DGIdb - SLCO1B3 Gene Record

SLCO1B3 28234 Druggable Genome

Alternate Names:

28234
SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3
SLCO1B3
HBLRR
LST-2
LST-3TM13
LST3
OATP-8
OATP1B3
OATP8
SLC21A8
605495
10961
ENSG00000111700
OTTHUMG00000169011
1221
Q9NPD5
PA35844
BE0003659
SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B3 (SOLUTE CARRIER FAMILY 21, MEMBER 8) (ORGANIC ANION TRANSPORTER 8) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 8) (OATP8) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 2) (LST-2). [SOURCE:UNIPROT/SWISSPR

Gene Info:

GuideToPharmacology Gene Category Name	SLCO family of organic anion transporting polypeptides
GuideToPharmacology Gene Category ID	238
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
Noé et al., 2007, Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3., Drug Metab. Dispos.
Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
Vavricka et al., 2002, Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver., Hepatology
Kloth JSL et al., 2018, Genetic polymorphisms as predictive biomarker of survival in patients with gastrointestinal stromal tumors treated with sunitinib., Pharmacogenomics J
Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
Kiyotani K et al., 2008, Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia., Cancer Sci
Zhang A et al., 2013, Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans., Drug Metab Dispos
De Bruyn et al., 2013, Structure-based identification of OATP1B1/3 inhibitors., Mol. Pharmacol.
Park HS et al., 2016, Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy., Pharmacogenet Genomics
Mbatchi LC et al., 2015, Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination., Pharmacogenomics
Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
Oballa RM et al., 2011, Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia., J Med Chem
Jiang R et al., 2015, Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3., Br J Pharmacol

GINSENOSIDE RG1 SLCO1B3

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25297453

Sources:
DrugBank
GINSENOSIDE RB1 SLCO1B3

Interaction Score: 4.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25297453

Sources:
DrugBank
SILYDIANIN SLCO1B3

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
MK-8245 SLCO1B3

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21661758

Sources:
DTC
DIOSCIN SLCO1B3

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23396419

Sources:
DTC
ISOSILYBIN B SLCO1B3

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
SULFOBROMOPHTHALEIN SLCO1B3

Interaction Score: 0.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
ELTROMBOPAG SLCO1B3

Interaction Score: 0.6

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
GEMFIBROZIL SLCO1B3

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
17470528

Sources:
DrugBank GuideToPharmacology
SILIBININ SLCO1B3

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
GLYCYRRHIZIN SLCO1B3

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLARITHROMYCIN SLCO1B3

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23571415

Sources:
DrugBank
SIMEPREVIR SLCO1B3

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
RIFAMPIN SLCO1B3

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
12085361

Sources:
GuideToPharmacology
SILDENAFIL SLCO1B3

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ROSUVASTATIN SLCO1B3

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PRAVASTATIN SLCO1B3

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615

Sources:
PharmGKB
SUNITINIB SLCO1B3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28117434

Sources:
PharmGKB
FLUVASTATIN SLCO1B3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PACLITAXEL SLCO1B3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26641474 26267044 21151855

Sources:
PharmGKB
CARBOPLATIN SLCO1B3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26641474 26267044

Sources:
PharmGKB
DOCETAXEL SLCO1B3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21151855 18294295

Sources:
PharmGKB
RUCAPARIB SLCO1B3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOVASTATIN SLCO1B3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE SLCO1B3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21317831

Sources:
PharmGKB
SIMVASTATIN SLCO1B3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ATORVASTATIN SLCO1B3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000111700
- Version: 101_38
Alternate Names:

SLCO1B3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000111700

Version: 26-July-2011

Alternate Names:

SLCO1B3 Display Id

ENSG00000111700 Ensembl Gene Id

SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B3 (SOLUTE CARRIER FAMILY 21, MEMBER 8) (ORGANIC ANION TRANSPORTER 8) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 8) (OATP8) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 2) (LST-2). [SOURCE:UNIPROT/SWISSPR Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 28234
- Version: 29-September-2020
Alternate Names:

10961 HUGO Gene ID

10961 HUGO Gene Symbol

solute carrier organic anion transporter family member 1B3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLCO family of organic anion transporting polypeptides

GuideToPharmacology Gene Category ID 238

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: SLCO1B3

Version: 18-August-2020

Alternate Names:

PA35844 PharmGKB ID

Gene Info:

Publications:

Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics

Mbatchi LC et al., 2015, Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination., Pharmacogenomics

Park HS et al., 2016, Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy., Pharmacogenet Genomics

DrugBank: BE0003659

Version: 5.1.7

Alternate Names:

SLCO1B3 DrugBank Gene Name

Q9NPD5 UniProt Accession

28234 Entrez Gene Id

Gene Info:

Publications:

De Bruyn et al., 2013, Structure-based identification of OATP1B1/3 inhibitors., Mol. Pharmacol.

Noé et al., 2007, Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3., Drug Metab. Dispos.

Jiang R et al., 2015, Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3., Br J Pharmacol

DTC: SLCO1B3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos

Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos

Oballa RM et al., 2011, Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia., J Med Chem

HingoraniCasas: ENSG00000111700
- Version: 31-May-2017
Alternate Names:

ENSG00000111700 Gene Symbol

SLCO1B3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: SLCO1B3
- Version: 19.3
Alternate Names:

Q9NPD5 UniProt ID

ENSG00000111700 Ensembl Gene ID

OATP1B3 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
Pharos: SLCO1B3
- Version: 03-September-2020
Alternate Names:

Solute carrier organic anion transporter family member 1B3 Gene Name

Q9NPD5 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

SLCO1B3	Display Id
ENSG00000111700	Ensembl Gene Id
SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B3 (SOLUTE CARRIER FAMILY 21, MEMBER 8) (ORGANIC ANION TRANSPORTER 8) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 8) (OATP8) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 2) (LST-2). [SOURCE:UNIPROT/SWISSPR	Description

10961	HUGO Gene ID
10961	HUGO Gene Symbol
solute carrier organic anion transporter family member 1B3	HUGO Gene Name

SLCO1B3	DrugBank Gene Name
Q9NPD5	UniProt Accession
28234	Entrez Gene Id

Q9NPD5	UniProt ID
ENSG00000111700	Ensembl Gene ID
OATP1B3	Human Protein Atlas Gene Synonym

Solute carrier organic anion transporter family member 1B3	Gene Name
Q9NPD5	UniProt ID

SLCO1B3 Gene Record

SLCO1B3 28234 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25297453

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25297453

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21661758

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23396419

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 17470528

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23571415

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 12085361

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25502615

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28117434

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
25297453

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25297453

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21661758

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23396419

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
17470528

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23571415

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
12085361

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25502615

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28117434

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26641474 26267044 21151855

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26641474 26267044

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21151855 18294295

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21317831

Sources:
PharmGKB

Interaction Types & Directionality:

n/a