DGIdb - ST14 Gene Record

ST14 6768 Druggable Genome

Alternate Names:

6768
SUPPRESSION OF TUMORIGENICITY 14
ST14
ARCI11
HAI
MT-SP1
MTSP1
PRSS14
SNC19
TADG15
TMPRSS14
606797
11344
ENSG00000149418
OTTHUMG00000165768
2418
NM_021978
NP_068813
Q9Y5Y6
SUPPRESSOR OF TUMORIGENICITY 14 (EC 3.4.21.-) (MATRIPTASE) (MEMBRANE- TYPE SERINE PROTEASE 1) (MT-SP1) (PROSTAMIN) (SERINE PROTEASE TADG-15) (TUMOR ASSOCIATED DIFFERENTIALLY-EXPRESSED GENE-15 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y6]
BE0001656
ST14_HUMAN
SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN
T31543
ST14 transmembrane serine protease matriptase

Gene Info:

GuideToPharmacology Gene Category Name	S1: Chymotrypsin
GuideToPharmacology Gene Category ID	751
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	PROTEASE
Interpro Short Name	Peptidase_S1_S6
Uniprot Status	Swiss-Prot
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001254
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Lee et al., 2005, Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells., Am. J. Physiol., Cell Physiol.
Kirchhofer et al., 2003, Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1., J. Biol. Chem.
Suzuki et al., 2004, Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase., J. Biol. Chem.
Kitamura K et al., 2012, Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension., Clin Exp Nephrol

CAMOSTAT ST14

Interaction Score: 5.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22038264

Sources:
DrugBank
UROKINASE ST14

Interaction Score: 4.26

Interaction Types & Directionality:

substrate

Interaction Info:

PMIDs:
12815039 14747469

Sources:
DrugBank
BENZAMIDINE ST14

Interaction Score: 4.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
SURAMIN ST14

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15590895

Sources:
NCI

Ensembl: ENSG00000149418
- Version: 101_38
Alternate Names:

ST14 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000149418

Version: 26-July-2011

Alternate Names:

ST14 Display Id

ENSG00000149418 Ensembl Gene Id

SUPPRESSOR OF TUMORIGENICITY 14 (EC 3.4.21.-) (MATRIPTASE) (MEMBRANE- TYPE SERINE PROTEASE 1) (MT-SP1) (PROSTAMIN) (SERINE PROTEASE TADG-15) (TUMOR ASSOCIATED DIFFERENTIALLY-EXPRESSED GENE-15 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y6] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q9Y5Y6
- Version: 11-September-2012
Alternate Names:

ST14_HUMAN Uniprot Id

Q9Y5Y6 Uniprot Accession

ST14 Uniprot Gene Name

Gene Info:

Human Readable Name PROTEASE

Interpro Short Name Peptidase_S1_S6

Uniprot Status Swiss-Prot

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 6768
- Version: 29-September-2020
Alternate Names:

11344 HUGO Gene ID

11344 HUGO Gene Symbol

ST14 transmembrane serine protease matriptase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name S1: Chymotrypsin

GuideToPharmacology Gene Category ID 751

Gene Categories:

ENZYME

Publications:

DrugBank: BE0001656

Version: 5.1.7

Alternate Names:

ST14 DrugBank Gene Name

Q9Y5Y6 UniProt Accession

6768 Entrez Gene Id

Gene Info:

Publications:

Kirchhofer et al., 2003, Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1., J. Biol. Chem.

Suzuki et al., 2004, Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase., J. Biol. Chem.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: ST14

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lee et al., 2005, Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells., Am. J. Physiol., Cell Physiol.

Lin et al., 1999, Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk., J. Biol. Chem.

