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STS Gene Record

  • Summary
  • Interactions
  • Claims
  • STS 412 Druggable Genome

    Alternate Names:

    412
    STEROID SULFATASE
    STS
    ARSC
    ARSC1
    ASC
    ES
    SSDD
    XLI
    300747
    11425
    ENSG00000101846
    OTTHUMG00000021102
    Steryl-sulfatase
    Arylsulfatase C
    Steryl-sulfate sulfohydrolase
    STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842]
    P08842
    STS_HUMAN
    T33489

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:3.1.6
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Sulfatase
    Interpro Type Domain
    Interpro Short Name Sulfatase
    Interpro Acc IPR000917
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Mestdagh et al., 1992, Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions., Biochem. Pharmacol.
    Prost-Avallet et al., 1991, In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma., J. Steroid Biochem. Mol. Biol.
    Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem
    Purohit A et al., 2000, In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE., Cancer Res
    Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
    Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi
    Chetrite et al., 1995, Effect of Decapeptyl (a GnRH analogue) and of transforming growth factor-alpha (TGF-alpha), in the presence of heparin, on the sulfatase activity of human breast cancer cells., J. Steroid Biochem. Mol. Biol.
  • CHEMBL1627429   STS

    Interaction Score: 13.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21782294


    Sources:
    DTC

  • IROSUSTAT   STS

    Interaction Score: 13.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Steryl-sulfatase inhibitor

    PMIDs:
    10910045


    Sources:
    ChemblInteractions

  • CHEMBL1823787   STS

    Interaction Score: 13.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21782294


    Sources:
    DTC

  • TRIPTORELIN   STS

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7748810


    Sources:
    NCI

  • ESTRONE   STS

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6581863 2796962


    Sources:
    NCI

  • PENICILLAMINE   STS

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1567476


    Sources:
    NCI

  • DANAZOL   STS

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1751397


    Sources:
    NCI

  • TRANILAST   STS

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PROGESTERONE   STS

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1751397


    Sources:
    NCI

  • Ensembl: ENSG00000101846

    • Version: 101_38

    Alternate Names:
    STS Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P08842

    • Version: 11-September-2012

    Alternate Names:
    412 Entrez Gene Id
    STS_HUMAN Uniprot Id
    STERYL-SULFATASE Uniprot Protein Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Sulfatase
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000101846

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000101846 Ensembl Gene Id
    STS Display Id
    STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P08842

    • Version: January-2014

    Alternate Names:
    STS Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.6

    Publications:

  • NCI: STS

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Walter et al., 2004, Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells., Arch. Pharm. (Weinheim)
    Santner et al., 1993, Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens., J. Steroid Biochem. Mol. Biol.
    Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.

  • DTC: STS

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem

  • HingoraniCasas: ENSG00000101846

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101846 Gene Symbol
    STS Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ARSC1

    • Version: chembl_23

    Alternate Names:
    ARSC1 GENE_SYMBOL
    STS GENE_SYMBOL
    Steryl-sulfatase UNIPROT

    Gene Info:

    Publications:

  • HumanProteinAtlas: STS

    • Version: 19.3

    Alternate Names:
    ENSG00000101846 Ensembl Gene ID
    ARSC Human Protein Atlas Gene Synonym
    ARSC1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Steryl-sulfatase

    • Version: 2020.06.01

    Alternate Names:
    STS TTD Gene Abbreviation
    T33489 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21