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SLC2A4 Gene Record

  • Summary
  • Interactions
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  • SLC2A4 6517 Druggable Genome

    Alternate Names:

    6517
    SOLUTE CARRIER FAMILY 2 MEMBER 4
    SLC2A4
    GLUT4
    138190
    11009
    ENSG00000181856
    OTTHUMG00000102181
    P14672
    SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 4 (GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE). [SOURCE:UNIPROT/SWISSPROT;ACC:P14672]
    Glucose transporter type 4
    T67658
    Solute carrier family 2, facilitated glucose transporter member 4

    Gene Info:

    Target Class Transporters
    Target Subclass TC:2.A.1.1.80
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Lira et al., 2007, Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
    Kondapaka et al., 2004, 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport., Clin. Cancer Res.
    Yan et al., 2008, [Induction of insulin resistance induced by PI-3K inhibitor in porcine granulosa cells]., Zhonghua Fu Chan Ke Za Zhi
    Semiz et al., 2003, Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules., EMBO J.
    Bose et al., Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c., Nature
    Somwar et al., 2001, Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport., J. Biol. Chem.
    Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.
    Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol
    Egert et al., 1999, Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart., Circ. Res.
    Ros-Baro et al., 2001, Lipid rafts are required for GLUT4 internalization in adipose cells., Proc. Natl. Acad. Sci. U.S.A.
    Young et al., 2002, Effects of rearing temperature on sympathoadrenal activity in young adult rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Ohtake et al., 1995, Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET., J. Nucl. Med.
    McFalls et al., Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium., J Nucl Cardiol
    Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.
    Vettor et al., 2000, Substrate competition and insulin action in animal models., Int. J. Obes. Relat. Metab. Disord.
    Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.
    Sajan et al., 2002, Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D., Biochem. J.
    Shimoyama et al., 2006, Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation., Metab. Clin. Exp.
    Jacob et al., 1996, Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle., Metab. Clin. Exp.
    Goto et al., 1997, Effect of triiodothyronine on glucose transport in rat adipocytes., Life Sci.
    Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.
    Huang et al., 2005, Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes., J. Biol. Chem.
    Hawkins et al., 1997, The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake., J. Biol. Chem.
    Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.
    Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.
    Tarn et al., 2006, Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms., Cancer Res.
    Ledwig et al., 2002, Early acarbose treatment ameliorates resistance of insulin-regulated GLUT4 trafficking in obese Zucker rats., Eur. J. Pharmacol.
    Sato et al., 2008, Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
    Hruz et al., 2002, Indinavir induces acute and reversible peripheral insulin resistance in rats., Diabetes
    Dombrowski et al., 1998, Selective impairment in GLUT4 translocation to transverse tubules in skeletal muscle of streptozotocin-induced diabetic rats., Diabetes
    Maor et al., 1999, The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor., Endocrinology
    Pedersen et al., 1990, Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM., Diabetes
    Date et al., 2005, Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury., Am. J. Physiol., Cell Physiol.
    Ordóñez et al., 2007, Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17beta-oestradiol or progesterone., Exp. Physiol.
    Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.
    James et al., 2004, Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes., J. Biol. Chem.
    Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res
    Marshall et al., 1999, GLUT-1 or GLUT-4 transgenes in obese mice improve glucose tolerance but do not prevent insulin resistance., Am. J. Physiol.
    Noguchi et al., 1998, Insulin resistance in cancer patients is associated with enhanced tumor necrosis factor-alpha expression in skeletal muscle., Biochem. Biophys. Res. Commun.
    Anai et al., 1998, Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2., J. Biol. Chem.
    Hansen et al., 1998, A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms., J. Biol. Chem.
    Garvey et al., 1998, Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance., J. Clin. Invest.
    Katayama et al., 1997, Glucose intolerance in spontaneously hypertensive and Wistar-Kyoto rats: enhanced gene expression and synthesis of skeletal muscle glucose transporter 4., Hypertens. Res.
    Shimaya et al., 1997, Insulin sensitizer YM268 ameliorates insulin resistance by normalizing the decreased content of GLUT4 in adipose tissue of obese Zucker rats., Eur. J. Endocrinol.