HingoraniCasas: ENSG00000149418
- Version: 31-May-2017
Alternate Names:

ENSG00000149418 Gene Symbol

ST14 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: ST14
- Version: 19.3
Alternate Names:

ENSG00000149418 Ensembl Gene ID

HAI Human Protein Atlas Gene Synonym

MT-SP1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
dGene: ST14
- Version: 27-Jun-2013
Alternate Names:

6768 Gene ID

HAI dGene Synonym

MT-SP1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Suppressor of tumorigenicity 14 protein
- Version: 2020.06.01
Alternate Names:

ST14 TTD Gene Abbreviation

T31543 TTD Target ID

Gene Info:

Publications:

ST14	Display Id
ENSG00000149418	Ensembl Gene Id
SUPPRESSOR OF TUMORIGENICITY 14 (EC 3.4.21.-) (MATRIPTASE) (MEMBRANE- TYPE SERINE PROTEASE 1) (MT-SP1) (PROSTAMIN) (SERINE PROTEASE TADG-15) (TUMOR ASSOCIATED DIFFERENTIALLY-EXPRESSED GENE-15 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y6]	Description

ST14_HUMAN	Uniprot Id
Q9Y5Y6	Uniprot Accession
ST14	Uniprot Gene Name

11344	HUGO Gene ID
11344	HUGO Gene Symbol
ST14 transmembrane serine protease matriptase	HUGO Gene Name

ST14	DrugBank Gene Name
Q9Y5Y6	UniProt Accession
6768	Entrez Gene Id

ENSG00000149418	Ensembl Gene ID
HAI	Human Protein Atlas Gene Synonym
MT-SP1	Human Protein Atlas Gene Synonym

ST14 Gene Record

ST14 6768 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CAMOSTAT ST14

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22038264

Sources: DrugBank

UROKINASE ST14

Interaction Types & Directionality: substrate

Interaction Info:

PMIDs: 12815039 14747469

Sources: DrugBank

BENZAMIDINE ST14

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

SURAMIN ST14

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15590895

Sources: NCI

Ensembl: ENSG00000149418

Alternate Names: ST14 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000149418

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q9Y5Y6

Alternate Names: ST14_HUMAN Uniprot Id Q9Y5Y6 Uniprot Accession ST14 Uniprot Gene Name

Gene Info: Human Readable Name PROTEASE Interpro Short Name Peptidase_S1_S6 Uniprot Status Swiss-Prot

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6768

Alternate Names: 11344 HUGO Gene ID 11344 HUGO Gene Symbol ST14 transmembrane serine protease matriptase HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name S1: Chymotrypsin GuideToPharmacology Gene Category ID 751

Gene Categories: ENZYME

Publications:

DrugBank: BE0001656

Alternate Names: ST14 DrugBank Gene Name Q9Y5Y6 UniProt Accession 6768 Entrez Gene Id

Gene Info:

NCI: ST14

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000149418

Alternate Names: ENSG00000149418 Gene Symbol ST14 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: ST14

Alternate Names: ENSG00000149418 Ensembl Gene ID HAI Human Protein Atlas Gene Synonym MT-SP1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

dGene: ST14

Alternate Names: 6768 Gene ID HAI dGene Synonym MT-SP1 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

TTD: Suppressor of tumorigenicity 14 protein

Alternate Names: ST14 TTD Gene Abbreviation T31543 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22038264

Sources:
DrugBank

Interaction Types & Directionality:

substrate

PMIDs:
12815039 14747469

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15590895

Sources:
NCI

Alternate Names:

ST14 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ST14_HUMAN Uniprot Id

Q9Y5Y6 Uniprot Accession

ST14 Uniprot Gene Name

Gene Info:

Human Readable Name PROTEASE

Interpro Short Name Peptidase_S1_S6

Uniprot Status Swiss-Prot

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

11344 HUGO Gene ID

11344 HUGO Gene Symbol

ST14 transmembrane serine protease matriptase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name S1: Chymotrypsin

GuideToPharmacology Gene Category ID 751

Gene Categories:

ENZYME

Alternate Names:

ST14 DrugBank Gene Name

Q9Y5Y6 UniProt Accession

6768 Entrez Gene Id

Alternate Names:

ENSG00000149418 Gene Symbol

ST14 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000149418 Ensembl Gene ID

HAI Human Protein Atlas Gene Synonym

MT-SP1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

6768 Gene ID

HAI dGene Synonym

MT-SP1 dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

ST14 TTD Gene Abbreviation

T31543 TTD Target ID