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ST14 Gene Record

  • Summary
  • Interactions
  • Claims
  • ST14 6768 Druggable Genome

    Alternate Names:

    6768
    SUPPRESSION OF TUMORIGENICITY 14
    ST14
    ARCI11
    HAI
    MT-SP1
    MTSP1
    PRSS14
    SNC19
    TADG15
    TMPRSS14
    606797
    11344
    ENSG00000149418
    OTTHUMG00000165768
    2418
    NM_021978
    NP_068813
    Q9Y5Y6
    SUPPRESSOR OF TUMORIGENICITY 14 (EC 3.4.21.-) (MATRIPTASE) (MEMBRANE- TYPE SERINE PROTEASE 1) (MT-SP1) (PROSTAMIN) (SERINE PROTEASE TADG-15) (TUMOR ASSOCIATED DIFFERENTIALLY-EXPRESSED GENE-15 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y6]
    BE0001656
    ST14_HUMAN
    SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN
    T31543
    ST14 transmembrane serine protease matriptase

    Gene Info:

    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name PROTEASE
    Interpro Short Name Peptidase_S1_S6
    Uniprot Status Swiss-Prot
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001254
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Lee et al., 2005, Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells., Am. J. Physiol., Cell Physiol.
    Kirchhofer et al., 2003, Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1., J. Biol. Chem.
    Suzuki et al., 2004, Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase., J. Biol. Chem.
    Kitamura K et al., 2012, Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension., Clin Exp Nephrol
  • CAMOSTAT   ST14

    Interaction Score: 5.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22038264


    Sources:
    DrugBank

  • UROKINASE   ST14

    Interaction Score: 4.26

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    12815039 14747469


    Sources:
    DrugBank

  • BENZAMIDINE   ST14

    Interaction Score: 4.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • SURAMIN   ST14

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15590895


    Sources:
    NCI

  • Ensembl: ENSG00000149418

    • Version: 101_38

    Alternate Names:
    ST14 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000149418

    • Version: 26-July-2011

    Alternate Names:
    ST14 Display Id
    ENSG00000149418 Ensembl Gene Id
    SUPPRESSOR OF TUMORIGENICITY 14 (EC 3.4.21.-) (MATRIPTASE) (MEMBRANE- TYPE SERINE PROTEASE 1) (MT-SP1) (PROSTAMIN) (SERINE PROTEASE TADG-15) (TUMOR ASSOCIATED DIFFERENTIALLY-EXPRESSED GENE-15 PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y6] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q9Y5Y6

    • Version: 11-September-2012

    Alternate Names:
    ST14_HUMAN Uniprot Id
    Q9Y5Y6 Uniprot Accession
    ST14 Uniprot Gene Name

    Gene Info:
    Human Readable Name PROTEASE
    Interpro Short Name Peptidase_S1_S6
    Uniprot Status Swiss-Prot

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 6768

    • Version: 29-September-2020

    Alternate Names:
    11344 HUGO Gene ID
    11344 HUGO Gene Symbol
    ST14 transmembrane serine protease matriptase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0001656

    • Version: 5.1.7

    Alternate Names:
    ST14 DrugBank Gene Name
    Q9Y5Y6 UniProt Accession
    6768 Entrez Gene Id

    Gene Info:

    Publications:
    Kirchhofer et al., 2003, Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1., J. Biol. Chem.
    Suzuki et al., 2004, Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase., J. Biol. Chem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • NCI: ST14

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lee et al., 2005, Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells., Am. J. Physiol., Cell Physiol.
    Lin et al., 1999, Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk., J. Biol. Chem.

  • HingoraniCasas: ENSG00000149418

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000149418 Gene Symbol
    ST14 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: ST14

    • Version: 19.3

    Alternate Names:
    ENSG00000149418 Ensembl Gene ID
    HAI Human Protein Atlas Gene Synonym
    MT-SP1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: ST14

    • Version: 27-Jun-2013

    Alternate Names:
    6768 Gene ID
    HAI dGene Synonym
    MT-SP1 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Suppressor of tumorigenicity 14 protein

    • Version: 2020.06.01

    Alternate Names:
    ST14 TTD Gene Abbreviation
    T31543 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21