DGIdb - SLC7A11 Gene Record

SLC7A11 23657 Druggable Genome

Alternate Names:

23657
SOLUTE CARRIER FAMILY 7 MEMBER 11
SLC7A11
CCBR1
xCT
607933
11059
ENSG00000151012
OTTHUMG00000133396
CYSTINE/GLUTAMATE TRANSPORTER (AMINO ACID TRANSPORT SYSTEM XC-) (XCT) (CALCIUM CHANNEL BLOCKER RESISTANCE PROTEIN CCBR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UPY5]
Q9UPY5
BE0000030
902
Cystine/glutamate transporter

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Transporters
Target Subclass	TC:2.A.3.8.18
GuideToPharmacology Gene Category Name	SLC7 family
GuideToPharmacology Gene Category ID	169
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
DRUGGABLE GENOME

Publications:

Hosoya et al., 2002, Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment., J. Pharmacol. Exp. Ther.
Ruiz et al., 2003, Vitamin C inhibits diethylmaleate-induced L-cystine transport in human vascular smooth muscle cells., Free Radic. Biol. Med.
Tomi et al., 2003, Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL)., Glia
Bridges et al., 2005, Cystine and glutamate transport in renal epithelial cells transfected with human system x(-) (c)., Kidney Int.
Tomi et al., 2002, Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier., Invest. Ophthalmol. Vis. Sci.
Dean et al., 2011, N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action., J Psychiatry Neurosci
Natale et al., 2006, Can selective ligands for glutamate binding proteins be rationally designed?, Curr Top Med Chem
Azbill et al., 2000, Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes., Brain Res.
Gosselin et al., 2010, Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms., Gastroenterology
Dunlop et al., 2003, Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis., J. Neurosci.
Hayashida et al., 2010, Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats., Brain Res.
Wokke, 1996, Riluzole., Lancet
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Gout et al., 2001, Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug., Leukemia

CYSTINE SLC7A11

Interaction Score: 24.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12065721 12498985 12898700 16014042 11867597

Sources:
DrugBank
RILUZOLE SLC7A11

Interaction Score: 2.47

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name riluzole,Rilutek

Novel drug target Established target

PMIDs:
10899284 20226190 12629173 20059984 8813989

Sources:
TdgClinicalTrial DrugBank
QUISQUALATE SLC7A11

Interaction Score: 1.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
SULFASALAZINE SLC7A11

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352 11587223

Sources:
DrugBank
ACETYLCYSTEINE SLC7A11

Interaction Score: 0.65

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
21118657

Sources:
DrugBank
THIMEROSAL SLC7A11

Interaction Score: 0.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
GLUTAMIC ACID SLC7A11

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16719820

Sources:
DrugBank

Ensembl: ENSG00000151012
- Version: 101_38
Alternate Names:

SLC7A11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9UPY5
- Version: January-2014
Alternate Names:

SLC7A11 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.3.8.18

Publications:

RussLampel: ENSG00000151012

Version: 26-July-2011

Alternate Names:

SLC7A11 Display Id

CYSTINE/GLUTAMATE TRANSPORTER (AMINO ACID TRANSPORT SYSTEM XC-) (XCT) (CALCIUM CHANNEL BLOCKER RESISTANCE PROTEIN CCBR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UPY5] Description

ENSG00000151012 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 23657
- Version: 29-September-2020
Alternate Names:

11059 HUGO Gene ID

11059 HUGO Gene Symbol

solute carrier family 7 member 11 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC7 family

GuideToPharmacology Gene Category ID 169

Gene Categories:

TRANSPORTER

Publications:

DrugBank: BE0000030

Version: 5.1.7

Alternate Names:

SLC7A11 DrugBank Gene Name

Q9UPY5 UniProt Accession

23657 Entrez Gene Id

Gene Info:

Publications:

Hosoya et al., 2002, Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment., J. Pharmacol. Exp. Ther.

Ruiz et al., 2003, Vitamin C inhibits diethylmaleate-induced L-cystine transport in human vascular smooth muscle cells., Free Radic. Biol. Med.

