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SLC1A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC1A1 6505 Druggable Genome

    Alternate Names:

    6505
    SOLUTE CARRIER FAMILY 1 MEMBER 1
    SLC1A1
    DCBXA
    EAAC1
    EAAT3
    SCZD18
    133550
    10939
    ENSG00000106688
    OTTHUMG00000019468
    Excitatory amino acid transporter 3
    P43005
    PA35826

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Schmitt et al., 2003, Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain., Neurosci. Lett.
    Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.
    Kim et al., 2003, Effects of ethanol on the rat glutamate excitatory amino acid transporter type 3 expressed in Xenopus oocytes: role of protein kinase C and phosphatidylinositol 3-kinase., Alcohol. Clin. Exp. Res.
    Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
    Do et al., 2003, Effects of propofol on the activity of rat glutamate transporter type 3 expressed in Xenopus oocytes: the role of protein kinase C., Neurosci. Lett.
  • WORTMANNIN   SLC1A1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9502808 14574224 12401608


    Sources:
    NCI

  • LIDOCAINE   SLC1A1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12401608


    Sources:
    NCI

  • STAUROSPORINE   SLC1A1

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12759177 12401608


    Sources:
    NCI

  • CLOZAPINE   SLC1A1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12873733


    Sources:
    NCI

  • HALOPERIDOL   SLC1A1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12873733


    Sources:
    NCI

  • ALCOHOL   SLC1A1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14574224


    Sources:
    NCI

  • Ensembl: ENSG00000106688

    • Version: 101_38

    Alternate Names:
    SLC1A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SLC1A1

    • Version: 18-August-2020

    Alternate Names:
    PA35826 PharmGKB ID

    Gene Info:

    Publications:
    Real E et al., 2013, Interaction of SLC1A1 gene variants and life stress on pharmacological resistance in obsessive-compulsive disorder., Pharmacogenomics J

  • NCI: SLC1A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Schmitt et al., 2003, Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain., Neurosci. Lett.
    Do et al., 2002, The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and phosphatidylinositol 3-kinase., Anesth. Analg.
    Davis et al., 1998, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma., J. Neurosci.

  • HingoraniCasas: ENSG00000106688

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000106688 Gene Symbol
    SLC1A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: SLC1A1

    • Version: 19.3

    Alternate Names:
    ENSG00000106688 Ensembl Gene ID
    EAAC1 Human Protein Atlas Gene Synonym
    EAAT3 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: SLC1A1

    • Version: 01-February-2022

    Alternate Names:
    EAAC1 GO Gene Synonym
    EAAT3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • Pharos: SLC1A1

    • Version: 01-February-2022

    Alternate Names:
    Excitatory amino acid transporter 3 Gene Name
    P43005 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21