DGIdb - STS Gene Record

STS 412 Druggable Genome

Alternate Names:

412
STEROID SULFATASE
STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
300747
11425
ENSG00000101846
OTTHUMG00000021102
Steryl-sulfatase
Arylsulfatase C
Steryl-sulfate sulfohydrolase
STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842]
P08842
STS_HUMAN
T33489

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:3.1.6
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Sulfatase
Interpro Type	Domain
Interpro Short Name	Sulfatase
Interpro Acc	IPR000917
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Mestdagh et al., 1992, Effect of L-penicillamine hydantoin, an analogue of glutathione, on rat liver glutathione peroxidase, reductase and transferase reactions., Biochem. Pharmacol.
Prost-Avallet et al., 1991, In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma., J. Steroid Biochem. Mol. Biol.
Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem
Purohit A et al., 2000, In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE., Cancer Res
Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi
Chetrite et al., 1995, Effect of Decapeptyl (a GnRH analogue) and of transforming growth factor-alpha (TGF-alpha), in the presence of heparin, on the sulfatase activity of human breast cancer cells., J. Steroid Biochem. Mol. Biol.

CHEMBL1627429 STS

Interaction Score: 13.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21782294

Sources:
DTC
IROSUSTAT STS

Interaction Score: 13.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steryl-sulfatase inhibitor

PMIDs:
10910045

Sources:
ChemblInteractions
CHEMBL1823787 STS

Interaction Score: 13.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21782294

Sources:
DTC
TRIPTORELIN STS

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7748810

Sources:
NCI
ESTRONE STS

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6581863 2796962

Sources:
NCI
PENICILLAMINE STS

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1567476

Sources:
NCI
DANAZOL STS

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1751397

Sources:
NCI
TRANILAST STS

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PROGESTERONE STS

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1751397

Sources:
NCI

Ensembl: ENSG00000101846
- Version: 101_38
Alternate Names:

STS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P08842
- Version: 11-September-2012
Alternate Names:

412 Entrez Gene Id

STS_HUMAN Uniprot Id

STERYL-SULFATASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Sulfatase

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000101846

Version: 26-July-2011

Alternate Names:

ENSG00000101846 Ensembl Gene Id

STS Display Id

STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P08842
- Version: January-2014
Alternate Names:

STS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.6

Publications:

NCI: STS

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Walter et al., 2004, Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells., Arch. Pharm. (Weinheim)

Santner et al., 1993, Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens., J. Steroid Biochem. Mol. Biol.

Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.

DTC: STS
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem
HingoraniCasas: ENSG00000101846
- Version: 31-May-2017
Alternate Names:

ENSG00000101846 Gene Symbol

STS Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ARSC1
- Version: chembl_23
Alternate Names:

ARSC1 GENE_SYMBOL

STS GENE_SYMBOL

Steryl-sulfatase UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: STS
- Version: 19.3
Alternate Names:

ENSG00000101846 Ensembl Gene ID

ARSC Human Protein Atlas Gene Synonym

ARSC1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Steryl-sulfatase
- Version: 2020.06.01
Alternate Names:

STS TTD Gene Abbreviation

T33489 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Steryl-sulfatase inhibitor

412	Entrez Gene Id
STS_HUMAN	Uniprot Id
STERYL-SULFATASE	Uniprot Protein Name

ENSG00000101846	Ensembl Gene Id
STS	Display Id
STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842]	Description

STS Gene Record

STS 412 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21782294

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Steryl-sulfatase inhibitor

PMIDs: 10910045

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21782294

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7748810

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6581863 2796962

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1567476

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1751397

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1751397

Sources: NCI

Ensembl: ENSG00000101846

Alternate Names: STS Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P08842

Alternate Names: 412 Entrez Gene Id STS_HUMAN Uniprot Id STERYL-SULFATASE Uniprot Protein Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Name Sulfatase Interpro Type Domain

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000101846

Alternate Names: ENSG00000101846 Ensembl Gene Id STS Display Id STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P08842

Alternate Names: STS Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.1.6

Publications:

NCI: STS

Alternate Names:

Gene Info:

DTC: STS

Alternate Names:

Gene Info:

Publications: Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem

HingoraniCasas: ENSG00000101846

Alternate Names: ENSG00000101846 Gene Symbol STS Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: ARSC1

Alternate Names: ARSC1 GENE_SYMBOL STS GENE_SYMBOL Steryl-sulfatase UNIPROT

Gene Info:

Publications:

HumanProteinAtlas: STS

Alternate Names: ENSG00000101846 Ensembl Gene ID ARSC Human Protein Atlas Gene Synonym ARSC1 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Interaction Types & Directionality:

n/a

PMIDs:
21782294

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Steryl-sulfatase inhibitor

PMIDs:
10910045

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21782294

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7748810

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6581863 2796962

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1567476

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1751397

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
1751397

Sources:
NCI

Alternate Names:

STS Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

412 Entrez Gene Id

STS_HUMAN Uniprot Id

STERYL-SULFATASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Sulfatase

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000101846 Ensembl Gene Id

STS Display Id

STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID SULFATASE) (STERYL- SULFATE SULFOHYDROLASE) (ARYLSULFATASE C) (ASC). [SOURCE:UNIPROT/SWISSPROT;ACC:P08842] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

STS Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.6

Publications:

Fournier D et al., 2011, Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase., Eur J Med Chem

Alternate Names:

ENSG00000101846 Gene Symbol

STS Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ARSC1 GENE_SYMBOL

STS GENE_SYMBOL

Steryl-sulfatase UNIPROT

Alternate Names:

ENSG00000101846 Ensembl Gene ID

ARSC Human Protein Atlas Gene Synonym

ARSC1 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

STS TTD Gene Abbreviation

T33489 TTD Target ID