    Yoshikawa et al., Insulin resistance and the alterations of glucose transporter-4 in adipose cells from cachectic tumor-bearing rats., JPEN J Parenter Enteral Nutr
    Buse et al., 1997, Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice., Am. J. Physiol.
    Smith et al., 1997, Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4., Am. J. Physiol.
    Etgen et al., 1997, Exercise training reverses insulin resistance in muscle by enhanced recruitment of GLUT-4 to the cell surface., Am. J. Physiol.
    Sato et al., 1997, Plasma membrane content of insulin-regulated glucose transporter in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a model of non-insulin-dependent diabetes mellitus., FEBS Lett.
    Torrance et al., 1997, Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats., Endocrinology
    Stephens et al., 1997, Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction., J. Biol. Chem.
    Seböková et al., 1995, Decreased glucose transporter protein (GLUT4) in skeletal muscle of hypertriglyceridaemic insulin-resistant rat., Physiol Res
    Baron et al., 1995, Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity., J. Clin. Invest.
    Kono-Sugita et al., 1996, Insulin-induced GLUT4 recycling in rat adipose cells by a pathway insensitive to brefeldin A., Eur. J. Biochem.
    Thompson et al., 1996, Insulin regulation of multiple ribonucleic acid species in human skeletal muscle in insulin-sensitive and insulin-resistant subjects., J. Clin. Endocrinol. Metab.
    Rett et al., 1996, Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin., Diabetes
    Tsao et al., 1996, Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle., Diabetes
    Kahn et al., 1993, Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity., Endocrinology
    Weinstein et al., 1993, Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle., Metab. Clin. Exp.
    Matthaei et al., 1993, In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes., Endocrinology
    Robinson et al., 1993, Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor., Diabetes
    Müller et al., 1993, The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro., Diabetes
    Schalin-Jäntti et al., 1994, Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives., Diabetologia
    Brozinick et al., 1994, Glucose uptake and GLUT-4 protein distribution in skeletal muscle of the obese Zucker rat., Am. J. Physiol.
    Ricort et al., 1994, Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states., FEBS Lett.
    Didyk et al., 1994, Effect of immobilization on glucose transporter expression in rat hindlimb muscles., Metab. Clin. Exp.
    Ferreras et al., 1994, Early decrease in GLUT4 protein levels in brown adipose tissue of New Zealand obese mice., Int. J. Obes. Relat. Metab. Disord.
    Livingstone et al., 1995, Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism?, Mol. Cell. Endocrinol.
    Bähr et al., 1995, Direct stimulation of myocardial glucose transport and glucose transporter-1 (GLUT1) and GLUT4 protein expression by the sulfonylurea glimepiride., Endocrinology
    Hirshman et al., 1995, Pioglitazone treatment for 7 days failed to correct the defect in glucose transport and glucose transporter translocation in obese Zucker rat (fa/fa) skeletal muscle plasma membranes., Biochem. Biophys. Res. Commun.
    Paternostro et al., 1995, Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart., Cardiovasc. Res.
    Uphues et al., 1995, Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins., Biochem. J.
    Cusin et al., 1990, Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles: a clue for increased fat depot and insulin resistance., Endocrinology
    Kozka et al., 1991, Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes., J. Biol. Chem.
    Kahn et al., 1991, Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats., J. Clin. Invest.
    Garvey et al., 1991, Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity., J. Clin. Invest.
    Friedman et al., 1991, Muscle insulin resistance in uremic humans: glucose transport, glucose transporters, and insulin receptors., Am. J. Physiol.
    Pedersen et al., 1991, High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats., Endocrinology
    Jensterle et al., 2008, Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome., Eur. J. Endocrinol.
    Liu et al., 2007, Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats., Life Sci.
    Qin et al., 2007, Voluntary running improves in vivo insulin resistance in high-salt diet fed rats., Exp. Biol. Med. (Maywood)
    Cohen, 2008, Obesity in men: the hypogonadal-estrogen receptor relationship and its effect on glucose homeostasis., Med. Hypotheses
    Seraphim et al., 2007, Age related obesity-induced shortening of GLUT4 mRNA poly(A) tail length in rat gastrocnemius skeletal muscle., Mol. Cell. Endocrinol.
    Cao et al., 2007, Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet., J. Agric. Food Chem.
    Park et al., 2007, The depletion of cellular mitochondrial DNA causes insulin resistance through the alteration of insulin receptor substrate-1 in rat myocytes., Diabetes Res. Clin. Pract.
    Deng et al., 2007, Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats., Am. J. Physiol. Heart Circ. Physiol.
    D'Alessandris et al., 2007, C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport., Diabetologia
    Bouzakri et al., 2007, MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance., J. Biol. Chem.
