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TBXA2R Gene Record

  • Summary
  • Interactions
  • Claims
  • TBXA2R 6915 Druggable Genome

    Alternate Names:

    6915
    THROMBOXANE A2 RECEPTOR
    TBXA2R
    BDPLT13
    TXA2-R
    188070
    11608
    ENSG00000006638
    OTTHUMG00000180806
    P21731
    PROSTANOID TP RECEPTOR
    TA2R_HUMAN
    THROMBOXANE A2 RECEPTOR (TXA2-R) (PROSTANOID TP RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P21731]
    PA348
    T76198

    Gene Info:

    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Perico et al., 1992, Thromboxane receptor blockade attenuates chronic cyclosporine nephrotoxicity and improves survival in rats with renal isograft., J. Am. Soc. Nephrol.
    Molimard et al., 1995, Furosemide inhibits bradykinin-induced contraction of human bronchi: role of thromboxane A2 receptor antagonism., Eur. J. Pharmacol.
    Ragni et al., 1996, [Inactivated factor VII exercises a powerful antithrombotic activity in an experimental model of recurrent arterial thrombosis]., Cardiologia
    Hempelmann et al., 1999, Threshold concentrations of endothelin-1: the effects on contractions induced by 5-hydroxytryptamine in isolated rat cerebral and mesenteric arteries., Pharmacol. Toxicol.
    Heinisch et al., 1996, On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel., J. Med. Chem.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Carvalho et al., 1997, The role of thromboxane A2 in the altered microvascular reactivity in two-kidney, one-clip hypertension., Endothelium
    Soyka et al., 1994, 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors., J. Med. Chem.
    Parmar et al., 1987, Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats., Arch Int Pharmacodyn Ther
    Wang Z et al., 2013, Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting., Scand Cardiovasc J
    Fujiwara T et al., 2007, Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity., Pharmacogenomics J
    Kim SH et al., 2005, Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma., Clin Exp Allergy
    Sheridan et al., 1996, Microtubules regulate pulmonary vascular smooth muscle contraction., J. Surg. Res.
  • RIDOGREL   TBXA2R

    Interaction Score: 43.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8697470 10522750 8831771 11752352 9272380 8289199


    Sources:
    TTD

  • TERUTROBAN   TBXA2R

    Interaction Score: 6.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thromboxane A2 receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RAMATROBAN   TBXA2R

    Interaction Score: 1.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FUROSEMIDE   TBXA2R

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7589163


    Sources:
    NCI

  • LAROPIPRANT   TBXA2R

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ALPROSTADIL   TBXA2R

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VINBLASTINE   TBXA2R

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8632653


    Sources:
    NCI

  • MORPHINE   TBXA2R

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3435201


    Sources:
    NCI

  • ASPIRIN   TBXA2R

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23688183 17245331 15898979


    Sources:
    PharmGKB

  • CYCLOSPORINE   TBXA2R

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1385733


    Sources:
    NCI

  • Ensembl: ENSG00000006638

    • Version: 101_38

    Alternate Names:
    TBXA2R Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P21731

    • Version: 11-September-2012

    Alternate Names:
    TA2R_HUMAN Uniprot Id
    ENSG00000006638 Ensembl Gene Id
    TBXA2R Uniprot Gene Name

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000006638

    • Version: 26-July-2011

    Alternate Names:
    TBXA2R Display Id
    THROMBOXANE A2 RECEPTOR (TXA2-R) (PROSTANOID TP RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P21731] Description
    ENSG00000006638 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: TBXA2R

    • Version: 18-August-2020

    Alternate Names:
    PA348 PharmGKB ID

    Gene Info:

    Publications:
    Kim SH et al., 2005, Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma., Clin Exp Allergy
    Wang Z et al., 2013, Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting., Scand Cardiovasc J
    Fujiwara T et al., 2007, Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity., Pharmacogenomics J

  • NCI: TBXA2R

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Perico et al., 1992, Thromboxane receptor blockade attenuates chronic cyclosporine nephrotoxicity and improves survival in rats with renal isograft., J. Am. Soc. Nephrol.
    Molimard et al., 1995, Furosemide inhibits bradykinin-induced contraction of human bronchi: role of thromboxane A2 receptor antagonism., Eur. J. Pharmacol.
    Parmar et al., 1987, Studies on the possible mechanism of morphine-induced potentiation of the gastroulcerogenic effect of indomethacin in rats., Arch Int Pharmacodyn Ther

  • ChemblInteractions: TBXA2R

    • Version: chembl_23

    Alternate Names:
    TBXA2R GENE_SYMBOL
    Thromboxane A2 receptor UNIPROT
    Prostanoid TP receptor UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000006638

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000006638 Gene Symbol
    TBXA2R Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: TBXA2R

    • Version: 27-Jun-2013

    Alternate Names:
    6915 Gene ID
    BDPLT13 dGene Synonym
    TXA2-R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Thromboxane A2 receptor

    • Version: 2020.06.01

    Alternate Names:
    TBXA2R TTD Gene Abbreviation
    T76198 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21