• Interaction Score: 5.67

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name BI-10773
    Novel drug target Established target
    Mechanism of Interaction Sodium/glucose cotransporter 2 inhibitor

  • Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium/glucose cotransporter 2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium/glucose cotransporter 2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium/glucose cotransporter 2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium/glucose cotransporter 2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name BMS-512148, dapagliflozin
    Specific Action of the Ligand Inhibition

  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ASP1941
    Novel drug target Established target
    Details of the Assay for Interaction Measuring inhibition of sodium-dependent [<sup>14</sup>C]AMG-uptake in CHO cells expressing hSGLT2.

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Canagliflozin
    Specific Action of the Ligand Inhibition

  • Interaction Score: 2.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 2.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 2.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 2.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 1.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measuring inhibition of sodium-dependent [14]C- alpha-methyl-glucopyranoside (AMG) transport into the interior of cells transfected with hSGLT2.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Glufosfamide
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

    • Version: 101_38

    Alternate Names:
    SLC5A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    SLC5A2 Display Id
    SODIUM/GLUCOSE COTRANSPORTER 2 (NA(+)/GLUCOSE COTRANSPORTER 2) (LOW AFFINITY SODIUM-GLUCOSE COTRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P31639] Description
    ENSG00000140675 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    SLC5A2 Gene Symbol

    Gene Info:
    Target Class Transporter
    Target Subclass TC:9.A.53.1.3

    Publications:

    • Version: January-2014

    Alternate Names:
    SLC5A2 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:2.A.21.3.16

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    11037 HUGO Gene ID
    11037 HUGO Gene Symbol
    solute carrier family 5 member 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Hexose transporter family
    GuideToPharmacology Gene Category ID 173

    Gene Categories:
    TRANSPORTER

    Publications:

    • Version: chembl_23

    Alternate Names:
    SGLT2 GENE_SYMBOL
    SLC5A2 GENE_SYMBOL
    Sodium/glucose cotransporter 2 UNIPROT

    Gene Info:

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000140675 Gene Symbol
    SLC5A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    SGLT2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Sodium/glucose cotransporter 2 Gene Name
    P31639 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications: