DGIdb - STAT3 Gene Record

STAT3 6774 Druggable GenomeClinically Actionable

Alternate Names:

6774
SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
STAT3
ADMIO
ADMIO1
APRF
HIES
102582
11364
ENSG00000168610
OTTHUMG00000150645
P40763
PA337
T29130

Gene Info:

Target Class	Miscellaneous
Target Subclass	Transcription factor
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
TUMOR SUPPRESSOR
KINASE
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Li H et al., 2011, Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3)., J Med Chem
Ioannidis et al., 2011, Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway., J. Med. Chem.
Hou S et al., 2014, Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6., J Med Chem
Ai Y et al., 2015, Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer., J Med Chem
Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem
Nakashima S et al., 2010, Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells., Bioorg Med Chem Lett
Miklossy G et al., 2015, Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma., J Med Chem
Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem
Bhasin D et al., 2008, Design, synthesis, and studies of small molecule STAT3 inhibitors., Bioorg Med Chem Lett
Kim J et al., 2011, Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell., Bioorg Med Chem

COSMOMYCIN C STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071520

Sources:
DTC
CHEMBL2062868 STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26331426

Sources:
DTC
CHEMBL2062869 STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26331426

Sources:
DTC
OCHROMYCINONE STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18006313

Sources:
DTC
CUCURBITACIN E STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20347305

Sources:
DTC
CHEMBL2062863 STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26331426

Sources:
DTC
CHEMBL2062862 STAT3

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26331426

Sources:
DTC
GOLOTIMOD STAT3

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ATIPRIMOD STAT3

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1687979 STAT3

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-1480 STAT3

Interaction Score: 1.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21138246 24978112

Sources:
DTC
CHEMBL530664 STAT3

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CUCURBITACIN B STAT3

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20347305

Sources:
DTC
CIGLITAZONE STAT3

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20170185

Sources:
DTC
BARDOXOLONE METHYL STAT3

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25675144

Sources:
DTC
PYRIMETHAMINE STAT3

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25984755

Sources:
DTC
CHEMBL578504 STAT3

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OUABAIN STAT3

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN STAT3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIGITOXIN STAT3

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NICLOSAMIDE STAT3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB STAT3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21678971

Sources:
DTC
DIGOXIN STAT3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000168610
- Version: 101_38
Alternate Names:

STAT3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P40763
- Version: January-2014
Alternate Names:

STAT3 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Transcription factor

Publications:
PharmGKB: STAT3
- Version: 18-August-2020
Alternate Names:

PA337 PharmGKB ID

Gene Info:

Publications:

Ito N et al., 2007, STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma., J Clin Oncol
NCI: STAT3
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Mackey et al., 2004, CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes., J. Biol. Chem.

DTC: STAT3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bhasin D et al., 2008, Design, synthesis, and studies of small molecule STAT3 inhibitors., Bioorg Med Chem Lett

Miklossy G et al., 2015, Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma., J Med Chem

Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem

HingoraniCasas: ENSG00000168610
- Version: 31-May-2017
Alternate Names:

ENSG00000168610 Gene Symbol

STAT3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: STAT3
- Version: 12-May-2016
Alternate Names:

STAT3 Gene Symbol

Gene Info:

Publications:
GO: STAT3
- Version: 01-February-2022
Alternate Names:

APRF GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, NUCLEAR HORMONE RECEPTOR

Publications:
Tempus: STAT3
- Version: 11-November-2018
Alternate Names:

STAT3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Signal transducer and activator of transcription 3
- Version: 2020.06.01
Alternate Names:

STAT3 TTD Gene Abbreviation

T29130 TTD Target ID

Gene Info:

Publications:
Pharos: STAT3
- Version: 01-February-2022
Alternate Names:

Signal transducer and activator of transcription 3 Gene Name

P40763 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
FoundationOneGenes: STAT3
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: STAT3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: STAT3
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Signal transducer and activator of transcription 3	Gene Name
P40763	UniProt ID

STAT3 Gene Record

STAT3 6774 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22071520

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26331426

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26331426

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18006313

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20347305

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26331426

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26331426

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21138246 24978112

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20347305

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20170185

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25675144

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25984755

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22071520

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26331426

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26331426

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18006313

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20347305

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26331426

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26331426

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21138246 24978112

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20347305

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20170185

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25675144

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25984755

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21678971

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

STAT3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

STAT3 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Transcription factor

Alternate Names:

PA337 PharmGKB ID

Publications:

Ito N et al., 2007, STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma., J Clin Oncol

Publications:

Mackey et al., 2004, CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes., J. Biol. Chem.

Alternate Names:

ENSG00000168610 Gene Symbol

STAT3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

STAT3 Gene Symbol