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SLCO1B3 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLCO1B3 28234 Druggable Genome

    Alternate Names:

    28234
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B3
    SLCO1B3
    HBLRR
    LST-2
    LST-3TM13
    LST3
    OATP-8
    OATP1B3
    OATP8
    SLC21A8
    605495
    10961
    ENSG00000111700
    OTTHUMG00000169011
    Q9NPD5
    PA35844
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B3 (SOLUTE CARRIER FAMILY 21, MEMBER 8) (ORGANIC ANION TRANSPORTER 8) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 8) (OATP8) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 2) (LST-2). [SOURCE:UNIPROT/SWISSPR

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
    Kloth JSL et al., 2018, Genetic polymorphisms as predictive biomarker of survival in patients with gastrointestinal stromal tumors treated with sunitinib., Pharmacogenomics J
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
    Kiyotani K et al., 2008, Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia., Cancer Sci
    Zhang A et al., 2013, Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans., Drug Metab Dispos
    Park HS et al., 2016, Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy., Pharmacogenet Genomics
    Mbatchi LC et al., 2015, Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination., Pharmacogenomics
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Oballa RM et al., 2011, Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia., J Med Chem
  • DIOSCIN   SLCO1B3

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23396419


    Sources:
    DTC

  • SILYDIANIN   SLCO1B3

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • MK-8245   SLCO1B3

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21661758


    Sources:
    DTC

  • ISOSILYBIN B   SLCO1B3

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • SULFOBROMOPHTHALEIN   SLCO1B3

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • ELTROMBOPAG   SLCO1B3

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • SILIBININ   SLCO1B3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • SIMEPREVIR   SLCO1B3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ROSUVASTATIN   SLCO1B3

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PRAVASTATIN   SLCO1B3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25502615


    Sources:
    PharmGKB

  • SUNITINIB   SLCO1B3

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28117434


    Sources:
    PharmGKB

  • FLUVASTATIN   SLCO1B3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PACLITAXEL   SLCO1B3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26641474 26267044 21151855


    Sources:
    PharmGKB

  • DOCETAXEL   SLCO1B3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21151855 18294295


    Sources:
    PharmGKB

  • CARBOPLATIN   SLCO1B3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26641474 26267044


    Sources:
    PharmGKB

  • RUCAPARIB   SLCO1B3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOVASTATIN   SLCO1B3

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SIMVASTATIN   SLCO1B3

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHOTREXATE   SLCO1B3

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21317831


    Sources:
    PharmGKB

  • ATORVASTATIN   SLCO1B3

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000111700

    • Version: 101_38

    Alternate Names:
    SLCO1B3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000111700

    • Version: 26-July-2011

    Alternate Names:
    SLCO1B3 Display Id
    ENSG00000111700 Ensembl Gene Id
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B3 (SOLUTE CARRIER FAMILY 21, MEMBER 8) (ORGANIC ANION TRANSPORTER 8) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 8) (OATP8) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 2) (LST-2). [SOURCE:UNIPROT/SWISSPR Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLCO1B3

    • Version: 18-August-2020

    Alternate Names:
    PA35844 PharmGKB ID

    Gene Info:

    Publications:
    Oshiro C et al., 2009, Taxane pathway., Pharmacogenet Genomics
    Mbatchi LC et al., 2015, Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination., Pharmacogenomics
    Park HS et al., 2016, Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy., Pharmacogenet Genomics

  • DTC: SLCO1B3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
    Oballa RM et al., 2011, Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia., J Med Chem

  • HingoraniCasas: ENSG00000111700

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111700 Gene Symbol
    SLCO1B3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: SLCO1B3

    • Version: 19.3

    Alternate Names:
    Q9NPD5 UniProt ID
    ENSG00000111700 Ensembl Gene ID
    OATP1B3 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • Pharos: SLCO1B3

    • Version: 01-February-2022

    Alternate Names:
    Solute carrier organic anion transporter family member 1B3 Gene Name
    Q9NPD5 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21