    Fernández-Veledo et al., 2006, Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression., Diabetologia
    Vahsen et al., 2006, Altered GLUT4 translocation in skeletal muscle of 12/15-lipoxygenase knockout mice., Horm. Metab. Res.
    Fernández-Veledo et al., 2006, Ceramide mediates TNF-alpha-induced insulin resistance on GLUT4 gene expression in brown adipocytes., Arch. Physiol. Biochem.
    Florholmen et al., 2006, Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure., Diabetologia
    Barros et al., 2006, Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha., Proc. Natl. Acad. Sci. U.S.A.
    Brichard et al., 1992, Vanadate treatment markedly increases glucose utilization in muscle of insulin-resistant fa/fa rats without modifying glucose transporter expression., Endocrinology
    Haber et al., 1992, Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone., Diabetes
    Das, 2005, A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome., Prostaglandins Leukot. Essent. Fatty Acids
    Tejero et al., 2004, Quantitative genetic analysis of glucose transporter 4 mRNA levels in baboon adipose., Obes. Res.
    Strobel et al., 2005, Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes., Biochem. J.
    Hernandez et al., 2004, Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases., Diabetologia
    Vargas et al., 2004, Abnormal subcellular distribution of GLUT4 protein in obese and insulin-treated diabetic female dogs., Braz. J. Med. Biol. Res.
    Cheng et al., 2004, In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator., J. Cell. Biochem.
    Krook et al., 2004, Sending the signal: molecular mechanisms regulating glucose uptake., Med Sci Sports Exerc
    Ivy, 2004, Muscle insulin resistance amended with exercise training: role of GLUT4 expression., Med Sci Sports Exerc
    Wu et al., 2004, Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model., Eur J Nutr
    Miura et al., 2003, Regulatory sequence elements of mouse GLUT4 gene expression in adipose tissues., Biochem. Biophys. Res. Commun.
    Bader et al., 1992, Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats., Diabetologia
    Dalen et al., 2003, Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha., J. Biol. Chem.
    Zanquetta et al., 2003, Calorie restriction reduces pinealectomy-induced insulin resistance by improving GLUT4 gene expression and its translocation to the plasma membrane., J. Pineal Res.
    Koster et al., 2003, HIV protease inhibitors acutely impair glucose-stimulated insulin release., Diabetes
    Thamotharan et al., 2003, Aberrant insulin-induced GLUT4 translocation predicts glucose intolerance in the offspring of a diabetic mother., Am. J. Physiol. Endocrinol. Metab.
    de Carvalho Papa et al., 2002, GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice., Life Sci.
    Kaburagi et al., 1999, The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family., Endocr. J.
    Abe et al., 2001, Postnatal development of glucose transporter proteins in bovine skeletal muscle and adipose tissue., J. Vet. Med. Sci.
    James et al., 2001, Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin., Diabetes
    Jaquet et al., 2001, Impaired regulation of glucose transporter 4 gene expression in insulin resistance associated with in utero undernutrition., J. Clin. Endocrinol. Metab.
    Watson et al., 2001, Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5., Am. J. Physiol., Cell Physiol.
    Gaster et al., 2001, GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?, Diabetes
    Maier et al., 2000, Long-term insulin treatment of 3T3-L1 adipocytes results in mis-targeting of GLUT4: implications for insulin-stimulated glucose transport., Diabetologia
    Maier et al., 2000, v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats., Diabetes
    Carvalho et al., 2000, Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4., Mol. Cell. Biochem.
    Li et al., 2000, Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice., FASEB J.
    Das, 1999, GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity., J Assoc Physicians India
    Storz et al., 1999, Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake., Eur. J. Biochem.
    Foran et al., 1999, Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin., J. Biol. Chem.
    Kim et al., 1999, Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle., Diabetes
    Thorell et al., 1999, Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization., Am. J. Physiol.
    Yoshikawa et al., 1999, Inhibition of IRS-1 phosphorylation and the alterations of GLUT4 in isolated adipocytes from cachectic tumor-bearing rats., Biochem. Biophys. Res. Commun.
    Nishimura et al., 1994, Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells., Biochem. J.
    Smith et al., 1993, Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin., Arch. Biochem. Biophys.
    Ikonomov et al., 2002, Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects., Endocrinology
    Fliegner et al., 2008, Up-regulation of PPARgamma in myocardial infarction., Eur. J. Heart Fail.
    Kern et al., 1993, Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein., Int. J. Biochem.
    Lapointe et al., 2005, Effects of the vasopeptidase inhibitor omapatrilat on peri- and postmyocardial infarction in Zucker lean rats., Can J Cardiol
  • OMAPATRILAT   SLC2A4

