DGIdb - SLC22A6 Gene Record

SLC22A6 9356 Druggable Genome

Alternate Names:

9356
SOLUTE CARRIER FAMILY 22 MEMBER 6
SLC22A6
HOAT1
OAT1
PAHT
ROAT1
607582
10970
ENSG00000197901
OTTHUMG00000167767
hROAT1
Renal organic anion transporter 1
hPAHT
Organic anion transporter 1
PAH transporter
Q4U2R8
1025
PA388
SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008]

Gene Info:

GuideToPharmacology Gene Category Name	Organic anion transporters (OATs)
GuideToPharmacology Gene Category ID	198
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Bleasby K et al., 2005, Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)., J Pharmacol Exp Ther
Sheng XC et al., 2012, Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity., Bioorg Med Chem Lett
Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hashimoto et al., 2004, Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters., Drug Metab. Dispos.
Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

CIDOFOVIR SLC22A6

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15914676

Sources:
PharmGKB
PROBENECID SLC22A6

Interaction Score: 6.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Details of Interaction Inhibition of urate transport by human SCL22A6.

Endogenous Drug? False

PMIDs:
11426832 12130730 11752352 15377641 11669456

Sources:
ChemblInteractions GuideToPharmacology
GS-9256 SLC22A6

Interaction Score: 5.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22244938

Sources:
DTC
PRATOSARTAN SLC22A6

Interaction Score: 1.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Solute carrier family 22 member 6 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TENOFOVIR SLC22A6

Interaction Score: 1.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15914676

Sources:
PharmGKB
ZIDOVUDINE SLC22A6

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662

Sources:
PharmGKB
RUCAPARIB SLC22A6

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PRAVASTATIN SLC22A6

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000197901
- Version: 101_38
Alternate Names:

SLC22A6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000197901
- Version: 26-July-2011
Alternate Names:

SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008] Description

SLC22A6 Display Id

ENSG00000197901 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 9356
- Version: 29-September-2020
Alternate Names:

10970 HUGO Gene ID

10970 HUGO Gene Symbol

solute carrier family 22 member 6 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Organic anion transporters (OATs)

GuideToPharmacology Gene Category ID 198

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: SLC22A6

Version: 18-August-2020

Alternate Names:

PA388 PharmGKB ID

Gene Info:

Publications:

Bleasby K et al., 2005, Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6)., J Pharmacol Exp Ther

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

Fujita T et al., 2005, Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)., Pharmacogenet Genomics

DTC: SLC22A6
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Sheng XC et al., 2012, Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity., Bioorg Med Chem Lett
HingoraniCasas: ENSG00000197901
- Version: 31-May-2017
Alternate Names:

ENSG00000197901 Gene Symbol

SLC22A6 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: OAT1
- Version: chembl_23
Alternate Names:

PAHT GENE_SYMBOL

SLC22A6 GENE_SYMBOL

Solute carrier family 22 member 6 UNIPROT

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Details of Interaction	Inhibition of urate transport by human SCL22A6.
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	Solute carrier family 22 member 6 inhibitor

SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008]	Description
SLC22A6	Display Id
ENSG00000197901	Ensembl Gene Id

10970	HUGO Gene ID
10970	HUGO Gene Symbol
solute carrier family 22 member 6	HUGO Gene Name

PAHT	GENE_SYMBOL
SLC22A6	GENE_SYMBOL
Solute carrier family 22 member 6	UNIPROT

SLC22A6 Gene Record

SLC22A6 9356 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15914676

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Details of Interaction Inhibition of urate transport by human SCL22A6. Endogenous Drug? False

PMIDs: 11426832 12130730 11752352 15377641 11669456

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22244938

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Solute carrier family 22 member 6 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15914676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000197901

Alternate Names: SLC22A6 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000197901

Alternate Names: SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008] Description SLC22A6 Display Id ENSG00000197901 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 9356

Alternate Names: 10970 HUGO Gene ID 10970 HUGO Gene Symbol solute carrier family 22 member 6 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Organic anion transporters (OATs) GuideToPharmacology Gene Category ID 198

Gene Categories: TRANSPORTER

Publications:

PharmGKB: SLC22A6

Alternate Names: PA388 PharmGKB ID

Gene Info:

DTC: SLC22A6

Alternate Names:

Gene Info:

Publications: Sheng XC et al., 2012, Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000197901

Alternate Names: ENSG00000197901 Gene Symbol SLC22A6 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: OAT1

Alternate Names: PAHT GENE_SYMBOL SLC22A6 GENE_SYMBOL Solute carrier family 22 member 6 UNIPROT

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
15914676

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Details of Interaction Inhibition of urate transport by human SCL22A6.

Endogenous Drug? False

PMIDs:
11426832 12130730 11752352 15377641 11669456

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22244938

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Solute carrier family 22 member 6 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15914676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22960662

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

SLC22A6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SOLUTE CARRIER FAMILY 22 MEMBER 6 ISOFORM B [SOURCE:REFSEQ_PEPTIDE;ACC:NP_695008] Description

SLC22A6 Display Id

ENSG00000197901 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10970 HUGO Gene ID

10970 HUGO Gene Symbol

solute carrier family 22 member 6 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Organic anion transporters (OATs)

GuideToPharmacology Gene Category ID 198

Gene Categories:

TRANSPORTER

Alternate Names:

PA388 PharmGKB ID

Publications:

Sheng XC et al., 2012, Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity., Bioorg Med Chem Lett

Alternate Names:

ENSG00000197901 Gene Symbol

SLC22A6 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PAHT GENE_SYMBOL

SLC22A6 GENE_SYMBOL

Solute carrier family 22 member 6 UNIPROT