Tomi et al., 2003, Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL)., Glia

Pharos: SLC7A11
- Version: 03-September-2020
Alternate Names:

Cystine/glutamate transporter Gene Name

Q9UPY5 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC7A11
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Trial Name	riluzole,Rilutek
Novel drug target	Established target

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

SLC7A11	Display Id
CYSTINE/GLUTAMATE TRANSPORTER (AMINO ACID TRANSPORT SYSTEM XC-) (XCT) (CALCIUM CHANNEL BLOCKER RESISTANCE PROTEIN CCBR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UPY5]	Description
ENSG00000151012	Ensembl Gene Id

11059	HUGO Gene ID
11059	HUGO Gene Symbol
solute carrier family 7 member 11	HUGO Gene Name

SLC7A11	DrugBank Gene Name
Q9UPY5	UniProt Accession
23657	Entrez Gene Id

SLC7A11 Gene Record

SLC7A11 23657 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CYSTINE SLC7A11

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12065721 12498985 12898700 16014042 11867597

Sources: DrugBank

RILUZOLE SLC7A11

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name riluzole,Rilutek Novel drug target Established target

PMIDs: 10899284 20226190 12629173 20059984 8813989

Sources: TdgClinicalTrial DrugBank

QUISQUALATE SLC7A11

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

SULFASALAZINE SLC7A11

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11752352 11587223

Sources: DrugBank

ACETYLCYSTEINE SLC7A11

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 21118657

Sources: DrugBank

THIMEROSAL SLC7A11

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: DrugBank

GLUTAMIC ACID SLC7A11

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16719820

Sources: DrugBank

Ensembl: ENSG00000151012

Alternate Names: SLC7A11 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q9UPY5

Alternate Names: SLC7A11 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:2.A.3.8.18

Publications:

RussLampel: ENSG00000151012

Alternate Names: SLC7A11 Display Id CYSTINE/GLUTAMATE TRANSPORTER (AMINO ACID TRANSPORT SYSTEM XC-) (XCT) (CALCIUM CHANNEL BLOCKER RESISTANCE PROTEIN CCBR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UPY5] Description ENSG00000151012 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 23657

Alternate Names: 11059 HUGO Gene ID 11059 HUGO Gene Symbol solute carrier family 7 member 11 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name SLC7 family GuideToPharmacology Gene Category ID 169

Gene Categories: TRANSPORTER

Publications:

DrugBank: BE0000030

Alternate Names: SLC7A11 DrugBank Gene Name Q9UPY5 UniProt Accession 23657 Entrez Gene Id

Gene Info:

Pharos: SLC7A11

Alternate Names: Cystine/glutamate transporter Gene Name Q9UPY5 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER

Publications:

GO: SLC7A11

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
12065721 12498985 12898700 16014042 11867597

Sources:
DrugBank

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name riluzole,Rilutek

Novel drug target Established target

PMIDs:
10899284 20226190 12629173 20059984 8813989

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11752352 11587223

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
21118657

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16719820

Sources:
DrugBank

Alternate Names:

SLC7A11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SLC7A11 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.3.8.18

Alternate Names:

SLC7A11 Display Id

CYSTINE/GLUTAMATE TRANSPORTER (AMINO ACID TRANSPORT SYSTEM XC-) (XCT) (CALCIUM CHANNEL BLOCKER RESISTANCE PROTEIN CCBR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UPY5] Description

ENSG00000151012 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

11059 HUGO Gene ID

11059 HUGO Gene Symbol

solute carrier family 7 member 11 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC7 family

GuideToPharmacology Gene Category ID 169

Gene Categories:

TRANSPORTER

Alternate Names:

SLC7A11 DrugBank Gene Name

Q9UPY5 UniProt Accession

23657 Entrez Gene Id

Alternate Names:

Cystine/glutamate transporter Gene Name

Q9UPY5 UniProt ID

Gene Categories:

TRANSPORTER

Gene Categories:

CELL SURFACE