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STAT5B Gene Record

  • Summary
  • Interactions
  • Claims
  • STAT5B 6777 Druggable GenomeClinically Actionable

    Alternate Names:

    6777
    SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
    STAT5B
    STAT5
    604260
    11367
    ENSG00000173757
    OTTHUMG00000150724
    P51692
    STA5B_HUMAN
    GHISID2

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Transcription factor
    Target Main Class Other
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Fiskus et al., 2006, Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells., Clin. Cancer Res.
    Nam et al., 2007, Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells., Mol. Cancer Ther.
    Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.
    Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science
  • TOFACITINIB   STAT5B

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14593182


    Sources:
    DTC

  • EPOETIN ALFA   STAT5B

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9195960


    Sources:
    NCI

  • DASATINIB   STAT5B

    Interaction Score: 1.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name dasatinib, BMS-354825,Sprycel
    Novel drug target Established target

    PMIDs:
    17020995 17431118


    Sources:
    TdgClinicalTrial TEND

  • Ensembl: ENSG00000173757

    • Version: 101_38

    Alternate Names:
    STAT5B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P51692

    • Version: 01-August-2011

    Alternate Names:
    6777 Entrez Gene Id
    STAT5B Gene Symbol
    ENSG00000173757 Ensembl Gene Id

    Gene Info:
    Target Subclass Transcription factor
    Target Main Class Other

    Publications:

  • TdgClinicalTrial: P51692

    • Version: January-2014

    Alternate Names:
    STAT5B Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Transcription factor

    Publications:

  • NCI: STAT5B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ortiz et al., 2000, Comparison of STAT5 mRNA levels in GH-treated male and female rats analysed by a solution hybridization assay., Growth Horm. IGF Res.
    Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.

  • DTC: STAT5B

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science

  • HingoraniCasas: ENSG00000173757

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000173757 Gene Symbol
    STAT5B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: STAT5B

    • Version: 11-November-2018

    Alternate Names:
    STAT5B Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: STAT5B

    • Version: 01-February-2022

    Alternate Names:
    Signal transducer and activator of transcription 5B Gene Name
    P51692 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • FoundationOneGenes: STAT5B

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: STAT5B

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21