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SLC28A2 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC28A2 9153 Druggable Genome

    Alternate Names:

    9153
    SOLUTE CARRIER FAMILY 28 MEMBER 2
    SLC28A2
    CNT2
    HCNT2
    HsT17153
    SPNT1
    606208
    11002
    ENSG00000137860
    OTTHUMG00000131426
    O43868
    Sodium/nucleoside cotransporter 2
    PA386

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos
    Lang et al., 2001, Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells., Mol. Pharmacol.
    Tanaka M et al., 2010, Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer., Cancer
    Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer
    Ampuero J et al., 2015, Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment., J Clin Virol
    Cusato J et al., 2015, Intracellular accumulation of boceprevir according to plasma concentrations and pharmacogenetics., Int J Antimicrob Agents
    Li et al., 2001, Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood-brain barrier., J. Pharmacol. Exp. Ther.
  • URIDINE   SLC28A2

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11641443 23388705


    Sources:
    DTC NCI

  • THYMIDINE   SLC28A2

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11602688


    Sources:
    NCI

  • BOCEPREVIR   SLC28A2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25836019


    Sources:
    PharmGKB

  • ADENOSINE   SLC28A2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23388705


    Sources:
    DTC

  • RIBAVIRIN   SLC28A2

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26071337


    Sources:
    PharmGKB

  • GEMCITABINE   SLC28A2

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20665488 18538445


    Sources:
    PharmGKB

  • Ensembl: ENSG00000137860

    • Version: 101_38

    Alternate Names:
    SLC28A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SLC28A2

    • Version: 18-August-2020

    Alternate Names:
    PA386 PharmGKB ID

    Gene Info:

    Publications:
    Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer
    Tanaka M et al., 2010, Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer., Cancer
    Ampuero J et al., 2015, Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment., J Clin Virol

  • NCI: SLC28A2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lang et al., 2001, Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells., Mol. Pharmacol.
    Li et al., 2001, Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood-brain barrier., J. Pharmacol. Exp. Ther.

  • DTC: SLC28A2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

  • HingoraniCasas: ENSG00000137860

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137860 Gene Symbol
    SLC28A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: SLC28A2

    • Version: 01-February-2022

    Alternate Names:
    CNT2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • Pharos: SLC28A2

    • Version: 01-February-2022

    Alternate Names:
    Sodium/nucleoside cotransporter 2 Gene Name
    O43868 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21