DGIdb - STAT5B Gene Record

STAT5B 6777 Druggable GenomeClinically Actionable

Alternate Names:

6777
SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5B
STAT5B
STAT5
604260
11367
ENSG00000173757
OTTHUMG00000150724
P51692
BE0000891
STA5B_HUMAN

Gene Info:

Target Class	Miscellaneous
Target Subclass	Transcription factor
Target Main Class	Other
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Nam et al., 2007, Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells., Mol. Cancer Ther.
Fiskus et al., 2006, Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells., Clin. Cancer Res.
Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.
Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science

TOFACITINIB STAT5B

Interaction Score: 4.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14593182

Sources:
DTC
EPOETIN ALFA STAT5B

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9195960

Sources:
NCI
DASATINIB STAT5B

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name dasatinib, BMS-354825,Sprycel

Novel drug target Established target

PMIDs:
17431118 17020995

Sources:
TEND TdgClinicalTrial DrugBank

Ensembl: ENSG00000173757
- Version: 101_38
Alternate Names:

STAT5B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P51692
- Version: 01-August-2011
Alternate Names:

6777 Entrez Gene Id

STAT5B Gene Symbol

ENSG00000173757 Ensembl Gene Id

Gene Info:

Target Subclass Transcription factor

Target Main Class Other

Publications:
TdgClinicalTrial: P51692
- Version: January-2014
Alternate Names:

STAT5B Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Transcription factor

Publications:

DrugBank: BE0000891

Version: 5.1.7

Alternate Names:

STAT5B DrugBank Gene Name

P51692 UniProt Accession

6777 Entrez Gene Id

Gene Info:

Publications:

Nam et al., 2007, Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells., Mol. Cancer Ther.

Fiskus et al., 2006, Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells., Clin. Cancer Res.

NCI: STAT5B

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ortiz et al., 2000, Comparison of STAT5 mRNA levels in GH-treated male and female rats analysed by a solution hybridization assay., Growth Horm. IGF Res.

Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.

DTC: STAT5B
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science
HingoraniCasas: ENSG00000173757
- Version: 31-May-2017
Alternate Names:

ENSG00000173757 Gene Symbol

STAT5B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: STAT5B
- Version: 03-September-2020
Alternate Names:

Signal transducer and activator of transcription 5B Gene Name

P51692 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
Tempus: STAT5B
- Version: 11-November-2018
Alternate Names:

STAT5B Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: STAT5B
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: STAT5B
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Trial Name	dasatinib, BMS-354825,Sprycel
Novel drug target	Established target

6777	Entrez Gene Id
STAT5B	Gene Symbol
ENSG00000173757	Ensembl Gene Id

STAT5B	DrugBank Gene Name
P51692	UniProt Accession
6777	Entrez Gene Id

Signal transducer and activator of transcription 5B	Gene Name
P51692	UniProt ID

STAT5B Gene Record

STAT5B 6777 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TOFACITINIB STAT5B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14593182

Sources: DTC

EPOETIN ALFA STAT5B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9195960

Sources: NCI

DASATINIB STAT5B

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name dasatinib, BMS-354825,Sprycel Novel drug target Established target

PMIDs: 17431118 17020995

Sources: TEND TdgClinicalTrial DrugBank

Ensembl: ENSG00000173757

Alternate Names: STAT5B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P51692

Alternate Names: 6777 Entrez Gene Id STAT5B Gene Symbol ENSG00000173757 Ensembl Gene Id

Gene Info: Target Subclass Transcription factor Target Main Class Other

Publications:

TdgClinicalTrial: P51692

Alternate Names: STAT5B Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Transcription factor

Publications:

DrugBank: BE0000891

Alternate Names: STAT5B DrugBank Gene Name P51692 UniProt Accession 6777 Entrez Gene Id

Gene Info:

NCI: STAT5B

Alternate Names:

Gene Info:

Publications: Ortiz et al., 2000, Comparison of STAT5 mRNA levels in GH-treated male and female rats analysed by a solution hybridization assay., Growth Horm. IGF Res. Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.

DTC: STAT5B

Alternate Names:

Gene Info:

Publications: Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science

HingoraniCasas: ENSG00000173757

Alternate Names: ENSG00000173757 Gene Symbol STAT5B Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: STAT5B

Alternate Names: Signal transducer and activator of transcription 5B Gene Name P51692 UniProt ID

Gene Info:

Gene Categories: KINASE, TRANSCRIPTION FACTOR

Publications:

Tempus: STAT5B

Alternate Names: STAT5B Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: STAT5B

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: STAT5B

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
14593182

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9195960

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name dasatinib, BMS-354825,Sprycel

Novel drug target Established target

PMIDs:
17431118 17020995

Sources:
TEND TdgClinicalTrial DrugBank

Alternate Names:

STAT5B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

6777 Entrez Gene Id

STAT5B Gene Symbol

ENSG00000173757 Ensembl Gene Id

Gene Info:

Target Subclass Transcription factor

Target Main Class Other

Alternate Names:

STAT5B Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Transcription factor

Alternate Names:

STAT5B DrugBank Gene Name

P51692 UniProt Accession

6777 Entrez Gene Id

Publications:

Ortiz et al., 2000, Comparison of STAT5 mRNA levels in GH-treated male and female rats analysed by a solution hybridization assay., Growth Horm. IGF Res.

Kirito et al., 1997, A distinct function of STAT proteins in erythropoietin signal transduction., J. Biol. Chem.

Publications:

Changelian PS et al., 2003, Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor., Science

Alternate Names:

ENSG00000173757 Gene Symbol

STAT5B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Signal transducer and activator of transcription 5B Gene Name

P51692 UniProt ID

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Alternate Names:

STAT5B Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE