• Interaction Score: 4.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium/glucose cotransporter 1 inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 4.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    23590413


  • Interaction Score: 2.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of sodium-dependent [14]C- alpha-methyl-glucopyranoside (AMG) transport into the interior of cells transfected with hSGLT1.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of sodium-dependent [<sup>14</sup>C]AMG-uptake in CHO cells expressing hSGLT1.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 2.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of sodium-dependent [<sup>14</sup>C]AMG-uptake in CHO cells expressing hSGLT1.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name Glufosfamide

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1722397


    Sources:
    NCI

    • Version: 101_38

    Alternate Names:
    SLC5A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    SLC5A1 Display Id
    SODIUM/GLUCOSE COTRANSPORTER 1 (NA(+)/GLUCOSE COTRANSPORTER 1) (HIGH AFFINITY SODIUM-GLUCOSE COTRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P13866] Description
    ENSG00000100170 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    SLC5A1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:2.A.21.3.1
    Target Subclass TC:2.A.21.3.16

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    11036 HUGO Gene ID
    11036 HUGO Gene Symbol
    solute carrier family 5 member 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Hexose transporter family
    GuideToPharmacology Gene Category ID 173

    Gene Categories:
    TRANSPORTER

    Publications:

    • Version: 14-September-2017
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100170 Gene Symbol
    SLC5A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    SGLT1 GENE_SYMBOL
    SLC5A1 GENE_SYMBOL
    Sodium/glucose cotransporter 1 UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000100170 Ensembl Gene ID
    D22S675 Human Protein Atlas Gene Synonym
    NAGT Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

    • Version: 03-September-2020

    Alternate Names:
    Sodium/glucose cotransporter 1 Gene Name
    P13866 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

    • Version: 05-September-2020

    Alternate Names:
    NAGT GO Gene Synonym
    SGLT1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    SGLT1 TTD Gene Abbreviation
    T54771 TTD Target ID

    Gene Info:

    Publications: