DGIdb - SLC29A1 Gene Record

SLC29A1 2030 Druggable Genome

Alternate Names:

2030
SOLUTE CARRIER FAMILY 29 MEMBER 1 (AUGUSTINE BLOOD GROUP)
SLC29A1
ENT1
602193
11003
ENSG00000112759
OTTHUMG00000014759
Equilibrative nucleoside transporter 1
Q99808
Equilibrative NBMPR-sensitive nucleoside transporter
Solute carrier family 29 member 1
Nucleoside transporter, es-type
Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
PA154
T13491

Gene Info:

Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Lee SY et al., 2014, Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy., Eur J Cancer
Alvarellos ML et al., 2014, PharmGKB summary: gemcitabine pathway., Pharmacogenet Genomics
Liu ZQ et al., 2014, Prognostic value of human equilibrative nucleoside transporter1 in pancreatic cancer receiving gemcitabin-based chemotherapy: a meta-analysis., PLoS One
Maréchal R et al., 2012, Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma., Gastroenterology
Tanaka M et al., 2010, Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer., Cancer
Choi et al., 2004, The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference., Nat. Neurosci.
Allen-Gipson et al., 2009, Ethanol blocks adenosine uptake via inhibiting the nucleoside transport system in bronchial epithelial cells., Alcohol. Clin. Exp. Res.
Morello J et al., 2010, Influence of a single nucleotide polymorphism at the main ribavirin transporter gene on the rapid virological response to pegylated interferon-ribavirin therapy in patients with chronic hepatitis C virus infection., J Infect Dis
Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos
Hammond, 2000, Interaction of a series of draflazine analogues with equilibrative nucleoside transporters: species differences and transporter subtype selectivity., Naunyn Schmiedebergs Arch. Pharmacol.
Suenaga M et al., 2017, Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer., Eur J Cancer
Lagisetty P et al., 2009, Synthesis of radiolabeled cytarabine conjugates., Bioorg Med Chem Lett

NITROBENZYLMERCAPTOPURINE RIBONUCLEOSIDE SLC29A1

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19574048

Sources:
DTC
TRIFLURIDINE SLC29A1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28992563

Sources:
PharmGKB
TECADENOSON SLC29A1

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23388705

Sources:
DTC
URIDINE SLC29A1

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10763851

Sources:
NCI
LIDOFLAZINE SLC29A1

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FLUDARABINE SLC29A1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23388705

Sources:
DTC
GEMCITABINE SLC29A1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25162786 24475233 24361227 22705007 20665488

Sources:
PharmGKB
RIBAVIRIN SLC29A1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20812847

Sources:
PharmGKB
ALCOHOL SLC29A1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15258586 19298329

Sources:
NCI
PACLITAXEL SLC29A1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24361227

Sources:
PharmGKB
DIPYRIDAMOLE SLC29A1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Equilibrative nucleoside transporter 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000112759
- Version: 101_38
Alternate Names:

SLC29A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: SLC29A1

Version: 18-August-2020

Alternate Names:

PA154 PharmGKB ID

Gene Info:

Publications:

Lee SY et al., 2014, Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy., Eur J Cancer

Morello J et al., 2010, Influence of a single nucleotide polymorphism at the main ribavirin transporter gene on the rapid virological response to pegylated interferon-ribavirin therapy in patients with chronic hepatitis C virus infection., J Infect Dis

Suenaga M et al., 2017, Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer., Eur J Cancer

NCI: SLC29A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Soler et al., 2003, Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways., Biochem. J.

Takagaki et al., 2004, Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells., J. Biochem.

Choi et al., 2004, The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference., Nat. Neurosci.

DTC: SLC29A1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

Lagisetty P et al., 2009, Synthesis of radiolabeled cytarabine conjugates., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000112759
- Version: 31-May-2017
Alternate Names:

ENSG00000112759 Gene Symbol

SLC29A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ENT1
- Version: chembl_23
Alternate Names:

ENT1 GENE_SYMBOL

SLC29A1 GENE_SYMBOL

Equilibrative nucleoside transporter 1 UNIPROT

Gene Info:

Publications:
GO: SLC29A1
- Version: 01-February-2022
Alternate Names:

ENT1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Solute carrier family 29 member 1
- Version: 2020.06.01
Alternate Names:

SLC29A1 TTD Gene Abbreviation

T13491 TTD Target ID

Gene Info:

Publications:
Pharos: SLC29A1
- Version: 01-February-2022
Alternate Names:

Equilibrative nucleoside transporter 1 Gene Name

Q99808 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

Direct Interaction	yes
Mechanism of Interaction	Equilibrative nucleoside transporter 1 inhibitor

ENT1	GENE_SYMBOL
SLC29A1	GENE_SYMBOL
Equilibrative nucleoside transporter 1	UNIPROT

Equilibrative nucleoside transporter 1	Gene Name
Q99808	UniProt ID

SLC29A1 Gene Record

SLC29A1 2030 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19574048

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28992563

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23388705

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10763851

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23388705

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25162786 24475233 24361227 22705007 20665488

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20812847

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15258586 19298329

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24361227

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Equilibrative nucleoside transporter 1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000112759

Alternate Names: SLC29A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: SLC29A1

Alternate Names: PA154 PharmGKB ID

Gene Info:

NCI: SLC29A1

Alternate Names:

Gene Info:

DTC: SLC29A1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000112759

Alternate Names: ENSG00000112759 Gene Symbol SLC29A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ENT1

Alternate Names: ENT1 GENE_SYMBOL SLC29A1 GENE_SYMBOL Equilibrative nucleoside transporter 1 UNIPROT

Gene Info:

Publications:

GO: SLC29A1

Alternate Names: ENT1 GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Solute carrier family 29 member 1

Alternate Names: SLC29A1 TTD Gene Abbreviation T13491 TTD Target ID

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
19574048

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
28992563

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23388705

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10763851

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
23388705

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25162786 24475233 24361227 22705007 20665488

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20812847

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15258586 19298329

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24361227

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Equilibrative nucleoside transporter 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

SLC29A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA154 PharmGKB ID

Alternate Names:

ENSG00000112759 Gene Symbol

SLC29A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENT1 GENE_SYMBOL

SLC29A1 GENE_SYMBOL

Equilibrative nucleoside transporter 1 UNIPROT

Alternate Names:

ENT1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

SLC29A1 TTD Gene Abbreviation

T13491 TTD Target ID

Alternate Names:

Equilibrative nucleoside transporter 1 Gene Name

Q99808 UniProt ID

Gene Categories:

TRANSPORTER