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SLC22A6 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC22A6 9356 Druggable Genome

    Alternate Names:

    9356
    SOLUTE CARRIER FAMILY 22 MEMBER 6
    SLC22A6
    HOAT1
    OAT1
    PAHT
    ROAT1
    607582
    10970
    ENSG00000197901
    OTTHUMG00000167767
    hROAT1
    Renal organic anion transporter 1
    hPAHT
    Organic anion transporter 1
    PAH transporter
    PA388
    SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008]

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Bleasby K et al., 2005, Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)., J Pharmacol Exp Ther
    Sheng XC et al., 2012, Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity., Bioorg Med Chem Lett
    Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
    Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Hashimoto et al., 2004, Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters., Drug Metab. Dispos.
    Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
  • CIDOFOVIR   SLC22A6

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15914676


    Sources:
    PharmGKB

  • PROBENECID   SLC22A6

    Interaction Score: 6.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Solute carrier family 22 member 6 inhibitor
    Direct Interaction yes

    PMIDs:
    11426832 12130730 11752352 15377641 11669456


    Sources:
    ChemblInteractions

  • GS-9256   SLC22A6

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22244938


    Sources:
    DTC

  • PRATOSARTAN   SLC22A6

    Interaction Score: 1.93

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Solute carrier family 22 member 6 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TENOFOVIR   SLC22A6

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15914676


    Sources:
    PharmGKB

  • ZIDOVUDINE   SLC22A6

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • RUCAPARIB   SLC22A6

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PRAVASTATIN   SLC22A6

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000197901

    • Version: 101_38

    Alternate Names:
    SLC22A6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000197901

    • Version: 26-July-2011

    Alternate Names:
    SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008] Description
    SLC22A6 Display Id
    ENSG00000197901 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLC22A6

    • Version: 18-August-2020

    Alternate Names:
    PA388 PharmGKB ID

    Gene Info:

    Publications:
    Bleasby K et al., 2005, Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)., J Pharmacol Exp Ther
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Fujita T et al., 2005, Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)., Pharmacogenet Genomics

  • DTC: SLC22A6

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Sheng XC et al., 2012, Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000197901

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000197901 Gene Symbol
    SLC22A6 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: OAT1

    • Version: chembl_23

    Alternate Names:
    PAHT GENE_SYMBOL
    SLC22A6 GENE_SYMBOL
    Solute carrier family 22 member 6 UNIPROT

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21