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15776120


    Sources:
    NCI

  • INSULIN   SLC2A4

    Interaction Score: 2.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9950801 9918825 9792680 9748297 9616209 9453263 9437239 9421368 9406133 9227455 9227454 9176187 9175878 9048628 8995390 8789319 8675649 8665891 8636261 8529803 8522056 8419118 8412752 8391425 8349045 8243832 8063042 8048627 8013658 7968595 7884509 7866477 7796936 7750476 7695642 7585807 7575448 2249650 2050674 2040701 1999488 1858877 1855475 18366935 18322300 17976658 17959846 17825496 17709177 17616136 17462778 17400720 17279354 17227768 17072583 16823721 16754199 16489447 16423895 1612011 1587399 15850715 15536229 15469417 15365619 15264018 15258906 15235328 15235327 15083319 14637133 1324860 12970362 12932196 12829635 12540375 12490950 12175706 12054114 11916910 11714021 11522683 11443199 11401844 11375332 11079746 10871200 10839189 10834933 10778531 10542046 10497159 10334307 10198313 10080958


    Sources:
    NCI

  • SORBITOL   SLC2A4

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11879194


    Sources:
    NCI

  • PSYLLIUM SEED HUSKS   SLC2A4

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10696527


    Sources:
    NCI

  • NYSTATIN   SLC2A4

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593015


    Sources:
    NCI

  • FLUDEOXYGLUCOSE-F18   SLC2A4

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7884509 12900743


    Sources:
    NCI

  • NEOMYCIN   SLC2A4

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15024008


    Sources:
    NCI

  • SOYBEAN OIL   SLC2A4

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10997602


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   SLC2A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15496478


    Sources:
    NCI

  • ACARBOSE   SLC2A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12065205


    Sources:
    NCI

  • GLIPIZIDE   SLC2A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8043894


    Sources:
    NCI

  • PENICILLAMINE   SLC2A4

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17666490


    Sources:
    NCI

  • URIDINE   SLC2A4

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9030547


    Sources:
    NCI

  • PHENTOLAMINE   SLC2A4

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10381893


    Sources:
    NCI

  • IRBESARTAN   SLC2A4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18162196


