DGIdb - STS Gene Record

STS 412 Druggable Genome

Alternate Names:

412
STEROID SULFATASE
STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
300747
11425
ENSG00000101846
OTTHUMG00000021102
Steryl-sulfatase
Arylsulfatase C
Steryl-sulfate sulfohydrolase
STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842]
P08842
BE0001197
STS_HUMAN
T33489

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:3.1.6
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Sulfatase
Interpro Type	Domain
Interpro Short Name	Sulfatase
Interpro Acc	IPR000917
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Mestdagh et al., 1992, Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions., Biochem. Pharmacol.
Prost-Avallet et al., 1991, In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma., J. Steroid Biochem. Mol. Biol.
Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem
Purohit A et al., 2000, In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE., Cancer Res
Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi
Chetrite et al., 1995, Effect of Decapeptyl (a GnRH analogue) and of transforming growth factor-alpha (TGF-alpha), in the presence of heparin, on the sulfatase activity of human breast cancer cells., J. Steroid Biochem. Mol. Biol.

CHEMBL1627429 STS

Interaction Score: 12.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21782294

Sources:
DTC
CHEMBL1823787 STS

Interaction Score: 12.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21782294

Sources:
DTC
IROSUSTAT STS

Interaction Score: 9.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steryl-sulfatase inhibitor

PMIDs:
10910045

Sources:
DrugBank ChemblInteractions
TRIPTORELIN STS

Interaction Score: 6.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7748810

Sources:
NCI
PENICILLAMINE STS

Interaction Score: 1.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1567476

Sources:
NCI
ESTRONE STS

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6581863 2796962

Sources:
NCI
DANAZOL STS

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1751397

Sources:
NCI
TRANILAST STS

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PROGESTERONE STS

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1751397

Sources:
NCI

Ensembl: ENSG00000101846
- Version: 101_38
Alternate Names:

STS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P08842
- Version: 11-September-2012
Alternate Names:

412 Entrez Gene Id

STS_HUMAN Uniprot Id

STERYL-SULFATASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Sulfatase

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000101846

Version: 26-July-2011

Alternate Names:

ENSG00000101846 Ensembl Gene Id

STS Display Id

STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P08842
- Version: January-2014
Alternate Names:

STS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.6

Publications:

DrugBank: BE0001197

Version: 5.1.7

Alternate Names:

STS DrugBank Gene Name

P08842 UniProt Accession

412 Entrez Gene Id

Gene Info:

Publications:

Purohit A et al., 2000, In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE., Cancer Res

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

NCI: STS

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Walter et al., 2004, Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells., Arch. Pharm. (Weinheim)

Santner et al., 1993, Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens., J. Steroid Biochem. Mol. Biol.

Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.

DTC: STS
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem
HingoraniCasas: ENSG00000101846
- Version: 31-May-2017
Alternate Names:

ENSG00000101846 Gene Symbol

STS Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ARSC1
- Version: chembl_23
Alternate Names:

ARSC1 GENE_SYMBOL

STS GENE_SYMBOL

Steryl-sulfatase UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: STS
- Version: 19.3
Alternate Names:

ENSG00000101846 Ensembl Gene ID

ARSC Human Protein Atlas Gene Synonym

ARSC1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Steryl-sulfatase
- Version: 2020.06.01
Alternate Names:

STS TTD Gene Abbreviation

T33489 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Steryl-sulfatase inhibitor

412	Entrez Gene Id
STS_HUMAN	Uniprot Id
STERYL-SULFATASE	Uniprot Protein Name

ENSG00000101846	Ensembl Gene Id
STS	Display Id
STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842]	Description

STS	DrugBank Gene Name
P08842	UniProt Accession
412	Entrez Gene Id

STS Gene Record

STS 412 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21782294

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21782294

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Steryl-sulfatase inhibitor

PMIDs: 10910045

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7748810

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1567476

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6581863 2796962

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1751397

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1751397

Sources: NCI

Ensembl: ENSG00000101846

Alternate Names: STS Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P08842

Alternate Names: 412 Entrez Gene Id STS_HUMAN Uniprot Id STERYL-SULFATASE Uniprot Protein Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Name Sulfatase Interpro Type Domain

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000101846

Alternate Names: ENSG00000101846 Ensembl Gene Id STS Display Id STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P08842

Alternate Names: STS Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.1.6

Publications:

DrugBank: BE0001197

Alternate Names: STS DrugBank Gene Name P08842 UniProt Accession 412 Entrez Gene Id

Gene Info:

NCI: STS

Alternate Names:

Gene Info:

DTC: STS

Alternate Names:

Gene Info:

Publications: Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem

HingoraniCasas: ENSG00000101846

Alternate Names: ENSG00000101846 Gene Symbol STS Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ARSC1

Alternate Names: ARSC1 GENE_SYMBOL STS GENE_SYMBOL Steryl-sulfatase UNIPROT

Gene Info:

Publications:

HumanProteinAtlas: STS

Interaction Types & Directionality:

n/a

PMIDs:
21782294

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21782294

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steryl-sulfatase inhibitor

PMIDs:
10910045

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
7748810

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1567476

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6581863 2796962

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1751397

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
1751397

Sources:
NCI

Alternate Names:

STS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

412 Entrez Gene Id

STS_HUMAN Uniprot Id

STERYL-SULFATASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Sulfatase

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000101846 Ensembl Gene Id

STS Display Id

STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

STS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.6

Alternate Names:

STS DrugBank Gene Name

P08842 UniProt Accession

412 Entrez Gene Id

Publications:

Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem

Alternate Names:

ENSG00000101846 Gene Symbol

STS Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ARSC1 GENE_SYMBOL

STS GENE_SYMBOL

Steryl-sulfatase UNIPROT

Alternate Names:

ENSG00000101846 Ensembl Gene ID

ARSC Human Protein Atlas Gene Synonym

ARSC1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

STS TTD Gene Abbreviation

T33489 TTD Target ID