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TBXAS1 Gene Record

  • Summary
  • Interactions
  • Claims
  • TBXAS1 6916 Druggable Genome

    Alternate Names:

    6916
    THROMBOXANE A SYNTHASE 1
    TBXAS1
    BDPLT14
    CYP5
    CYP5A1
    GHOSAL
    THAS
    TS
    TXAS
    TXS
    274180
    11609
    ENSG00000059377
    OTTHUMG00000157302
    THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS). [SOURCE:UNIPROT/SWISSPROT;ACC:P24557]
    P24557
    THROMBOXANE-A SYNTHASE
    1353
    BE0001893
    PA349
    THAS_HUMAN
    T78356

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:5.3.99.5
    GuideToPharmacology Gene Category Name CYP5, CYP7 and CYP8 families
    GuideToPharmacology Gene Category ID 265
    Interpro Short Name Cyt_P450
    Interpro Acc IPR001128
    Interpro Type Family
    Human Readable Name CYTOCHROME P450
    Interpro Name Cytochrome P450
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Prostaglandin synthases
    GuideToPharmacology Gene Category ID 270
    (7 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CYTOCHROME P450
    ENZYME

    Publications:

    Oh SH et al., 2011, Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients., Pharmacogenomics
    1994, Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT)., Circulation
    Tytgat et al., 2002, Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies., Aliment. Pharmacol. Ther.
    De Cree et al., 1993, The effect of a combined administration of ridogrel and ketanserin in patients with intermittent claudication., Int Angiol
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Park et al., 1999, Endothelin-1 releases endothelium-derived endoperoxides and thromboxane A2 in porcine coronary arteries with regenerated endothelium., Zhongguo Yao Li Xue Bao
    Carty et al., 2000, Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease., Aliment. Pharmacol. Ther.
    Stenson et al., 1983, Inhibition of platelet thromboxane synthetase by sulfasalazine., Biochem. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • DAZOXIBEN   TBXAS1

    Interaction Score: 47.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10592235 11752352 17139284 17016423


    Sources:
    DrugBank

  • RIDOGREL   TBXAS1

    Interaction Score: 33.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8313547 11856082 8376914 10592235 11270983 10848666


    Sources:
    DrugBank

  • OZAGREL   TBXAS1

    Interaction Score: 9.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Inhibition of thromboxane A2 synthetase activity in human washed platelets.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PYRIDINE   TBXAS1

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SULFASALAZINE   TBXAS1

    Interaction Score: 0.65

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6135423


    Sources:
    DrugBank

  • ASPIRIN   TBXAS1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449675


    Sources:
    PharmGKB

  • Ensembl: ENSG00000059377

    • Version: 101_38

    Alternate Names:
    TBXAS1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000059377

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000059377 Ensembl Gene Id
    THROMBOXANE-A SYNTHASE (EC 5.3.99.5) (TXA SYNTHASE) (TXS). [SOURCE:UNIPROT/SWISSPROT;ACC:P24557] Description
    TBXAS1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P24557

    • Version: 11-September-2012

    Alternate Names:
    P24557 Uniprot Accession
    ENSG00000059377 Ensembl Gene Id
    TBXAS1 Uniprot Gene Name

    Gene Info:
    Interpro Short Name Cyt_P450
    Interpro Acc IPR001128
    Interpro Type Family

    Gene Categories:
    DRUGGABLE GENOME, CYTOCHROME P450

    Publications:

  • TdgClinicalTrial: P24557

    • Version: January-2014

    Alternate Names:
    TBXAS1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:5.3.99.5

    Publications:

  • GuideToPharmacology: 6916

    • Version: 29-September-2020

    Alternate Names:
    11609 HUGO Gene ID
    11609 HUGO Gene Symbol
    thromboxane A synthase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name CYP5, CYP7 and CYP8 families
    GuideToPharmacology Gene Category ID 265
    GuideToPharmacology Gene Category Name Prostaglandin synthases

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: TBXAS1

    • Version: 18-August-2020

    Alternate Names:
    PA349 PharmGKB ID

    Gene Info:

    Publications:
    Oh SH et al., 2011, Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients., Pharmacogenomics

  • DrugBank: BE0001893

    • Version: 5.1.7

    Alternate Names:
    TBXAS1 DrugBank Gene Name
    P24557 UniProt Accession
    6916 Entrez Gene Id

    Gene Info:

    Publications:
    Stenson et al., 1983, Inhibition of platelet thromboxane synthetase by sulfasalazine., Biochem. Pharmacol.
    1994, Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT)., Circulation
    Tytgat et al., 2002, Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies., Aliment. Pharmacol. Ther.

  • NCI: TBXAS1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Matijevic-Aleksic et al., 1995, Differential expression of thromboxane A synthase and prostaglandin H synthase in megakaryocytic cell line., Biochim. Biophys. Acta

  • HingoraniCasas: ENSG00000059377

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000059377 Gene Symbol
    TBXAS1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: TBXAS1

    • Version: 03-September-2020

    Alternate Names:
    Thromboxane-A synthase Gene Name
    P24557 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Thromboxane-A synthase

    • Version: 2020.06.01

    Alternate Names:
    TBXAS1 TTD Gene Abbreviation
    T78356 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21