DGIdb - TBXA2R Gene Record

TBXA2R 6915 Druggable GenomeDrug Resistance

Alternate Names:

6915
THROMBOXANE A2 RECEPTOR
TBXA2R
BDPLT13
TXA2-R
188070
11608
ENSG00000006638
OTTHUMG00000180806
P21731
PROSTANOID TP RECEPTOR
346
TP receptor
TA2R_HUMAN
THROMBOXANE A2 RECEPTOR (TXA2-R) (PROSTANOID TP RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P21731]
NP_001051
NM_001060
PA348
T76198

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
GuideToPharmacology Gene Category Name	Prostanoid receptors
GuideToPharmacology Gene Category ID	58
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Perico et al., 1992, Thromboxane receptor blockade attenuates chronic cyclosporine nephrotoxicity and improves survival in rats with renal isograft., J. Am. Soc. Nephrol.
Molimard et al., 1995, Furosemide inhibits bradykinin-induced contraction of human bronchi: role of thromboxane A2 receptor antagonism., Eur. J. Pharmacol.
Ragni et al., 1996, [Inactivated factor VII exercises a powerful antithrombotic activity in an experimental model of recurrent arterial thrombosis]., Cardiologia
Hempelmann et al., 1999, Threshold concentrations of endothelin-1: the effects on contractions induced by 5-hydroxytryptamine in isolated rat cerebral and mesenteric arteries., Pharmacol. Toxicol.
Heinisch et al., 1996, On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel., J. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Carvalho et al., 1997, The role of thromboxane A2 in the altered microvascular reactivity in two-kidney, one-clip hypertension., Endothelium
Soyka et al., 1994, 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors., J. Med. Chem.
Parmar et al., 1987, Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats., Arch Int Pharmacodyn Ther
Wang Z et al., 2013, Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting., Scand Cardiovasc J
Fujiwara T et al., 2007, Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity., Pharmacogenomics J
Kim SH et al., 2005, Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma., Clin Exp Allergy
Sheridan et al., 1996, Microtubules regulate pulmonary vascular smooth muscle contraction., J. Surg. Res.

RIDOGREL TBXA2R

Interaction Score: 21.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8697470 10522750 8831771 11752352 9272380 8289199

Sources:
TTD
TERUTROBAN TBXA2R

Interaction Score: 6.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Mechanism of Interaction Thromboxane A2 receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
ONO-3708 TBXA2R

Interaction Score: 3.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
DALTROBAN TBXA2R

Interaction Score: 3.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
VAPIPROST TBXA2R

Interaction Score: 3.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
IFETROBAN TBXA2R

Interaction Score: 3.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
DOMITROBAN TBXA2R

Interaction Score: 3.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL2448578 TBXA2R

Interaction Score: 3.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
RAMATROBAN TBXA2R

Interaction Score: 1.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD
FLUPROSTENOL TBXA2R

Interaction Score: 1.01

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
CLOPROSTENOL TBXA2R

Interaction Score: 0.61

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
FUROSEMIDE TBXA2R

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7589163

Sources:
NCI
LAROPIPRANT TBXA2R

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CARBACYCLIN TBXA2R

Interaction Score: 0.38

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPROST TBXA2R

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DINOPROSTONE TBXA2R

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology
ALPROSTADIL TBXA2R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VINBLASTINE TBXA2R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8632653

Sources:
NCI
MORPHINE TBXA2R

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3435201

Sources:
NCI
ASPIRIN TBXA2R

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23688183 17245331 15898979

Sources:
PharmGKB
CYCLOSPORINE TBXA2R

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1385733

Sources:
NCI

Ensembl: ENSG00000006638
- Version: 101_38
Alternate Names:

TBXA2R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P21731
- Version: 11-September-2012
Alternate Names:

TA2R_HUMAN Uniprot Id

ENSG00000006638 Ensembl Gene Id

TBXA2R Uniprot Gene Name

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000006638
- Version: 26-July-2011
Alternate Names:

TBXA2R Display Id

THROMBOXANE A2 RECEPTOR (TXA2-R) (PROSTANOID TP RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P21731] Description

ENSG00000006638 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 6915
- Version: 29-September-2020
Alternate Names:

11608 HUGO Gene ID

11608 HUGO Gene Symbol

thromboxane A2 receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Prostanoid receptors

GuideToPharmacology Gene Category ID 58

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

PharmGKB: TBXA2R

Version: 18-August-2020

Alternate Names:

PA348 PharmGKB ID

Gene Info:

Publications:

Kim SH et al., 2005, Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma., Clin Exp Allergy

Wang Z et al., 2013, Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting., Scand Cardiovasc J

Fujiwara T et al., 2007, Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity., Pharmacogenomics J

NCI: TBXA2R

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Perico et al., 1992, Thromboxane receptor blockade attenuates chronic cyclosporine nephrotoxicity and improves survival in rats with renal isograft., J. Am. Soc. Nephrol.

Molimard et al., 1995, Furosemide inhibits bradykinin-induced contraction of human bronchi: role of thromboxane A2 receptor antagonism., Eur. J. Pharmacol.

Parmar et al., 1987, Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats., Arch Int Pharmacodyn Ther

ChemblInteractions: TBXA2R
- Version: chembl_23
Alternate Names:

TBXA2R GENE_SYMBOL

Thromboxane A2 receptor UNIPROT

Prostanoid TP receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000006638
- Version: 31-May-2017
Alternate Names:

ENSG00000006638 Gene Symbol

TBXA2R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: TBXA2R
- Version: 27-Jun-2013
Alternate Names:

6915 Gene ID

BDPLT13 dGene Synonym

TXA2-R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Thromboxane A2 receptor
- Version: 2020.06.01
Alternate Names:

TBXA2R TTD Gene Abbreviation

T76198 TTD Target ID

Gene Info:

Publications:
GO: TBXA2R
- Version: 01-May-2021
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Mechanism of Interaction	Thromboxane A2 receptor antagonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

TA2R_HUMAN	Uniprot Id
ENSG00000006638	Ensembl Gene Id
TBXA2R	Uniprot Gene Name

TBXA2R	Display Id
THROMBOXANE A2 RECEPTOR (TXA2-R) (PROSTANOID TP RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P21731]	Description
ENSG00000006638	Ensembl Gene Id

11608	HUGO Gene ID
11608	HUGO Gene Symbol
thromboxane A2 receptor	HUGO Gene Name

TBXA2R	GENE_SYMBOL
Thromboxane A2 receptor	UNIPROT
Prostanoid TP receptor	UNIPROT

TBXA2R Gene Record

TBXA2R 6915 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 8697470 10522750 8831771 11752352 9272380 8289199

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Mechanism of Interaction Thromboxane A2 receptor antagonist

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Full agonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7589163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8632653

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
8697470 10522750 8831771 11752352 9272380 8289199

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Mechanism of Interaction Thromboxane A2 receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
7589163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8632653

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3435201

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23688183 17245331 15898979

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1385733

Sources:
NCI

Alternate Names:

TBXA2R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TA2R_HUMAN Uniprot Id

ENSG00000006638 Ensembl Gene Id

TBXA2R Uniprot Gene Name

Gene Info:

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level