    Sources:
    NCI

  • INDINAVIR   SLC2A4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11916910


    Sources:
    NCI

  • WORTMANNIN   SLC2A4

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18366935 12743033 12490950 11598141


    Sources:
    NCI

  • CLOFIBRATE   SLC2A4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8557642


    Sources:
    NCI

  • GLYBURIDE   SLC2A4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8224371


    Sources:
    NCI

  • ACETYLCYSTEINE   SLC2A4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16713429


    Sources:
    NCI

  • GLUFOSFAMIDE   SLC2A4

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name Glufosfamide

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PRASTERONE   SLC2A4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18349113


    Sources:
    NCI

  • MIRTAZAPINE   SLC2A4

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002093


    Sources:
    NCI

  • UCN-01   SLC2A4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15534092


    Sources:
    NCI

  • STREPTOZOCIN   SLC2A4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9421368 10098523 2354749


    Sources:
    NCI

  • TROGLITAZONE   SLC2A4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11947963


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   SLC2A4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18591783


    Sources:
    NCI

  • STAUROSPORINE   SLC2A4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8068015


    Sources:
    NCI

  • HEPARIN   SLC2A4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10997602


    Sources:
    NCI

  • ESTRADIOL   SLC2A4

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17068109


    Sources:
    NCI

  • LIOTHYRONINE SODIUM   SLC2A4

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9217278


    Sources:
    NCI

  • EPINEPHRINE   SLC2A4

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12376414


    Sources:
    NCI

  • VERAPAMIL   SLC2A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8622594


    Sources:
    NCI

  • INDOMETHACIN   SLC2A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8557642


    Sources:
    NCI

  • CHEMBL35482   SLC2A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11978788


    Sources:
    NCI

  • RESVERATROL   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18065527


    Sources:
    NCI

  • COLCHICINE   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16239226


    Sources:
    NCI

  • GENISTEIN   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8424658


    Sources:
    NCI

  • DIPYRIDAMOLE   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1716731


    Sources:
    NCI

  • IMATINIB   SLC2A4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16707477


    Sources:
    NCI

  • HALOPERIDOL   SLC2A4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002093


    Sources:
    NCI

  • PROGESTERONE   SLC2A4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17068109


    Sources:
    NCI

  • CURCUMIN   SLC2A4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12446602


    Sources:
    NCI

  • DEXAMETHASONE   SLC2A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1587399


    Sources:
    NCI

  • Ensembl: ENSG00000181856

    • Version: 101_38

    Alternate Names:
    SLC2A4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000181856

    • Version: 26-July-2011

    Alternate Names:
    SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 4 (GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE). [SOURCE:UNIPROT/SWISSPROT;ACC:P14672] Description
    ENSG00000181856 Ensembl Gene Id
    SLC2A4 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P14672

    • Version: January-2014

    Alternate Names:
    SLC2A4 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:2.A.1.1.80

    Publications:

  • NCI: SLC2A4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.
    Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.
    Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

  • HingoraniCasas: ENSG00000181856

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000181856 Gene Symbol
    SLC2A4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: SLC2A4

    • Version: 19.3

    Alternate Names:
    ENSG00000181856 Ensembl Gene ID
    GLUT4 Human Protein Atlas Gene Synonym
    Solute carrier family 2 member 4 Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: SLC2A4

    • Version: 01-February-2022

    Alternate Names:
    GLUT4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Glucose transporter type 4

    • Version: 2020.06.01

    Alternate Names:
    SLC2A4 TTD Gene Abbreviation
    T67658 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SLC2A4

    • Version: 01-February-2022

    Alternate Names:
    Solute carrier family 2, facilitated glucose transporter member 4 Gene Name
    P14672 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21