• SLC10A2 6555 Druggable Genome

    Alternate Names:

    6555
    SOLUTE CARRIER FAMILY 10 MEMBER 2
    SLC10A2
    ASBT
    IBAT
    ISBT
    NTCP2
    PBAM
    601295
    10906
    ENSG00000125255
    OTTHUMG00000017313
    Ileal sodium/bile acid cotransporter
    Apical sodium-dependent bile acid transporter
    Ileal Na(+)/bile acid cotransporter
    Ileal sodium-dependent bile acid transporter
    Na(+)-dependent ileal bile acid transporter
    Sodium/taurocholate cotransporting polypeptide, ileal
    PA318
    ILEAL SODIUM/BILE ACID COTRANSPORTER (ILEAL NA(+)/BILE ACID COTRANSPORTER) (NA(+) DEPENDENT ILEAL BILE ACID TRANSPORTER) (ILEAL SODIUM-DEPENDENT BILE ACID TRANSPORTER) (ISBT) (SODIUM/TAUROCHOLATE COTRANSPORTING POLYPEPTIDE, ILEAL). [SOURCE:UNIPROT/SWISSPR
    Q12908
    NTCP2_HUMAN
    960
    Sodium/bile acid and sulphated solute cotransporter 2
    T24982

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Name Bile acid:sodium symporter
    Interpro Acc IPR002657
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name TRANSPORTER
    Uniprot Status Swiss-Prot
    Interpro Short Name BilAc/Na_symport
    GuideToPharmacology Gene Category Name SLC10 family of sodium-bile acid co-transporters
    GuideToPharmacology Gene Category ID 182
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME
  • Interaction Score: 38.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ileal bile acid transporter inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction Measuring inhibition of IBAT-mediated glycocholic acid uptake in HEK cells.

    PMIDs:
    None found


  • Interaction Score: 12.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 12.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20038957


    Sources:
    PharmGKB