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SREBF1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SREBF1 6720

    Alternate Names:

    6720
    STEROL REGULATORY ELEMENT BINDING TRANSCRIPTION FACTOR 1
    SREBF1
    SREBP-1c
    SREBP1
    SREBP1a
    bHLHd1
    184756
    11289
    ENSG00000072310
    OTTHUMG00000059313
    PA335
    HMD
    IFAP2
    Sterol regulatory element-binding protein 1
    P36956

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    NUCLEAR HORMONE RECEPTOR
    TRANSCRIPTION FACTOR

    Publications:

    Wagner et al., 2004, Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis., J. Lipid Res.
    Zhang et al., 2003, SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes., J. Lipid Res.
    Kotzka et al., 2000, Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade., J. Lipid Res.
  • INSULIN   SREBF1

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14594997 12576518 10627507


    Sources:
    NCI

  • FLUVASTATIN   SREBF1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000072310

    • Version: 101_38

    Alternate Names:
    SREBF1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SREBF1

    • Version: 18-August-2020

    Alternate Names:
    PA335 PharmGKB ID

    Gene Info:

    Publications:
    Vassas TJ et al., 2014, Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics., Pharmacogenomics

  • NCI: SREBF1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kotzka et al., 2000, Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade., J. Lipid Res.
    Zhang et al., 2003, SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes., J. Lipid Res.
    Wagner et al., 2004, Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis., J. Lipid Res.

  • GO: SREBF1

    • Version: 01-February-2022

    Alternate Names:
    BHLHD1 GO Gene Synonym
    SREBP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • Pharos: SREBF1

    • Version: 01-February-2022

    Alternate Names:
    Sterol regulatory element-binding protein 1 Gene Name
    P36956 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21