• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

STAT3 Gene Record

  • Summary
  • Interactions
  • Claims
  • STAT3 6774 Druggable GenomeClinically Actionable

    Alternate Names:

    6774
    SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
    STAT3
    ADMIO
    ADMIO1
    APRF
    HIES
    102582
    11364
    ENSG00000168610
    OTTHUMG00000150645
    P40763
    PA337
    T29130

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Transcription factor
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    TUMOR SUPPRESSOR
    KINASE
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Li H et al., 2011, Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3)., J Med Chem
    Ioannidis et al., 2011, Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway., J. Med. Chem.
    Hou S et al., 2014, Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6., J Med Chem
    Ai Y et al., 2015, Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer., J Med Chem
    Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem
    Nakashima S et al., 2010, Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells., Bioorg Med Chem Lett
    Miklossy G et al., 2015, Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma., J Med Chem
    Tropak MB et al., 2015, Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity., J Med Chem
    Bhasin D et al., 2008, Design, synthesis, and studies of small molecule STAT3 inhibitors., Bioorg Med Chem Lett
    Kim J et al., 2011, Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell., Bioorg Med Chem
  • COSMOMYCIN C   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22071520


    Sources:
    DTC

  • CHEMBL2062868   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26331426


    Sources:
    DTC

  • CHEMBL2062869   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26331426


    Sources:
    DTC

  • OCHROMYCINONE   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18006313


    Sources:
    DTC

  • CUCURBITACIN E   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20347305


    Sources:
    DTC

  • CHEMBL2062863   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26331426


    Sources:
    DTC

  • CHEMBL2062862   STAT3

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26331426


    Sources:
    DTC

  • GOLOTIMOD   STAT3

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ATIPRIMOD   STAT3

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL1687979   STAT3

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-1480   STAT3

    Interaction Score: 1.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21138246 24978112


    Sources:
    DTC

  • CHEMBL530664   STAT3

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CUCURBITACIN B   STAT3

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20347305


    Sources:
    DTC

  • CIGLITAZONE   STAT3

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20170185


    Sources:
    DTC

  • BARDOXOLONE METHYL   STAT3

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25675144


    Sources:
    DTC

  • PYRIMETHAMINE   STAT3

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25984755


    Sources:
    DTC

  • CHEMBL578504   STAT3

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OUABAIN   STAT3

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ACITRETIN   STAT3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIGITOXIN   STAT3

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NICLOSAMIDE   STAT3

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CELECOXIB   STAT3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21678971


    Sources:
    DTC

  • DIGOXIN   STAT3

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000168610

    • Version: 101_38

    Alternate Names:
    STAT3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P40763

    • Version: January-2014

    Alternate Names:
    STAT3 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Transcription factor

    Publications:

  • PharmGKB: STAT3

    • Version: 18-August-2020

    Alternate Names:
    PA337 PharmGKB ID

    Gene Info:

    Publications:
    Ito N et al., 2007, STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma., J Clin Oncol

  • NCI: STAT3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Mackey et al., 2004, CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes., J. Biol. Chem.

  • DTC: STAT3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bhasin D et al., 2008, Design, synthesis, and studies of small molecule STAT3 inhibitors., Bioorg Med Chem Lett
    Miklossy G et al., 2015, Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α-2 Expression, and Induce Antitumor Effects against Human Glioma., J Med Chem
    Guh JH et al., 2010, Development of novel adenosine monophosphate-activated protein kinase activators., J Med Chem

  • HingoraniCasas: ENSG00000168610

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000168610 Gene Symbol
    STAT3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: STAT3

    • Version: 12-May-2016

    Alternate Names:
    STAT3 Gene Symbol

    Gene Info:

    Publications:

  • GO: STAT3

    • Version: 01-February-2022

    Alternate Names:
    APRF GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, NUCLEAR HORMONE RECEPTOR

    Publications:

  • Tempus: STAT3

    • Version: 11-November-2018

    Alternate Names:
    STAT3 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Signal transducer and activator of transcription 3

    • Version: 2020.06.01

    Alternate Names:
    STAT3 TTD Gene Abbreviation
    T29130 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: STAT3

    • Version: 01-February-2022

    Alternate Names:
    Signal transducer and activator of transcription 3 Gene Name
    P40763 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • FoundationOneGenes: STAT3

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: STAT3

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: STAT3

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21