patients with pulmonary thromboembolism]., Zhonghua Jie He He Hu Xi Za Zhi
    Lee et al., 2007, Enoxaparin in acute coronary syndromes., Expert Rev Cardiovasc Ther
    Florian-Kujawski et al., 2004, Differential regulation of thrombin activatable fibrinolytic inhibitor by low molecular weight heparins. Pharmacologic implications., Int Angiol
    Morris et al., 2005, Pharmacokinetics of UH and LMWH are similar with respect to antithrombin activity., Thromb. Res.
    Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J
    Garcia DA et al., 2012, Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines., Chest
    Lin et al., 2001, Antithrombin binding of low molecular weight heparins and inhibition of factor Xa., Biochim. Biophys. Acta
    Shaughnessy et al., 1995, The effects of low molecular weight and standard heparin on calcium loss from fetal rat calvaria., Blood
    Mousa, 2002, The low molecular weight heparin, tinzaparin, in thrombosis and beyond., Cardiovasc Drug Rev
  • FONDAPARINUX   SERPINC1

    Interaction Score: 16.13

    Interaction Types & Directionality:
    activator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12383039 12501872 15317404 12383040


    Sources:
    TdgClinicalTrial TEND

  • ARDEPARIN SODIUM   SERPINC1

    Interaction Score: 10.75

    Interaction Types & Directionality:
    activator (activating)
    potentiator

    Interaction Info:
    Mechanism of Interaction Antithrombin-III activator
    Direct Interaction yes

    PMIDs:
    11287128 7632944 12397367


    Sources:
    ChemblInteractions

  • SULODEXIDE   SERPINC1

    Interaction Score: 8.06

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name sulodexide, KRX-101,Sulonex

    PMIDs:
    12818259 11752352 9436179


    Sources:
    TdgClinicalTrial TEND TTD

  • DELPARANTAG   SERPINC1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22315264


    Sources:
    TTD

  • TINZAPARIN   SERPINC1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    activator (activating)
    potentiator

    Interaction Info:
    Trial Name tinzaparin sodium injection,Innohep
    Novel drug target Established target

    PMIDs:
    15767980 15567452 19888521


    Sources:
    TdgClinicalTrial

  • ENOXAPARIN   SERPINC1

    Interaction Score: 5.38

    Interaction Types & Directionality:
    activator (activating)
    potentiator

    Interaction Info:

    PMIDs:
    16686945 19888521 16207425 17489664


    Sources:
    TEND TTD

  • SEMULOPARIN SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Antithrombin-III inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ANTITHROMBIN ALFA   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • HEPARIN SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Antithrombin-III activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEPARIN CALCIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Antithrombin-III activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DANAPAROID SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Antithrombin-III activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DALTEPARIN SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Antithrombin-III activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FONDAPARINUX SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Antithrombin-III activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TINZAPARIN SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Antithrombin-III activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENOXAPARIN SODIUM   SERPINC1

    Interaction Score: 2.69

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Antithrombin-III activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEPARIN   SERPINC1

    Interaction Score: 0.93

    Interaction Types & Directionality:
    activator (activating)
    potentiator

    Interaction Info:
    Trial Name heparin
    Novel drug target Established target
    Trial Name heparin, oral, liquid

    PMIDs:
    11278930 20816747 17201083 17600786 10201371 11752352 17537059 19818773


    Sources:
    TdgClinicalTrial TEND

  • LUSUTROMBOPAG   SERPINC1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ELTROMBOPAG   SERPINC1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • AVATROMBOPAG   SERPINC1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • ESTRADIOL   SERPINC1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Estradiol,Progesterone

    PMIDs:
    None found


    Sources:
    FDA

  • CARBOPLATIN   SERPINC1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31616045


    Sources:
    PharmGKB

  • GEMCITABINE   SERPINC1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31616045


    Sources:
    PharmGKB

  • PROGESTERONE   SERPINC1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Estradiol,Progesterone

    PMIDs:
    None found


    Sources:
    FDA

  • Ensembl: ENSG00000117601

    • Version: 101_38

    Alternate Names:
    SERPINC1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P01008

    • Version: 01-August-2011

    Alternate Names:
    462 Entrez Gene Id
    SERPINC1 Gene Symbol
    ANT3_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Other
    Target Subclass Enzyme Inhibitor

    Publications:

  • RussLampel: ENSG00000117601

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000117601 Ensembl Gene Id
    ANTITHROMBIN-III PRECURSOR (ATIII). [SOURCE:UNIPROT/SWISSPROT;ACC:P01008] Description
    SERPINC1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P01008

    • Version: January-2014

    Alternate Names:
    SERPINC1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Enzyme regulator
    Target Class Other

    Publications:

  • HopkinsGroom: P01008

    • Version: 11-September-2012

    Alternate Names:
    SERPINC1 Uniprot Gene Name
    P01008 Uniprot Accession
    462 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Serpin_fam
    Interpro Acc IPR000215

    Gene Categories:
    PROTEASE INHIBITOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: SERPINC1

    • Version: 18-August-2020

    Alternate Names:
    PA35026 PharmGKB ID

    Gene Info:

    Publications:
    Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J

  • TTD: Antithrombin-III

    • Version: 2020.06.01

    Alternate Names:
    ATIII TTD Gene Abbreviation
    T73476 TTD Target ID

    Gene Info:

    Publications:
    Garcia DA et al., 2012, Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines., Chest
    Arbit E et al., 2006, Oral heparin: status review., Thromb J

  • HingoraniCasas: ENSG00000117601

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000117601 Gene Symbol
    SERPINC1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: AT3

    • Version: chembl_23

    Alternate Names:
    AT3 GENE_SYMBOL
    SERPINC1 GENE_SYMBOL
    Antithrombin-III UNIPROT

    Gene Info:

    Publications:

  • dGene: SERPINC1

    • Version: 27-Jun-2013

    Alternate Names:
    462 Gene ID
    AT3 dGene Synonym
    AT3D dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • FDA: SERPINC1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21